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Assessment of CareStart G6PD rapid diagnostic test and CareStart G6PD biosensor in Mauritania

Infectious Diseases of Poverty 2021年第4期10卷 33-45页

作者： Oum Kelthoum mamadou djigo Yacoub Ould Khalef Mohamed Salem Ould Ahmedou Salem Nicolas Gomez Leonardo Basco Sebastien Briolant Ali Ould Mohamed Salem Boukhary Unite de Recherche"Genomes et Milieux"(Jeune Equipe Associee a I'lnstitut de Recherche pour le Developpement) Faculte des Sciences et lechniquesUniversite de Nouakchott Al-AasriyaNouakchottMauritania Service de Pediatrie Centre Hospitalier Mere et EnfantNouakchottMauritania IHU Mediterrande InfectionMarseilleFrance Aix Marseille Univ IRDAP-HMSSAVITROMEMarseilleFrance Unite de Parasitologie Entomologie Departement de Microbiologie et Maladies InfectieusesInstitut de Recherche Biomedicale des Armees(IRBA)MarseilleFrance

Background::The elimination of Plasmodium vivax malaria requires 8-aminoquinolines,which are contraindicated in patients with glucose-6-phosphate dehydrogenase(G6PD)deficiency due to the risk of acute haemolytic *** point-of-care devices have been developed to detect G6PD *** objective of the present study was to evaluate the performance of two of these devices against G6PD genotypes in ***::Outpatients were screened for G6PD deficiency using CareStart?rapid diagnostic test(RDT)and CareStart?G6PD biosensor in Nouakchott,Mauritania,in ***-type and Mediterranean-type G6PD genotypes commonly observed in Africa were determined by polymerase chain reaction-restriction fragment length polymorphism and *** variables were compared using Fisher’s exact ***::Of 323 patients(74 males and 249 females),5 males and 2 homozygous females had the African-type A-genotype:A-(202)in 3 males and 2 females and G6PD A-(968)in 2 *** heterozygous females,13 carried G6PD A-(202),12 G6PD A-(968),and 3 G6PD A-(542)*** had the Mediterranean-type G6PD *** had a positive G6PD RDT result,including all 7 hemizygous males and homozygous females with A-or A-A-(0.12 to 2.34 IU/g haemoglobin,according to G6PD biosensor),but RDT performed poorly(sensitivity,11.1%at the cutoff level of<30%)and yielded many false negative ***-seven(50.0%)males and 141(56.6%)females were *** adjusted median values of G6PD activity were 5.72 and 5.34 IU/g haemoglobin in non-anaemic males(n=35)and non-anaemic males and females(n=130)with normal G6PD genotypes using G6PD biosensor,*** on the adjusted median of 5.34 IU/g haemoglobin,the performance of G6PD biosensor against genotyping was as follows:at 30%cut-off,the sensitivity and specificity were 85.7%and 91.7%,respectively,and at 80%cut-off,the sensitivity was 100%while the specificity was 64.9%.Conclusions::Although this pilot study

关键词： Glucose-6-phosphate dehydrogenase Malaria Plasmodium vivax Primaquine Tafenoquine

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Prolapsed Juvenile Polyp of the Anus in 2 Cases

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Open Journal of Pediatrics 2023年第6期13卷 785-790页

作者： Mohamed Lamine Sadou Sacko Balla Keita Thierno Saidou Barry Mory Sangare mamadou Madiou Barry Moussa Conde Seydou Keita salif Mariértou Sylla Daniel Agbo-Panzo Department of Pediatric Surgery CHU de Donka Conakry Guinea Gamal Abdel Nasser University Conakry Guinea General Surgery Department Ignace Deen University Hospital Conakry Guinea Gastroenterology Department Conakry Military Hospital Conakry Guinea

Introduction :Rectal polyps are well-circumscribed, sessile or pedunculated formations that develop on the digestive mucosa. Juvenile polyps are seen in 4% - 12% of cases during pediatric colonoscopies. In children, rectal bleeding is a frequent warning sign, often a recurrent bleed with no impact on general condition. Diagnosis is based on clinical, imaging and digestive investigations, but anatomopathological examination remains the only means of confirmation. There are a number of treatment options, ranging from abstention to surgical excision. We report two (2) cases of isolated hemorrhagic juvenile polyp prolapsed to the anus in order to analyze the diagnostic and therapeutic features of this pathology. Patients and observations: A 7-year-old female patient presented to the pediatric emergency department of the Donka National Hospital with a hemorrhagic anal mass. On clinical examination, the patient was found to be in satisfactory general condition, with a hemorrhagic pedicle mass prolapsed to the anus. The mass was removed under general anesthesia. Postoperative management was straightforward. Conclusion: Juvenile polyps are the most common proctological condition in this age group. Clinical examination must be meticulous, as certain signs may point to a particular pathology. Colonoscopy is the diagnostic test of choice, and can also be used as a therapeutic tool.

关键词： Polyp Juvenile Prolapse Child

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Traumatic Digestive Perforation in the Hospital of Sikasso: Epidemio-Clinical and Therapeutic Aspects

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Surgical Science 2023年第6期14卷 405-413页

作者： Moussa Diassana Bathio Traoré Aly Boubacar Diallo mamadou Bernad Coulibaly Doh Sylla Amadou Maiga Aboubacar Karambé Amadou Bah Aboubacar Yoro Sidibé Layes Touré Ternan Traoré Ousmane Dembelé salif Traoré Moussa Kanté mamadou Sangaré Kokoroba Sidibé Youssouf Diakité Mahamadou Coulibaly Moro Sidibé Soumaila Alama Traoré Moussa Samaké Nana Kadidia Fofana Bakary Tientigui Dembélé General Surgery Department of the Sikasso Hospital Sikasso Mali General Surgery Department CHU Gabriel-Touré Bamako Mali Traumatology Department of the Sikasso Hospital Sikasso Mali Urology Department of the Sikasso Hospital Sikasso Mali Anesthesia and Resuscitation Department of the Sikasso Hospital Sikasso Mali Odontostomatology Department Sikasso Hospital Sikasso Mali Surgery Department Koutiala Reference Center Koutiala Mlai Ophthalmology Department Sikasso Hospital Sikasso Mali Gyneco-Obstetrics Department Sikasso Mali Surgery Department Bamako District Hospital Bamako Mali Commune IV District Hospital Bamako Mali

Traumatic digestive perforation is the pathological opening of the wall of a hollow organ of the digestive tract (esophagus, stomach, small intestine, large intestine, rectum, and extrahepatic bile ducts) following trauma. Injuries to the digestive viscera, especially from trauma, have been known since antiquity. Aristotle recognized that a slight blow can cause an intestinal injury. Perforation of a hollow organ of the digestive sphere results in peritonitis, which in this case is the consequence of an infection of the peritoneal cavity by spreading of the digestive contents. The aim of the work was to describe the epidemiological, clinical and therapeutic aspects of traumatic digestive perforation. Patients and method: The study was retrospective and descriptive from January 1, 2016 to December 31, 2020, in the general surgery department of the hospital of Sikasso (Mali). Patients operated for traumatic digestive perforation were included. Results: The clinical records of 42 patients were collected. Traumatic digestive perforations represented 12.3% of patients hospitalized for abdominal trauma. The average age of the patients was 26.6 years, with a sex ratio of 6:1. The most frequent etiology was road traffic accidents with 38% of patients. The average delay of consultation was 5 days. Abdominal pain was present in 38 patients, vomiting in 17 patients. On physical examination, the most frequent signs were abdominal contracture in 61.9% of patients, and disappearance of pre-hepatic dullness in 54.7% of patients. On rectal examination, the douglas was bulging and painful in 21 patients. X-ray of the abdomen without preparation showed pneumoperitoneum in 54.1% of patients. Excision, suture and peritoneal lavage were performed in 31 patients. The postoperative course was marked by parietal suppurations in 5 patients, a digestive fistula in 2 patients and 4 cases of death (9.5%). Conclusion: Traumatic digestive perforation is a frequent pathology in surgery. Road acci

关键词： Perforation Digestive Traumatic Sikasso (Mali)

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Treatment of Pelvic Limb Fractures in a Hospital of 2^e Reference in Mali

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Surgical Science 2023年第5期14卷 347-354页

作者： Souleymane Diallo Sory Ibrahim Tambassi Bilal Bore Terna Traore Kalifa Coulibaly Laye Touré Ibrahima Djire Aboubacar Sidiki Sangare salif Kone Drissa Kaloga Bagayogo Aboucar Diallo Souleymane Kone mamadou Konaté Soumana Traoré Cheick Oumar Sanogo Ahmadou Ibrahim Drame Abdoulaye G. Diarra Orthopedic Surgery and Traumatology Unit Tombouctou Hospital Tombouctou Mali Department of Orthopedic Surgery and Traumatology CHU BSS of Kati Kati Mali Department of Orthopedic Surgery and Traumatology Sikasso Hospital Sikasso Mali Department of Neurosurgery Mali Hospital Bamako Mali Department of Anesthesia and Resuscitation CHU Mère Enfant “Le Luxemburg” Bamako Mali Department of Surgical Hospital in Mopti Mopti Mali Department of Anesthesia and Resuscitation Mali Hospital Bamako Mali Department of General Surgery CHU of Kati Kati Mali

Introduction: A fracture is a solution in the continuity of a bone. Pelvic limb fractures may involve one or more of the bones. They constitute a real public health problem, which requires the identification of the factors inherent to this phenomenon for better prevention, but also for quality management of fractures and sequelae. Objectives: Were to describe the epidemiological, clinical and therapeutic profile of pelvic limb fractures in Timbuktu Hospital. Patients and Method: We conducted a prospective, descriptive study in the Surgery Department of Timbuktu Hospital, covering a period of one year from January 1 to December 31, 2017. We collected 39 patients who presented with fractures of the pelvic limbs, who were hospitalized and monitored throughout our study. Results: We obtained a hospital frequency of 2.86% limb fractures. Among the 39 patients included in our study, the male sex was predominant in 69.2% of cases, the average age of our patients was 20.5 years. Pupils and students were in the majority in 48.7% of cases. Road traffic accidents were the most common cause of fracture with 59.0% of cases. The tibia was the most affected segment in 38.5% of cases. Surgical treatment was predominant in 64.0% of cases. We obtained very good results in 94.87% of cases. Conclusion: Limb fractures remain frequent due to road traffic accidents. Osteosynthesis treatment provides a good result with fewer complications.

关键词： Fractures Pelvic Limb Surgical

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