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Accuracy of shoulder joint injections with ultrasound guidance:Confirmed by magnetic resonance arthrography

World Journal of Orthopedics 2022年第3期13卷 259-266页

作者： Kosuke Kuratani makoto tanaka Hiroto Hanai Kenji Hayashida Department of Orthopedic Surgery Japan Community Healthcare Organization Osaka HospitalOsaka 553-0003Japan Center for Sports Medicine Daini Osaka Police HospitalOsaka 543-8922Japan Department of Orthopaedic Surgery Osaka University Graduate School of MedicineSuita 565-0871Japan Department of Orthopaedic Surgery Daini Osaka Police HospitalOsaka 543-8922Japan

BACKGROUND Intra-articular glenohumeral joint injections are essential procedures for treating various shoulder disorders. Fluoroscopy-guided injections have been extensively used;however, they pose a risk of radiation exposure and are expensive and timeconsuming. Recently, it has been suggested that ultrasound-guided injections are accurate and cost effective *** To evaluate the accuracy of ultrasound-guided glenohumeral injections using a posterior approach that is confirmed using magnetic resonance arthrography(MRA).METHODS The study included 179 shoulders of patients with recurrent anterior instability(150 patients;103 and 76 right and left shoulders, respectively;160 males and 19 females;average age = 20.5 years;age range: 14-63 years) who underwent MRA for preoperative diagnosis. They were injected with 12 m L lidocaine(1%) using the ultrasound-guided posterior approach and then underwent magnetic resonance imaging. Two shoulder surgeons, except for the injector, evaluated the transverse relaxation(T2)-weighted images of axial planes and classified the intraarticular condition of injected contrast into three groups based on one of the three following scenarios: no leakage, injection into the glenohumeral joint without leakage;minor leakage, practical intra-articular injection with some leakage outside the posterior rotator cuffs;and major leakage, inaccurate injection with mass leakage without any contrast into the joint. The inter-rater reliability between two assessors was also evaluated by calculating Cohen’s kappa coefficient. The learning curve was assessed regarding the inaccurate injection rate by analyzing Spearman’s rank correlation *** Of the 179 injections, 163 shoulders(91.0%) had no leakage, 10 shoulders(5.6%) had minor leakage, and six shoulders(3.4%) had major leakage. In total, 173 shoulders(96.6%) were intraarticularly injected;thus, we could detect anterior labrum and capsular pathologies. Regarding the inter-rater

关键词： Shoulder injections Glenohumeral injections Ultrasound guidance Magnetic resonance arthrography

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SMALL ORGAN SIZE 1 and SMALL ORGAN SIZE 2/DWARF AND LOW-TILLERING Form aComplex to Integrate Auxin and Brassinosteroid Signaling in Rice

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Molecular Plant 2017年第4期10卷 590-604页

作者： Ko Hirano Hideki Yoshida Koichiro Aya Mayuko Kawamura makoto Hayashi Tokunori Hobo Karma Sato-lzawa Hidemi Kitano Miyako Ueguchi-tanaka makoto Matsuoka Bioscience and Biotechnology Center Nagoya University Nagoya 464-8601 Japan

Although auxin and brassinosteroid （BR） synergistically control various plant responses, the molecular mechanism underlying the auxin-BR crosstalk is not wen understood. We previously identified SMOS1, an auxin-regulated APETALA2-type transcription factor, as the causal gene of the small organ size 1 （smosl） mutant that is characterized by a decreased final size of various organs in rice. In this study, we identified another smos mutant, smos2, which shows the phenotype indistinguishable from smosl. SMOS2 was identical to the previously reported DWARF AND LOWoTILLERING （DLT）, which encodes a GRAS protein involved in BR signaling. SMOS1 and SMOS2/DLT physically interact to cooperatively enhance transcriptional transactivation activity in yeast and in rice nuclei. Consistently, the expression of OsPHI-1, a direct target of SMOS1, is upregulated only when SMOS1 and SMOS2/DLT proteins are both present in rice ceils. Taken together, our results suggest that SMOS1 and SMOS2/DLT form a keystone complex on auxin-BR signaling crosstalk in rice.

关键词： auxin brassinosteroid crosstalk rice transcription factor

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Intention Formation Process for the Use of Tracheostomy and Invasive Ventilation in Patients with Amyotrophic Lateral Sclerosis

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Open Journal of Nursing 2017年第10期7卷 1101-1114页

作者： Woojung Shin Tomoko Inoue Yuki Nakayama Takanori Yokota Hide Yoshino makoto tanaka Department of Critical and Invasive-Palliative Care Nursing Graduate School of Health Care Sciences Tokyo Medical and Dental University Tokyo Japan National College of Nursing Tokyo Japan ALS Nursing Care Project Tokyo Metropolitan Institute of Medical Science Tokyo Japan Department of Neurology and Neurological Science Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan Yoshino Neurology Clinic Chiba Japan

Background: Little is known about the intention formation process regarding the use of tracheostomy and invasive ventilation (TIV) in amyotrophic lateral sclerosis (ALS) patients in the course of disease progression. Objective: To clarify the intention formation process in the use of TIV in ALS patients for the purpose of providing decision-making support. Methods: We conducted a follow-up study of 14 patients using semi-structured interviews, participant observation, and medical records review. Results: The patients’ various intentions regarding the use of TIV were formed as their symptoms progressed (e.g., declining motor, swallowing, and respiratory functions). Other factors influencing their decision were their considerations, such as their ability to communicate after receiving TIV treatment, the degree of support they would receive from professionals after TIV treatment, palliative care for physical distress, value of life after TIV treatment, and to what degree they would be a burden on their families. Conclusion: Patients’ intentions regarding the use of TIV were diverse and changeable. The decision of whether or not to use TIV was made out of conviction as well as considering individual experiences of symptom progression and quality of life after TIV use.

关键词： Amyotrophic Lateral Sclerosis Tracheostomy and Invasive Ventilation Decision-Making Case Study Research Design Qualitative Approach

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体外试验中HPLC同时测定茶碱及其代谢物的研究

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华西药学杂志 1999年第4期14卷 225-227页

作者：徐小平陈聪 NorikoMasubuchi 田中真华西医科大学药学院成都610041 日本第一制药(株)东京开发研究中心代谢研究所

用高效液相色谱法（ＨＰＬＣ）同时测定体外试验中经大鼠肝药酶Ｐ４５０代谢的茶碱代谢物，以及受依诺沙星和左氟诺沙星抑制后的茶碱代谢物的含量变化。讨论了ＥＮＸ、ＬＶＸ与茶碱的相互作用。方法的精密度ＲＳＤ ... 详细信息

用高效液相色谱法（ＨＰＬＣ）同时测定体外试验中经大鼠肝药酶Ｐ４５０代谢的茶碱代谢物，以及受依诺沙星和左氟诺沙星抑制后的茶碱代谢物的含量变化。讨论了ＥＮＸ、ＬＶＸ与茶碱的相互作用。方法的精密度ＲＳＤ为（３２～４６）％、回收率为（８５～９２）％和最低检测限０５ｎｇ。线性范围（００２～１０）μｇ／ｍｌ，ｒ＞０９９９９，该法可用于研究药物相互作用中评定茶碱及其代谢物的变化。

关键词：依诺沙星左氟沙星茶碱代谢物体外试验

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High efficiency HITTM Solar Cells and the Effects of Open Circuit Voltage on Temperature Coefficients

High efficiency HITTM Solar Cells and the Effects of Open Ci...

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第十五届国际光伏科学与工程大会

作者： Akira Terakawa Toshio Asaumi Shinji Kobayashi Yasufumi Tsunomura Toshio Yagiura Mikio Taguchi Yukihiro Yoshimine Hitoshi Sakata Eiji Maruyama makoto tanaka Advanced Energy Research Center Sanyo Electric Co. Ltd.7-3-2 Ibukidai-higashimachi Nishi-ku Kobe Hyogo 651-2242 Japan

We have established a new record conversion efficiency of 21.5% for HIT solar cell (Voc: 712mV, Jsc: 38.26mA/cm2, FF: 0.787, 100.3cm2, measured at AIST). Also worthy of special mentions are the very high fill factor (FF) of 0.802 and the very high open circuit voltage (Voc) of over 725mV for other efficient solar cells. Additional practical advantage of the HIT cells is the relatively small temperature coefficients, which is another practical advantage of the HIT cell. The insight of the small temperature coefficients is also discussed by comparing other solar cells.

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Exploiting fly models to investigate rare human neurological disorders

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Neural Regeneration Research 2025年第1期20卷 21-28页

作者： Tomomi tanaka Hyung-Lok Chung Department of Neurology Houston Methodist Research InstituteHoustonTXUSA Department of Neurology Weill Cornell Medical CollegeNew YorkNYUSA

Rare neurological diseases,while individually are rare,collectively impact millions globally,leading to diverse and often severe neurological *** attributed to genetic mutations that disrupt protein function or structure,understanding their genetic basis is crucial for accurate diagnosis and targeted *** investigate the underlying pathogenesis of these conditions,researchers often use non-mammalian model organisms,such as Drosophila(fruit flies),which is valued for their genetic manipulability,cost-efficiency,and preservation of genes and biological functions across evolutionary *** tools available in Drosophila,including CRISPR-Cas9,offer a means to manipulate gene expression,allowing for a deep exploration of the genetic underpinnings of rare neurological *** boasts a versatile genetic toolkit,rapid generation turnover,and ease of large-scale experimentation,making it an invaluable resource for identifying potential drug *** can expose flies carrying disease-associated mutations to various compounds,rapidly pinpointing promising therapeutic agents for further investigation in mammalian models and,ultimately,clinical *** this comprehensive review,we explore rare neurological diseases where fly research has significantly contributed to our understanding of their genetic basis,pathophysiology,and potential therapeutic *** discuss rare diseases associated with both neuron-expressed and glial-expressed *** cases include mutations in CDK19 resulting in epilepsy and developmental delay,mutations in TIAM1 leading to a neurodevelopmental disorder with seizures and language delay,and mutations in IRF2BPL causing seizures,a neurodevelopmental disorder with regression,loss of speech,and abnormal *** we explore mutations in EMC1 related to cerebellar atrophy,visual impairment,psychomotor retardation,and gain-of-function mutations in ACOX1 causing Mitchell ***-of-fun

关键词： ACOX1 Drosophila melanogaster glia lipid metabolism model organisms neuroinflammation neurologic disorders neuron rare disease VLCFA

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质子泵抑制剂盘托拉唑对大鼠肝药酶中P450的影响

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华西医科大学学报 2000年第4期31卷 449-451页

作者：徐小平王曙陈聪贺英菊田中真华西医科大学药学院药物分析教研室成都 610041 第一制药东京代谢研究所

为探讨质子泵抑制剂 (PPI)盘托拉唑 (PAN)对大鼠肝药酶中药物代谢酶的影响 ,给试验大鼠连续7天口服不同剂量〔5 m g/ (kg· d)、5 0 m g/ (kg· d)和 30 0 mg/ (kg· d)〕的 PAN,而后测定大鼠肝药酶中细胞色素P45 0 (P45 0 )、细胞色素 ... 详细信息

为探讨质子泵抑制剂 (PPI)盘托拉唑 (PAN)对大鼠肝药酶中药物代谢酶的影响 ,给试验大鼠连续7天口服不同剂量〔5 m g/ (kg· d)、5 0 m g/ (kg· d)和 30 0 mg/ (kg· d)〕的 PAN,而后测定大鼠肝药酶中细胞色素P45 0 (P45 0 )、细胞色素 b5 (b5 )、NADPH细胞色素 C还原酶 (NADPH)的含量和活性变化 ,以及细胞色素 P45 0同功酶 (CYP)的活性变化 ,并与奥美拉唑 (OM)、兰索拉唑 (L AN)、3-甲基胆醌 (3- MC)和苯巴比妥 (PB)比较。结果 :口服高剂量〔30 0 m g/ (kg· d)〕PAN后大鼠肝药酶中 P45 0、b5 以及 NADPH的含量和活性升高 ,但不及 PB的作用强 ,其中 3- MC对 NADPH的作用最弱 ,CYP1A、CYP2 B和 CYP3A的活性也升高 ,且 3- MC对 CYP1A作用极强 ,PB对 CYP2 B和 CYP3A的作用最强。三个 PPI中 ,OM和 L AN在同一条件下比 PAN更易引起 CYP1A活性的升高 ,PAN对 CYP2 B的作用强于 OM和 L AN。上述结果表明 ,PAN与 OM和 L AN对肝药酶中代谢酶的作用类似 ,但作用更弱 ,并提示 PAN在体内代谢中具有更小的药物相互作用性。

关键词：盘托拉唑质子泵抑制剂细胞色素P450 抗溃疡药

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大豆异黄酮抗血小板聚集作用的实验研究

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延边大学医学学报 2002年第2期25卷 94-96页

作者：全吉淑田中真实金泽武道延边大学医学院生物化学教研室吉林延吉133000 东北食效科学研究所日本青森县青森市0300842

[目的 ]研究大豆异黄酮对血小板聚集性的影响 .[方法 ]普通饲料中添加 2 0 g/kg大豆异黄酮混合物 ,饲喂GK/Jcl糖尿病大鼠 2 0周 ,测定其血小板聚集率 .利用ODS柱层析和高效液相色谱技术分离大豆异黄酮 ,体外观察大豆异黄酮单体对人血小... 详细信息

[目的 ]研究大豆异黄酮对血小板聚集性的影响 .[方法 ]普通饲料中添加 2 0 g/kg大豆异黄酮混合物 ,饲喂GK/Jcl糖尿病大鼠 2 0周 ,测定其血小板聚集率 .利用ODS柱层析和高效液相色谱技术分离大豆异黄酮 ,体外观察大豆异黄酮单体对人血小板聚集率的影响 .[结果 ]长期食用大豆异黄酮的GK/Jcl糖尿病大鼠血小板聚集率显著降低 .在人体外血小板聚集实验中 ,大豆异黄酮均抑制腺嘌呤核苷二磷酸钠、胶原蛋白和肾上腺素诱导的血小板聚集 ,大豆异黄酮类型中金雀异黄素的最强 ,其 5 0 %抑制浓度值分别为 0 38,0 30 ,0 2 3mmol/L .[结论 ]大豆异黄酮具有血小板聚集抑制效应 ,在大豆抗血小板聚集中起着重要作用 .

关键词：大豆异黄酮抗血小板聚集实验研究体外观察 ODS柱层析高效液相色谱技术

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Future Strategy of Breeding:Learn by Two Important Genes of Miracle Rice

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Molecular Plant 2020年第6期13卷 823-824页

作者： Kyosuke Kawai Miyako Ueguchi-tanaka makoto Matsuoka Bioscience and Biotechnology Center Nagoya University464-8601 NagoyaJapan

In the"Analects of Confucius",there is a classic sentence that"too much is as bad as too little".The work by Wang et al.(2020)published in this issue reminds us that crop breeders should bear this sentence in mind whe... 详细信息

关键词： breed Learn she

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Turbo-pump with Isolated Two Stage Impellers for Future Rocket Engine (Trial to Drive Impellers Independently)

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Journal of Thermal Science 2008年第1期17卷 28-34页

作者： Toshiaki Kanemoto makoto Shimojyo Ryunosuke Kawashima Daisuke tanaka Akira Inagaki Shin Oba Kyushu Institute of Technology:Sensui 1-1 TobataKitakyushu 804-8550Japan Professor Kyushu Institute of Technology:Sensui 1-1 TobataKitakyushu 804-8550Japan DMW Corporation:Miyoshi 3-27 Mishima 411-8560Japan

To suppress the cavitation in the impellers and to make the turbo-pump lives longer, the inducer was separated from the main impeller and both impellers were driven independently. The performance of the pump and the flow conditions around the impellers were investigated experimentally and the following results were obtained. （1）The main impeller contributes to the flow interaction between the inducer and the main impeller. （2）The rotational speeds of both impellers can be controlled independently in order to suppress simultaneously the cavitation not only in the main impeller, but also in the inducer.

关键词： Turbo-pump Inducer Impeller Rocket Engine Cavitation NPSH

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