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Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 91-92页

作者： antonios athanasiou eleftherios spartalis mairead hennessy michael spartalis demetrios moris christos damaskos emmanouil pikoulis department of upper gastrointestinal surgery university hospitals birmingham nhs foundation trustBirmingham UK laboratory of experimental surgery and surgical research university of athens medical schoolAg. Thoma 15B Athens 11527 Greece department of surgery wexford general hospitalIreland department of surgery duke universityDurham NC USA first surgery department laikon general hospital national and kapodistrian university of athensGreece

To the editor:We read with great interest the article entitled "Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats" by Ulmer et al.[1].The aim o... 详细信息

关键词： Effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats What we know so far

Conduit necrosis following esophagectomy: An up-to-date literature review

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World Journal of Gastrointestinal Surgery 2019年第3期11卷 155-168页

作者： Antonios Athanasiou mairead hennessy Eleftherios Spartalis Benjamin H L Tan Ewen A Griffiths Department of Upper GI Bariatric and Minimally Invasive Surgery St.James' University Hospital Leeds Teaching Hospitals NHS Trust Department of Anaesthesia University Hospital of Waterford Laboratory of Experimental Surgery and Surgical Research University of Athens Medical School Department of Upper Gastrointestinal Surgery University Hospitals Birmingham NHS Foundation Trust

Esophageal conduit ischaemia and necrosis is an uncommon but devastating complication of esophagectomy and remains one of the most challenging issues in surgical practice. The incidence, time interval to develop symptoms, and clinical presentation are highly variable with no predictable pattern. Evidence comes from case reports and case series rather than randomized controlled *** describe the issues surrounding conduit necrosis affecting the stomach,jejunum and colon as an esophageal replacement and the advantages,disadvantages and challenges of each type of reconstruction. Diagnosis is challenging for the most experienced surgeon. Upper gastrointestinal endoscopy and computed tomography thorax with both oral and intravenous contrast is the gold standard. Management, either conservative or interventional is also a difficult decision. Management options include conservative treatment and more aggressive treatments such as stent insertion, surgical debridement and repair of the esophagus using jejunum, colon or a musculocutaneous flap. In spite of recent advances in surgical techniques, there is no reliable strategy to manage esophageal conduit necrosis. Our review covers the pathophysiology and clinical significance of esophageal necrosis while highlighting current techniques of prevention, diagnosis and treatment of this life-threatening condition.

关键词： Esophagectomy Esophageal cancers Esophagogastric anastomosis

Pancreatic cancer: Are 'liquid biopsies' ready for prime-time?

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World Journal of Gastroenterology 2016年第32期22卷 7175-7185页

作者： Alexandra R Lewis Juan W Valle mairead G Mc Namara The Christie NHS Foundation Trust M20 4BX ManchesterUnited Kingdom Institute of Cancer Sciences University of ManchesterM20 4BX ManchesterUnited Kingdom

Pancreatic cancer is a disease that carries a poor prognosis. Accurate tissue diagnosis is required. Tumours contain a high content of stromal tissue and therefore biopsies may be inconclusive. Circulating tumour cells(CTCs) have been investigated as a potential "liquid biopsy" in several malignancies and have proven to be of prognostic value in breast, prostate and colorectal cancers. They have been detected in patients with localised and metastatic pancreatic cancer with sensitivities ranging from 38%-100% using a variety of platforms. Circulating tumour DNA(ct DNA) has also been detected in pancreas cancer with a sensitivity ranging from 26%-100% in studies across different platforms and using different genetic markers. However, there is no clear consensus on which platform is the most effective for detection, nor which genetic markers are the most useful to use. Potential roles of liquid biopsies include diagnosis, screening, guiding therapies and prognosis. The presence of CTCs or ct DNA has been shown to be of prognostic value both at diagnosis and after treatment in patients with pancreatic cancer. However, more prospective studies are required before this promising technology is ready for adoption into routine clinical practice.

关键词： Pancreatic Cancer Liquid biopsy Circulating Tumour Cells Circulating Tumour DNA

Are school uniforms associated with gender inequalities in physical activity? A pooled analysis of population-level data from 135 countries/regions

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Journal of Sport and Health Science 2024年第4期13卷 590-598页

作者： mairead Ryan Luiza I.C.Ricardo Nicole Nathan Riikka Hofmann Esther van Sluijs Medical Research Council Epidemiology Unit University of CambridgeCambridge CB20QQUK Faculty of Education University of CambridgeCambridge CB28PQUK Hunter New England Population Health WallsendNSW 2287Australia School of Medicine and Public Health College of HealthMedicine and WellbeingUniversity of NewcastleCallaghanNSW 2308Australia Hunter Medical Research Institute New Lambton HeightsNSW 2305Australia National Centre of Implementation Science University of NewcastleCallaghanNSW 2308Australia

Purpose:It is aimed to assess whether school uniforms are associated with population-level gender inequalities in physical activity,and whether associations differ by school level,country/region income,and assessment ***:An ecological study design was *** collected data about global uniform practices using an online *** searched for country/region-level estimates of school-aged youth meeting physical activity guidelines from international surveillance *** selection was conducted in duplicate using a systematic process,and a random sample of all data was checked to ensure extraction and pooling processes were *** calculated absolute and relative gender inequalities in physical activity for each *** regression examined associations between country/region-level uniform practices(binary yes/no exposure variable) and country/region-level gender inequalities in physical activity guideline compliance(absolute and relative inequalities).We investigated moderation by school level,stratified analyses by income group,and repeated primary analyses using device-measured ***:Pooling data from 135 countries/regions(n=1,089,852),we found no association between population-level uniform practices and gender inequalities in physical activity across all ages(absolute:β=-0.2;95% confidence interval(95%CI):-1.7 to 1.3,p=0.74;relative:β=0.1;95%CI:-0.1 to 0.2,p=0.51).Subgroup analysis suggested a positive association in primary school settings(absolute:β=4.3;95%CI:-0.0 to 8.6,p=0.05).Among high-income countries,absolute inequalities were significantly greater in countries/regions with uniform practices(N=37) compared to those without(N=48)(9.1(SD=3.6) vs.7.8 percentage points(SD=4.3)).Repeating analyses using device-measured data(n=32,130;N=24) did not alter our primary *** initial descriptive statistics,we found that in countries/regions where a maj ority of schools(>50%) reportedly use uniforms,there was lower compli

关键词： School policy Clothing Child Adolescent Accelerometer

高年资医务人员成为运动倡导者所有医务人员都应该成为运动倡导者

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英国医学杂志中文版 2020年第3期23卷 177-177页

作者： mairead McErlean 黄铃沂(译) Tottenham Court Road London W1T7NFUK 福建省立医院重症医学五科

Mahase在她的研究中发现,护士和未经注册的护理员中的肥胖问题十分严峻,令人担心1。尽管英国国家健康与临床优选研究所(NICE)建议高年资医务人员应作出表率,倡导加强体育锻炼,可我认为所有医务人员都应该参与到其中。NICE在2015年对英... 详细信息

Mahase在她的研究中发现,护士和未经注册的护理员中的肥胖问题十分严峻,令人担心1。尽管英国国家健康与临床优选研究所(NICE)建议高年资医务人员应作出表率,倡导加强体育锻炼,可我认为所有医务人员都应该参与到其中。NICE在2015年对英国国家健康体系(NHS)员工、患者及各类护理人员的体育锻炼量作出量化的指导2。

关键词：医务人员肥胖问题护理员护理人员高年资健康体系倡导者 NICE

Racial disparities in immune-related adverse events of immune checkpoint inhibitors and association with survival based on clinical and biochemical responses

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World Journal of Clinical Oncology 2021年第2期12卷 103-114页

作者： Monica Peravali Cristiane Gomes-Lima Eshetu Tefera mairead Baker Mamta Sherchan Saira Farid Kenneth Burman Florina Constantinescu Irina Veytsman Department of Hematology/Oncology MedStar Washington Hospital CenterWashingtonDC 20010United States Department of Endocrinology MedStar Washington Hospital CenterWashingtonDC 20010United States Department of Biostatistics and Bioinformatics MedStar Health Research InstituteWashingtonDC 20010United States Department of Internal Medicine MedStar Washington Hospital CenterWashingtonDC 20010United States Department of Rheumatology MedStar Washington Hospital CenterWashingtonDC 20010United States

BACKGROUND Immune checkpoint inhibitors(ICPi)cause various immune-related adverse events(irAE)with thyroid dysfunction as a commonly reported *** is increasing evidence showing positive association with development of irAE and ***,prior trials with ICPi had underrepresentation of minorities with<5%African *** To evaluate the association between development of irAE and survival outcomes among a racially diverse patient *** Data on patients with stage IV solid malignancies treated with programmed cell death-protein 1/programmed death ligand 1 blockers between January 2013 and December 2018 across MedStar Georgetown Cancer Institute facilities were retrospectively *** treated with cytotoxic T-lymphocyte-associated protein 4 inhibitors were *** free survival(PFS)and overall survival(OS)were primary endpoints and were calculated using Kaplan-Meier methods and Wilcoxon rank sum test for *** Out of 293 patients who met eligibility criteria,91 pts(31%)had any grade irAE;most common AE were endocrine(40.7%)specifically TSH elevation,dermatological(23.1%)and rheumatologic(18.7%).Proportion of irAE was significantly higher in Caucasians vs African Americans(60.4%vs 30.8%),in patients with low programmed death ligand 1,lower LDH,older age,and those who had more treatment cycles with *** of progression was lower in patients with irAE(30.8%vs 46.0%,P=0.0140).Median PFS(5.8 vs 3.0 mo,P=0.0204)and OS(17.1 vs 7.2 mo,P<0.0001)were higher with *** significant difference in OS(17.1 vs 8.6 mo,P=0.0002)but not in PFS(5.8 vs 3.3 mo,P=0.0545)was noted with endocrine *** differences in survival were observed among other commonly reported *** in survival among subgroups of patients with irAE are *** Development of irAE positively correlated with improved PFS and OS as reported in previous *** our knowledge,this is the first study obse

关键词： Immunotherapy Adverse events Endocrine Survival Race Minority

Early pregnancy maternal cardiovascular profiling in the prediction of hypertensive disease in pregnancy

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Open Journal of Obstetrics and Gynecology 2014年第2期4卷 61-65页

作者： Jennifer Hogan Vicky O’Dwyer Nadine Farah mairead M. Kennelly Michael J. Turner Bernard Stuart UCD Centre for Human Reproduction Coombe Women and Infants University Hospital Dublin Ireland

Prediction of hypertensive disease in pregnancy remains challenging. Risk factor based screening utilizing history, physical characteristics, uterine artery Doppler and serum markers have been used with varying success. As hypertension in pregnancy appears to be associated with changes in the maternal vasculature, we have investigated the utility of maternal arterial elasticity measurement, prior to 20 weeks gestation, in the prediction of hypertensive disease in pregnancy. A HDI/Pulsewave CR2000 Research Cardiovascular Profiling System was used to obtain radial artery pulse pressure waveforms from 623 Caucasian women at the time of their first antenatal visit. Outcome data were available in 610 cases and these comprised the study group. The results showed that women who subsequently developed gestational hypertension (n = 20) had higher baseline systolic, diastolic and pulse pressure values (though within the normal range) but similar arterial elasticity to those patients who did not develop hypertension. Women who later developed pre-eclampsia (n = 23) had, in addition, reduced large artery elasticity and increased systemic vascular resistance compared with women who did not develop hypertension. The measurement of maternal radial artery elasticity in early pregnancy may provide an additional refinement in screening for hypertensive disease, particularly pre-eclampsia, in pregnancy.

关键词： Pre-Eclampsia Gestational Hypertension Arterial Wall Elasticity Pulse Pressure Wave Analysis

慕课同心圈式发展:从高等教育破坏性创新向持续性创新模式的转变

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中国远程教育 2019年第3期 58-68,93页

作者：梅雷亚德.尼克.朱拉.梅西尔马克.布朗肖俊洪爱尔兰都柏林城市大学国家数字学习研究院美国圣母大学都柏林城市大学人文和社会科学学院欧洲创新型大学联盟教与学创新指导委员会欧洲远程与数字学习网络汕头广播电视大学

本文批判地分析了2012年以来慕课的发展。慕课在大学的实施受到多种并存且相互冲突的因素的影响。本文并非对相关研究文献进行深度述评,而是旨在揭示这些驱动因素并非泾渭分明、一成不变的关系。从这个角度看,本文认为慕课本质上是一种... 详细信息

本文批判地分析了2012年以来慕课的发展。慕课在大学的实施受到多种并存且相互冲突的因素的影响。本文并非对相关研究文献进行深度述评,而是旨在揭示这些驱动因素并非泾渭分明、一成不变的关系。从这个角度看,本文认为慕课本质上是一种政策手段,被大学公开或间接地用于达成某个具体背景下政策过程的特定目标。本文的理论框架建立在教育政策过程和发展的基础上。慕课是一种全球现象,等同于在线学习或成为其代名词。但是,如此认识慕课是把问题简单化了,强调的是学习的传送方式而非对有效教学设计的深入理解。本文用相互交织的同心圈喻指慕课的不同发展阶段,以说明不同发展阶段的驱动因素具有连续性。换言之,有些驱动因素的作用可能不如从前了,但是它们依然对慕课的全球和本地实施环境产生影响。文章最后反思了慕课的下一个"发展圈",即大学可以选择部署慕课,以实现自身的目标和(或)更宏大的目标。

关键词：慕课(大规模公开在线课程) 在线学习大学政策过程全球高等教育学习创新

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发展变化中的微证书领域:来自全球的启示

中国远程教育 2021年第6期 46-59,77页

作者： [爱尔兰]马克·布朗 [爱尔兰]梅雷亚德·尼克·朱拉·梅西尔 [爱尔兰]伊莱恩·贝尔尼 [爱尔兰]孔丘尔·麦克洛赫莱恩肖俊洪(译) 爱尔兰都柏林城市大学国家数字学习研究院欧洲创新型大学联盟教与学创新指导委员会都柏林城市大学人文和社会科学学院爱尔兰都柏林城市大学国家数字学习研究院创意实验室汕头开放大学

本文概述了正在快速发展的微证书领域以及微证书与新在线教育模式的关系。虽然目前尚没有全球认可的微证书定义,但是与经过认证并能最终获得诸如学位这些常规资格证书的传统学习形式和课程相比,微证书指的是学习内容较少而且通常学时更... 详细信息

本文概述了正在快速发展的微证书领域以及微证书与新在线教育模式的关系。虽然目前尚没有全球认可的微证书定义,但是与经过认证并能最终获得诸如学位这些常规资格证书的传统学习形式和课程相比,微证书指的是学习内容较少而且通常学时更短的学习单元。本文旨在向中国教育工作者简要介绍发展迅速的全球微证书领域,特别是其对大学、业界利益相关者和政府决策者的意义。文章围绕以下五个方面展开:(1)什么是微证书?(2)为什么需要微证书?(3)谁是微证书的主要利益相关者?(4)全球微证书的发展情况如何?(5)有哪些主要经验?本研究基于欧洲视角和近年爱尔兰共和国微证书的发展情况,我们的研究结论是微证书很可能成为证书生态中一个更加常态化的特征。虽然从全球看目前各国的微证书尚不互联互通,但是随着全球各国政府越来越重视把认证领域新发展与各国现有的国家资格框架对应起来,这个领域的"混乱"和"各自为政"局面会得到改观。微证书运动还能为政府和大学在后新冠疫情时期发挥在线教育模式的优势提供机会。

关键词：证书微证书数字徽章就业能力 21世纪技能