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Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model

World Journal of Gastrointestinal Oncology 2022年第1期14卷 242-252页

作者： Fereshteh Asgharzadeh Alex Tarnava Asma Mostafapour majid khazaei Tyler W LeBaron Department of Physiology Faculty of MedicineMashhad University of Medical SciencesMashhad ***Iran Drink HRW New WestminsterBC V3j0b6 Canada Department of Medical Genetics and Molecular Medicine Faculty of MedicineMashhad University of Medical SciencesMashhad ***Iran Centre of Experimental Medicine Institute for Heart Research Slovak Academy of SciencesBratislava 984104Slovakia Department of Kinesiology and Outdoor Recreation Southern Utah UniversityUT 84720United States Biological Research Molecular Hydrogen InstituteUT 84721United States Department of Physical Science Southern Utah UniversityUT 84720United States

BACKGROUND Colorectal cancer(CRC)is the third leading cause of cancer-related deaths in the *** removal remains the preferred frontline treatment;however,effective non-surgical interventions remain a high priority.5-fluorouracil(5-FU)is a widely used chemotherapy agent,and molecular hydrogen(H2)has been recognized for its antioxidant and anti-inflammatory effects,with research also suggesting its potential anti-tumor ***,H2 dissolved in water[hydrogen-rich water(HRW)],with or without 5-FU,may present itself as a novel therapeutic for *** To investigate the effects of HRW,with or without 5-FU,as a novel therapeutic for *** CRC was induced in the left flank of inbred Balb/c mice.A total of 24 mice bearing tumors were randomly divided into four groups(n=6 per group)and treated as follows:(1)Control group;(2)5-FU group that received intraperitoneal injection of 5-FU(5 mg/kg)every other day;(3)H2 group that received HRW,created and delivered via dissolving the H2-generating tablet in the animals’drinking water,with 200μL also delivered by oral gavage;and(4)The combination group,H2(administered in same way as for group three)combined with 5-FU administered same way as group *** Administration of HRW+5-FU significantly improved tumor weight,tumor size,collagen content and fibrosis as compared to the CRC control ***,HRW attenuated oxidative stress(OS)and potentiated antioxidant activity(AA),whereas 5-FU treatment exacerbated OS and blunted *** combination of HRW+5-FU significantly reduced tumor weight and size,as well as reduced collagen deposition and the degree of fibrosis,while further increasing OS and decreasing AA compared to administration of 5-FU *** Administration of HRW,with or without 5-FU,may serve as a therapeutic for treating CRC.

关键词： Colorectal cancer Molecular hydrogen 5-fluorouracil Oxidative stress Antioxidants Inflammation

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Sensitivity of optimal double-layer grid designs to geometrical imperfections and geometric nonlinearity conditions in the analysis phase

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Frontiers of Structural and Civil Engineering 2024年第8期18卷 1209-1224页

作者： Amirali REZAEIZADEH Mahsa ZANDI majid ILCHI GHAZAAN School of Civil Engineering Iran University of Science and TechnologyTehran 16846-13114Iran

This study focuses on exploring the effects of geometrical imperfections and different analysis methods on the optimum design of Double-Layer Grids(DLGs),as used in the construction industry.A total of 12 notable metaheuristics are assessed and contrasted,and as a result,the Slime Mold Algorithm is identified as the most effective approach for size optimization of *** evaluate the influence of geometric imperfections and nonlinearity on the optimal design of real-size DLGs,the optimization process is carried out by considering and disregarding geometric nonlinearity while incorporating three distinct forms of geometrical imperfections,namely local imperfections,global imperfections,and combinations of *** light of the uncertain nature of geometrical imperfections,probabilistic distributions are used to define these imperfections randomly in direction and *** results demonstrate that it is necessary to account for these imperfections to obtain an optimal ***’s worth noting that structural imperfections can increase the maximum stress ratio by up to 70%.The analysis also reveals that the initial curvature of members has a more significant impact on the optimal design of structures than the nodal installation error,indicating the need for greater attention to local imperfection issues in space structure construction.

关键词： double-layer grid sizing optimization metaheuristic algorithms geometrical imperfections analysis approach

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Nonlinear vibration of Timoshenko FG porous sandwich beams subjected to a harmonic axial load

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 649-662页

作者： Milad Lezgi Moein Zanjanchi Nikoo majid Ghadiri Department of Civil Engineering Sharif University of TechnologyTehran ***Iran Civil Engineering Department K.N.Toosi University of TechnologyTehran ***Iran Faculty of Engineering Department of MechanicsImam Khomeini International UniversityQazvin ***Iran

In this study,the instability and bifurcation diagrams of a functionally graded(FG)porous sandwich beam on an elastic,viscous foundation which is influenced by an axial load,are investigated with an analytical *** do so,the Timoshenko beam theory is utilized to take the shear deformations into account,and the nonlinear Von-Karman approach is adopted to acquire the equations of ***,to turn the partial differential equations(PDEs)into ordinary differential equations(ODEs)in the case of equations of motion,the method of Galerkin is employed,followed by the multiple time scale method to solve the resulting *** impact of parameters affecting the response of the beam,including the porosity distribution,porosity coefficient,temperature increments,slenderness,thickness,and damping ratios,are explicitly *** is found that the parameters mentioned above affect the bifurcation points and instability of the sandwich porous beams,some of which,including the effect of temperature and porosity distribution,are less noticeable.

关键词： sandwich beam Timoshenko beam parametric excitation bifurcation diagrams dynamic instability

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Reinforcing the management of type 1 gastric esophageal varices

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World Journal of Gastroenterology 2024年第19期30卷 2615-2617页

作者： Zain majid Ghazi Abrar Department of Gastroenterology Sindh Institute of Urology and TransplantationKarachi 75500Pakistan

Variceal bleed represents an important complication of cirrhosis,with its presence reflecting the severity of liver *** varices,though less frequently seen than esophageal varices,present a distinct clinical challenge due to its higher intensity of bleeding and associated *** upon the Sarin classification,GOV1 is the most common subtype of gastric varices seen in clinical practice.

关键词： Gastric varices Sarin classification Gastroesophageal varices Cyanoacrylate Endoscopic variceal ligation Trans jugular intrahepatic portosystemic shunt

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Energy evolution and structural health monitoring of coal under different failure modes:An experimental study

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 917-928页

作者： Yarong Xue Xueqiu He Dazhao Song Zhenlei Li majid Khan Taoping Zhong Fei Yang School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China Zhong-an Academy of Safety Engineering Beijing 100083China

Structural instability in underground engineering,especially in coal-rock structures,poses significant safety ***,the development of an accurate monitoring method for the health of coal-rock bodies is *** focus of this work is on understanding energy evolution patterns in coal-rock bodies under complex conditions by using shear,splitting,and uniaxial compression *** examine the changes in energy parameters during various loading stages and the effects of various failure modes,resulting in an innovative energy dissipation-based health evaluation technique for *** results show that coal bodies go through transitions between strain hardening and softening mechanisms during loading,indicated by fluctuations in elastic energy and dissipation energy *** tensile failure,the energy profile of coal shows a pattern of “high dissipation and low accumulation” before peak *** the other hand,shear failure is described by “high accumulation and low dissipation” in energy *** failure modes correlate with an accelerated increase in the dissipation energy before destabilization,and a significant positive correlation is present between the energy dissipation rate and the stress state of the coal samples.A novel mathematical and statistical approach is developed,establishing a dissipation energy anomaly index,W,which categorizes the structural health of coal into different danger *** method provides a quantitative standard for early warning systems and is adaptable for monitoring structural health in complex underground engineering environments,contributing to the development of structural health monitoring technology.

关键词： energy dissipation structural health monitoring early warning coal-rock mechanics failure mode

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An Updated Overview of the Treatment of Colorectal and Gastric Cancer Using Saffron

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Journal of Clinical and Nursing Research 2022年第2期6卷 173-179页

作者： Mahdieh Darroudi Elnaz Nazari Nima Khalili-Tanha majid Rezayi majid khazaei Department of Physiology Faculty of MedicineMashhad University of Medical ScienceMashhadIran Medical Toxicology Research Centre Mashhad University of Medical ScienceMashhadIran Metabolic Syndrome Research Centre Mashhad University of Medical ScienceMashhadIran Department of Medical Biotechnology and Nanotechnology School of ScienceMashhad University of Medical ScienceMashhadIran

Despite the increasing number of drugs and treatments available for cancer patients,the effect of cancer on the quality of life of patients and their life expectancy is ***,many new therapeutic options have shown to have adverse effects without improving *** days,natural plants and chemopreventive drugs are commonly *** is a new form of therapy that targets specific premalignant-malignant ***-derived substances,such as polyphenols,flavonoids,carotenoids,alkaloids,etc.,have a range of biological *** extensive studies on the anti-inflammatory effect of saffron carotenoids,they are also bioactive in some other ways,including the inhibition of tumor growth and the induction of cell *** addition to interfering with a wide array of signaling molecules,this substance has pleiotropic effects:it inhibits pro-inflammatory molecules,transcription factors,enzymes,protein kinases,protein transport proteins,proteins that are crucial for cell survival,growth factors,proteins that regulate the cell cycle,and *** has high oral bioavailability and is,therefore,suitable for treating gastrointestinal *** antioxidant and anti-proliferative property of saffron makes it a promising chemopreventive agent for colorectal *** contrast with in vitro studies devoted to saffron and in vivo studies on animal models,saffron has rarely been assessed in clinical studies dealing with gastrointestinal ***,several clinical trials are in progress in this domain,although saffron has no approved medical indication as of yet.

关键词： Safron Colorectal cancer Gastric cancer Chemoprevention Treatment

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Design parameter optimization method for a prestressed steel structure driven by multi-factor coupling

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 1066-1083页

作者： Guo-Liang SHI Zhan-Sheng LIU De-Chun LU Qing-Wen ZHANG majid DEZHKAM Ze-Qiang WANG Faculty of Architecture Civil and Transportation EngineeringBeijing University of TechnologyBeijing 100124China The Key Laboratory of Urban Security and Disaster Engineering of the Ministry of Education Beijing University of TechnologyBeijing 100124China Beijing Building Construction Research Institute Co. Ltd.Beijing 100039China

To achieve efficient structural design,it is crucial to reduce the cost of materials while ensuring structural *** study proposes an optimization method for design parameters(DPs)in a prestressed steel structure driven by multi-factor *** accomplish this,a numerical proxy model of prestressed steel structures is established with integration of DPs and mechanical parameters(MPs).A data association-parameter analysis-optimization selection system is established.A correlation between DPs and MPs is established using a back propagation(BP)neural *** correlation provides samples for parameter analysis and optimization *** are used to characterize the safety of the *** on the safety grade analysis,the key DPs that affect the mechanical properties of the structure are obtained.A mapping function is created to match the MPs and the key *** optimal structural DPs are obtained by setting structural materials as the optimization objective and safety energy as the constraint *** theoretical model is applied to an 80-m-span gymnasium and verified with a scale test physical *** MPs obtained using the proposed method are in good agreement with the experimental *** with the traditional design method,the design cycle can be shortened by more than 90%.Driven by the optimal selection method,a saving of more than 20% can be achieved through reduction of structural material ***,the cross-sectional dimensions of radial cables have a substantial influence on vertical *** initial tension and cross-sectional size of the upper radial cable exhibit the most pronounced impact on the stress distribution in that *** initial tension and cross-sectional size of the lower radial cable hold the greatest sway over the stress distribution in that cable.

关键词： structure design association relationship performance analysis optimum selection experimental verification

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应用欧拉-拉格朗日方法分析动脉粥样硬化性颈动脉血流的流-固相互作用

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Journal of Central South University 2024年第1期31卷 151-168页

作者： majid SIAVASHI Ava BINA Mojtaba SAYADNEJAD Borhan BEIGZADEH Applied Multi-Phase Fluid Dynamics Lab. School of Mechanical EngineeringIran University of Science and TechnologyTehranIran Biomechatronics and Cognitive Engineering Research Lab. School of Mechanical EngineeringIran University of Science and TechnologyTehranIran

本研究旨在模拟不同狭窄程度和脉搏率的颈动脉搏动血流。采用流-固耦合(FSI)和任意拉格朗日-欧拉(ALE)方法研究了不同狭窄程度、脉搏率和动脉壁性质对周围流体的影响。分别应用Carreau-Yasuda非牛顿超弹性模型和修正Mooney-Rivin超弹性... 详细信息

本研究旨在模拟不同狭窄程度和脉搏率的颈动脉搏动血流。采用流-固耦合(FSI)和任意拉格朗日-欧拉(ALE)方法研究了不同狭窄程度、脉搏率和动脉壁性质对周围流体的影响。分别应用Carreau-Yasuda非牛顿超弹性模型和修正Mooney-Rivin超弹性模型于具有非牛顿行为的血液和超弹性血管壁。结果得到血液的壁面径向位移、压力分布、轴向速度分布和壁面剪切应力。通过增加狭窄的严重程度,轴向速度、血压变化、最大壁面剪切应力和壁面径向位移均呈增长趋势。当脉率在狭窄程度为75%时,最大流量矩、壁面径向位移、压力、轴向速度和壁面剪应力的最大值均增大。此外,与弹性和刚性模型相比,将动脉壁视为超弹性模型,将其周围流体视为非牛顿和非定常,可以使模拟更加真实。在严重程度高达50%的狭窄中,红细胞受到轻微损害,而在严重程度为75%的狭窄中观察到溶血。通过改善动脉粥样硬化,弹性模量从500 k Pa提高到2 MPa,在60 bpm脉率和狭窄程度75%下,剪切应力最大值增长65%。与刚性和弹性动脉壁相比,动脉壁的超弹性模型导致较低的轴向速度、较低的血压、较低的剪切应力和较高的径向位移。

关键词：流-固耦合狭窄严重程度脉率变化超弹性的动脉动脉粥样硬化

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The effect of celastrol in combination with 5-fluorouracil on proliferation and apoptosis of gastric cancer cell lines

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Oncology Research 2024年第7期32卷 1231-1237页

作者： MOHAMMAD-TAGHI MORADI DHIYA ALTEMEMY majid ASADI-SAMANI PEGAH KHOSRAVIAN MARZIYEH SOLTANI LEILA HASHEMI AZADEH SAMIEI-SEFAT Medical Plants Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran Department of Pharmaceutics College of PharmacyAl-Zahraa University for WomenKarbalaIraq Cellular and Molecular Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran

Background:Despite the availability of chemotherapy drugs such as 5-ﬂuorouracil(5-FU),the treatment of some cancers such as gastric cancer remains challenging due to drug resistance and side *** study aimed to investigate the effect of celastrol in combination with the chemotherapy drug 5-FU on proliferation and induction of apoptosis in human gastric cancer cell lines(AGS and EPG85-257).Materials and Methods:In this in vitro study,AGS and EPG85-257 cells were treated with different concentrations of celastrol,5-FU,and their *** proliferation was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT)*** synergistic effect of 5-FU and celastrol was studied using Compusyn *** DNA content at different phases of the cell cycle and apoptosis rate was measured usingﬂow ***:Co-treatment with low concentrations(10%inhibitory concentration(IC10))of celastrol and 5-FU signiﬁcantly reduced IC50(p<0.05)so that 48 h after treatment,IC50 was calculated at 3.77 and 6.9μM for celastrol,20.7 and 11.6μM for 5-FU,and 5.03 and 4.57μM for their combination for AGS and EPG85-257 cells,*** mean percentage of apoptosis for AGS cells treated with celastrol,5-FU,and their combination was obtained 23.9,41.2,and 61.9,and for EPG85-257 cells 5.65,46.9,and 55.7,*** addition,the 5-FU and celastrol-5-FU combination induced cell cycle arrest in the synthesis ***:Although celastrol could decrease the concentration of 5-ﬂuorouracil that sufﬁced to suppress gastric cancer cells,additional studies are required to arrive at conclusive evidence on the anticancer effects of celastrol.

关键词： Gastric cancer Celastrol Terpenoid Cell cycle regulation Apoptosis Synergism

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Nanomaterial-assisted wearable glucose biosensors for noninvasive real-time monitoring:Pioneering point-of-care and beyond

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Nano Materials Science 2024年第3期6卷 263-283页

作者： Moein Safarkhani Abdullah Aldhaher Golnaz Heidari Ehsan Nazarzadeh Zare majid Ebrahimi Warkiani Omid Akhavan YunSuk Huh Navid Rabiee NanoBio High-Tech Materials Research Center Department of Biological Sciences and BioengineeringInha UniversityIncheon22212Republic of Korea Department of Chemistry Sharif University of TechnologyTehranIran School of Natural Sciences Massey UniversityPrivate Bag 11222Palmerston North4410New Zealand School of Chemistry Damghan UniversityDamghan36716-45667Iran School of Biomedical Engineering University of Technology SydneySydneyNSW2007Australia Department of Physics Sharif University of TechnologyP.O.Box 11155-9161TehranIran Centre for Molecular Medicine and Innovative Therapeutics Murdoch UniversityPerthWA 6150Australia School of Engineering Macquarie UniversitySydneyNew South Wales2109Australia

This review explores glucose monitoring and management strategies,emphasizing the need for reliable and userfriendly wearable sensors that are the next generation of sensors for continuous glucose *** addition,examines key strategies for designing glucose sensors that are multi-functional,reliable,and cost-effective in a variety of *** unique features of effective diabetes management technology are highlighted,with a focus on using nano/biosensor devices that can quickly and accurately detect glucose levels in the blood,improving patient treatment and control of potential diabetes-related *** potential of next-generation wearable and touch-sensitive nano biomedical sensor engineering designs for providing full control in assessing implantable,continuous glucose monitoring is also *** challenges of standardizing drug or insulin delivery doses,low-cost,real-time detection of increased blood sugar levels in diabetics,and early digital health awareness controls for the adverse effects of injectable medication are identified as unmet ***,the market for biosensors is expected to expand significantly due to the rising need for portable diagnostic equipment and an ever-increasing diabetic *** paper concludes by emphasizing the need for further research and development of glucose biosensors to meet the stringent requirements for sensitivity and specificity imposed by clinical diagnostics while being cost-effective,stable,and durable.

关键词： Glucose sensor Biosensor Wearable devices Noninvasive Real-time monitoring

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