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Insulin receptor substrate 1 may play divergent roles in human colorectal cancer development and progression

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World Journal of Gastroenterology 2020年第28期26卷 4140-4150页

作者： Karolina Lomperta Katarzyna jakubowska malgorzata Grudzinska Luiza Kanczuga-Koda Andrzej Wincewicz Eva Surmacz Stanislaw Sulkowski Mariusz Koda Department of General Pathomorphology Medical University of BialystokBialystok 15269Poland Department of Pathomorphology Comprehensive Cancer CentreBialystok 15027Poland Department of Pathology Nonpublic Health Care UnitKielce 25734Poland Allysta Pharmaceuticals Incorporated BelmontCA 94002United States

BACKGROUND Despite effective prevention and screening methods,the incidence and mortality rates associated with colorectal cancer(CRC)are still *** receptor substrate 1(IRS-1),a signaling molecule involved in cell proliferation,survival and metabolic responses has been implicated in carcinogenic processes in various cellular and animal ***,the role of IRS-1 in CRC biology and its value as a clinical CRC biomarker has not been well *** To evaluate if and how IRS-1 expression and its associations with the apoptotic and proliferation tumor markers,Bax,Bcl-xL and Ki-67 are related to clinicopathological features in human *** The expression of IRS-1,Bax,Bcl-xL and Ki-67 proteins was assessed in tissue samples obtained from 127 patients with primary CRC using immunohistochemical *** assays were performed using specific antibodies against IRS-1,Bax,Bcl-xL,*** associations between the expression of IRS-1,Bax,Bcl-xL,Ki-67 were analyzed in relation to clinicopathological parameters,i.e.,patient age,sex,primary localization of tumor,histopathological type,grading,staging and lymph node *** between variables were examined by Spearman rank correlation test and Fisher exact test with a level of significance at P<*** Immunohistochemical analysis of 127 CRC tissue samples revealed weak cytoplasmatic staining for IRS-1 in 66 CRC sections and strong cytoplasmatic staining in 61 ***-1 expression at any level in primary CRC was associated with tumor grade(69%in moderately differentiated tumors,G2 vs 31%in poorly differentiated tumors,G3)and with histological type(81.9%in adenocarcinoma vs 18.1%in adenocarcinoma with mucosal component cases).Strong IRS-1 positivity was observed more frequently in adenocarcinoma cases(95.1%)and in moderately differentiated tumors(85.2%).We also found statistically significant correlations between expression of IRS-1 and both Bax and Bcl-xL in all CRC cases *** relat

关键词： Colorectal cancer Insulin receptor substrate-1 Bax protein Bcl-xL protein Apoptosis Antigen Ki-67

Comparison of the sediment composition in relation to basic chemical,physical,and geological factors

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International Journal of Sediment Research 2020年第3期35卷 307-314页

作者： Witold Reczyński Katarzyna Szar?owicz Ma?gorzata jakubowska Peter Bitusik Barbara Kubica AGH University of Science and Technology Faculty of Materials Science and Ceramics AGH University of Science and Technology Faculty of Energyand Fuels Matej Bel University Faculty of Natural Sciences

Sediment constitutes an interesting and valuable material for observation of human impact on the *** on the sediment core samples in two Tatra Mountains lakes,determination of the selected elements（including cesium 137 radionuclide activity and heavy metals' concentrations） and dating of the obtained layers by the lead 210 method,chemometric analysis of the resulting data set was *** was established,as a result of Cluster Analysis,that the variability of the determined parameters was distinct in the lakes with much higher concentrations of heavy metals in Smreczynski staw ***,the influence of human activity（long distance transport of contaminants） is notable on the north slopes of the Tatras（Smreczynski staw lake） comparing to Popradske pleso *** examined elements can be divided into two groups-natural to the site origin（iron,manganese,and magnesium）,and elements whose accumulation in the sediments can be related（at least in part） to human activity(137Cs,zinc,copper,cadmium,lead,and chromium).The results confirm the existence of the so called "screen effect",meaning that the Tatra Mountains' crest delimits to a considerable extent further transport of pollutants to the south side of the Tatra Mountains slopes.

关键词： Sediment Tatra mountains Metals Radionuclides Chemometry

Monocyte-to-lymphocyte ratio as a prognostic factor in peripheral whole blood samples of colorectal cancer patients

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World Journal of Gastroenterology 2020年第31期26卷 4639-4655页

作者： Katarzyna jakubowska Mariusz Koda Małgorzata Grudzinska Luiza Kanczuga-Koda Waldemar Famulski Department of Pathomorphology Comprehensive Cancer CentreBialystok 15027Poland Department of General Pathomorphology Medical University of BialystokBialystok 15027Poland Department of Medical Pathomorphology Medical University of BialystokBialystok 15027Poland

BACKGROUND Colorectal cancer is the third most common malignancy ***,it is critically important to identify new useful markers that can be easily obtained in routine *** is a crucial issue in the pathogenesis and development of *** To evaluate the prognostic value of absolute monocyte count,monocyte to lymphocyte ratio(MLR),the combination of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio(NLR-PLR),and combined platelet and neutrophilto-lymphocyte ratio(PLT-NLR)in peripheral blood samples of patients with colorectal cancer undergoing *** We conducted a retrospective study of 160 patients with colorectal cancer who underwent surgery,and 42 healthy *** status of absolute monocyte count,MLR,NLR-PLR and PLT-NLR was calculated on the basis of blood samples obtained before and after *** factors were examined in correlation with the type of tumour growth,tumour size,histological type,percentage of mucinous component,grade of malignancy,Tumour-Node-Metastasis stage,venous,lymphatic and perineural invasion of cancer cells,status of lymph node invasion and the presence of cancer cell *** Kaplan-Meier method and the long-rank test were used to compare survival *** determine independent prognostic factors,univariate and multivariate Cox proportional hazards regression models were *** The PLT-NLR status was correlated with tumour size and the presence of perineural invasion(P=0.015;P=-0.174,P=0.037).Moreover,high NLR-PLR and PLR-NLR ratios in the blood samples obtained after surgery were positively associated with histological type of cancer and percentage of the mucinous component(NLR-PLR:P=0.002;P=0.009;PLR-NLR status:P=0.002;P=0.007).The analysis of 5-year disease-free survival showed that the MLR of whole blood obtained after surgery[HR=2.903,95%CI:(1.368-6.158),P=0.005]and the status of lymph node metastasis[HR=0.813,95%CI:(0.653-1.013),P=0.050]were inde

关键词： Monocyte count Monocyte to lymphocyte ratio Platelet Neutrophil-tolymphocyte ratio Colorectal cancer Prognosis

Determination of Effective Degree-Day for Supporting Chemical Control Against Cutworms （Lep. Noctuinae） in the Sugar Beet

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Journal of Agricultural Science and Technology(A) 2012年第3期2卷 314-326页

作者： Magdalena jakubowska Felicyta Walczak JerzyJ6zefatLipa Department of Methods Forecasting and Pest Registration Institute of Plant Protection National Research Institute （IPP-NRI） W.W~gorka 20 Poznah 60-318 Poland Department of Biological Control Institute of Plant Protection National Research Institute （IPP-NRI） W. Wcgorka 20 Poznah60-318 Poland

The aim of the research was to connect two methods of the chemical control. The first chemical treatments were applied according to the signalling method. The second method was applied according to the phonological criterion i.e., on the basis of the values of effective temperatures sums or heat sums for cutworms. The studies on cutworms infesting sugar beet crops were carried out in the years 2005-2008. The observation performed during the moth flights from May to September included two species, turnip moth （Agrotis segetum Den. ＆ Schiff.） and heart-and-dart moth （A. exclamationis L.）. The dynamics of moth flights was recorded in reference to readings of climatic conditions registered with the field meteorological stations set up near the light traps. Observations on cutworm occurrence during the vegetation season were done every 5-7 days. Moreover, additional studies were conducted under control conditions in the growth chambers at three programmed temperatures （17°C, 20 °C, 24 °C） and relative humidity （50%-70%）. Based on the results the values for the heat sum of 501.1 °C and effective temperatures sum of 230.0 °C were determined for the developmental stages of cutworm. On the base of the results obtained it can be stated that the improved method of short-term forecasting can be an alternative solution in the integrated protection management against pest.

关键词： Cutworms monitoring degree-day sums of effective temperatures light trap sugar beet (Beta vulgaris L.).

Bone Mineral Density and Vitamin D Status in Children with Chronic Neurological Syndromes—Clinical Observations

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Case Reports in Clinical Medicine 2018年第5期7卷 315-323页

作者： Elzbieta jakubowska-Pietkiewicz Gabriela Orzechowska Elzbieta Wozniak Joanna Kudzin Ewa Toporowska-Kowalska Department of Paediatric Propaedeutics and Bone Metabolism Diseases Medical University of LodzLodzPoland Department of Paediatric Allergology Gastroenterology and NutritionMedical University of LodzLodzPoland

Background: Some of the risk factors for osteoporosis population include: chronic immobilisation, insufficient dietary supply of calcium and vitamin D, decreased physical activity and long-term pharmacological treatment (glucocorticoids, anticonvulsant drugs). In disabled children and adolescents, the negative impact of these factors may cumulate to considerably impair the quality of life. Objectives: The aim of our study was to assess the vitamin D status and bone mineral density in children with chronic neurological syndromes. Material and Methods: A total of 34 children between 3 and 18 years of age were examined: 9 children with muscular dystrophy, 17 with cerebral palsy and 8 with lumbar myelomeningocele. All the subjects underwent the following assessments: measurement of the concentration of the hepatic metabolite of vitamin D and total body less head and/or lumbar spine densitometry by dual energy X-ray absorptiometry (DEXA). Low bone mass or low bone mineral density was diagnosed if the Z-score value was found to be equal to or below −2.0. Results: Indications for the above tests were chronic immobilisation or motor activity restriction, and—in 10/34 children—femoral or vertebral fracture. Vitamin D deficiency (81%). Low bone mass on densitometry was demonstrated in 27/34 and osteoporosis in 10/34 subjects (Z-score ≤−2.0). Conclusion: Bone densitometry should be included in the standard of care for children with chronic neurological syndromes, and early detection of low bone mass should be an indication for treatment with calcium and vitamin D.

关键词： Children Densitometry Cerebral Palsy Muscular Dystrophy Myelomeningocele

Phylogenetic Analysis of Orgyia pseudotsugata Single-nucleocapsid Nucleopolyhedrovirus

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中国病毒学 2007年第4期22卷 257-265页

作者： Agata jakubowska Monique M. van Oers Imre S. Otvos Just M. Vlak Laboratory of Virology Wageningen UniversityBinnenhaven 11Wageningen6709 PDThe Netherlands Department of Biological Control and Quarantine Institute of Plant ProtectionMiczurina 20 Poznan 60-318 Poland Natural Resources Canada Canadian Forest Service Pacific Forestry Centre 506 West Burnside Road BC V8Z 1M5 Victoria Canada

The Douglas-fir tussock moth Orgyia pseudotsugata (Lepidoptera: Lymantriidae) is a frequent defoliator of Douglas-fir and true firs in western USA and Canada. A single nucleopolyhedrovirus (SNPV) isolated from O. pseudotsugata larvae in Canada (OpSNPV) was previously analyzed via its polyhedrin gene, but is phylogenetic status was ambiguous. Sequences of four conserved baculovirus genes, polyhedrin, lef-8, pif-2 and dpol, were amplified from OpSNPV DNA in polymerase chain reactions using degenerate primer sets and their sequences were analyzed phylogenetically. The analysis revealed that OpSNPV belongs to group II NPVs and is most closely related to SNPVs that infect O. ericae and O. anartoides, respectively. These results show the need for multiple, concatenated gene phylogenies to classify baculoviruses.

关键词：基因分析核型多角体病毒单核壳体生物防治花旗松鳞翅目害虫系统演化

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Reflecting laser-driven shocks in diamond in the megabar pressure range

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High Power Laser Science and Engineering 2021年第1期9卷 29-41页

作者： K.jakubowska D.Mancelli R.Benocci J.Trela I.Errea A.S.Martynenko P.Neumayer O.Rosmej B.Borm A.Molineri C.Verona D.Cannatà A.Aliverdiev H.E.Roman D.Batani IPPLM Institute of Plasma Physics and Laser Microfusion WarsawPoland CNRS CEACELIAUniversite de BordeauxTalenceFrance Donostia International Physics Center(DIPC) Donostia-San SebastianBasque CountrySpain Department of Earth and Environmental Sciences University of Milano-BicoccaMilanoItaly Fisika Aplikatua 1 Saila Ingeniaritza EskolaUniversity of the Basque Country(UPV/EHU)Basque CountrySpain&Centro de Física de Materiales(CSIC-UPV/EHU)Donostia/San SebastianBasque CountrySpain Department of Plasma Physics National Research Nuclear University MEPh IMoscowRussia Joint Institute for High Temperature RAS MoscowRussia GSI Helmholtzzentrum für Schwerionenforschung GmbH DarmstadtGermany Dipartimento di Ingegneria Industriale Universitàdegli studi di Roma“Tor Vergata”RomaItaly Institute for Microelectronics and Microsystems-CNR RomaItaly IGRRE-Joint Institute for High Temperatures RAS MakhachkalaRussia Department of Physics“G.Occhialini” University of Milano-BicoccaMilanoItaly

In this work we present experimental results on the behavior of diamond at megabar pressure. The experiment was performed using the PHELIX facility at GSI in Germany to launch a planar shock into solid multi-layered diamond samples. The target design allows shock velocity in diamond and in two metal layers to be measured as well as the free surface velocity after shock breakout. As diagnostics, we used two velocity interferometry systems for any reflector(VISARs). Our measurements show that for the pressures obtained in diamond(between 3 and 9 Mbar),the propagation of the shock induces a reflecting state of the material. Finally, the experimental results are compared with hydrodynamical simulations in which we used different equations of state, showing compatibility with dedicated SESAME tables for diamond.

关键词： carbon dynamic compression equation of state shock wave VISAR

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奥米纽姆摩天大楼

城市环境设计 2019年第2期118卷 220-227页

作者： Dominic James Black David Verbeek Gunther Weber Helen Chen Joanna Gajda Joseph James Haberl Lukas Kerner Maria Teresa Fernandez Rojo Natalie Isabel Stachnik Nicolas Millot Sabine Kokina Thomas Sebastian Krall Viktoria Millentrup Yan Ma Emily King Enea Michelesio Gabriel? Ubarevi?iūt? Giedrius Mamavicius Jesper Boye Andersen Jakob Lange Joanna jakubowska Katarzyna Joanna Piekarczyk Julieta Muzillo Lorenzo Boddi Lucas Carriere Lucian Tofan Max Aldunate Reitour Raphael Cirani Sabine Kokina Tore Banke Frank Dinger Nils Koenning 陈思瑾

法兰克福是一座集欧洲古典街区与当代大都市高楼于一体的城市,在城市中心形成了一个充满生机的建筑群落。这种建筑上的结合提供了紧密与动态变化的天际线,与连接法兰克福北部的陶纳斯山脉遥相呼应。奥米纽姆大厦位于城市中建筑高低混合... 详细信息

法兰克福是一座集欧洲古典街区与当代大都市高楼于一体的城市,在城市中心形成了一个充满生机的建筑群落。这种建筑上的结合提供了紧密与动态变化的天际线,与连接法兰克福北部的陶纳斯山脉遥相呼应。奥米纽姆大厦位于城市中建筑高低混合区域的中心,通过周围的环境和建筑来提供一个合理的、具有雕塑感的剪影。BIG建议设计一座塔楼,扩张其中心以捕捉和容

关键词：法兰克福天际线平面图建筑群落

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阿梅格尔巴克/哥本山

城市环境设计 2019年第2期 172-183页

作者： Nanna Gyldholm M?ller Alberto Cumerlato Aleksander Wadas Alexander Codda Alexander Ejsing Alexandra Gustafsson Alina Tamosiunaite Armor Gutierrez Anders Hjortn?s Andreas Klok Pedersen Annette Jensen Ariel Wallner Ask Andersen Balaj IIulian Blake Smith Borko Nikolic Brygida Zawadzka Buster Christensen Chris Falla Chris Zhongtian Yuan Daniel Selensky Dennis Rasmussen Espen Vik Finn N?rkj?r Franck Fdida Gonzalo Castro Gül Ertekin George Abraham Helen Chen Henrick Poulsen Henrik R?mer Kania Horia Spirescu Jakob Ohm Laursen Jelena Vucic Jeppe Ecklon Ji-young Yoon Jing Xu Joanna jakubowska Johanna Nenander Kamilla Heskje Katarzyna Siedlecka Krzysztof Marciszewski Laura W?tte Liang Wang Lise Jessen Long Zuo Maciej Zawadzki Mads Enggaard Stidsen Marcelina Kolasinska Marcos Bano Maren Allen Mathias Bank Matti N?rgaard Michael Andersen Narisara Ladawal Schr?der Niklas A. Rasch Nynne Madsen ?ssur Nols? Pero Vukovic Richard Howis Ryohei Koike Se Hyeon Kim Simon Masson Sunming Lee Toni Mateu Xing Xiong Zoltan David Kalaszi Rasmus Hjortshoj 陈子钰

垃圾焚烧发电厂阿梅格尔巴克/哥本山位于工业区,多年来,该工业区已成为冒险者们的极限运动目的地。原始的工业设施为各种极限运动活动提供了场所,如缆绳滑水、卡丁车和攀岩等。阿梅格尔巴克/哥本山是该地区最重要的地标,其建筑亟须更新... 详细信息

垃圾焚烧发电厂阿梅格尔巴克/哥本山位于工业区,多年来,该工业区已成为冒险者们的极限运动目的地。原始的工业设施为各种极限运动活动提供了场所,如缆绳滑水、卡丁车和攀岩等。阿梅格尔巴克/哥本山是该地区最重要的地标,其建筑亟须更新。我们提出了一种新型的垃圾焚烧发电厂,这种工厂能产生经济、环保和社会效益。我们不将阿梅格尔巴克/哥本山视为一个孤立的对象,而是调动起建筑的

关键词：巴克本山