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Journal of Innovative Optical Health Sciences 2014年第2期7卷 143-152页

作者： Zhongxing Zhang maja Schneider Ursula Fritschi Lsabela Lehner Ramin Khatami Sleep Center Clinic BarmelweidSwitzerland Department of Neurology Uniuersity Hospital Zurich University of ZurichSuitzerland

In obstructive sleep apnea syndrome(OSA)the periodic reduction or cessation of breathing dueto narrowing or occlusion of the upper airway during slep leads to an impaired cerebral vascularautoregulation that is associated with an increased cardiovascular risk,including ***-tinuous positive airways pressure(CPAP)therapy at night is the most effective treatment forOSA and has been shown to reduce the cardiovascular risk in OSA ***,there is nosuitable bedside monitoring method evaluating the recovery of cerebral hemodynamics duringCPAP ***-infrared spectroscopy(NiRS)is idelly suited for non-invasive monitoringthe cerebral hemodynamics during sleep due to its properties of local measurement,totally sa feapplication and good tolerance to *** this pilot study,we monitored cerebral hemody-namics during standard CPAP therapy at night in thre patients with severe OSA using *** found periodic oscllations in HbO2,HHb,tisue oxygenation index(TO1)and blood volume(BV)associa ted with periodic apnea events without CPAP in all OSA *** osillationswere eliminated under the optimal CPAP pressures in all *** results sugg ested thatthe recovery of cerebral hemodynamics impaired by apnea events can be evaluated by bedsideNIRS measurements in real time during ll night CPAP *** is a usefi bedsidemonitoring tool to evaluate the treatment elicacy of CPAP therapy in patients with OSA.

关键词： Sleep cerebral hemodynamics hemodynamic oscillations bedside monitoring.

The Legacy and Future of Saussurean Semiology in the Study of Art and Visual Communication

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Language and Semiotic Studies 2022年第1期8卷 123-132页

作者： maja Rudloff Rasmus Kjærboe Roskilde University Denmark The Hirschsprung Collection Denmark

The present study discusses how the emergence of semiology has outlined a new trajectory for visual and pictorial ***,we outline how Ferdinand de Saussure’s thoughts on the sign and its relation to visual communication has ***,we interrogate its impact on art history,an already established science of visuality,throughout the 20th and 21st ***,we briefly discuss whether art history’s answer to reading Saussure is a denial or a positive affirmation of political responsibility shared by visual studies in *** study highlights some of the most pertinent parts of the Saussurean legacy for the study of visual communication as a system,and some of the challenges and opportunities this legacy has created.

关键词： visual communication semiology images art art history

Quadricuspid aortic valve and right ventricular type of myocardial bridging in an asymptomatic middle-aged woman:A case report

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World Journal of Clinical Cases 2022年第25期10卷 8954-8961页

作者： Ivana Sopek Merkaš Nenad Lakušić maja Hrabak Paar Department of Cardiology Special Hospital for Medical Rehabilitation Krapinske TopliceKrapinske Toplice 49217Croatia Department of Clinical Medicine Faculty of Dental Medicine and Health OsijekOsijek 31000Croatia Department of Internal Medicine Family Medicine and History of MedicineFaculty of Medicine OsijekOsjiek 31000Croatia Department of Diagnostic and Interventional Radiology University Hospital Centre ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia

BACKGROUND Quadricuspid aortic valve(QAV)is a very rare congenital cardiac defect with the incidence of 0.0125%-0.033%(<0.05%)predominantly causing aortic regurgitation.A certain number of patients(nearly one-half)have abnormal function and often require surgery,commonly in their fifth or sixth *** usually appears as an isolated anomaly but may also be associated with other cardiac congenital *** is considered the main diagnostic method although more and more importance is given to computed tomography(CT)and magnetic resonance imaging(MRI)as complementary *** SUMMARY A 60-year-old female patient was referred for transthoracic ultrasound of the heart as part of a routine examination in the treatment of arterial *** did not have any significant *** was confirmed and there were no elements of valve stenosis with moderate aortic *** first,it seemed that in the projection of the presumed left coronary cusp,there were two smaller and equally large cusps along with two larger and normally developed *** CT imaging was performed to obtain an even more precise valve morphology and it showed that the location of the supernumerary cusp is between the right and left coronary cusp,with visible central malcoaptation of the ***,coronary computed angiography confirmed the right-type of myocardial bridging at the distal segment of the left anterior descending coronary *** valve dysfunction often occurs in middle-aged patients and results in surgical treatment,therefore,a 1-year transthoracic echocardiogram control examination and follow-up was recommended to our *** This case highlights the importance of diagnosing QAV since it leads to progressive valve dysfunction and can be associated with other congenital heart defects which is important to detect,emphasizing the role of cardiac CT and MRI.

关键词： Quadricuspid aortic valve Congenital cardiac defect Aortic insufficiency Multimodal imaging Myocardial bridging Case report

Semaglutide might be a key for breaking the vicious cycle of metabolically associated fatty liver disease spectrum?

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World Journal of Clinical Cases 2022年第20期10卷 6759-6768页

作者： maja Cigrovski Berkovic Tanja Rezic Ines Bilic-Curcic Anna Mrzljak Department of Endocrinology DiabetesMetabolism and Clinical PharmacologyClinical Hospital DubravaZagreb 10000Croatia Faculty of Kinesiology University of ZagrebZagreb 10000Croatia Department of Endocrinology and Diabetes Clinical Hospital DubravaZagreb 10000Croatia Department of Endocrinology and Diabetes University Hospital Centre OsijekOsijek 31000Croatia Department of Gastroenterology and Hepatology University Hospital Centre ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia

Metabolically associated fatty liver disease(MAFLD)is a liver manifestation of metabolic syndrome potentially related to unfavorable hepatic and extrahepatic outcomes and progression to *** to date,there are no approved pharmacotherapies for the treatment of MAFLD,so management focused on lifestyle interventions to encourage weight loss,and treatment of coexisting conditions is the only available ***,the aforementioned is often not potent enough to offer reversal or slow down hepatic inflammation and ***-like peptide-1 receptor agonists have a favorable effect on glycemic management and weight loss of patients with type 2 diabetes mellitus and recently published data suggest their potential in MAFLD *** addition,some of the agents have proven cardiovascular and renal benefits in dedicated cardiovascular outcome trials,making them an interesting therapeutic *** this opinion review,we discuss the role of semaglutide in MAFLD.

关键词： Semaglutide Non-alcoholic fatty liver disease Glucagon-like peptide-1 receptor agonists Metabolically associated fatty liver disease

What is the gut feeling telling us about physical activity in colorectal carcinogenesis?

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World Journal of Clinical Cases 2020年第23期8卷 5844-5851页

作者： maja Cigrovski Berkovic Vjekoslav Cigrovski Ines Bilic-Curcic Anna Mrzljak Department for Endocrinology Diabetes and MetabolismClinical Hospital DubravaZagreb 10000Croatia Faculty of Kinesiology University of ZagrebZagreb 10000Croatia Department of Pharmacology Faculty of MedicineJ J Strossmayer University OsijekOsijek 31000Croatia Department of Medicine Merkur University HospitalZagreb 10000Croatia Department of Medicine School of MedicineUniversity of ZagrebZagreb 10000Croatia

In the last decades,more efforts are focused on the prevention and treatment of malignant diseases,given the increase in all cancers incidence A lifestyle change,including healthy eating habits and regular physical activity,has significantly impacted colorectal cancer *** effect of dose-dependent physical activity on mortality and recurrence rates of colorectal carcinoma has been unequivocally demonstrated in observational ***,clear recommendations are not available on the frequency,duration,and intensity of exercise in patients with colorectal cancer due to the lack of evidence in randomized clinical *** pathophysiological mechanisms,the most plausible explanation appears to be the influence of physical activity on reducing chronic inflammation and insulin resistance with a consequent positive effect on insulin growth factor 1 signaling pathways.

关键词： Physical activity Colorectal cancer Insulin signaling pathway Inflammation Gut microbiota

New era of electrochemotherapy in treatment of liver tumors in conjunction with immunotherapies

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World Journal of Gastroenterology 2021年第48期27卷 8216-8226页

作者： BlažTrotovšek Mihajlo Djokić majaČemažar Gregor Serša Department of Abdominal Surgery University Medical Centre LjubljanaLjubljana 1000Slovenia Medical Faculty Ljubljana University of LjubljanaLjubljana 1000Slovenia Department of Experimental Oncology Institute of OncologyLjubljana 1000Slovenia Faculty of Health Sciences University of PrimorskaIzola 6310Slovenia Faculty of Health Sciences University of LjubljanaLjubljana 1000Slovenia

Electrochemotherapy is a local ablative therapy that increases the cytotoxicity of either bleomycin or cisplatin by applying electric pulses(electroporation)to *** has already been widely used throughout Europe for the treatment of various types of human and veterinary cutaneous tumors,with an objective response rate ranging from 70%-90%,depending on the tumor ***,electrochemotherapy was introduced for the treatment of primary liver tumors,such as hepatocellular carcinoma(HCC).The complete response rate was 85%per treated lesion,with a durable ***,electrochemotherapy could become a treatment of choice for HCC,especially after achieving a transition from an open surgery approach to a percutaneous approach that uses dedicated *** elicits a local immune response and can be considered an in situ ***,among others,is a potentially immunogenic tumor;thus,electrochemotherapy could boost adjuvant immunotherapy to achieve a better and longer-lasting antitumor ***,therapeutic strategies that combine electrochemotherapy with immune checkpoint inhibitors or adjuvant treatment with cytokines are indicated for *** therapy using electroporation as a delivery system for plasmid DNA coding for interleukin-12 is a highly promising *** electroporation approach has shown efficacy in preclinical settings and veterinary oncology and is awaiting translation for the treatment of liver tumors,i.e.,HCC.

关键词： Electroporation Electrochemotherapy Gene therapy Gene electrotransfer Interleukin-12 Immune checkpoint inhibitors Hepatocellular carcinoma

Ground cover management and farmyard manure effects on soil nitrogen dynamics, productivity and economics of organically grown lettuce (Lactuca sativa L. subsp, secalina)

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Journal of Integrative Agriculture 2017年第4期16卷 947-958页

作者： Manojlovic maja Cabilovski Ranko Nikolic Ljiljana Dzigurski Dejana Seremesic Srdan Bavec Martina Faculty of Agriculture University of Novi Sad Novi Sad 21000 Serbia Faculty of Agriculture and Life Sciences University of Maribor Maribor 2000 Slovenia

Ground cover management and farmyard manure （FYM） management have important roles in organic lettuce production. However, there is not enough information about their combined effects. In order to assess the effects of individual and combined ground cover and FYM management on soil mineral N （NH4-N and NO3-N） dynamics, lettuce yield and economics in organic farming, a two-year field experiment was conducted on a certified organic farm in Kisa6 （Vojvodina, Serbia）. The experiment had a two-factorial split-plot completely randomized block design. FYM was applied on the half of the experimental field as a whole-plot factor, while ground cover management included the following four treatments：（I） control, without ground cover management （0）; （11） hoeing （H）; （111） agrotextile cover; （IV） straw mulch （SM）, which were applied on split plots. The applied SM and AT increased soil moisture by 12.83 and 3.73%, respectively, compared to the control treatment. FYM increased soil mineral N concentration, the lettuce fresh matter （FM） yield and nitrate concentration in lettuce. However, nitrate concentration in lettuce in all treatments was below the limit required by the European Commission （EC）（2001）. The highest lettuce yield was obtained by AT （39 122 kg）, followed by SM （33 925 kg）, and it was higher with FYM application by 16.85%. Hoeing did not positively affect the yield, probably due to its negative effect on soil moisture. Additional profit was higher with FYM, showing the following decreasing order： AT〉H〉SM〉Ф. However, value/cost ratio （VCR） was in the order Ф〉H〉SM〉AT on FYM fertilized plots. FYM application led to higher lettuce yield and higher profit and VCR. In case a farm does not have FYM, SM is the best alternative due to its positive effect on the yield and low investment costs. Keywords： hoeing, agrotextile cover, straw mulch, farmyard manure, FYM, mulch

关键词： hoeing agrotextile cover straw mulch farmyard manure FYM mulch

A Comparative Study on the Role of Cytokinins in Caryopsis Development in the Maize miniature1 Seed Mutant and Its Wild Type

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Journal of Integrative Plant Biology 2009年第9期51卷 840-849页

作者： Tomaz Rijavec maja Kova Ale Kladnik Prem S.Chourey Marina Dermastia National Institute of Biology Department of Biotechnology and Systems Biology Department of Biology Biotechnical FacultyUniversity of Ljubljana US Department of Agriculture Agricultural Research ServiceChemistry Research Unit

We report here on a comparative developmental profile of plant hormone cytokinins in relation to cell size, cell number and endoreduplicaUon in developing maize caryopsis of a cell wall invertase-deficient miniature1 （mn1） seed mutant and its wild type, Mn1, genotype. Both genotypes showed extremely high levels of total cytokinins during the very early stages of development, followed by a marked and genotype specific reduction. While the decrease of cytokinins in Mn1 was associated with their deactivation by 9-glucosylation, the absolute and the relative part of active cytokinin forms was higher in the mutant. During the exponential growth phase of endosperm between 6 d after pollination and 9 d after pollination, the mean cell doubling time, the absolute growth rate and the level of endoreduplication were similar in the two genotypes. However, the entire duration of growth was longer in Mnl compared with mnl, resulting in a significantly higher cell number in the Mnl endosperm. These data correlate with the previously reported peak levels of the Mn1-encoded cell wall invertase-2 （INCW2） at 12 d after pollination in the Mn1 endosperm. A model showing possible crosstalk among cytokinins, cell cycle and cell wall invertase as causal to increased cell number and sink strength of the Mn1 developing endosperm is discussed.

关键词： 9-glucosylation cell wall invertase cytokinins maize caryopsis miniature1.

How far along are we in revealing the connection between metformin and colorectal cancer?

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World Journal of Gastroenterology 2021年第14期27卷 1362-1368页

作者： maja Cigrovski Berkovic Danko Mikulic Ines Bilic-Curcic Anna Mrzljak Department of Kinesiological Anthropology and Methodology Faculty of KinesiologyUniversity of ZagrebZagreb 10000Croatia Clinical Hospital Dubrava Zagreb 10000Croatia Department of Surgery Merkur University HospitalZagreb 10000Croatia Department of Pharmacology Faculty of MedicineUniversity of J.J.Strossmayer OsijekOsijek 31000Croatia Clinical Hospital Center Osijek Osijek 31000Croatia Department of Medicine Merkur University HospitalSchool of MedicineZagreb 10000Croatia

Colorectal cancer(CRC)is among the most prevalent cancers worldwide,and its prevention and reduction of incidence is *** presence of diabetes has been associated with a 30%increased risk of CRC,likely through the mechanism of hyperinsulinemia,which promotes tumorigenesis via the insulin receptor in the epithelium or by insulin-like growth factor pathways,inflammation,or adipokines,inducing cancer cell proliferation and cancer ***,the first-line agent in treating type 2 diabetes,has a chemopreventive role in CRC ***,preclinical studies suggest synergistic effects of metformin with oxaliplatin in inhibiting in vitro models of colon *** preclinical studies on the post diagnostic use of metformin were promising and suggested its synergistic effects with chemotherapy,the data on the possible effects of metformin after surgery and other CRC treatment in the clinical setting are less conclusive,and randomized controlled trials are still lacking.

关键词： Metformin Type 2 diabetes mellitus Colorectal cancer Chemoprevention Recurrence-free survival Surgery

Prognostic role of metformin in diabetes mellitus type 2 patients with hepatocellular carcinoma:A systematic review and meta-analysis

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World Journal of Diabetes 2023年第8期14卷 1289-1300页

作者： maja Cigrovski Berkovic Francesco Giovanardi Anna Mrzljak Quirino Lai Department of Kinesiological Anthropology and Methodology Faculty of KinesiologyUniversity of ZagrebZagreb 10000Croatia General Surgery and Organ Transplantation Unit Department of SurgerySapienza University of RomeRome 00018Italy Department of Gastroenterology and Hepatology University Hospital Center ZagrebZagreb 10000Croatia Department of Medicine School of MedicineZagreb 10000Croatia

BACKGROUND Hepatocellular carcinoma(HCC)is among the commonest malignancies associated with significant cancer-related *** identification of chemopreventive agents following HCC treatments with the potential to lower the risk of HCC adverse course is ***,a first-line agent used in the treatment of type 2 diabetes mellitus(T2DM),has been associated with inhibition of HCC *** To determine whether metformin can prevent adverse events(i.e.,death,tumor progression,and recurrence)after any HCC treatment in T2DM *** A systematic review of the published literature was undertaken focused on the role of metformin on outcomes in patients with T2DM and HCC receiving any tumor therapy.A search of the PubMed and Cochrane Central Register of Controlled Trials Databases was *** A total of 13 studies(n=14886 patients)were included in this *** regard to the risk of death,a decreased risk was reported in cases receiving metformin,although this decrease was not statistically significant[odds ratio(OR)=0.89,P=0.42].When only patients treated with curative strategies were considered,a more marked correlation between metformin and favorable cases was reported(OR=0.70,P=0.068).When analyzing palliative treatment,there was no statistical significance in terms of the correlation between metformin and favorable cases(OR=0.74,P=0.66).As for the risks of progressive disease and recurrence,no obvious correlation between metformin use and reduced risk was *** sub-analyses were performed for patients from different regions,the results for patients from Eastern countries showed a tendency for decreased risk of death in T2DM cases receiving metformin(OR=0.69,P=0.17),but the same was not seen in patients from Western countries(OR=1.19,P=0.31).CONCLUSION Metformin failed to show a marked impact in preventing adverse effects after HCC treatment.A trend was reported in T2DM cases receiving curative therapies in relation to the ri

关键词： Hepatocellular carcinoma Metformin Type 2 diabetes mellitus Death Recurrence Progression Treatment