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Food and Nutrition Sciences 2024年第5期15卷 351-360页

作者： Maurice Jean François Sylvestre Lopy Ndèye Fatou Ndiaye Malick Mbengue mamadou salif sow Abdou Diouf Department of Cereals and Legumes Institute of Food Technology (ITA) Dakar Senegal Polytechnic School Cheikh Anta Diop University Dakar Senegal

This study aimed to evaluate the nutritional and sensory characteristics of penne-type pasta produced from locally sourced cereals, tubers, and legumes. To achieve this, we formulated four different types of pasta with varying levels of incorporation ranging from 10 to 50% cereals such as millet, fonio, and rice, tubers such as manioc and sweet potato, and legumes such as cowpea. The results showed that the incorporation of local products considerably improved the nutrient content of penne without being rejected by consumers. Sensory analysis showed that the best results were obtained with mixtures of sweet potato, cowpea, and wheat, as well as with rice, manioc, cowpea, and sample wheat. These results are of great importance to manufacturers in a world where developing nutritious and attractive food products is a crucial challenge.

关键词： Pasta Tubers Cereals Legumes

Ambulatory Radio Iodine Therapy in the Management of Hyperthyroidism in Africa: African Systematic Review and Perspectives in Burkina Faso

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Open Journal of Biophysics 2024年第1期14卷 1-10页

作者： Ki Thierry Romuald mamadou salif Djigo Gora Thiaw Arsène Sanou Mamounata Zoungrana mamadou Mbodj Nuclear Medicine Department of the Yalgado OUEDRAOGO University Hospital Center in Ouagadougou Ouagadougou Burkina Faso Biophysics and Nuclear Medicine Laboratory of the Cheikh Anta DIOP University of Dakar Dakar Senegal Radiology Departement of the Bobo Dioulasso University Hospital Center in Bobo Dioulasso Bobo Dioulasso Burkina Faso

Introduction: In hyperthyroidism, selective irradiation of the thyroid gland with radioactive iodine is a radical treatment and an alternative to surgery. The aim of this review is to assess the medium-term efficacy of outpatient treatment of hyperthyroidism with iodine-131 in Africa. Methods: We identified the studies carried out in Africa on outpatient radiation therapy between 2016 and 2020. For each article included, we noted the country concerned and the year of publication, the numbers studied, the socio-demographic characteristics of the patients, the indications for radio iodine therapy, the dose administered, the results of the hormonal dosage 6 months after radiation. Results: 13 retrospective studies were included to constitute a total population of 925 patients. The average age was 40.77 years, the sex ratio of 1/5.4 with a clear female predominance. The 3 main etiologies of hyperthyroidism justifying outpatient radio iodine therapy were Graves’ disease (55.89%), toxic multinodular goiter (22.70%) and toxic adenoma (21.40%). The average dose of iodine 131 administered per course is 13.7 mCi. No short-and medium-term complications were reported. The radio iodine therapy was effective in 86.08% (n = 796) of the patients with extremes of 72% and 100%. Conclusion: Radio iodine therapy is effective in Africa. It is simple, inexpensive on an outpatient basis and well tolerated. The introduction of outpatient radio iodine therapy could improve the management of patients with hyperthyroidism in Burkina Faso.

关键词： Hyperthyroidism Outpatient Radio Iodine Therapy Africa

Place of Bone Scintigraphy in the Assessment of Extension and Follow-Up of Breast Cancer in Senegal: Study of 165 Cases in the Nuclear Medicine Department of Idrissa Pouye General Hospital (Dakar)

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Open Journal of Medical Imaging 2024年第1期14卷 10-30页

作者： El Hadji Amadou Lamine Bathily Mamoudou salif Djigo Djimby Ba Gora Thiaw Ousseynou Diop Kalidou Gueye Olatounde Herbert Fachinan Boucar Ndong Omar Ndoye mamadou Mbodj Nuclear Medicine Department Idrissa Pouye General Hospital (HOGIP) Dakar Senegal Biophysics Laboratory FMPO UCAD Dakar Senegal Nuclear Medicine Department Hospital Dalal Jamm Dakar Senegal Nursing and Obstetrics Training Institute Parakou University Parakou Benin

Introduction: Breast cancer is the most common cancer in women worldwide, accounting for an estimated 22% of all female cancers. It is the leading cause of cancer mortality in women, almost all of which is due to metastases, with 73% of metastases occurring in the bone. In oncology, metastable technetium 99-labelled methylene bisphosphonate bone scintigraphy (BS) remains the standard examination for detecting and assessing the extent of bone metastases. The aim of this study was to assess the role of BS in the evaluation and follow-up of breast cancer in Senegal. Methodology: This was a retrospective study of breast cancer patients who underwent bone scintigraphy with 99mTc-HMDP in the nuclear medicine department of Idrissa Pouye General Hospital (IPGHO), from July 2009 to June 2022. Results: We enrolled 165 patients, mean age 46.79 years (27 - 87 years). BS was performed in 94.37% of cases for post-therapeutic monitoring and in 5.63% for pre-therapeutic assessment. Results were contributory in 131 patients (92.25%), of whom 72 cases (50.70%) were normal and 59 cases (41.55%) positive or presenting bone metastases;and non-contributory or doubtful in 11 cases (7.75%). Secondary bone locations were multiple in 57 cases (96.61%) and single or solitary in 2 cases (3.39%). The scintigraphic appearance of bone metastases was hyper-fixative in 58 cases (98.31%) and mixed in 1 case (1.69%). Bone lesions were quantified using the Soloway’s grading classification. Conclusion: BS with 99mTc-labelled bisphosphonates remains the examination of choice for skeletal exploration, in the detection and extension of bone metastases in breast cancer. Performance has been enhanced by the development of SPECT coupled with CT (SPECT-CT).

关键词： Breast Cancer Bone Scintigraphy 99mTc-HMDP Bone Metastases

Contribution of Bone Scintigraphy in the Metastatic Extension Assessment of Prostate Cancer: A Study of 288 Cases in the Nuclear Medicine Department of Idrissa Pouye General Hospital, Dakar

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Open Journal of Biophysics 2024年第2期14卷 79-98页

作者： El Hadji Amadou Lamine Bathily Ousseynou Diop Mamoudou salif Djigo Gora Thiaw Kalidou Gueye Mohamed Chekhma Olatounde Herbert Fachinan Boucar Ndong Omar Ndoye mamadou Mbodj Department of Nuclear Medicine Idrissa Pouye General Hospital (HOGIP) Dakar Senegal Biophysical Laboratory FMPO Cheikh Anta Diop University (UCAD) Dakar Senegal Department of Nuclear Medicine Hospital Dalal Jamm Dakar Senegal

Introduction: Prostate cancer is the most frequently diagnosed male malignancy and the fifth leading cause of cancer death in men worldwide. Since the advent of screening methods such as Prostate Specific Antigen (PSA) assay, digital rectal examination (DRE) and prostate biopsy, its incidence has increased significantly. The aim of our study was to analyse aspects of bone scintigraphy (BS) as part of the metastatic extension assessment of prostate cancer in Senegal. Patients and Methods: This was a retrospective descriptive and analytical study, running from January 1er 2022 to August 31 2023. Patients with histologically confirmed prostate cancer were included. Whole-body scans (WBS) were performed using a dual-head SPECT gamma camera (Mediso Nucline TM Spirit DH-V type), 3 hours after intravenous injection of 8 MBq/kg (555 to 740 MBq) of 99mTc-HMDP. Results: A total of 288 patients with a mean age of 68.37 ± 7.79 years were included. The median total PSA level was 97.6 ng/ml, with 144 patients having a level greater than or equal to 20 ng/ml. All patients had adenocarcinoma, and the Gleason score was available in 202 (70.13%) patients, 75.75% of whom had a score greater than or equal to 7. BS was contributory in 70.48% of cases, with 30.90% positive and 39.58% negative. The result was inconclusive in 85 patients (29.51%). The mean PSA for patients with a positive scan was 190.2 ng/ml and 40.6 ng/ml for those with a negative scan. Multiple metastatic lesions predominated (87.35% of cases). Metastatic lesions occurred preferentially in the axial skeleton, with a proportion of 68% versus 32% in the appendicular skeleton. Classification of bone metastases according to the SOLOWAY score revealed grade I (62.07%), grade II (35.63%) and grade IV (2.30%). Conclusion: In Senegal, prostate cancer is generally diagnosed in men of advanced age. The presence of bone metastases is frequent in its evolution, transforming a curable localized disease into a g

关键词： Prostate Cancer Bone Metastasis Bone Scintigraphy Senegal

Iodine 131 Treatment in Graves’ Disease in a West African Country: Preliminary Study about 25 Cases in Senegal

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Open Journal of Biophysics 2024年第1期14卷 56-72页

作者： El Hadji Amadou Lamine Bathily Serigne Moussa Badiane Mamoudou salif Djigo Gora Thiaw Kalidou Gueye Ousseynou Diop Boucar Ndong Kokou Fofo Toussaint Adambounou Alphonse Rodrigue Djiboune Papa Mady Sy mamadou Soumbounou Mohamed Chekhma Louis Augustin Diaga Diouf Gora Mbaye Omar Ndoye Mounibé Diarra mamadou Mbodj Nuclear Medicine Department General Hospital of Idrissa Pouye (HOGIP) Dakar Senegal Biophysical Laboratory Cheikh Anta Diop University (UCAD) Dakar Senegal Biophysical Laboratory Gaston Berger University (UGB) Saint-Louis Nuclear Medicine Department Hospital Dalal Jamm Dakar Senegal Biophysical Laboratory University of Lome Lome Togo Laboratory of Physical and Pharmaceutical Biophysics Cheikh Anta Diop University Dakar Senegal

Introduction: Graves’ disease is the most common cause of hyperthyroidism. Its treatment uses synthetic antithyroid drugs but the use of aggressive radical therapy such as surgery or non-aggressive therapy such as iodine-131 is not uncommon. Treatment of Graves’ disease with radioactive iodine or iratherapy is a simple, inexpensive, well-tolerated treatment. It was introduced in Senegal in 2016. We report through this work the preliminary assessment of the only nuclear medicine service in Senegal in the management of Graves’ disease by iodine-131. Patients and Methods: Retrospective study of the first cases of Graves’ disease treated with iratherapy in Senegal. Socio-demographic, clinical, paraclinical, therapeutic and evolutionary aspects were studied. Radiation protection rules have been implemented and contraception has been effective for six months in women of childbearing age. Results: 25 patients were collected with a mean age of 45 years, twenty women (80%), a family goiter in 24% and a psycho-affective context in 64% of cases. Thyrotoxicosis syndrome was associated with goiter in 68% of patients and exophthalmos in 64%. Thyroid ultrasound performed in 20 patients showed vascular goiter in 80% and thyroid scintigraphy in 3 patients, homogeneous and diffuse hyperfixation. TRAK dosed in 8 patients was still positive. All patients had received first-line medical treatment. The average duration of this treatment was more than 18 months in 92%. The empirically used iodine-131 activity averaged 15.35 mCi. Oral corticosteroid therapy was prescribed in 7 patients for the prevention of malignant orbitopathy. No early side effects were noted. The remission rate at 3 months was 52% and at 6 months was 88% to 92%. Conclusion: The effectiveness of radioactive iodine, in particular ablative doses in the treatment of hyperthyroidism, is no longer to be demonstrated. Taking into account our socioeconomic context, iratherapy should be a treatment of choice for hyperthyroidism

关键词： Graves’ Disease Iratherapy Iodine-131 Senegal

Contribution of Bone Scintigraphy in the Diagnosis of a Case of SAPHO in the Nuclear Medicine Department of Idrissa Pouye General Hospital (Dakar, Senegal)

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Open Journal of Medical Imaging 2024年第1期14卷 1-9页

作者： El Hadji Amadou Lamine Bathily Kalidou Gueye Serigne Moussa Badiane Mamoudou salif Djigo Gora Thiaw Ousseynou Diop Olatounde Herbert Fachinan Papa Mady Sy Alfonse Rodrigue Djiboune Kokou Fofo Toussaint Adambounou Louis Augustin Diaga Diouf Boucar Ndong Gora Mbaye Omar Ndoye Mounibé Diarra mamadou Mbodj Nuclear Medicine Department Idrissa Pouye General Hospital (HOGIP) Dakar Senegal Biophysical Laboratory FMPO Cheikh Anta Diop University (UCAD) Dakar Senegal Biophysical Laboratory UFR2S Gaston Berger University (UGB) Saint-Louis Senegal Nuclear Medicine Department Hospital Dalal Jamm Dakar Senegal Laboratory of Physical and Pharmaceutical Biophysics FMPO Cheikh Anta Diop University Dakar Senegal Biophysical Laboratory University of Lome Lome Togo

Introduction: The acronym SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) is a syndrome combining osteoarticular and cutaneous manifestations. It occurs mainly between the ages of 30 and 50. Sternocostoclavicular hyperostosis is one of the main distinguishing features. We report a case of SAPHO in Dakar diagnosed by bone scintigraphy. Observation: 28-year-old Senegalese women presented with left shoulder pain and relative functional impotence for over 2 years. Examination revealed right sternoclavicular hyperostosis and left shoulder pain on palpation. Questioning revealed a history of acne and hyperostosis of the right first toe. Bone scintigraphy, performed after injection of 630 MBq of 99mTc-HMDP, revealed: hyperfixation of the bilateral (right++) manubrio-sternal and sternoclavicular junction, producing the classic bull’s horn image;hyperfixation of the left shoulder with an inflammatory appearance;hyperfixation of the sacroiliac joints suggestive of bilateral sacroiliitis;hyperfixation of the right first toe;two mandibular hyper fixations probably related to dental damage. This scintigraphic appearance in one was strongly suggestive of SAPHO syndrome. Conclusion: SAPHO syndrome, related to spondyloarthropathy, associates cutaneous and osteoarticular signs. It is characterized by frequent delays in diagnosis due to poor recognition. Soy is an invaluable diagnostic tool, enabling us to assess the extent of the disease and its evolution.

关键词： SAPHO Bone Scintigraphy Young Woman Senegalese

Migration of a Progestin Implant into a Pulmonary Artery: Observation of a Case at the Reference Health Center of Commune III of the District of Bamako in Mali

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Open Journal of Obstetrics and Gynecology 2024年第9期14卷 1431-1436页

作者： Hamady Sissoko Souma Kodio Hamidou Albachar Cheickna Sylla salif Diarra Sidy Moctar Diakité Mohamed Traoré Souleymane Traoré Ibrahim Fomba Ouncoumba Diarra Nana Bah Drissa Diarra Mahamoudou Coulibaly Bocary Sidi Koné Hawa Samaké Ahmadou Coulibaly mamadou Traoré Seydou Z. Dao Sitapha Dembélé Samou Diarra Konimba Koné Alou Samaké Sanogo Siaka Amara Reference Health Centre of Commune III of the District of Bamako Bamako Mali Department of Gynecology and Obstetrics Gabriel Toure University Hospital Center in Bamako Bamako Mali Department of Gynecology and Obstetrics Kalaban Coro Reference Health Centre Bamako Mali Mohamed VI Perinatal Clinic Bamako Mali Reference Health Centre of Commune V of the District of Bamako Bamako Mali Point-G Obstetrics and Gynecology Department of University Hospital Center Bamako Mali Reference Health Centre of Commune II of the District of Bamako Bamako Mali H Department of Gynecology and Obstetrics of the Fousseyni Daou Hospital in Kayes Kayes Mali Reference Health Centre of Commune VI of the District of Bamako Bamako Mali

It was a 36-year-old patient, 5th Pregnancy, 5th Delivery, 4 live children, and I deceased, had a consultation in the department for the removal of implants. Questioning revealed that she had had the implant three years ago without medical follow-up. It was in view of the difficulties in extracting the capsule that the chest X-ray and CT scan carried out concluded that the implant had migrated into a branch of the left pulmonary artery. Therapeutic abstention has been the attitude of cardiovascular surgeons.

关键词： Migration Implant Pulmonary Artery Bamako

Thermophysical Characterization of Typha’s Concrete for Its Integration into Construction

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Journal of Building Construction and Planning Research 2021年第1期9卷 56-65页

作者： Ababacar Sadikh Diaw Harouna mamadou Bal Oumar Diallo mamadou Babacar Ndiaye mamadou Wade salif Gaye Laboratory of Materials and Energetics (LME) University Institute of Technology (IUT) Thies Senegal Laboratory of Sciences and Technology of Water and Environment (LaSTEE) Polytechnic School of Thies Thies Senegal

Energy consumption in the building sector is constantly increasing and represents more than 44% in the residential and tertiary sectors in many countries [1]. Thus, the building represents a real possibility of energy saving and is the subject of several studies particularly in actual context of experimentation with materials based on plant fibers (hemp, flax, millet wastage, etc.). These biobased materials such as typha have shown real interest in the buildings construction due to their light and porous nature. It’s in this context that we were interested in typha australis mixed with classic aggregates (cement, sand, gravel 3/8) to make typha’s concrete. On this concrete, we carried out experimental measurements in order to better understand its contributions in the building. The interesting results obtained show that typha australis, which is an invasive and harmful grass, can be valued and integrated among local building materials in the form of typha’s concrete in order to improve the energy efficiency of buildings.

关键词： Typha Australis Bio-Based Materials Thermal Conductivity Thermal Diffusivity Energy Efficiency Asymmetric Hot Plane

Spontaneous Pneumothorax Complicating Miliary Tuberculosis: About a Case at the “Centre Medical Principal De La Gendarmerie Nationale Du Mali”

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Journal of Tuberculosis Research 2023年第2期11卷 67-73页

作者： Souleymane Coulibaly Marius Pembé Sanou Kassim Sidibe Ladji Mohamed Diaby Lassina Diallo Daouda Amara Traore salif Kone Ami Diarra salif sow Abasse Sanogo salif Satao mamadou Cherif Kante Mahamadou Coulibaly Aminata Bagayoko Soumaila Keita Polyclinique des Armées Kati Mali Centre Médical Principal de la Gendarmerie Nationale Bamako Mali Centre Médico-Chirurgical des Armées Bamako Mali Service de Pneumologie CHU Point G Bamako Mali

Introduction: Spontaneous pneumothorax is a rare but serious complication of tuberculosis. Miliary tuberculosis (MT) is a severe form of tuberculosis secondary to hematogenous spread of Mycobacterium tuberculosis. Objective: To report a case of MT complicated by pneumothorax. Methodology: This was a 25-year-old patient, farmer, followed up at the Pneumo-phtisiology department of the CHU du Point G for MT whose condition was improving after the introduction of anti-tuberculosis chemotherapy. He consulted again after experiencing chest pain. Clinical and imaging revealed a Spontaneous pneumothorax complicating MT. The treatment combined anti-tuberculosis chemotherapy, chest drainage and respiratory physiotherapy. Outcome was favorable with improvement of clinical and radiological signs. Conclusion: Pneumothorax complicating MT requires a reflective diagnostic approach and rapid management to improve its prognosis.

关键词： Spontaneous Pneumothorax Miliary Tuberculosis Antituberculous Chemotherapy Pleural Drainage Respiratory Physiotherapy

Improving the Stability of the Inflatable Soil of Diamniadio by Using Typha Australis in Order to Value It in Partitioning Wall

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Journal of Building Construction and Planning Research 2020年第4期8卷 273-284页

作者： Ahmadou Diop Macodou Thiam mamadou Babacar Ndiaye Oumar Diallo Harouna mamadou Bal salif Gaye Laboratory of Materials and Energetics (LME) University Institute of Technology (IUT) Thiès Senegal

The construction industry in Senegal is experiencing an upsurge in the development of residential housing units and administrative buildings within the new Diamniadio municipality, an area located just about 35 km from the capital city of Dakar. Laboratory oedometer or expansive-index tests, however, show poor density and compromised shear strength in the soil samples within the area -posing serious construction problems due to significant volume changes (swellings) that occur when subjected to moisture, thus, bringing into question the structural performance integrity of the soil, and the financial implications of substitute soil types used to compensate for its poor tensile strength. By way, the companies collect the soil of this location (Diamniadio) and throw it to make pile or micro-pile (pious) for their structures. This article demonstrates how we can value the soil of Diamniadio and the Typha Australis in residential building with a reasonable cost. Typha Australis is a plant generally luxuriant within the northern and central belts of Senegal but also known for its negative ecological impacts on the agricultural production of rice. The valorisation of the soil of Diamniadio will pass by the ability to increase its stability or to decrease its shrinkage/swelling rate. When we achieve it, the soil associate with Typha Australis will be used for small bricks which can be useful for partition wall and so the soil will not be ever thrown as a non-useful material. Tests results of soil specimens extracted from the site show a shrinkage rate of 29.19% with estimated cracking depths of 3.5 cm. But by adding gradually Typha Australis, the shrinkage rate will pass from 29.19% to 5.13% with the material treats with 10% by mass of Typha Australis. Moreover, the crackings in the cylindrical specimen disappear. That shows the increase of the stability;thus the composition will be used for building bricks. However, the densities will also be affected by the presence of Ty

关键词： Buildings Clay Cracking Fine Particle Shrinkage Rate Stabilization Typha Australis Valorisation