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Frilled Lizard Optimization: A Novel Bio-Inspired Optimizer for Solving Engineering Applications

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Computers, Materials & Continua 2024年第6期79卷 3631-3678页

作者： Ibraheem Abu Falahah Osama Al-Baik Saleh Alomari Gulnara Bektemyssova Saikat Gochhait Irina Leonova OmParkash malik Frank Werner mohammad Dehghani Department of Mathematics Faculty of ScienceThe Hashemite UniversityP.O.Box 330127Zarqa13133Jordan Department of Software Engineering Al-Ahliyya Amman UniversityAmman19328Jordan Faculty of Science and Information Technology Software EngineeringJadara UniversityIrbid21110Jordan Department of Computer Engineering International Information Technology UniversityAlmaty050000Kazakhstan Symbiosis Institute of Digital and Telecom Management Constituent of Symbiosis International Deemed UniversityPune412115India Neuroscience Research Institute Samara State Medical UniversitySamara443001Russia Faculty of Social Sciences Lobachevsky UniversityNizhny Novgorod603950Russia Department of Electrical and Software Engineering University of CalgaryCalgaryAB T2N 1N4Canada Faculty of Mathematics Otto-von-Guericke UniversityP.O.Box 4120Magdeburg39016Germany Department of Electrical and Electronics Engineering Shiraz University of TechnologyShiraz***Iran

This research presents a novel nature-inspired metaheuristic algorithm called Frilled Lizard Optimization(FLO),which emulates the unique hunting behavior of frilled lizards in their natural *** draws its inspiration from the sit-and-wait hunting strategy of these *** algorithm’s core principles are meticulously detailed and mathematically structured into two distinct phases:(i)an exploration phase,which mimics the lizard’s sudden attack on its prey,and(ii)an exploitation phase,which simulates the lizard’s retreat to the treetops after *** assess FLO’s efficacy in addressing optimization problems,its performance is rigorously tested on fifty-two standard benchmark *** functions include unimodal,high-dimensional multimodal,and fixed-dimensional multimodal functions,as well as the challenging CEC 2017 test ***’s performance is benchmarked against twelve established metaheuristic algorithms,providing a comprehensive comparative *** simulation results demonstrate that FLO excels in both exploration and exploitation,effectively balancing these two critical aspects throughout the search *** balanced approach enables FLO to outperform several competing algorithms in numerous test ***,FLO is applied to twenty-two constrained optimization problems from the CEC 2011 test suite and four complex engineering design problems,further validating its robustness and versatility in solving real-world optimization ***,the study highlights FLO’s superior performance and its potential as a powerful tool for tackling a wide range of optimization problems.

关键词： Optimization engineering bio-inspired metaheuristic frilled lizard exploration exploitation

Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir Poornima Shaji Ana Martinez Bulnes Anupam Dhasmana Swathi Holla Nivesh K.Mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni mohammad Sikander Andrew E.Massey Bilal B.Hafeez Manish K.Tripathi Vincent P.Diego Meena Jaggi Junming Yue nadeem Zafar Murali M.Yallapu Stephen W.Behrman Sheema khan Subhash C.Chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of Computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas Center of Excellence in Cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and Cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough Center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory Medicine&Pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast ***-EXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-EXs for PDAC tumors,thus imply feasibility of developing a novel personalized medicine for PDAC patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia Extracellular vesicles Exosomes Tumor targeting Ormeloxifene Personalized medicine

National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma

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World Journal of Gastroenterology 2024年第9期30卷 1018-1042页

作者： Faisal Saud Dar Zaigham Abbas Irfan Ahmed Muhammad Atique Usman Iqbal Aujla Muhammad Azeemuddin Zeba Aziz Abu Bakar Hafeez Bhatti Tariq Ali Bangash Amna Subhan Butt Osama Tariq Butt Abdul Wahab Dogar Javed Iqbal Farooqi Faisal Hanif Jahanzaib Haider Siraj Haider Syed Mujahid Hassan Adnan Abdul Jabbar Aman Nawaz khan Muhammad Shoaib khan Muhammad Yasir khan Amer Latif Nasir Hassan Luck Ahmad Karim malik Kamran Rashid Sohail Rashid mohammad Salih Abdullah Saeed Amjad Salamat Ghias-un-Nabi Tayyab Aasim Yusuf Haseeb Haider Zia Ammara Naveed Department of Hepatopancreatic Biliary Surgery&Liver Transplant Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Hepatogastroenterology and Liver Transplantation Dr.Ziauddin University HospitalKarachi 75600SindhPakistan University of Aberdeen Aberdeen B243FXUnited Kingdom Department of Pathology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Gastroenterology&Hepatology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Radiology Aga Khan UniversityKarachi 74800Pakistan Department of Oncology Hameed Latif HospitalLahore 54000Pakistan Division of Hepatopancreatic Biliary Surgery&Liver Transplantation Shifa International HospitalIslamabad 44000Pakistan Department of Hepatopancreatic Biliary Surgery&Liver Transplant Shaikh Zayed Hospital and Post Graduate Medical InstituteLahore 54000Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan Department of Liver Transplant Pir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Medicine&Gastroenterology Lifecare Hospital and Research CentrePeshawar 25000Khyber PakhtunkhwaPakistan Department of Hepatopancreatobiliary&Liver Transplant Bahria International HospitalLahore 54000Pakistan Department of Surgery Hepatopancreatobiliary&Liver TransplantDow University of Health SciencesKarachi 74800Pakistan Department of Gastroenterology Hepatology&NutritionPir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Oncology Dr.Ziauddin HospitalKarachi 74800Pakistan Department of Radiology Rehman Medical InstitutePeshawar 25000Pakistan Army Liver Transplant Unit Pak Emirates Military HospitalRawalpindi 46000Pakistan Department of Gastroenterology Sindh Institute of Urology and TransplantationKarachi 75500Pakistan Rashid Nursing Home and Cancer Clinic Rashid Nursing Home and Cancer ClinicRawalpindi 46000Pakistan Department of Gastroentero

A consensus meeting of national experts from all major national hepatobiliary centres in the country was held on May 26,2023,at the Pakistan Kidney and Liver Institute&Research Centre(PKLI&RC)after initial consultations with the *** Pakistan Society for the Study of Liver Diseases(PSSLD)and PKLI&RC jointly organised this *** effort was based on a comprehensive literature review to establish national practice guidelines for hilar cholangiocarcinoma(hCCA).The consensus was that hCCA is a complex disease and requires a multidisciplinary team approach to best manage these *** coordinated effort can minimise delays and give patients a chance for curative treatment and effective *** diagnostic and staging workup includes high-quality computed tomography,magnetic resonance imaging,and magnetic resonance *** cytology or biopsy utilizing endoscopic retrograde cholangiopancreatography is a mainstay for ***,histopathologic confirmation is not always required before *** ultrasound with fine needle aspiration of regional lymph nodes and positron emission tomography scan are valuable adjuncts for *** only curative treatment is the surgical resection of the biliary tree based on the Bismuth-Corlette *** patients with unresectable hCCA can be considered for liver *** chemotherapy should be offered to patients with a high risk of *** use of preoperative biliary drainage and the need for portal vein embolisation should be based on local multidisciplinary *** with acute cholangitis can be drained with endoscopic or percutaneous biliary *** chemotherapy with cisplatin and gemcitabine has shown improved survival in patients with irresectable and recurrent hCCA.

关键词： Hilar cholangiocarcinoma Bismuth-Corlette classification Memorial Sloan Kettering Cancer Centre Staging Preoperative biliary drainage Portal vein embolisation Surgical resection Hepatectomy

FlowBreakdown of Hybrid Nanofluid on a Rigid Surface with Power Law Fluid as Lubricated Layers

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1485-1499页

作者： Mirza Naveed Jahangeer Baig nadeemSalamat Sohail nadeem NaeemUllah Mohamed Bechir Ben Hamida Hassan Ali Ghazwani Sayed M.Eldin A.S.Al-Shafay Instituite of Mathematics Khwaja Fareed University of Engineering and Information TechnologyRahim yar Khan64200Pakistan Department of Mathematics Quaid-I-Azam UniversityIslamabad44000Pakistan Department of Mathematics Wenzhou UniversityWenzhou325035China College of Engineering Department of Mechanical EngineeringImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11564Saudi Arabia Research Laboratory of Ionized Backgrounds and Reagents Studies(EMIR) Preparatory Institute for Engineering Studies of Monastir(IPEIM)University of MonastirMonastir5060Tunisia Higher School of Sciences and Technology of Hammam Sousse Department of PhysicsJazan82511Kingdom of Saudia Arabia Department of Mechanical Engineering Faculty of engineeringJazan UniversityP.O.Box 45124JazanKingdom of Saudia Arabia Center of Research Faculty of EngineeringFuture University in EgyptNew Cairo11835Egypt Department of Mechanical Engineering College of EngineeringPrince Sattam bin Abdulaziz UniversityAlkharj16436Saudi Arabia

Thiswork investigates an oblique stagnation point flowof hybrid nanofluid over a rigid surface with power lawfluidas lubricated layers. Copper (Cu) and Silver (Ag) solid particles are used as hybrid particles acting in water H2O asa base fluid. The mathematical formulation of flow configuration is presented in terms of differential systemthat isnonlinear in nature. The thermal aspects of the flow field are also investigated by assuming the surface is a heatedsurface with a constant temperature T. Numerical solutions to the governing mathematical model are calculatedby the RK45 algorithm. The results based on the numerical solution against various flow and thermal controllingparameters are presented in terms of line graphs. The specific results depict that the heat flux increases over thelubricated-indexed parameter.

关键词： Oblique stagnation point flow hybrid nanofluid lubricated layer magnetohydrodynamics

Cd and Hg Mediated Oxidative Stress,Antioxidative Metabolism and Molecular Changes in Soybean(Glycine max L.)

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Phyton-International Journal of Experimental Botany 2023年第6期92卷 1725-1742页

作者： Sheeba Naaz nadeem Ahmad Asma AAl-Huqail mohammad Irfan Faheema khan mohammad Irfan Qureshi Department of Biotechnology Faculty of Natural SciencesJamia Millia IslamiaNew Delhi110025India Department of Biosciences Faculty of Natural SciencesJamia Millia IslamiaNew Delhi110025India Department of Botany and Microbiology College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia Plant Biology Section School of Integrative Plant ScienceCornell UniversityIthacaUSA

Cadmium(Cd)and Mercury(Hg)is among the heavy metals most hazardous for plant and human *** to induce oxidative stress in plants and disbalance equilibrium in the antioxidant defence system,these metals alter plant growth and cause damage at the cellular and molecular *** is an important oilseed crop that is raised in soils often contaminated by Cd and *** comparative studies on the deleterious effect of Cd and Hg and the defence system of antioxidants were not studied earlier in soybean *** this study,soybean plants were exposed to Cd(100μM CdCl_(2))and Hg(100μM HgCl_(2))and studied for physiological,biochemical and molecular *** Cd and Hg treatment increased the magnitude of oxidative *** of antioxidant enzymes were significantly upregulated in response to Cd and Hg *** and qualitative assessment of isolated RNA showed significant differences in RNA under *** values of RNA confirmed *** level of the Actin gene,involved in the morphogenesis of plants and also used as referenced gene in expression studies was analyzed using qRT-PCR just to check its stability and response under heavy metal *** showed significant upregulation of the gene in the presence of *** can be concluded that both Cd and Hg caused oxidative damage to plants,and adversely affected the quality of ***,soybean tried to limit the adverse impacts of Cd and Hg stress by elevating the antioxidant system and upregulating Actin gene.

关键词： Soybean heavy metal stress actin gene enzymatic antioxidant activity qRT-PCR

Reinforcing Artificial Neural Networks through Traditional Machine Learning Algorithms for Robust Classification of Cancer

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Computers, Materials & Continua 2023年第5期75卷 4293-4315页

作者： Muhammad Hammad Waseem malik Sajjad Ahmed nadeem Ishtiaq Rasool khan Seong-O-Shim Wajid Aziz Usman Habib Department of Computer Sciences and Information Technology University of Azad Jammu and KashmirMuzaffarabad13100Pakistan Department of Computer Science and AI College of Computer Science and EngineeringUniversity of JeddahJeddah23890Saudi Arabia Department of Computer and Network Engineering College of Computer Science and EngineeringUniversity of JeddahJeddah23890Saudi Arabia Department of AI&DS School of ComputingNational University of Computer and Emerging SciencesIslamabad44000Pakistan

Machine Learning(ML)-based prediction and classification systems employ data and learning algorithms to forecast target ***,improving predictive accuracy is a crucial step for informed *** the healthcare domain,data are available in the form of genetic profiles and clinical characteristics to build prediction models for complex tasks like cancer detection or *** ML algorithms,Artificial Neural Networks(ANNs)are considered the most suitable framework for many classification *** network weights and the activation functions are the two crucial elements in the learning process of an *** weights affect the prediction ability and the convergence efficiency of the *** traditional settings,ANNs assign random weights to the *** research aims to develop a learning system for reliable cancer prediction by initializing more realistic weights computed using a supervised setting instead of random *** proposed learning system uses hybrid and traditional machine learning techniques such as Support Vector Machine(SVM),Linear Discriminant Analysis(LDA),Random Forest(RF),k-Nearest Neighbour(kNN),and ANN to achieve better accuracy in colon and breast cancer *** system computes the confusion matrix-based metrics for traditional and proposed *** proposed framework attains the highest accuracy of 89.24 percent using the colon cancer dataset and 72.20 percent using the breast cancer dataset,which outperforms the other *** results show that the proposed learning system has higher predictive accuracies than conventional classifiers for each dataset,overcoming previous research ***,the proposed framework is of use to predict and classify cancer patients ***,this will facilitate the effective management of cancer patients.

关键词： ANN decision support systems gene-expression data hybrid classification machine learning predictive analytics

A Deep Learning Based Sentiment Analytic Model for the Prediction of Traffic Accidents

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Computers, Materials & Continua 2023年第11期77卷 1599-1615页

作者： nadeem malik Saud Altaf Muhammad Usman Tariq Ashir Ahmed Muhammad Babar University Institute of Information Technology PMAS Arid Agriculture UniversityRawalpindi46000Pakistan Department of Marketing Operationsand Information SystemAbu Dhabi UniversityAbu Dhabi6844United Arab Emirates College of Computer and Information Sciences Prince Sultan UniversityRiyadh11442Saudi Arabia Robotics and Internet of Things Lab Prince Sultan UniversityRiyadh11442Saudi Arabia

The severity of traffic accidents is a serious global concern,particularly in developing *** the main causes and contributing circumstances may reduce the severity of traffic *** exist many machine learning models and decision support systems to predict road accidents by using datasets from different social media forums such as Twitter,blogs and *** such approaches are popular,there exists an issue of data management and low prediction *** article presented a deep learning-based sentiment analytic model known as Extra-large Network Bi-directional long short term memory(XLNet-Bi-LSTM)to predict traffic collisions based on data collected from social ***,a Tweet dataset has been formed by using an exhaustive keyword-based searching *** the next phase,two different types of features named as individual tokens and pair tokens have been obtained by using POS tagging and association rule *** output of this phase has been forwarded to a three-layer deep learning model for final *** experiment has been performed to test the efficiency of the proposed XLNet-Bi-LSTM *** has been shown that the proposed model achieved 94.2%prediction accuracy.

关键词： Accident XLNet Bi-LSTM association rule mining Twitter

Remimazolam for sedation in gastrointestinal endoscopy:A comprehensive review

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World Journal of Gastrointestinal Endoscopy 2024年第7期16卷 385-395页

作者： Dushyant Singh Dahiya Ganesh Kumar Syeda Parsa Manesh Kumar Gangwani Hassam Ali Amir Humza Sohail Saqr Alsakarneh Umar Hayat Sheza malik Yash R Shah Bhanu Siva Mohan Pinnam Sahib Singh Islam Mohamed Adishwar Rao Saurabh Chandan mohammad Al-Haddad Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityMO 66160United States Department of Internal Medicine Chandka Medical CollegeSindh 77280Pakistan Department of Gastroenterology and Hepatology University of Arkansas For Medical SciencesLittle RockAR 72205United States Division of Gastroenterology Hepatology and NutritionEast Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Surgery University of New Mexico School of MedicineAlbuquerqueNM 87106United States Department of Internal Medicine University of Missouri-Kansas CityKansas CityMO 64108United States Department of Internal Medicine Geisinger Wyoming Valley Medical CenterWilkes BarrePA 18711United States Department of Internal Medicine Rochester General HospitalRochesterNY 14621United States Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Department of Internal Medicine John H.Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine Sinai hospitalBaltimoreMD 21215United States Department of Hepatology University of MissouriColumbiaMO 65211United States Department of Internal Medicine Guthrie Robert Packer HospitalSayrePA 18840United States Division of Gastroenterology and Hepatology Creighton University School of MedicineOmahaNE 68131United States Division of Gastroenterology and Hepatology Indiana University School of MedicineIndianapolisIN 46202United States

Worldwide,a majority of routine endoscopic procedures are performed under some form of sedation to maximize patient ***,benzodiazepines and opioids continue to be widely ***,in recent years,Remimazolam is gaining immense popularity for procedural sedation in gastrointestinal(GI)*** is an ultra-short-acting benzodiazepine sedative which was approved by the Food and Drug Administration in July 2020 for use in procedural *** has shown a favorable pharmacokinetic and pharmacodynamic profile in terms of its non-specific metabolism by tissue esterase,volume of distribution,total body clearance,and negligible drug-drug *** also has satisfactory efficacy and has achieved high rates of successful sedation in GI ***,studies have demonstrated that the efficacy of Remimazolam is non-inferior to Propofol,which is currently a gold standard for procedural sedation in most parts of the ***,the use of Propofol is associated with hemodynamic instability and respiratory *** contrast,Remimazolam has lower incidence of these adverse effects intra-procedurally and hence,may provide a safer alternative to Propofol in procedural *** this comprehensive narrative review,highlight the pharmacologic characteristics,efficacy,and safety of Remimazolam for procedural *** also discuss the potential of Remimazolam as a suitable alternative and how it can shape the future of procedural sedation in gastroenterology.

关键词： Remimazolam Endoscopy Sedation Outcomes Efficacy Safety Pharmacokinetics

Coagulation abnormalities and their relationship with bleeding manifestations in patients with dengue-A single center observational study

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Asian Pacific Journal of Tropical Medicine 2023年第2期16卷 65-71页

作者： Govind R.Patel Indu Thanvi mohammad nadeem Rahul Kanwaria Department of Clinical Hematology Dr.SN Medical CollegeJodhpurRajasthanIndia Department of General Medicine Dr.SN Medical CollegeJodhpurRajasthanIndia

Objective:To evaluate coagulation abnormalities and their relationship with bleeding manifestations among patients with ***:This observational study was conducted on 292 adult dengue patients who were admitted to a tertiary care hospital of Western India from July 2021 to June *** tests including prothrombin time(PT),international normalized ratio(INR),activated partial thromboplastin time(aPTT),fibrinogen,and D-dimer were *** were monitored for bleeding ***:Coagulation abnormalities were reported in 42.8%of the ***,prolonged aPTT was the most common coagulation abnormality(40.8%),followed by low fibrinogen(38.7%),raised D-dimer(31.2%),raised INR(26.0%)and prolonged PT(19.2%).Bleeding manifestations were present in 19.9%***,INR,aPTT and D-dimer levels were significantly higher(P<0.01)and fibrinogen level was significantly lower(P<0.001)in patients with bleeding compared to patients without *** with bleeding had a significantly higher rate of all coagulation abnormalities than patients without bleeding(P<0.01).Conclusions:Patients with bleeding showed a significantly higher frequency of coagulation abnormalities compared to patients without *** with dengue should be assessed for coagulation abnormalities.

关键词： Dengue Coagulation abnormalities Coagulation parameters Prothrombin time Activated partial thromboplastin time Bleeding manifestations