检索结果-南通市图书馆

Influence of anastomoses on intestine ischemia and cefuroxime concentrations:Evaluated in the ileum and colon in a porcine model

引用

World Journal of Gastrointestinal Pathophysiology 2021年第1期12卷 1-13页

作者： Pelle Hanberg Mats Bue maja thomassen Uffe Schou Løve Josephine Olsen Kipp Christina Harlev Elisabeth Petersen Kjeld Søballe Maiken Stilling Department of Orthopaedic Surgery Horsens Regional HospitalHorsens 8700Denmark Aarhus Microdialysis Research Group Orthopaedic Research UnitAarhus University HospitalAarhus N 8200Denmark Department of Clinical Medicine Aarhus UniversityAarhus N 8200Denmark Department of Orthopaedic Surgery Aarhus University HospitalAarhus N 8200Denmark Department of Surgery Viborg Regional HospitalViborg 8800Denmark

BACKGROUND Anastomotic leakage is a serious complication following gastrointestinal surgery and is associated with increased morbidity and *** incidence of anastomotic leakage is determined by anatomy and is reported to be between 4%-33%for colon anastomosis and 1%-3%for small intestine *** etiology of anastomotic leakage of the intestine has been divided into three main factors:healing disturbances,communication between intra-and extra-luminal compartments,and *** three factors interact,and one factor will inevitably lead to the other two factors resulting in tissue ischemia,tissue necrosis,and anastomotic *** To evaluate ischemic metabolites and cefuroxime concentrations in both anastomosis and non-anastomosis ileum and colon in a porcine *** Eight healthy female pigs(Danish Landrace breed,weight 58-62 kg)were included in this *** catheters were placed for sampling of ischemic metabolites(glucose,lactate,glycerol,and pyruvate)and cefuroxime concentrations in both anastomosis and non-anastomosis ileum and *** 1.5 g was administered as an intravenous infusion over 15 ***,dialysates and blood samples were collected over 8 h and the ischemic metabolites and cefuroxime concentrations were quantified in all *** concentrations of glucose,lactate,glycerol and pyruvate were determined using the CMA 600 Microdialysis Analyzer with Reagent Set A(M Dialysis AB,Sweden),and the concentrations of cefuroxime and meropenem were quantified using a validated ultra-high-performance liquid chromatography *** Only the colon anastomosis induced mean ischemic lactate/pyruvate ratios above 25(ischemic cut-off)throughout the entire sampling interval,and simultaneously decreased glucose *** mean time for which cefuroxime concentrations were maintained above the clinical breakpoint minimal inhibitory concentration for Escherichia coli(8μg/mL)ranged between 116-128 min

关键词： Anastomosis Cefuroxime Colon Ileum Ischemic metabolites Microdialysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：