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Eyelid Kaposi Sarcoma in HIV-Negative Patient

Journal of Cancer Therapy 2024年第3期15卷 92-97页

作者： malalaniaina Andrianarison malala razakanaivo Rindra Rafanomezantsoa Mendrika Fifaliana Rakotoarisaona Odilon Laza Fandresena Arilala Sendrasoa Irina Mamisoa Ranaivo Léa Raobela Lala Soavina Ramarozatovo Fahafahantsoa Rapelanoro Rabenja Unit of Dermatology University Hospital Center of Public Health and Care Analakely Antananarivo Madagascar Unit of Radiotherapy University Hospital Center Joseph Ravoahangy Andrianavalona Antananarivo Madagascar Unit of Ophthalmology University Hospital Center Joseph Ravoahangy Andrianavalona Antananarivo Madagascar Unit of Pathology University Hospital Center Tambohobe Fianarantsoa Madagascar Unit of Dermatology University Hospital Center of Joseph Raseta Befelatanana Antananarivo Madagascar Unit of Dermatology University Hospital Center Morafeno Toamasina Madagascar Unit of Dermatology and Internal Medicine University Hospital Center of Joseph Raseta Befelatanana Antananarivo Madagascar

Introduction: Kaposi sarcoma disease is a proliferative and multifocal disorder with dual components, vascular and fibroblastic cellular, cutaneous and visceral expression. Kaposi Sarcoma can affect the ocular surface and adnexa and can masquerade as other entities, delaying prompt diagnosis can lead to diagnostic wandering delaying treatment. Our aim is to describe a case of KS of the eyelid in an HIV seronegative patient. Case Presentation: A seventy-year-old man developed a bilateral growing tumoral reddish purple vascular mass on both the lower and upper eyelid involving rapidly for 6 months. Both feet and the two shanks show the presence of a brown-violet tumor-shaped formation. The patient was negative for HIV. Histology examination showed a nodular tumor-like mass with a fibro hemangioma-epitheliomatous. Polymerase chain reaction was positive for human herpes virus 8. Initial chemotherapy followed by surgery was proposed to the patient. Unfortunately, the patient rejected treatment and was lost to follow-up. Conclusion: This case reports the difficulty of managing KS in developing countries.

关键词： Eyelid HHV-8 Interferon Kaposi Sarcoma

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Breast Carcinoma Arising in Fibroadenoma in a 15-Year-Old Girl;Diagnosis and Treatment Challenge

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Journal of Cancer Therapy 2022年第10期13卷 615-620页

作者： malala razakanaivo Toky Rakotoarivo Ny Ony Andrianandrasana Florine Rafaramino Department of Radiotherapy University Hospital Joseph Ravoahangy Andrianavalona Antananarivo Madagascar Department of Oncology University Hospital Tanambao Antsiranana Madagascar Department of Oncology University Hospital Joseph Ravoahangy Andrianavalona Antananarivo Madagascar

Breast cancer in adolescents occurring in fibroadenomas is extremely rare. We report a case of right breast cancer in a 15-year-old female student diagnosed in 2020. This is the youngest reported case of breast cancer arising within fibroadenomas in the literature. The teenager has no personal or family history of cancer or known hereditary disease. Currently, there is no consensus on the management of breast cancer arising from adenofibromas in adolescents. Clinically, the tumor was inflammatory with axillary lymph node involvement (T4dN1M0). The fine-needle aspiration cytologic was suspicious of malignancy. The patient received four courses of neoadjuvant chemotherapy with 5-fluorouracil®, doxorubicin® and cyclosphosphamide®, followed by radical right mastectomy. The histological result of the surgical specimen is a non-specific carcinoma with a therapeutic effect greater than fifty percent. The patient received three courses of adjuvant chemotherapy with paclitaxel®. The adolescent underwent radiation therapy at her chest wall of 50 Gy and regional lymph node of 46 Gy. After radiotherapy, hormone therapy with Tamoxifene® at 20 mg per day was started. At 16 months from radiotherapy, there is no recurrence. The reconstruction of the right breast is planned in a few months.

关键词： Adolescent Breast Carcinoma Fibroadenoma Mastectomy

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Colorectal Cancer in the Oncology Department at the Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar: Retrospective Study

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Journal of Cancer Therapy 2022年第8期13卷 531-538页

作者： Toky Rakotoarivo malala razakanaivo Mirana Christiana Ranaivoson Ny Ony Andrianandrasana Florine Rafaramino Department of Oncology University Hospital Tanambao Antsiranana Madagascar Department of Radiotherapy University Hospital Joseph Ravoahangy Andrianavalona Antananarivo Madagascar Department of Oncology University Hospital Joseph Ravoahangy Andrianavalona Antananarivo Madagascar

Introduction: Colorectal cancer is one of the most common causes of cancer morbidity. The epidemiological and therapeutic data available are very limited in Antananarivo. The aim of this study was to provide an updated report on the management of colorectal cancer and know the survival of patients. Patients and Methods: A descriptive retrospective study during 2018 and 2019 carried out in the oncology department of Joseph Ravoahangy Andrianavalona Antananarivo Hospital. Newly diagnosed patients with histological evidence were included in the study. Results: Sixty-five cases of cancer were collected, including 39 colon cancers and 26 rectal cancers. The average age was 53 years with extremes of 18 and 83 years. In 41.53%, the patients were young people under 50 years old. The sex ratio was 0.95. Four patients (6.15%) had a family history of first degree cancer. The left colon was the most common location in 43.06% of cases. Only 39% of patients were diagnosed within 6 months of the first symptoms. The most common histological type was lieberkuhnian adenocarcinoma (87.69%). None of the patients underwent an immunohistochemistry examination. Stage IV and III accounted for 41.53% and 35.38% respectively. The majority (55.38%) of patients had benefited from surgery. Chemotherapy was performed in 56.89% of cases. One metastatic patient had received targeted therapy. Nine patients (34.61%) among the 26 with rectal cancers had benefited from concomitant radiochemotherapy. Survival at 30 months was 20%. Conclusion: The survival rate of patients at 30 months is very low. Improving the management of colorectal cancer requires awareness-raising and early detection.

关键词： Colorectal Cancer Surgery Chemotherapy Radiotherapy Antananarivo

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Advanced Cutaneous Scalp Eccrine Adenocarcinoma, Diagnosis and Treatment Challenges: A Case Report

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Journal of Cancer Therapy 2023年第1期14卷 1-5页

作者： Toky Rakotoarivo Christian Tomboravo malala razakanaivo Clairette Raharisolo Florine Rafaramino Department of Oncology University Hospital Tanambao Antsiranana Madagascar Department of Radiology University Hospital Place Kabary Antsiranana Madagascar Department of Radiotherapy University Hospital Joseph Ravoahangy Andrianavalona Antananarivo Madagascar Department of Anatomy Pathology Institute Pasteur of Madagascar Antananarivo Madagascar

In Madagascar, a country with a tropical climate;skin cancers are often of epidermal or melanic origin. Adnexal tumors are not well known. We report the first case of an eccrine tumor in a 57-year-old woman with no personal or family history of cancer. She has no comorbidities. The patient presented with a 50 × 60 mm frontal swelling and an ulcerative lesion of the left half of the face that had been evolving for 5 months. The cerebral and cervical CT scan revealed bone lysis of the vault of the skull and left cervical lymphadenopathy. The CT chest-abdomen-pelvis showed no abnormal lesions. The mammogram was normal. The result of the pathological examination was in favor of a round-cell tumor. The AE1/AE3, CK7 and P63 markers were positive in the immunohistochemical study. The diagnosis of an advanced eccrine adenocarcinoma was retained after the exclusion of a visceral adenocarcinoma with cutaneous metastasis. The patient receives radiotherapy of 40 Gy in 20 fractions followed by 6 courses of Carboplatin-paclitaxel type chemotherapy. The lesion has decreased in size and dried up after these treatments. 3 months after stopping treatment for lack of financial means, the patient died at home. The diagnosis of an adnexal tumor requires more in-depth complementary examinations. Treatments should be multidisciplinary and adapted to each patient.

关键词： Adenocarcinoma Eccrine Chemotherapy Radiotherapy Scalp Lesions

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5-Fluorouracil-Induced Hyperammonemia Encephalopathy in a Patient with Gastric Cancer

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Journal of Cancer Therapy 2023年第2期14卷 102-106页

作者： Toky Rakotoarivo Vonjy Andrianarison Ny Ony Andrianandrasana malala razakanaivo Florine Rafaramino Department of Oncology University Hospital Tanambao Antsiranana Madagascar Department of Radiotherapy University Hospital Joseph Ravoahangy Andrianavalona Antananarivo Madagascar Department of Oncology University Hospital Joseph Ravoahangy Andrianavalona Antananarivo Madagascar

Chemotherapy with 5-fluorouracil (5 FU) has been widely used to treat advanced gastric cancer. Knowing the side effects is therefore important in order to better prevent them. Fluoropyrimidine-induced hyperammonemic encephalopathy is a rare complication and characterized neurological status with elevated ammonia level without radiological abnormalities. We report the first case of 5 FU-induced hyperammonemic encephalopathy in women patients on induction chemotherapy for gastric cancer in Madagascar. His ammonia level (NH3) was 102 μmol/l. The patient recovered from his confusional state after two days of treatment with hyperhydration and vitamin therapy.

关键词： Encephalopathy Gastric Cancer Hyperammonemia 5-Fluororuracil

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Recurrent Dermatofibrosarcoma Protuberant of the Hand: A Case Report

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Journal of Cancer Therapy 2022年第7期13卷 425-429页

作者： Toky Rakotoarivo malala razakanaivo Norosoa Randriamaroson Clairette Raharisolo Jean Claude Razafimahandry Florine Rafaramino Department of Oncology University Hospital Tanambao Antsiranana Madagascar Department of Radiotherapy University Hospital Joseph Ravoahangy Andrianavalona Antananarivo Madagascar Department of Anatomy Pathology Institut Pasteur of Madagascar Antananarivo Madagascar Department of Traumatology and Orthopedics University Hospital Joseph Ravoahangy Andrianavalona Antananarivo Madagascar

Dermatofibrosarcoma is a rare, slow growing tumor with a tendency to local recurrence. The treatment is mainly surgical. In Madagascar there is no specialized center for the management of soft tissue sarcomas. It is in this context that we report a case of a 45-year-old man, driver, presenting with recurrent dermatofibrosarcoma of the left hand. The diagnosis was confirmed by the positivity of the CD34 marker. Extensive local excision surgery was performed with the patient’s consent. After free years of treatment, there is no tumor recurrence.

关键词： Dermatofibrosarcoma Hand Wide Surgery Recurrence

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Multi-Metastatic Hepatoid Adenocarcinoma of the Lung: Report of Case

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Journal of Cancer Therapy 2022年第5期13卷 304-309页

作者： Toky Rakotoarivo Christian Tomboravo malala razakanaivo Narindra Rajaonarison Ny Ony Clairette Raharisolo Florine Rafaramino Department of Oncology University Hospital Tanambao Antsiranana Antananarivo Madagascar Department of Radiology University Hospital Place Kabary Antsiranana Antananarivo Madagascar Department of Radiotherapy University Hospital Joseph Ravoahangy Andrianavalona Antananarivo Madagascar Department of Radiology University Hospital Joseph Ravoahangy Andrianavalona Antananarivo Madagascar Department of Anatomy Pathology Institut Pasteur of Madagascar Antananarivo Madagascar

Hepatoid adenocarcinoma of the lung is a rare tumor with a poor prognosis. There are no specific treatment-recommendations for this cancer. We report a 59-year-old man, a former smoker, with this condition. He presented with a cough and computed tomography revealed a pulmonary nodule (50 × 47 × 48 mm) with a right pleural effusion, together with a cerebral right temporal-lobe lesion and a right adrenal lesion. The serum alpha-fetoprotein value was normal. Histological examination via bronchoscopic biopsy revealed an adenocarcinoma. Positive CK7, AE1/AE2, and TTF1 with granular cytoplasmic staining on immunohistochemical study confirmed the diagnosis of hepatoid adenocarcinoma of the lung, stage IV-B. The patient had received chemotherapies (carboplatin-pemetrexed, gemcitabine) and cerebral radiotherapy, but he died at eight months of the treatment as a result of tumor progression.

关键词： Hepatoid Adenocarcinoma Lung Chemothérapy Metastasis

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A Blackish Gingiva Revealing a Metastatic Melanoma of the Oral Mucosa

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Journal of Biosciences and Medicines 2022年第5期10卷 1-6页

作者： malalaniaina Andrianarison malala razakanaivo Irina Mamisoa Ranaivo Fandresena Arilala Sendrasoa Lala Soavina Ramarozatovo Florine Rafaramino Fahafahantsoa Rapelanoro Rabenja Department of Dermatology University Hospital Joseph Raseta Befelatanana Antananarivo Madagascar Department of Radiotherapy Oncology University Hospital Joseph Ravoahangy Andrianavalona Antananarivo Madagascar Department of Dermatology University Hospital Morafeno Toamasina Madagascar Department of Internal Medecine-Dermatology University Hospital Joseph Raseta Befelatanana Antananarivo Madagascar

Background and Objective: Malignant melanoma is the most aggressive skin cancer because it has very strong metastatic power. Endobuccal localization is very rare. Its discovery is often made in the late stage, which leads to a consistently pessimistic diagnostic. We report a case of palatal melanoma at the metastatic stage. Case Report: A 43-year-old woman presented left lateral cervical swelling associated with dyspnea for 5 months. She had regularly taken chewing tobacco for 4 years and had developed blackish gums. The endobuccal examination showed a blackish non-haemorrhagic swelling of 5 cm of the long axis, located at the level of the palatal vault, associated with pigmentation in teeth 21, 22, and 23. The anatomopathological examination confirmed the melanoma. The spreading assessment revealed pleural and hepatic metastasis. The proposed treatment was palliative treatment. The patient died 2 months later. Conclusion: Melanoma of the oral mucosa is a very aggressive tumor. The scarcities of dental care among the Malagasy people exacerbate the delay in diagnosis. Its management is still challenging in Madagascar.

关键词： A Blackish Gingiva Revealing a Metastatic Melanoma of the Oral Mucosa

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Gestational Trophoblastic Neoplasia: Clinical and Therapeutic Profile in Madagascar

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Open Journal of Obstetrics and Gynecology 2020年第7期10卷 946-956页

作者： Norosoa Randriamaroson malala razakanaivo Ny Ony Andrianandrasana Zo Ambinintsoa Solofonirina Florine Rafaramino Radiotherapy Department University Hospital Joseph Ravoahangy Andrianavalona Antananarivo Madagascar Medical Oncology Department University Hospital Joseph Ravoahangy Andrianavalona Antananarivo Madagascar Faculty of Medicine Antananarivo Madagascar

Gestational trophoblastic disease (GTD) develops from abnormal cellular proliferation of trophoblasts following fertilization. This includes complete and partial hydatidiform mole (HM) and gestational trophoblastic neoplasia (GTN). The aim of this study was to report the epidemiological, clinical and therapeutic profile of gestational trophoblastic neoplasia (GTN) over period of ten years in the department of Oncology Radiotherapy at the University Hospital Joseph Ravoahangy Andrianavalona (HJRA) Antananarivo Madagascar. Medical records of women diagnosed with GTD in the department of Oncology Radiotherapy at HJRA from January 1st, 2007 to September 2017 were retrospectively reviewed. Only patients with the FIGO diagnosis GTN were included, while those with the histological diagnosis of hydatidiform mole (HM), also sometimes classified as GTD, were not included in this study. Also excluded were all cases with incomplete or missing data. Twenty four patients were included. Median age of patients at the time of diagnosis was 37 years (range 18 - 60). Most patients developed GTN following molar pregnancy (75%), had disease duration from antecedent pregnancy of less than 6 months (58.20%), and had the pre-treatment hCG level more than 10,000 IU/L (58.27%). At diagnosis, 14 patients (58.33%) had localized disease (M0). Most common metastatic sites at initial diagnosis were the liver and brain (20.8

关键词： Choriocarcinoma Gestational Trophoblastic Disease Gestational Trophoblastic Neoplasia Madagascar

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Overview of embryonal rhabdomyosarcoma of cervix in women over 40-year-old

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World Journal of Obstetrics and Gynecology 2016年第1期5卷 110-117页

作者： malala razakanaivo Nam P Nguyen Juliette Thariat Vincent Molinie Anne-Therese Vlastos Claire Verschraegen Vincent Vinh-Hung Joseph Ravoahangy Andrianavalona University Hospital Radiation Oncology Howard University Hospital International Geriatric Radiotherapy Group Antoine-Lacassagne Cancer Center University Nice Sophia Antipolis Rare Cancer Network Department of Pathology University Hospital of Martinique Geneva Gynecology and Obstetrics Division of Hematology Oncology University of Vermont Cancer Center Radiation Oncology University Hospital of Martinique Radiotherapy Department UZ BrusselVrije Universiteit Brussel

The literature on cervical embryonal rhabdomyosarcoma(RMS) is reviewed here to identify management guidelines for middle-aged women diagnosed with this rare type of gynecologic cancer. Specifically, the Pub Med, Web of Science and Google Scholar databases, were searched to find published case series on cervical embryonal RMS reporting on four or more patients, of whom at least one was > 40-year-old. The χ2 test was used to assess heterogeneity. Five articles published between 1986 and 2013 were identified, reporting on a total of 47 patients, of whom 22(46.8%) were older and 25(53.2%) younger than 40-year-old. Although the two age groups did not differ significantly by stage of disease or radiotherapy treatment, the older age groupreceived less chemotherapy(55% vs 90%, P = 0.008)and had more hysterectomy(86% vs 43%, P = 0.009).Follow-up data was missing for 18/47(38.3%) *** the 29 patients with follow-up data, survival was shorter in the older group, with 8/12(67%) alive and3 with disease at a median follow-up of 2.6 years, as compared with the younger group that had 15/17(88%)alive and none with disease at a median follow-up of 3.5years. The longest survivals among the older women were observed in those who received radiotherapy,including one case with a resected lung metastasis.A prospective multi-institutional collaboration and better follow-up are needed to determine the optimal management of cervical embryonal RMS. Long-term survival appears feasible if management is accompanied by chemotherapy and radiotherapy.

关键词： Embryonal rhabdomyosarcoma Botryoid sarcoma Cervix Middle-aged adults Chemotherapy Radiotherapy Review

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