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Liquid biopsy in metastatic breast cancer

Cancer Drug Resistance 2019年第4期2卷 1062-1068页

作者： malgorzata banys-paluchowski Peter paluchowski Department of Gynecology and Obstetrics Asklepios-Klinik Hamburg BarmbekHamburg 22307Germany Department of Gynecology and Obstetrics Regio Klinikum PinnebergPinneberg 25421Germany

The spread of single tumor cells shed by the primary tumor has been observed in most solid carcinomas and is generally associated with poor clinical *** cells detected in the peripheral blood are commonly referred to as circulating tumor cells(CTCs)and are seen as possible precursors of metastatic *** CTCs,circulating tumor DNA and non-coding RNA are increasingly the focus of translation cancer *** metastatic breast cancer(MBC),elevated levels of CTCs have been confirmed as an independent prognostic *** detection of elevated counts after the start of systemic therapy predicts poor response,it is unclear which treatment strategy should be offered in the case of CTC ***,the main potentials of blood-based diagnostics in BC are therapy monitoring and liquid biopsy-based treatment ***,the first positive study on CTC-guided therapy choices in hormone receptor positive HER2 negative MBC was *** the present review,we discuss the current data and potential clinical application of liquid biopsy in the metastatic setting.

关键词： Tumor cell dissemination circulating tumor cell liquid biopsy circulating tumor DNA breast cancer

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Male papillary breast cancer treated by wide resection and latissimus dorsi flap reconstruction: A case report and review of the literature

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World Journal of Clinical Oncology 2016年第5期7卷 420-424页

作者： malgorzata banys-paluchowski Eike Burandt Joanna banys Stefan Geist Guido Sauter Natalia Krawczyk Peter paluchowski Department of Obstetrics and Gynecology Marienkrankenhaus Hamburg Department of Pathology University of Hamburg Wroclaw Medical University Department of Obstetrics and Gynecology Regio Klinikum Pinneberg Department of Obstetrics and Gynecology University of Duesseldorf

Breast cancer(BC) in men represents between 0.5% and 1% of all BC diagnosed each year. We report a case of advanced BC in a 62-year-old male treated at our interdisciplinary Breast Cancer Center. The patient presented with a newly diagnosed large, symptomatic mass in his left breast. Clinical examination showed a not movable mass of 16 cm diameter, deforming the whole breast; the overlying skin was livid and hypervascularized. Enlarged lymph nodes were palpable in the axillary pit. He had no concomitant diseases at time of presentation. He denied any first- or second degree family medical history of cancer of any type and he never received radiotherapy. Ultrasound guided minimal-invasive 14-gauge core biopsy revealed a moderately differentiated encapsulated papillary carcinoma with high expression of estrogen and progesterone receptors(both > 80%, IRS 12) and HER2-negative. Because of the tumor size a mastectomy with axillary dissection and chest wall reconstruction using a latissimus dorsi flap was performed. Histological analysis showed invasive growth besides typical(non-invasive) papillary carcinoma and was classified as invasive solid papillary carcinoma; p T3(10 cm), p N0(0/15), M0,R0; Oncotype DX Recurrence Score indicated low risk(RS: 2). After discussion in the interdisciplinary tumor board meeting, radiation therapy and tamoxifen were recommended. The patient had an uneventful recovery and is disease-free after two years of follow-up. Male BC is typically diagnosed at an advanced stage, most likely due to a lack of awareness that men can develop BC. Therefore, in case of a large tumor, a flap-based thoracic reconstruction may be required.

关键词： Male breast cancer Papillary carcinoma Reconstruction Latissimus dorsi flap Rare tumors

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Liposarcoma of the breast arising in a malignant phyllodes tumor:A case report and review of the literature

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World Journal of Clinical Oncology 2015年第5期6卷 174-178页

作者： malgorzata banys-paluchowski Eike Burandt Alexander Quaas Waldemar Wilczak Stefan Geist Guido Sauter Natalia Krawczyk Klaus Pietzner Peter paluchowski Department of Obstetrics and Gynecology Marienkrankenhaus Hamburg22087 HamburgGermany Department of Pathology University of Hamburg Department of Obstetrics and Gynecology Regio Klinikum Pinneberg25421 PinnebergGermany Department of Obstetrics and Gynecology University of Duesseldorf Department of Obstetrics and Gynecology University of Berlin-Charite

Liposarcoma of the breast is a very rare malignant tumor. It can clinically manifest as a palpable breast mass and mimic primary breast cancer. We report an unusual case of a 51-year-old female who presented with an asymptomatic right breast mass, which was histologically diagnosed as well differentiated liposarcoma arisen within malignant phyllodes tumor. The patient underwent breast conserving surgery, received no adjuvant treatment and is disease-free after 2 years. Radiological and histopathological features are presented and described in detail. Data from the literature are presented and therapy recommendations discussed.

关键词： Liposarcoma Soft tissue sarcoma Breast cancer Phyllodes tumor Rare malignancies

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Isolated subcutaneous implantation of a borderline ovarian tumor:A case report and review of the literature

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World Journal of Clinical Oncology 2016年第2期7卷 270-274页

作者： malgorzata banys-paluchowski Borsu Yeganeh Jutta Luettges Achim Maibach Ruediger Langenberg Natalia Krawczyk Peter paluchowski Holger Maul Gerhard Gebauer Department of Obstetrics and Gynecology Marienkrankenhaus Hamburg Department of Pathology Marienkrankenhaus Hamburg Department of Obstetrics and Gynecology University Hospital Duesseldorf Department of Obstetrics and Gynecology Regio Klinik Pinneberg

Laparoscopy-related tumor implantations of gynecological malignancies into the subcutaneous tissue are rarely *** report an interesting case of a 46-year-old female who presented with an abdominal subcutaneous metastasis of a borderline ovarian *** patient received a laparoscopic unilateral adnexectomy for a solid-cystic tumor of the right *** workup showed a papillary borderline tumor of mucinous *** days later she underwent a hysterectomy,left adnexectomy,appendectomy and *** of the peritoneum revealed no intraperitoneal *** exploration showed a non-invasive implant of a borderline tumor in the subcutaneous tissue above the fascia that had no contact to the *** is hypothesized that tumor cells may have been implanted during a previous laparoscopy,the most recent of which had been fourteen years prior to her current *** risk factors for port-site malignancies have been *** manipulation and extraction of tumor tissue without a protective bag may contribute to development of trocarsite metastasis.

关键词： Laparoscopy Subcutaneous metastasis Tumor implantation Borderline tumor of the ovary

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