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Reinforcing Artificial Neural Networks through Traditional Machine Learning Algorithms for Robust Classification of Cancer

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Computers, Materials & Continua 2023年第5期75卷 4293-4315页

作者： Muhammad Hammad Waseem malik sajjad ahmed nadeem Ishtiaq Rasool Khan Seong-O-Shim Wajid Aziz Usman Habib Department of Computer Sciences and Information Technology University of Azad Jammu and KashmirMuzaffarabad13100Pakistan Department of Computer Science and AI College of Computer Science and EngineeringUniversity of JeddahJeddah23890Saudi Arabia Department of Computer and Network Engineering College of Computer Science and EngineeringUniversity of JeddahJeddah23890Saudi Arabia Department of AI&DS School of ComputingNational University of Computer and Emerging SciencesIslamabad44000Pakistan

Machine Learning(ML)-based prediction and classification systems employ data and learning algorithms to forecast target ***,improving predictive accuracy is a crucial step for informed *** the healthcare domain,data are available in the form of genetic profiles and clinical characteristics to build prediction models for complex tasks like cancer detection or *** ML algorithms,Artificial Neural Networks(ANNs)are considered the most suitable framework for many classification *** network weights and the activation functions are the two crucial elements in the learning process of an *** weights affect the prediction ability and the convergence efficiency of the *** traditional settings,ANNs assign random weights to the *** research aims to develop a learning system for reliable cancer prediction by initializing more realistic weights computed using a supervised setting instead of random *** proposed learning system uses hybrid and traditional machine learning techniques such as Support Vector Machine(SVM),Linear Discriminant Analysis(LDA),Random Forest(RF),k-Nearest Neighbour(kNN),and ANN to achieve better accuracy in colon and breast cancer *** system computes the confusion matrix-based metrics for traditional and proposed *** proposed framework attains the highest accuracy of 89.24 percent using the colon cancer dataset and 72.20 percent using the breast cancer dataset,which outperforms the other *** results show that the proposed learning system has higher predictive accuracies than conventional classifiers for each dataset,overcoming previous research ***,the proposed framework is of use to predict and classify cancer patients ***,this will facilitate the effective management of cancer patients.

关键词： ANN decision support systems gene-expression data hybrid classification machine learning predictive analytics

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A Deep Learning Based Sentiment Analytic Model for the Prediction of Traffic Accidents

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Computers, Materials & Continua 2023年第11期77卷 1599-1615页

作者： nadeem malik Saud Altaf Muhammad Usman Tariq Ashir ahmed Muhammad Babar University Institute of Information Technology PMAS Arid Agriculture UniversityRawalpindi46000Pakistan Department of Marketing Operationsand Information SystemAbu Dhabi UniversityAbu Dhabi6844United Arab Emirates College of Computer and Information Sciences Prince Sultan UniversityRiyadh11442Saudi Arabia Robotics and Internet of Things Lab Prince Sultan UniversityRiyadh11442Saudi Arabia

The severity of traffic accidents is a serious global concern,particularly in developing *** the main causes and contributing circumstances may reduce the severity of traffic *** exist many machine learning models and decision support systems to predict road accidents by using datasets from different social media forums such as Twitter,blogs and *** such approaches are popular,there exists an issue of data management and low prediction *** article presented a deep learning-based sentiment analytic model known as Extra-large Network Bi-directional long short term memory(XLNet-Bi-LSTM)to predict traffic collisions based on data collected from social ***,a Tweet dataset has been formed by using an exhaustive keyword-based searching *** the next phase,two different types of features named as individual tokens and pair tokens have been obtained by using POS tagging and association rule *** output of this phase has been forwarded to a three-layer deep learning model for final *** experiment has been performed to test the efficiency of the proposed XLNet-Bi-LSTM *** has been shown that the proposed model achieved 94.2%prediction accuracy.

关键词： Accident XLNet Bi-LSTM association rule mining Twitter

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ROLE OF ACULASER THERAPY IN CEREBRAL PALSY CHILDERN (INITIAL DATA & RESULTS)

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World Journal of Acupuncture-Moxibustion 2004年第1期14卷 18-25页

作者： Shahzad Anwar malik Mohammad nadeem Khan Imtiaz ahmed Abid Hareef Awan Anwar Shah's First C.P.& Paralysis Clinic and Research Center Children Hospital & Institute of Child HealthSheikh Zayed HospitalAnwar Shah's First C.P.& Paralysis Clinic and Research Center 17 C Main Boulevard Faisal Town LahoreLahoreLahore Pakistan 17 C Main Boulevard Faisal Town Lahore

A single, open and non-comparative study was conducted at Anwar Shah’s First C.P. & Paralysis Clinic and Research Center to evaluate the effects of Aculaser (acupoint-laser) Therapy for children suffering from cerebral palsy (CP) of various types. These children were further classified according to their major complaints. Analysis of the data indicated that 11 children with severe spasticity and stiffness all showed marked improvement (100% success rate); of the 8 children with epileptic fits, 6 patients had a significant reduction in the intensity, frequency and duration of epileptic fits, while the rest 2 cases showed no any improvement or aggravation (75% success rate); out of 5 children with cortical blindness, 2 cases showed complete recovery of vision and 3 had marked improvement (40% cure rate); out of 4 children with hearing difficulties, 2 showed marked improvement (50% success rate); out of 14 children with aphasis, 8 showed improvement (57% improvement rate). Results of this study show that Aculaser Therapy has a high improvement rate of CP children, not only improving the spasticity and stiffness but also the cortical blindness, epilepsy, deafness and speech.

关键词：大脑性瘫痪儿童 CP 强直状态癫痫针灸治疗

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Differential gene expression of chemokines in KRAS and BRAF mutated colorectal cell lines:Role of cytokines

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World Journal of Gastroenterology 2014年第11期20卷 2979-2994页

作者： sajjad Khan Silke Cameron Martina Blaschke Federico Moriconi Naila Naz Ahmad Amanzada Giuliano Ramadori Ihtzaz ahmed malik Clinic of Gastroenterology and Endocrinology University Medical CenterRobert-Koch-Str. 4037075 GoettingenGermany

AIM:To study KRAS/BRAF mutations in colorectalcancer(CRC)that influences the efficacy of *** develop strategies for overcoming combination of ***:Five colonic cell-lines were investigated:DLD-1 with KRAS(G13D)mutation,HT 29 and Colo205 with BRAF(V600E)mutation as well as the wild type(Wt)cell-lines Caco2 and ***-1(KRAS),HT-29(BRAF)and Caco2(Wt)cell lines were treated with cytokines(TNFα50 ng,IL-1β1 ng and IFNγ50ng)and harvested at different time points(1-24 h).KRAS inhibition was performed by the *** colorectal cancer cells DLD-1 and Caco2 were used for KRAS *** 70%confluency were confirmed before transfection with small interferring RNA(siRNA)*** the synthetic siRNA sequences were designed in our *** RNA and protein was isolated from the cells for RT-PCR and Western *** of the Western blotting was analyzed with the Image J software(NIH).Results are shown as mean±***:RT-PCR analysis in non-stimulated cells showed a low basal expression of TNFαand IL-1βin the DLD-1 KRAS-mutated cell-line,compared to Caco2wild *** detection was found for IL-6 and IFNγin any of the studied cell *** contrast,pro-angiogenic chemokines(CXCL1,CXCL8)showed a high constitutive expression in the mutated cell-lines DLD-1(KRAS),HT-29 and Colo205(BRAF),compared to wild type(Caco2).The anti-angiogenic chemokine(CXCL10)showed a high basal expression in wild-type,compared to mutated *** down-regulation by siRNA showed a significant decrease in CXCL1 and CXCL10gene expression in the DLD-1(KRAS)cell-line in comparison to wild type(Caco2)at 72 h after KRAS *** contrast,the specific KRAS inhibition resulted in an up-regulation of CXCL1 and *** results of our study show a higher expression of pro-angiogenic chemokines at basal level in mutated cell-lines,which was further increased by cytokine ***:To summarize,basal chemokine gene expres

关键词： Colorectal-cancer KRAS BRAF CXCL1(GROα) CXCL10(IP-

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Assessment of Biochemical and Antioxidative Status in Patients Suffering from Dengue Fever

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2015年第3期35卷 411-418页

作者： Mahmood Rasool Arif malik Khalid Mahmud Khan Muhammad Saeed Qureshi Beenish Shabbir Sara Zahid Muhammad Asif Abdul Manan Sana Rashid Saima Rubab Khan Hafiz Muhammad Arsalan Rabail Alam Mahwish Arooj Mahmood Husain Qazi Adeel Gulzar ahmed Chaudhary Adel Mohammed Abuzenadah Mohammed Hussain Al-Qahtani sajjad Karim Center of Excellence in Genomic Medicine Research Faculty of Applied Medical SciencesKing Abdulaziz University Institute of Molecular Biology and Biotechnology the University of Lahore Fatima Jinnah Medical College Sir Gangaram Hospital Lahore Institute of Molecular Biology and Biotechnology the University of Lahore Department of Biotechnology and Informatics BUITEMS Quetta 87300 Pakistan Center for Research in Molecular Medicine the University of Lahore KACST Technology Innovation Center in Personalized Medicine King Abdulaziz University Center of Excellence in Genomic Medicine Research Faculty of Applied Medical Sciences King Abdulaziz University

Summary：A multi-centred study was designed to collect dengue epidemiologic data from government and registered private hospitals/clinics and maintained archive of frozen specimens in bio-bank to be used for future dengue epidemic control program, and assess the epidemiology of dengue fever（DF） by evaluating biochemical and oxidative status of patients. ELISA Ig M antibodies test was done to confirm DF. From August 2010 to December 2011, 101 confirmed blood samples of DF patients referred to pathology lab of Jinnah Hospital Lahore were subjected to the epidemiologic assessment by evaluating the biochemical and physiological indices and alterations of circulating antioxidants. Clinical features of DF patients and effect of fever on blood components and serum proteins of liver were recorded. The hospital stay in DF, dengue hemorrhagic fever（DHF） and dengue shock syndrome（DSS） showed significant difference. Significant increases in serum alanine amino transferase（ALT）（P=0.000）, aspartate amino transferase（AST）（P=0.000）, alkaline phosphatase（ALP）（P=0.000）, malondialdehyde（MDA） along with significant decreases in total protein（TP）（P=0.000）, reduced glutathione（GSH）（P=0.000）, superoxide dismutase（SOD）, catalase（CAT）（P=0.000）, and sialic acid contents（P=0.016） were observed. A positive correlation existed between bound sialic acid levels, liver enzymes and circulating antioxidants（r=0.656, P=0.016）. In the present study, alterations of circulating antioxidants in DF suggest that DF might be a metabolic response to an acute, self-limiting tropical viral infection, and a consequence of the viral inflammatory process.

关键词： dengue fever alanine amino transferase aspartate amino transferase malondialdehyde superoxide dismutase catalase

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Thyroglossal Duct Anomalies in Pediatric and Adult Population: A 10-Year Experience in a Tertiary Care Hospital

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Surgical Science 2021年第7期12卷 226-235页

作者： Montasir Junaid Ghaleb Al-Sayed Sayed Agha Ali Shah Hareem U. Khan Ali Mahdi Al Qannass nadeem W. malik Yahya Al Kahtani ahmed Arghabi Abdul Aziz Ali Binhossan Sadaf Qadeer ahmed Department of Otolaryngology-Head and Neck Surgery Armed Forces Hospital Khamis Mushait KSA Department of Pathology Armed Forces Hospital Khamis Mushait KSA Department of Otolaryngology-Head and Neck Surgery Stanford University Palo Alto USA Department of Otolaryngology-Head and Neck Surgery Sir Syed University of Medical Sciences for Girls Karachi Pakistan

Introduction: Thyroglossal duct cyst is a well-recognized congenital midline neck swelling observed in early childhood and rarely in adults. It may reveal itself as a painless cyst, abscess, or as fistula. Several studies have been conducted across the world, but the literature is scarce on its presentation and complications in the Middle East. This indexing study aims to report a 10-year experience with thyroglossal duct cyst (TGDC) presentation, excision, and recurrence at a teaching hospital in Saudi Arabia (KSA). Methods: A retrospective chart review was conducted at the Armed Forces Hospital Southern Region, KSA from December 2008 to December 2018. Data were retrieved from the electronic medical record system of the hospital and validated with the histopathology records. A total of 48 patients diagnosed as TGDC, sinus or fistula were identified. Stata ver. 16.1 was used to analyze the data and results formulated using regression model and Pearson’s chi-square test. Results: The majority of our patients were female (60.4%), and the most common presentation was a midline neck swelling which moved with tongue protrusion. Surgical excision via Complete Sistrunk procedure was the operation of choice in 60.5% followed by excision of the cyst with tract and sinus tract. Previous infection and surgical history contributed to complications in our patients, but no association of age or gender was observed. Patients presenting with infected and discharging cysts were found to be much more likely to develop a recurrence (9 patients). Cysts deep to the hyoid showed more recurrence [n = 7 (78%)] compared to superficial cysts [n = 2 (22%)] and posterior and multi-tract lesions also showed significant recurrence. Conclusion: Despite being a common cause of neck swelling, thyroglossal duct cyst is often missed on physical exams. To reduce complications, timely diagnosis and treatment are necessary.

关键词： Midline Neck Swelling Thyroglossal Duct Cyst Sinus Tract Sistrunk Procedure

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