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Exploring expressive and functional capacities of knitted textiles exposed to wind influence

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Frontiers of Architectural Research 2021年第3期10卷 669-691页

作者： Erica Hörteborn malgorzata A.Zboinska Department of Architecture and Civil Engineering Chalmers University of TechnologyGöteborgSE-41296Sweden

This study explores the design possibilities with knitted architectural textiles subjected to *** purpose is to investigate how such textiles could be applied to alter the usual static expression of exterior architectural and urban elements,such as facades and *** design investigations were made on a manual knitting machine and on a CNC(computer numerically controlled)flat knitting *** knitting techniques-tuck stitch,hanging stitches,false lace,and drop stitch-were explored based on their ability to create a three-dimensional effect on the surface level as well as on an architectural *** textile samples produced using those four techniques were subjected to controlled action of *** experiments were also conducted,to probe the possibilities of digitally simulating textile behaviours in *** results indicate that especially the drop stitch technique exhibits interesting *** variations in the drop stitch pattern generate both an aesthetic effect of volumetric expression of the textile architectural surface and seem beneficial in terms of wind speed ***,these types of knitted textiles could be applied to design architecture that are efficient in terms of improving the aesthetic user experience and comfort in windy urban areas.

关键词： Textile architecture Knitted textiles Kinetic architecture Wind Aesthetic qualities Digital textile simulation

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Liquid biopsy in metastatic breast cancer

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Cancer Drug Resistance 2019年第4期2卷 1062-1068页

作者： malgorzata Banys-Paluchowski Peter Paluchowski Department of Gynecology and Obstetrics Asklepios-Klinik Hamburg BarmbekHamburg 22307Germany Department of Gynecology and Obstetrics Regio Klinikum PinnebergPinneberg 25421Germany

The spread of single tumor cells shed by the primary tumor has been observed in most solid carcinomas and is generally associated with poor clinical *** cells detected in the peripheral blood are commonly referred to as circulating tumor cells(CTCs)and are seen as possible precursors of metastatic *** CTCs,circulating tumor DNA and non-coding RNA are increasingly the focus of translation cancer *** metastatic breast cancer(MBC),elevated levels of CTCs have been confirmed as an independent prognostic *** detection of elevated counts after the start of systemic therapy predicts poor response,it is unclear which treatment strategy should be offered in the case of CTC ***,the main potentials of blood-based diagnostics in BC are therapy monitoring and liquid biopsy-based treatment ***,the first positive study on CTC-guided therapy choices in hormone receptor positive HER2 negative MBC was *** the present review,we discuss the current data and potential clinical application of liquid biopsy in the metastatic setting.

关键词： Tumor cell dissemination circulating tumor cell liquid biopsy circulating tumor DNA breast cancer

In elderly population prophylactic anticoagulation favors early detection of digestive track cancers: an observational study in eastern Poland

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Journal of Geriatric Cardiology 2019年第6期16卷 495-497页

作者： malgorzata Szlendak Wojciech Myslinski Jerzy Mosiewicz Wojciech Barud Department of Internal Diseases Medical University in Lublin Poland Human Anatomy Department Medical University in Lublin Poland

The launch of non-VKA oral anticoagulants (NOACs) caused revolution in thrombosis prevention, which was mainly due to their safety and simplicity in treatment when compared to vitamin K antagonists (VKA). Clinical observations indicate that despite the benefits of NOACs, many patients still use VKA even if they cannot cope with dose modifications and often do not control INR.

关键词： Anticoagulants Colonic neoplasms Gastrointestinal hemorrhage

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N-acetylcysteine does not prevent post-endoscopic retrograde cholangiopancreatography hyperamylasemia and acute pancreatitis

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World Journal of Gastroenterology 2006年第23期12卷 3751-3755页

作者： Janusz Milewski Grazyna Rydzewska malgorzata Degowska Maciej Kierzkiewicz Andrzej Rydzewski Department of Internal Medicine and Gastroenterology Central Clinical Hospital of Ministry of Internal Affairs and AdministrationWarsawPoland Department of Internal Medicine and Gastroenterology Central Clinical Hospital of Ministry of Internal Affairs and AdministrationWarsawand Institute of Experimental and Clinical MedicinePolish Academy of SciencesWarsawPoland Department of Internal Medicine and Gastroenterology Central Clinical Hospital of Ministry of Internal Affairs and AdministrationWarsawPoland Department of Internal Medicine & Nephrology Central Clinical Hospital of Ministry of Internal Affairs and AdministrationWarsawand Institute of of Experimental and Clinical MedicinePolish Academy of Sciences Warsaw Poland

AIM： Acute pancreatitis （AP） is the most common and often severe complication of endoscopic retrograde cholangiopancreatography （ERCP）. The early step in the pathogenesis of acute pancreatitis is probably the capillary endothelial injury mediated by oxygen-derived free radicals. N-acetylcysteine - a free radical scavenger may be potentially effective in preventing post-ERCP acute pancreatitis and it is also known that N-acetylcysteine （ACC） can reduce the severity of disease in experimental model of AP. METHODS： One hundred and six patients were randomly allocated to two groups. Fifty-five patients were given N-acetylcysteine （two 600 mg doses orally 24 and 12 h before ERCP and 600 mg was given iv, twice a day for two days after the ERCP）. The control group consisted of 51 patients who were given iv. isotonic saline twice a day for two days after the ERCP. Serum and urine amylase activities were measured before ERCP and 8 and 24 h after the procedure. The primary outcome parameter was post-ERCP acute pancreatitis and the secondary outcome parameters were differences between groups in serum and urine amylase activity. RESULTS： There were no significant differences in the rate of post-ERCP pancreatitis between two groups （10 patients overall, 4 in the ACC group and 6 in the controlgroup）. There were also no significant differences in baseline and post-ERCP serum and urine amylase activity between ACC group and control group. CONCLUSION： N-acetylcysteine fails to demonstrate any significant preventive effect on post-ERCP pancreatitis, as well as on serum and urine amylase activity.

关键词： N-acetylcysteine ERCP Acute pancreatitis Hyperarnylasemia

Biofunctionalized upconverting CaF2：Yb,Tm nanoparticles for Candida albicans detection and imaging

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Nano Research 2017年第10期10卷 3333-3345页

作者： malgorzata Misiak Michal Skowicki Tomasz Lipinski Agnieszka Kowalczyk Katarzyna Prorok Sebastian Arabasz Artur Bednarkiewicz Wroctaw Research Centre EIT+ ul. Stablowicka 147 54-066 Wroclaw Poland Insitute of Immunology and Experimental Therapy Polish Academy of Sciences ul. Rudolfa Weigla 12 53-114 Wroctaw Poland Centre of Polymer and Carbon Materials Polish Academy of Sciences M. Curie-Sklodowskiej 34 41-819 Zabrze Poland Institute of Low Temperature and Structure Research Polish Academy of Sciences ul. Okolna 2 50-422 Wroctaw Poland

Versatile optimization of the synthesis method and composition of Yb^3＋ and Tm^3＋ co-doped CaF2 nanoparticles as well as a novel biofunctionalization method were developed and evaluated. Through multistep synthesis, the luminescence intensity of the Tm3. activator was enhanced by more than 10-fold compared to standard one-step synthesis. The proposed methods were used to homogenously distribute the doping ions within the nanoparticle＇s volume and thus reduce luminescence quenching. Optimization of dopant ions concentration led to the selection of the most efficient visible and near-infrared up-converting nanoparticles, which were CaF2 doped with 10% Yb^3＋ 0.05% Tm^3＋ and 20% Yb3. 0.5% Tm^3＋, respectively. To illustrate the suitability of the synthesized nanoparticles as bio-labels, a dedicated biofunctionalization method was used, and the nanoparticles were applied for labeling and imaging of Candida albicans cells. This method shows great promise because of extremely low background and high specificity because of the presence of the attached molecules.

关键词： up-conversion luminescence nanomaterials fluoride nanoparticles bioimaging

Nonalcoholic fatty liver disease and HFE gene mutations:A Polish study

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World Journal of Gastroenterology 2010年第20期16卷 2531-2536页

作者： Joanna Raszeja-Wyszomirska Grzegorz Kurzawski malgorzata Lawniczak Joanna Miezynska-Kurtycz Jan Lubinski Liver Unit Pomeranian Medical University70-111 SzczecinPoland Department of Genetics and Pathology International Hereditary Cancer CentrePomeranian Medical University70-111 SzczecinPoland Department of Gastroenterology Pomeranian Medical University71-252 SzczecinPoland

AIM:To describe a Polish population with nonalcoholic fatty liver disease(NAFLD)with regard to HFE gene mutations,as well as analyzing demographic and clinical ***:Sixty-two consecutive patients with biopsy-proven NAFLD were included in the ***,clinical,and laboratory data were summarized in a database.C282Y and H63D mutations of the HFE gene were analyzed using polymerase chain reactionrestriction fragment lenght ***:The analyzed cohort consisted of 62 homo-geneic Caucasian participants,66.1%men and 33.9% women,with a median age of 48 *** median body mass index was 29.05 kg/m 2 .Hypercholesterolemia was observed in 74.2%of patients and hypertriglyceridemia in 32.2%;16.1%had type 2 diabetes mellitus(DMt2).On liver biopsy,22.6%of NAFLD patients were found to have severe *** were no differences between frequencies of HFE gene mutations in subgroups of NAFLD patients with less and more severe liver ***,older age,female gender and DMt2 were associated with more advanced fibrosis in this Polish cohort,as well as higher glucose level,serum iron and transaminase aspartate aminotransferase/alanine aminotransferase ***:HFE mutations conferred no additional hepatic fibrosis risk in NAFLD,but higher serum iron was a risk factor for severe liver damage in NAFLD,regardless of HFE mutations.

关键词： Nonalcoholic fatty liver disease HFE gene mutations Liver fibrosis

Antimicrobial activity of water and acetone extracts of some Eucomis taxa

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Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 892-895页

作者： malgorzata Mizielińska Piotr Salachna Magdalena Ordon Lukasz Lopusiewicz Center of Bioimmobilisation and Innovative Packaging Materials Faculty of Food Sciences and Fisheries West Pomeranian University of Technology Szczecin Department of Horticulture West Pomeranian University of Technology Szczecin

Objective: To evaluate the antibacterial and antifungal properties of acetone and water extracts of selected Eucomis ***: The bulbs of Eucomis bicolor, Eucomis comosa(E. comosa) and E. comosa cv. were dried and examples from each experimental treatment were ground separately into powder. Each sample was divided into two groups with equal amounts of powder,and respectively extracted with water and a 70% solution of aqueous acetone. The crude water extracts were then filtered through a 0.2 mm filter. The 70% aqueous acetone extracts were next concentrated at 40C. After the evaporation of the acetone, the samples were additionally filtered through a 0.2 mm filter. The antibacterial and antifungal activities of the extracts against chosen microorganisms were then ***: The results of the study demonstrated that the water and acetone extracts of Eucomis bulbs have an influence on the viability of Staphylococcus aureus and Bacillus atrophaeus strains. In the case of mediums containing E. comosa and E. comosa ***, a decrease in the number of gram-positive bacteria was dependent on the extract concentration. The best results were obtained in the case of the 25% extracts. The water and acetone extracts of Eucomis bulbs did not cause a decrease in the number of Escherichia coli cells. Additionally, antifungal activity against Aspergillus niger, Botrytis cinerea, Stachybotrys chartarum, Mucor circinelloides and Rhizopus oryzae cells were also not ***: The tested gram-negative and fungi microorganisms show resistance towards acetone and water extracts of Eucomis bulbs. The highest activity is found in the case of Aspergillus clavatus, Staphylococcus aureus and Bacillus atrophaeus strains,which shows water and acetone extracts of 25%.

关键词： Antibacterial Antifungal Medicinal plants Pineapple lily

Chronic allograft rejection:A significant hurdle to transplant success

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Burns & Trauma 2014年第1期2卷 3-10页

作者： malgorzata Kloc Rafik M.Ghobrial Department of Surgery Houston Methodist HospitalHouston Houston Methodist Hospital Research Institute HoustonTXUSA

The state-of-the-art immunosuppression drugs do not ensure indefi nite transplant survival,and most transplants are continuously lost to chronic rejection even years *** form of rejection is responsible for long-term failure of transplanted *** mechanisms involved in development of chronic rejection are not *** of the main features of chronic rejection is progressive luminal narrowing of graft vessels,which results in compromised blood flow,ischemia,cell death,and finally graft *** the existing immunosuppressive regimens are targeting acute rejection,and at present there is no available therapy for prevention of chronic *** rejection involves two major,but interrelated responses:The first is the host immune response against the transplant mediated primarily by alloreactive T and B cells,and the second is injury and repair of the graft(vasculopathy of graft vessels).Here we focus on recent advances in understanding the cellular and molecular aspects of chronic transplant vasculopathy and function of macrophages,topics pivotal for development of novel antichronic rejection therapies.

关键词： Chronic rejection macrophage neointima consists of smooth muscle cells vasculopathy

Chemistry of sediments from the Dobczyce Reservoir,Poland,and the environmental implications

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International Journal of Sediment Research 2010年第1期25卷 28-38页

作者： Witold RECZYNSKI malgorzata JAKUBOWSKA Janusz GOLAS Andrew PARKER Barbara KUBICA University of Science and Technology University of Reading Institute of Nuclear Physics

Sediments samples of the Dobczyce Reservoir(South Poland) were taken in three successive years(2004-06) at 17 points,analyzed for 12 elements by atomic absorption *** variations in elemental composition due to hydrological and environmental reasons were *** use of statistical and chemometric tools enabled objective and effective analysis of the data obtained,both in case of long term observations as well as in terms of interpretation of incidental changes in metal *** proposed methodology can be useful in:a) dividing monitored territories(lakes,rivers,catchments) into similar and dissimilar areas;b) distinguishing between typical and non-typical contaminants distribution;c) reducing the number of essential analytes and sampling points that should be controlled in the future,without loss of important environmental information.

关键词： Dobczyce Reservoir Sediments Metals CA PCA