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Assessment of hepatic fibrosis in pediatric cases with hepatitis C virus in Egypt

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World Journal of Gastroenterology 2007年第20期13卷 2846-2851页

作者： Manal A el-Hawary Mona S el-raziky Gamal Esmat Hanan Soliman Amr Abouzied maissa el-raziky Wafaa el-Akel Rokaya el-Sayed Fatma Shebl Abdel Aziz Shaheen Hanaa el-Karaksy Department of Pediatrics Fayoum UniversityEgypt Department of Pediatrics Cairo UniversityEgypt Department of Tropical Medicine Cairo UniversityEgypt Department of Pathology Cairo UniversityEgypt Department of Tropical Medicine Hepatitis C ProjectEgypt Department of Public Health National Liver InstituteEgypt

AIM: To assess hepatic fibrosis and factors associated with its progression in children with HCV infection. METHODS: At the Hepatology Unit,Cairo University Children's Hospital,a single liver biopsy was performed to 43 children with HCV infection after an informed consent between 1998-2004. Their mean age at liver biopsy was 8.67 ± 4.3 years. RESULTS: Among the 43 patients' biopsies,12 (27.9%) were having no fibrosis,20 (46.5%) mild fibrosis and 11 (25.6%) moderate to severe fibrosis. The median time for development of fibrosis was estimated to be 5.5 years. Developing fibrosis was significantly associated with shorter duration from first detected ALT elevation to biopsy (12 mo vs 1.2 mo,P = 0.015) and having higher levels of direct serum bilirubin (0.3 mg/dL vs 0.5 mg/dL,P = 0.048). No association was found between fibrosis stage and the presence of co-morbid conditions (P = 0.33). CONCLUSION: Hepatic fibrosis was present in 72.1% of children with HCV infection. The development of fibrosis was associated with higher levels of direct serum bilirubin. There was no significant association between fibrosis and age,duration of infection,risk factors,co-morbid conditions and most biochemical parameters.

关键词： Children Egypt Fibrosis Hepatitis C virus Liver

Regulatory and activated effector T cells in chronic hepatitis C virus: Relation to autoimmunity

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World Journal of Hepatology 2016年第30期8卷 1287-1294页

作者： Hanan Fouad maissa el raziky Eman Medhat Hassan Ghada Mahmoud Abdel Aziz Samar K Darweesh Ahmed Reda Sayed Department of Medical Biochemistry Faculty of Medicine Cairo University Department of Pharmacology and Toxicology Faculty of Pharmacy Hail University Department of Hepato-gastroenterology and Tropical Medicine Faculty of Medicine Cairo University Department of Medical Biochemistry Faculty of Medicine Beni Suef University

AIMTo investigate how Tregs are regulated in chronic hepatitis C virus (HCV) patients via assessment of Tregs markers (granzyme 2, CD69 and FoxP3), Teffs markers [TNFRSF4 (OX40), INFG] and CD4, CD25 genes. METHODSA prospective study was conducted on 120 subjects divided into 4 groups: Group I (n = 30) treatment naïve chronic HCV patients; Group II (n = 30) chronic HCV treated with Peg/Riba; Group III (n = 30) chronic HCV associated with non-organ specific autoantibody and Group IV (n = 30) healthy persons as a control group. Tregs and Teffs markers were assessed in peripheral blood mononuclear cells by quantitative real time reverse transcriptase-polymerase chain reaction. RESULTSChronic HCV patients exhibited significant higher levels of both Teffs and Tregs in comparison to healthy control group. Tregs markers were significantly decreased in Peg/Riba treated HCV patients in comparison to treatment naïve HCV group. In HCV patients with antinuclear antibody (ANA) +ve, Tregs markers were significantly decreased in comparison to all other studied groups. Teffs markers were significantly elevated in all HCV groups in comparison to control and in HCV group with ANA +ve in comparison to treatment naïve HCV group. CONCLUSIONelevated Tregs cells in chronic HCV patients dampen both CD4+ and CD8+ autologous T cell immune response. Interferon-α and ribavirin therapy suppress proliferation of Tregs. More significant suppression of Tregs was observed in HCV patients with autoantibodies favoring pathological autoimmune response.

关键词： Autoimmunity T regulatory cells Hepatitis C virus T activator cells Interferon

Coinfection with hepatitis C virus and schistosomiasis:Fibrosis and treatment response

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World Journal of Gastroenterology 2013年第17期19卷 2691-2696页

作者： Mahasen Abdel-Rahman Mohammad el-Sayed maissa el raziky Aisha elsharkawy Wafaa el-Akel Hossam Ghoneim Hany Khattab Gamal Esmat Department of Endemic Medicine and Hepatology Faculty of Medicine Cairo University Department of Endemic Medicine and Hepatology Faculty of Medicine Beni-Suef University Department of Pathology Faculty of MedicineCairo University

AIM:To assess whether schistosomiasis coinfection with chronic hepatitis C virus (HCV) influences hepatic fibrosis and pegylated-interferon/ribavirin (PEG-IFN/ RIB) therapy response. METHODS:This study was designed as a retrospective analysis of 3596 chronic HCV patients enrolled in the Egyptian National Program for HCV treatment with PEG-IFN/RIB. All patients underwent liver biopsy and anti-schistosomal antibodies testing prior to HCV treatment. The serology results were used to categorize the patients into group A (positive schistosomal serology) or group B (negative schistosomal serology). Patients in group A were given oral antischistosomal treatment(praziquantel, single dose) at four weeks prior to PEG-IFN/RIB. All patients received a 48-wk course of PEG-IFN (PEG-IFNα2a or PEG-IFNα2b)/RIB therapy. Clinical and laboratory follow-up examinations were carried out for 24 wk after cessation of therapy (to week 72). Correlations of positive schistosomal serology with fibrosis and treatment response were assessed by multiple regression analysis. RESULTS:Schistosomal antibody was positive in 27.3% of patients (15.9% females and 84.1% males). The patients in group A were older (P = 0.008) and had a higher proportion of males (P = 0.002) than the patients in group B. There was no significant association between fibrosis stage and positive schistosomal serology (P = 0.703). Early virological response was achieved in significantly more patients in group B than in group A (89.4% vs 86.5%, P = 0.015). However, significantly more patients in group A experienced breakthrough at week 24 than patients in group B (36.3% vs 32.3%, P = 0.024). End of treatment response was achieved in more patients in group B than in group A (62.0% vs 59.1%) but the difference did not reach statistical significance (P = 0.108). Sustained virological response occurred in significantly more patients in group B than in group A (37.6% vs 27.7%, P = 0.000). Multivariate logistic regression analysis of p

关键词： Hepatitis C virus Schistosomiasis Coinfection Fibrosis Treatment response

Predictors of Complete Early Virological Response to Pegylated Interferon and Ribavirin in Egyptian Patients with Chronic Hepatitis C Genotype 4

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Advances in Infectious Diseases 2013年第2期3卷 78-83页

作者： Gamal el Din Esmat Gamil maissa el Said el raziky Rabab Maamoun Salama Wafaa Ahmed el Akel Waleed Fouad Fathalah Dina Ismail Attia Endemic Medicine and Hepatology Department Faculty of Medicine Cairo University Cairo Egypt

We aim to determine the baseline factors associated with partial and cEVR by analyzing the data of 1861 Egyptian patients treated for 12 weeks with a course of Peg-IFN plus RBV. Base line data of 1861 Egyptian patients with chronic hepatitis C coming at Cairo-Fatemic Hospital for HCV treatment were studied including full clinical, Ultrasonographic examination, laboratory evaluation and liver biopsy. The most significant variables in relation to complete early virological response were low Hb level (13 gm/dl) with p 0.01, the stage of fibrosis p value eline before initiating treatment is mandatory to predict which patient will be more expected to achieve a cEVR and thus reducing the side-effects and healthcare costs associated with interferon therapies.

关键词： Predictors of Response cEVR HCV Treatment Peg IFN/Ribavirin

Prevalence of occult hepatitis C in egyptian patients with non alcoholic fatty liver disease

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Open Journal of Internal Medicine 2011年第2期1卷 33-37页

作者： Yasmin Saad Soheir Zakaria Iman Ramzy maissa el raziky Olfat Shaker Wafaa elakel Mohamed Said Mona Noseir Mai el-Daly Mohamed Abdel Hamid Gamal Esmat 不详

This study aim is to assess the prevalence of occult HCV infection among Egyptian patients with non alcoholic fatty liver disease (NAFLD) with elevated AST and ALT, and to correlate presence of occult HCV with severity of liver disease. Patients and Methods: After informed consent 27 patients with elevateed liver enzymes diagnosed as NAFLD were examined for demographic, clinical, laboratory data and Ultrasonography. Liver biopsy was done and tested for HCV RNA in tissue. Genotyping using RFLP analysis of PCR products in the 5’NCR was done for positive cases. Results: HCV RNA in tissue was positive in 11/27 patients (40.7%);genotype was 4a in all positive cases. AST and ALT values showed significantly lower values in occult HCV than the non HCV NAFLD group. Liver biopsy of studied patients showed no significant difference as regard inflammation and fibrosis according to METAVIR score. Conclusions: Occult HCV is highly prevalent among Egyptian NAFLD patients. It seems to induce a mild liver disease. Patients with elevated ALT and negative HCV RNA in sera might be investigated for tissue HCV RNA. Follow up is recommended for the occult HCV patients to monitor progression to overt disease.

关键词： Genotype 4 Liver Enzymes NAFLD Occult HCV

Dendritic cell co-stimulatory and co-inhibitory markers in chronic HCV: An Egyptian study

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World Journal of Gastroenterology 2013年第43期19卷 7711-7718页

作者： Hanan Fouad maissa Saeed el raziky Rasha Ahmed Abdel Aziz Dina Sabry Ghada Mahmoud Abdel Aziz Manal Ewais Ahmed Reda Sayed Medical Biochemistry Department Faculty of MedicineCairo University11562 CairoEgypt Gastroenterology and Tropical Department Faculty of MedicineCairo University11562 CairoEgypt Medical Biochemistry Department Faculty of MedicineBeni Sueif University19206 Kornish Al NileBani SweifEgypt

AIM:To assess co-stimulatory and co-inhibitory markers of dendritic cells(DCs)in hepatitis C virus(HCV)infected subjects with and without ***:Three subject groups were included in the study:group 1 involved 50 control subjects,group2 involved 50 patients with chronic HCV infection and group 3 involved 50 HCV uremic subjects undergoing ***83,CD86 and CD40 as co-stimulatory markers and PD-L1 as a co-inhibitory marker were assessed in peripheral blood mononuclear cells by realtime polymerase chain ***-10(IL-10)and hyaluronic acid(HA)levels were also *** findings were correlated with disease activity,viral load and ***:There was a significant decrease in costimulatory markers;CD83,CD86 and CD40 in groups2 and 3 vs the control ***-stimulatory markers were significantly higher in group 3 vs group *** was a significant elevation in PD-L1 in both HCV groups vs the control ***-L1 was significantly lower in group 3 vs group *** was a significant elevation in IL-10 and HA levels in groups 2 and 3,where IL-10was higher in group 3 and HA was lower in group 3 vs group *** level was significantly correlated with disease activity and fibrosis grade in group ***-10 was significantly correlated with fibrosis grade in group *** were significant negative correlations between co-stimulatory markers and viral load in groups 2 and3,except CD83 in dialysis *** was a significant positive correlation between PD-L1 and viral load in both HCV ***:A significant decrease in DC co-stimulatory markers and a significant increase in a DC coinhibitory marker were observed in HCV subjects and to a lesser extent in dialysis patients.

关键词： Hepatitis C virus Uremia Hemodialysis Dendritic cells CD83 CD86,CD40 PD-L1 Interleukin-10 Hyaluronic acid

Epidemiological and histopathological characteristics of thyroid carcinoma in a Tunisian health care center

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 37-42页

作者： maissa Ben Thayer Fatma Khanchel Imen Helal Dorra Chiboub Hedhli Raoueh Ehsen Ben Brahim Raja Jouini Aschraf Chadli-Debbiche Faculty of Medicine of Tunis Tunis El Manar UniversityTunisTunisia Depatment of Pathology Habib Thameur's HospitalTunisTunisia Department of Otorhinolaryngology-Head and Neck surgery Habib Thameur's HospitalTunisTunisia

Background:Thyroid carcinoma(TC)accounts for almost 0.5%–1%of total *** incidence is increasing rapidly *** studies have drawn up the epidemiological profile of TC and its clinical and pathological ***,to date,no similar studies have been conducted in ***:To establish an epidemiological profile of TC in a Tunisian health care institute and to analyze its clinical and histopathological characteristics in our *** and Methods:We present a retrospective study reviewing the cases of TC diagnosed in our institution in a 4-year ***:We collected a sample of 192 cases of *** consisted of 31 males and 161 females(83.8%)with a sex-ratio M/F of *** mean age was 46.4 *** thyroid carcinoma was the most frequent histological *** multifocality rate was 33.8%.The mean size of TC was 2.2±1.9 cm.60.9%of TC were staged pT1 and 20.3%had nodal *** thyroid microcarcinomas were noted in 37.5%of ***:Our results were consistent with those of the literature.A high proportion of pT1 and pN0 tumors were noted in our series,suggesting that TC's diagnosis and management was performed at an early stage of the disease in our *** addition,our study enabled us to notice the impact of the Coronavirus disease 19 crisis on the management of TC in our *** studies are needed to establish the epidemiological profile of TC in Tunisia and to assess its clinical and pathological features.

关键词： coronavirus disease 19 epidemiology papillary thyroid carcinoma papillary thyroid microcarcinoma pathology thyroid carcinoma

Prevalence of occult hepatitis C in Egyptian patients with non alcoholic fatty liver disease

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Neutron-gamma discrimination method based on blind source separation and machine learning

Open Journal of Internal Medicine（内科学期刊） 2011年第2期

作者： Yasmin Saad Soheir Zakaria Iman Ramzy maissa el raziky Olfat Shaker Wafaa elakel Mohamed Said Mona Noseir Mai el-Daly Mohamed Abdel Hamid Gamal Esmat

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Nuclear Science and Techniques 2021年第2期32卷 70-80页

作者： Hanan Arahmane el-Mehdi Hamzaoui Yann Ben maissa Rajaa Cherkaoui el Moursli Universite´Paris-Saclay CEAList91120 PalaiseauFrance Equipe des Sciences de la Matie`re et du Rayonnement(ESMaR) Faculty of SciencesMohammed V University in RabatB.P.1014 RPRabatMorocco National Centre for Nuclear Energy Science and Technology(CNESTEN)B.P.1382 R.P.10001RabatMorocco Laboratory of Telecommunications Networks and Service SystemsNational Institute of Posts and TelecommunicationsAllal El Fassi AvenueRabatMorocco

The discrimination of neutrons from gamma rays in a mixed radiation field is crucial in neutron detection *** approaches have been proposed to enhance the performance and accuracy of neutron-gamma ***,their performances are often associated with certain factors,such as experimental requirements and resulting mixed *** main purpose of this study is to achieve fast and accurate neutron-gamma discrimination without a priori information on the signal to be analyzed,as well as the experimental ***,a novel method is proposed based on two *** first method exploits the power of nonnegative tensor factorization(NTF)as a blind source separation method to extract the original components from the mixture signals recorded at the output of the stilbene scintillator *** second one is based on the principles of support vector machine(SVM)to identify and discriminate these *** addition to these two main methods,we adopted the Mexican-hat function as a continuous wavelet transform to characterize the components extracted using the NTF *** resulting scalograms are processed as colored images,which are segmented into two distinct classes using the Otsu thresholding method to extract the features of interest of the neutrons and gamma-ray components from the background *** subsequently used principal component analysis to select the most significant of these features wich are used in the training and testing datasets for ***-variance analysis is used to optimize the SVM model by finding the optimal level of model complexity with the highest possible generalization *** this framework,the obtained results have verified a suitable bias–variance trade-off *** achieved an operational SVM prediction model for neutron-gamma classification with a high true-positive *** accuracy and performance of the SVM based on the NTF was evaluated and validated by comparing it to the charge comparison

关键词： Blind source separation Nonnegative tensor factorization(NTF) Support vector machines(SVM) Continuous wavelets transform(CWT) Otsu thresholding method