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Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： j.son Philip Appleton Lisa j.Woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala Mark Dixon Timothy j.England Kailash Krishnan Grant mair Keith W Muir j.hn Potter Christopher I Price Marc Randall Thompson G Robinson Christine Roffe Else C Sandset j.ffrey L Saver Angela Shone Aloysius Niroshan Siriwardena j.anna M Wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adj.sted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KNOWN ON THIS TOPIC⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

Mitochondrial DNA analysis of human remains from the Yuansha site in Xinj.ang, China

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Science China(Life Sciences) 2008年第3期51卷 205-213页

作者： Idelisi ABUDURESULE Victor H. mair Xinj.ang Cultural Relics and Archaeology Institute Chinese Language and Literature Department of East Asian Languages and Civilizations University of Pennsylvania USA

The Yuansha site is located in the center of the Taklimakan Desert of Xinj.ang, in the southern Silk Road region. MtDNA was extracted from fifteen human remains excavated from the Yuansha site, dating back 2,000―2,500 years. Analysis of the phylogenetic tree and the multidimensional scaling (MDS) reveals that the Yuansha population has relatively close relationships with the modern populations of South Central Asia and Indus Valley, as well as with the ancient population of Chawuhu.

关键词： Yuansha site ancient DNA mtDNA Xinj.ang Central Asia

Hyperdense artery sign, symptomatic infarct swelling and effect of alteplase in acute ischaemic stroke

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Stroke & Vascular Neurology 2021年第2期6卷 238-243页

作者： Simiao Wu Grant mair Geoff Cohen Zoe Morris Anders von Heij.e Nick Bradey Lesley Cala Andre Peeters Andrew j.Farrall Alessandro Adami Gillian Potter Ming Liu Richard I Lindley Peter A G Sandercock j.anna M Wardlaw the IST-3 Collaborative Group Department of Neurology West China HospitalSichuan UniversityChengduSichuanChina Centre for Clinical Brain Sciences The University of EdinburghEdinburghUK Department of Clinical Sciences Danderyd HospitalStockholmSweden Neuroradiology James Cook University HospitalSouth Tees Hospital NHS TrustMiddlesbroughUK Division of Pathology and Laboratory Medicine School of MedicineThe University of Western AustraliaPerthWestern AustraliaAustralia Department of Neurology Cliniques universitaires Saint-LucBruxellesBelgium Stroke Center IRCCS Sacro Cuore Don CalabriaVeronaItaly Department of Neuroradiology Manchester Centre for Clinical NeurosciencesSalford Royal NHS Foundation TrustSalfordUK Westmead Applied Research Centre Westmead Clinical SchoolThe University of SydneySydneyNew South WalesAustralia The George Institute for Global Health NewtownNew South WalesAustralia UK Dementia Research Institute Centre at the University of Edinburgh EdinburghUnited Kingdom 不详

Background Alteplase improves functional outcomes of patients with acute ischaemic stroke,but its effects on symptomatic infarct swelling,an adverse complication of stroke and the influence of CT hyperdense artery sign(HAS)are *** substudy of the Third International Stroke Trial aimed to investigate the association between HAS and symptomatic infarct swelling and effect of intravenous alteplase on this *** We included stroke patients whose prerandomisation scan was non-contrast ***,masked to clinical information,assessed baseline(prerandomisation)and follow-up(24-48 hours postrandomisation)CT scans for HAS,defined as an intracranial artery appearing denser than contralateral *** infarct swelling was defined as clinically significant neurological deterioration≤7 days after stroke with radiological evidence of midline shift,effacement of basal cisterns or uncal *** Among 2961 patients,HAS presence at baseline was associated with higher risk of symptomatic infarct swelling(OR 2.21;95% CI 1.42 to 3.44).Alteplase increased the risk of swelling(OR 1.69;95% CI 1.11 to 2.57),with no difference between patients with and those without baseline HAS(p=0.49).In patients with baseline HAS,alteplase reduced the proportion with HAS at follow-up(OR 0.67;95% CI 0.50 to 0.91),where HAS disappearance was associated with reduced risk of swelling(OR 0.25,95% CI 0.14 to 0.47).Conclusion Although alteplase was associated with increased risk of symptomatic infarct swelling in patients with or without baseline HAS,it was also associated with accelerated clearance of HAS,which in return reduced swelling,providing further mechanistic insights to underpin the benefits of alteplase.

关键词： infarct swelling effect

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松软粘土中浅层隧道周围地面的运动

地下空间与工程学报 1988年第1期 75-80页

作者： R.j.mair,M.j.Gunn,M.P.O’Reilly,周成元助理研究员英国运输与道路研究实验室隧道及地下管道科英国Scott wilson Kirkpatrick股份公司主任四川省人防办公室助理总工程师英国剑桥大学工程系

对于松软粘土中建造浅层隧道时所引起的地面活动进行预测是工程师们面临的主要问题之一。已经用有限元和离心模型研究对隧道变形性能作了测定,并且根据十分明确的有效应力条件下得到的结果提出了一个新的预测地面活动的近似方法。

关键词：有限元分析法粘土土壤流失量中浅层离心模型试验周围

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软粘土中浅埋隧洞周围的地面沉降

地下空间与工程学报 1984年第3期 47-53页

作者： wilsom,kirkpatrick,partners,R j.mair,Mj.Gumn,M P O’Reilly,钟永贵英国运输和道路研究所隧道与地下管道室英国苏格兰研究助理副主任工程师英国剑桥大学工程系

在软粘土中建造浅埋隧洞引起附近地面下沉的预极是摆在设计者面前的主要问题之一。有限元法和离心模型研究目前已被用来研究隧道变形特性。在意义明确的有效应力条件下研究的结果,提出了予报地面下沉的新途径。

关键词：地面沉降荷载因素埋深有限元分析地表沉降工程地质现象数值分析浅埋隧洞隧洞开挖隧道开挖周围

世界胃肠病学组织全球指南——发展中国家幽门螺杆菌感染

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胃肠病学 2011年第7期16卷 423-428页

作者： Hunt RH Xiao SD Megraud F Leon-Barua R Bazzoli F van der Merwe S Vaz Coelho LG Fock M Fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BCY Krabshuis j.Le mair A 杜颖戴宁 WGO评审组浙江大学医学院附属邵逸夫医院消化科

世界上有一半人口感染幽门螺杆菌（***），其感染率因地理位置、种族、年龄和社会经济状况不同而存在很大差异．在发展中国家较高．发达国家较低。但总体而言，近年世界许多地区的***感染率均呈下降趋势。

关键词：幽门螺杆菌感染发展中国家胃肠病学世界 H.pylori 指南组织社会经济状况

在血压控制不良的高血压患者中使用数字化干预的家庭和在线血压管理:随机对照试验

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中华高血压杂志 2021年第5期29卷 427-427页

作者： McMa-nus Rj.Little P Stuart B Morton K Raftery j.Kelly j.Bradbury K Zhang j.Zhu S Murray E May CR mair FS Michie S Smith P Band R Ogburn E Allenj.Rice C Nut-tall j.Williams B Yardley L 陈嘉睿(译) 叶鹏(审校) 不详

HOME BP试验(The home and online management and evaluation of blood pressure)的目的是评估在初级预防中结合自我监测和自我管理的数字化干预在高血压管理中的作用。研究者纳入英国76个治疗中心经过治疗但血压控制不好(>140/90 mm H... 详细信息

HOME BP试验(The home and online management and evaluation of blood pressure)的目的是评估在初级预防中结合自我监测和自我管理的数字化干预在高血压管理中的作用。研究者纳入英国76个治疗中心经过治疗但血压控制不好(>140/90 mm Hg, 1 mm Hg=0.133 kPa)并能上网的患者622例,进行自动确定主要终点的公开随机对照试验。

关键词：初级预防血压管理随机对照试验自我监测血压控制高血压患者自我管理

Optical Detection of Distal Lung Enzyme Activity in Human Inflammatory Lung Disease

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Biomedical Engineering Frontiers 2021年第1期2卷 44-54页

作者： Alicia Megia-Fernandez Adam Marshall Ahsan R.Akram Bethany Mills Sunay V.Chankeshwara Emma Scholefield Amy Miele Bruce C.McGorum Chesney Michaels Nathan Knighton Tom Vercauteren Francois Lacombe Veronique Dentan Annya M.Bruce j.anne mair Robert Hitchcock Nik Hirani Chris Haslett Mark Bradley Kevin Dhaliwal EaStCHEM The University of Edinburgh School of ChemistryJoseph Black BuildingWest Mains RoadEdinburghUK EH93FJ Translational Healthcare Technologies Group Centre for Inflammation ResearchQueen’s Medical Research InstituteUniversity of Edinburgh47 Little France CrescentEdinburgh BioQuarterEdinburghUK EH164TJ The Roslin Institute and Royal(Dick)School of Veterinary Studies University of EdinburghEaster BushMidlothianUK EH259RG Department of Biomedical Engineering University of Utah36 S Wasatch DrSalt Lake CityUT 84112USA School of Biomedical Engineering&Imaging Sciences King’s College LondonLondonUK SE17EH Mauna Kea Technologies 9Rue d’EnghienParisFrance 75010

Obj.ctive and Impact *** is a need to develop platforms delineating inflammatory biology of the distal human *** describe a platform technology approach to detect in situ enzyme activity and observe drug inhibition in the distal human lung using a combination of matrix metalloproteinase(MMP)optical reporters,fibered confocal fluorescence microscopy(FCFM),and a bespoke delivery *** development of new therapeutic agents is hindered by the lack of in vivo in situ experimental methodologies that can rapidly evaluate the biological activity or drug-target engagement in *** optimised a novel highly quenched optical molecular reporter of enzyme activity(FIB One)and developed a translational pathway for in-human *** demonstrate the specificity for matrix metalloproteases(MMPs)2,9,and 13 and probe dequenching within physiological levels of MMPs and feasibility of imaging within whole lung models in preclinical ***,in a first-in-human exploratory experimental medicine study of patients with fibroproliferative lung disease,we demonstrate,through FCFM,the MMP activity in the alveolar space measured through FIB One fluorescence increase(with pharmacological inhibition).*** translational in situ approach enables a new methodology to demonstrate active drug target effects of the distal lung and consequently may inform therapeutic drug development pathways.

关键词： Lung lung specificity

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有和无心肌梗塞合并症患者内皮素Ⅰ水平比较

Oncology and Translational Medicine 1994年第2期11卷 96-96页

作者： P.Lenchleitner N.Gensera j.mair E.Artner-Dworzak F.Dienstl B.Puschendorf 胡文斌 Universittsklinik für Innere Medizin und Institut für Medizinische Chemie und Biochemie Universitt Innsbruck Austria 同济医科大学附属同济医院

近期实验结果提示,内皮素Ⅰ(ET-1)释放参与急性心肌梗塞(AMI)发病过程。本文目的在于观察在 AMI 病程中 ET-1浓度能否区别无并发症及有并发症或缺血病变的病态。依照世界卫生组织 AMI 诊断标准,连续观察确诊为 AMI 患者42例,其中男性35... 详细信息

近期实验结果提示,内皮素Ⅰ(ET-1)释放参与急性心肌梗塞(AMI)发病过程。本文目的在于观察在 AMI 病程中 ET-1浓度能否区别无并发症及有并发症或缺血病变的病态。依照世界卫生组织 AMI 诊断标准,连续观察确诊为 AMI 患者42例,其中男性35例,女性7例,年龄范围41～82岁,平均年龄59岁,所有病例均是在

关键词：合并症 ET AMI 并发症梗塞后心绞痛内皮素患者