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Predictors of survival in autoimmune liver disease overlap syndromes

World Journal of Hepatology 2024年第9期16卷 1269-1277页

作者： Dujinthan Jayabalan Yi Huang Luis Calzadilla-Bertot malik Janjua Bastiaan de Boer John Joseph Wendy Cheng Simon Hazeldine Briohny W Smith Gerry C MacQuillan Michael C Wallace George Garas Leon A Adams Gary P Jeffrey Medical School University of Western AustraliaNed-lands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Anatomical Pathology PathWest Laboratory MedicineNedlands 6009Western AustraliaAustralia Department of Gastroenterology and Hepatology Royal Perth HospitalPerth 6000Western AustraliaAustralia Department of Gastroenterology and Hepatology Fiona Stanley HospitalMurdoch 6150Western AustraliaAustralia Medical School University of Western AustraliaNedl-ands 6009Western AustraliaAustralia

BACKGROUND Survival in patients with autoimmune liver disease overlap syndromes(AILDOS)compared to those with single autoimmune liver disease is *** To investigate the survival of patients with AILDOS and assess the accuracy of non-invasive serum models for predicting liver-related *** Patients with AILDOS were defined as either autoimmune hepatitis and primary biliary cholangitis overlap(AIH-PBC)or autoimmune hepatitis and primary sclerosing cholangitis overlap(AIH-PSC)and were identified from three tertiary centres for this cohort ***-related death or transplantation(liver-related mortality)was determined using a population-based data linkage *** scores for liver-related death were compared for accuracy[including liver outcome score(LOS),Hepascore,Mayo Score,model for end-stage liver disease(MELD)score and MELD incorporated with serum sodium(MELD-Na)score].RESULTS Twenty-two AILDOS patients were followed for a median of 3.1 years(range,0.35-7.7).Fourteen were female,the median age was 46.7 years(range,17.8 to 82.1)and median Hepascore was 1(range,0.07-1).At five years post enrolment,57%of patients remained free from liver-related mortality(74%AIH-PBC,27%AIH-PSC).There was no significant difference in survival between AIH-PBC and *** was a significant predictor of liver-related mortality(P<0.05)in patients with AIH-PBC(n=14)but not AIH-PSC(n=8).A LOS cut-point of 6 discriminated liver-related mortality in AIH-PBC patients(P=0.012,log-rank test,100%sensitivity,77.8%specificity)(Harrell's C-statistic 0.867).The MELD score,MELD-Na score and Mayo Score were not predictive of liver-related mortality in any *** Survival in the rare,AILDOS is *** current study supports the LOS as a predictor of liver-related mortality in AIH-PBC *** trials investigating predictors of survival in AILDOS are required.

关键词： Autoimmune liver disease overlap syndromes Liver outcome score Liver-related death Hepascore Autoimmune hepatitis Primary biliary cholangitis Primary sclerosing cholangitis

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An Efficient Mechanism for Product Data Extraction from E-Commerce Websites

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Computers, Materials & Continua 2020年第12期65卷 2639-2663页

作者： malik javed Akhtar Zahur Ahmad Rashid Amin Sultan H.Almotiri Mohammed A.Al Ghamdi Hamza Aldabbas University of Engineering and Technology TaxilaPakistan Computer Science Department Umm Al-Qura UniversityMakkah CitySaudi Arabia Al-Balqa Applied University Al-SaltJordan

A large amount of data is present on the web which can be used for useful purposes like a product recommendation,price comparison and demand forecasting for a particular *** are designed for human understanding and not for ***,to make data machine-readable,it requires techniques to grab data from web *** have addressed the problem using two approaches,i.e.,knowledge engineering and machine *** of the art knowledge engineering approaches use the structure of documents,visual cues,clustering of attributes of data records and text processing techniques to identify data records on a web *** learning approaches use annotated pages to learn *** rules are used to extract data from unseen web *** structure of web documents is continuously ***,new techniques are needed to handle the emerging requirements of web data *** this paper,we have presented a novel,simple and efficient technique to extract data from web pages using visual styles and structure of *** proposed technique detects Rich Data Region(RDR)using query and correlative words of the *** is then divided into data records using style *** elements are removed using a Common Tag Sequence(CTS)and formatting *** system is implemented using JAVA and runs on the dataset of real-world working *** effectiveness of results is evaluated using precision,recall,and F-measure and compared with five existing systems.A comparison of the proposed technique to existing systems has shown encouraging results.

关键词： Document object model rich data region common tag sequence web data extraction deep web mining

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凉山州地质灾害发育特征与时空分布规律

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沉积与特提斯地质 2024年第3期44卷 478-492页

作者：徐伟铁永波郑玄殷万清付小麟欧文白永健 Ireneusz malik Małgorzata Wistuba 中国地质调查局成都地质调查中心(西南地质科技创新中心) 四川成都610218 自然资源部地质灾害风险防控工程技术创新中心四川成都611734 自然资源部成都地质灾害野外科学观测研究站四川成都610000 凉山州地质环境监测站四川西昌615000 四川省国土空间生态修复与地质灾害防治研究院四川成都610081 卡托维兹西里西亚大学地球科学研究所波兰卡托维兹41-200

凉山州地处横断山系东北缘、川滇构造带南段,受活动构造、地形地貌、河流切割等作用影响,发育有地质灾害总数4016处,以中、小型土质滑坡和中、小型沟谷泥石流为主,是四川省地质灾害高风险地区。本文采用资料收集、数理统计、ArcGIS软件... 详细信息

凉山州地处横断山系东北缘、川滇构造带南段,受活动构造、地形地貌、河流切割等作用影响,发育有地质灾害总数4016处,以中、小型土质滑坡和中、小型沟谷泥石流为主,是四川省地质灾害高风险地区。本文采用资料收集、数理统计、ArcGIS软件分析等方法分析发现,按行政区分析,德昌县是地质灾害发育数量最多的县市,为387处;宁南县是灾害发育密度最高的县市,为17.7处/100 km^(2);按流域分析,安宁河流域的地质灾害数量最多,达779处;美姑河流域的灾害发育密度最高,达11.18处/100 km^(2)。以灾害发育密度为指标对不同灾害类型地质灾害的空间分布进行分析,滑坡方面,划分为4个极高密度区和15个高密度区,滑坡发育受活动构造、易滑地层(红层、昔格达组等)控制作用影响较大;崩塌方面,划分为2个极高密度区和5个高密度区,崩塌沿河谷及支沟、活动构造呈带状分布,受水电站库区开发建设、公路建设等工程活动切坡影响较大;泥石流方面,划分为2个极高密度区和10个高密度区,泥石流发育受构造断裂、地形地貌和人类工程活动影响较大。研究成果可为凉山州的防灾减灾工作提供数据支撑和科学参考。

关键词：地质灾害发育特征时空分布规律

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Effects of drug-polymer dispersions on solubility and in vitro diffusion of artemisinin across a polydimethylsiloxane membrane

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Chinese Science Bulletin 2012年第14期57卷 1685-1692页

作者： SHAHZAD Yasser SHAH Syed Nisar Hussain ansari Muhammad Tayyab RIAZ Romana SAFDAR Aasma HUSSAIN Talib malik Madeeha Faculty of Pharmacy Bahauddin Zakariya University Division of Pharmacy and Pharmaceutical Sciences School of Applied SciencesUniversity of Huddersfield Hamdard Institute of Pharmaceutical Sciences Hamdard University

Artemisinin(ART) is a sesquiterpene lactone with an endo-peroxide bridge that is thought to be responsible for its antimalarial *** has low oral bioavailability because of aqueous insolubility,which leads to local toxicity at the site of *** present work focused on increasing its solubility and evaluating its permeation across a model membrane to mimic transdermal delivery that bypasses the hepatic *** this purpose,physical mixtures(PM),solid dispersions(SD) and lyophilized dispersions(LD) with different drug-polymer ratios(1:0.5,1:1,1:2,1:4 and 1:9) were prepared using the hydrophilic polymer polyvinylpyrrolidone(PVP).Drug-polymer dispersions were characterized using X-ray diffraction(XRD) and Fourier transform infrared spectroscopy(FTIR).Solubility was measured in three solvents:de-ionized water,phosphate buffered saline(PBS) and *** toluene-water partition coefficient was evaluated and compared with the literature and calculated logP *** vitro diffusion of ART was studied across a polydimethylsiloxane membrane from a saturated solution of drug-polymer *** patterns showed a gradual decrease in crystallinity of ART with increasing polymer concentration,while FTIR confirmed no interactions between ART and *** was increased up to 4-,5-and 8-fold for LD in water,PBS and methanol,*** logP for toluene-water was 2.65 ± 0.3,which is in good agreement with literature and calculated logP *** was enhanced,which is attributed to the decrease in crystallinity and increase in wettability of the *** ART flux was significantly higher than that of pure ART(0.12 ± 0.01) with increasing PVP concentration for SD and LD *** conclusion,drug-polymer dispersions with PVP improve the pharmaceutical properties of ART in the order LD>SD>PM.

关键词：聚合物分散体溶解度测定聚硅氧烷外扩散青蒿素药物傅里叶变换红外光谱水性高分子

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Impact of environmental factors on COVID-19 cases and mortalities in major cities of Pakistan

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Journal of Biosafety and Biosecurity 2021年第1期3卷 10-16页

作者： Rabia Basray Amber malik Wajiha Waqar Ambreen Chaudhry Muhammad Wasif malik Mumtaz Ali Khan Jamil A.ansari Aamir Ikram National Institute of Health Islamabad Pakistan

Introduction:Climate factors play an important role in the transmission of viruses,such as influenza viruses,MERS-CoV,and *** study aimed to determine the relationship between changes in temperature,humidity,rainfall,and SARS-CoV-2 *** ecologically and climatically distinct regions were considered—Karachi,Lahore,Islamabad,Peshawar,and ***:Data on daily COVID-19 cases and deaths were retrieved from government officials,while meteorological information was collected from Pakistan Meteorological *** analysis was performed using SPSS version 20 and the Spearman rank correlation test was used to analyze the correlation between the meteorological factors and COVID-19 cases and ***:Positive correlation of COVID-19 incidence was observed with all the temperature ranges(maximum,minimum and average)and negative correlation was seen with humidity,DTR and ***-19 deaths were positively associated with temperature and were negatively associated only with *** regression showed that for every unit increase in humidity,there was a3.345 daily signifi-cant decrease in COVID-19 cases,while in Karachi for every unit increase in humidity,there remained a 10.104 daily significant increase in *** Gilgit-Baltistan,for every unit increase in average temperature and rainfall respectively,significant increases of 0.534 and 1.286 in daily cases were ***:This study signifies the effect of climate factors on COVID-19 incidence and mortality rate,but climate factors are not the only variable and several other interlinked factors enhance the spread of ***,effective mitigation policies,enhancing testing capacities,and developing public attitudes toward adopting precautionary measures are important to overcome this overwhelming pandemic.

关键词： Climate COVID-19 Mortality Pakistan

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Economic and Social Impact Assessment of Chronic Diseases Among the Low-Income Population in Southern Punjab,Pakistan

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Proceedings of Anticancer Research 2024年第4期8卷 67-74页

作者： Mehran Khan Muhammad Arbab Nasir Muhammad Umar Asadullah Faiz Mirza Muhammad Abdul Bari Ayesha Saeed Fiza Nazeer Khan Saliha Mehboob malik Akashah Usama Tayyab Bahawalpur College of Pharmacy BMDC Complex63100BahawalpurPunjabPakistan

Introduction:Chronic diseases are becoming more prevalent *** effects of chronic illnesses are disastrous not only for the diagnosed person but also for their entire *** study explores chronic diseases’social and economic impact on low-income *** study aims to determine the economic and social implications of various chronic diseases and the loss of income due to these conditions among low-income individuals in Southern Punjab,***:A sample of 424 patients was selected from different areas of Southern *** were collected using a questionnaire that included questions about economic status,self-reported health status,social status,management strategies,and health insurance,among other ***:The mean monthly income of the respondents was found to be 57,097.6 Pakistani rupee(PKR),and the mean monthly expenses for treatment were 8,256.1 *** loss of income was calculated at 15%.Additionally,62%of patients spent more than 10%of their monthly income on managing their *** 85%of the respondents reported that chronic diseases affected their social ***,80%of patients lacked health ***:Chronic diseases impose significant economic and social burdens on patients and their families in Southern *** reduce the burden of chronic diseases,the government should enhance healthcare services in this region and provide health insurance to low-income families.

关键词： Chronic diseases Low-income families Economic impact Punjab Pakistan

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Air traffic monitoring using optimized ADS-B CubeSat constellation

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Astrodynamics 2024年第1期8卷 189-208页

作者： Ghulam Jaffer Rameez Amalik Elias Aboutanios Nazish Rubab Ronnie Nader Hans U.Eichelberger Guy A.E.Vandenbosch Interdisciplinary Centre for Security Reliability and Trust(SnT)University of LuxembourgLuxembourg1855Luxembourg

The primary technique used for air traffic surveillance is ***,nowadays,its role in surveillance is gradually being replaced by the recently adopted Automatic Dependent Surveillance-Broadcast(ADS-B).ADS-B offers a higher accuracy,lower power consumption,and longer range than radar,thus providing more safety to *** coverage of terrestrial radar and ADS-B is confined to continental parts of the globe,leaving oceans and poles uncovered by real-time surveillance *** study presents an optimized Low-Earth Orbit(LEO)-based ADS-B constellation for global air traffic surveillance over intercontinental trans-oceanic flight *** optimization algorithm is based on performance evaluation parameters,i.e.,coverage time,satellite availability,and orbit stability(precession and perigee rotation),and communication *** results indicate that the constellation provides ample coverage in the simulated global oceanic *** constellation is a feasible and cost-effective solution for global air supervision,which can supplement terrestrial ADS-B and radar systems.

关键词： constellation automatic dependent surveillance-broadcast (ADS-B) air traffic surveillance precession perigee rotation.

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青藏高原及其周边寒武纪综合地层、生物群与古地理演化

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中国科学：地球科学 2024年第4期54卷 968-991页

作者：孙智新孙郎赵方臣潘兵 malik Muhammad Saud Sajid KHAN Shehryar AHMED 杨传苗兰云殷宗军李国祥朱茂炎中国科学院南京地质古生物研究所现代古生物学和地层学国家重点实验室南京210008 中国科学院大学地球与行星科学学院北京100049

青藏高原及其周边地区具有漫长且复杂的构造演化历史.印度北部、拉萨、羌塘、柴达木、中祁连等大小不同的克拉通和地块,以及位于它们之间的造山带构成了青藏高原的主体.寒武纪时期,这些克拉通和地块大多位于冈瓦纳大陆的西北缘,并以发... 详细信息

青藏高原及其周边地区具有漫长且复杂的构造演化历史.印度北部、拉萨、羌塘、柴达木、中祁连等大小不同的克拉通和地块,以及位于它们之间的造山带构成了青藏高原的主体.寒武纪时期,这些克拉通和地块大多位于冈瓦纳大陆的西北缘,并以发育与原特提斯洋有关的复杂岩浆-构造运动而与周边的阿拉伯、中伊朗、阿富汗、塔里木、阿拉善、华北、华南和滇缅马等构造单元相关联.从地层记录上看,这一时期区域内的大部分稳定陆块上发育了由陆源碎屑岩和碳酸盐岩组成的浅水陆棚沉积,其中包含面貌相近的典型浅水相三叶虫组合.而在原特提斯洋中的祁连构造带,寒武系则是一套在大洋扩张环境下形成的、以中基性火山岩和硅质岩为主的复杂地层序列,其中包含的碳酸盐岩含有斜坡相三叶虫组合.本文在广泛文献调研的基础上,结合第二次青藏高原综合科学考察中的野外观察及新获得的化石证据,对青藏高原及其周边地区不同构造单元上寒武纪地层发育的总体特征进行了概述.在此基础上,利用可获得的生物地层学和同位素年代学等资料,总结了不同构造单元上寒武纪地层的划分和年代地层对比,编制了岩石和生物地层的综合对比表.此外,从生物古地理的角度,简要讨论了寒武纪研究区内主要构造单元的古地理相关性,以及与原特提斯构造带演变有关的问题.

关键词：青藏高原寒武系地层古地理生物群冈瓦纳大陆原特提斯洋

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Defocus blur detection using novel local directional mean patterns(LDMP)and segmentation via KNN matting

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Frontiers of Computer Science 2022年第2期16卷 110-122页

作者： Awais KHAN Aun IRTAZA Ali javed Tahira NAZIR Hafiz malik Khalid Mahmood malik Muhammad Ammar KHAN Department of Computer Science University of Engineering and TechnologyTaxila 47050Pakistan Department of Electrical and Computer Engineering University of MichiganDearbornMI 48128USA Department of Software Engineering University of Engineering and TechnologyTaxila 47050Pakistan Department of Computer Science and Engineering Oakland UniversityMI 48309USA

Detection and segmentation of defocus blur is a challenging task in digital imaging applications as the blurry images comprise of blur and sharp regions that wrap significant information and require effective methods for information *** defocus blur detection and segmentation methods have several limitations i.e.,discriminating sharp smooth and blurred smooth regions,low recognition rate in noisy images,and high computational cost without having any prior knowledge of images i.e.,blur degree and camera ***,there exists a dire need to develop an effective method for defocus blur detection,and segmentation robust to the above-mentioned *** paper presents a novel features descriptor local directional mean patterns(LDMP)for defocus blur detection and employ KNN matting over the detected LDMP-Trimap for the robust segmentation of sharp and blur *** argue/hypothesize that most of the image fields located in blurry regions have significantly less specific local patterns than those in the sharp regions,therefore,proposed LDMP features descriptor should reliably detect the defocus blurred *** fusion of LDMP features with KNN matting provides superior performance in terms of obtaining high-quality segmented regions in the ***,the proposed LDMP features descriptor is robust to noise and successfully detects defocus blur in high-dense noisy *** results on Shi and Zhao datasets demonstrate the effectiveness of the proposed method in terms of defocus blur *** and comparative analysis signify that our method achieves superior segmentation performance and low computational cost of 15 seconds.

关键词： defocus blur detection local directional mean patterns image matting sharpness metrics blur segmentation

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Active Queue Management Exploiting the Rate Information in TCP-IP Networks

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IEEE/CAA Journal of Automatica Sinica 2018年第1期5卷 223-231页

作者： Abderrahmane Boudi malik Loudini Laboratoire de la Communication dans les Systemes Informatiques Ecole nationale Superieure d'Informatique ESI Algiers 16309 Algeria IEEE

In this paper, we propose a new mechanism called explicit rate notification(ERN) to be used in end-to-end communications. The ERN scheme encodes in the header of transmission control protocol(TCP) packets information about the sending rate and the round trip time(RTT) of the flows. This new available information to the intermediate nodes(routers) is used to improve fairness, increase utilization, decrease the number of drops, and minimize queueing delays. Thus, it induces a better management of the queue. A comparison of our scheme with preexistent schemes, like the explicit congestion notification scheme, shows the effectiveness of the proposed mechanism.

关键词： Active queue management congestion control fairness transmission control protocol(TCP)

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