检索结果-南通市图书馆

Fetal lung growth predicts the risk for early-life respiratory infections and childhood asthma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第5期20卷 481-495页

作者： Dimitra E.Zazara Olympia Giannou Steven Schepanski Mirja Pagenkemper Anastasios D.Giannou maike Pincus Ioannis Belios Stefan Bonn Ania C.Muntau Kurt Hecher Anke Diemert Petra Clara Arck Division for Experimental Feto-Maternal Medicine Department of Obstetrics and Fetal MedicineUniversity Medical Center Hamburg-Eppendorf(UKE)Martinistraße 5220251HamburgGermany University Children’s Hospital UKEHamburgGermany Computer Engineering and Informatics Department Polytechnic SchoolUniversity of PatrasPatrasGreece Institute of Developmental Neurophysiology Center for Molecular Neurobiology Hamburg(ZMNH)UKEHamburgGermany Department of Obstetrics and Fetal Medicine UKEHamburgGermany Department of General Visceral and Thoracic SurgeryUKEHamburgGermany Section of Molecular Immunology and Gastroenterology Ⅰ.Department of MedicineUKEHamburgGermany Pediatrics and Pediatric Pneumology Practice BerlinGermany Institute of Medical Systems Biology ZMNHUKEHamburgGermany Hamburg Center for Translational Immunology UKEHamburgGermany

Background Early-life respiratory infections and asthma are major health burdens during *** predicting an increased risk for early-life respiratory diseases are ***,we identified the predictive value of ultrasound-monitored fetal lung growth for the risk of early-life respiratory infections and *** Fetal lung size was serially assessed at standardized time points by transabdominal ultrasound in pregnant women participating in a pregnancy *** between fetal lung growth and respiratory infections in infancy or early-onset asthma at five years were ***-learning models relying on extreme gradient boosting regressor or classifier algorithms were developed to predict respiratory infection or asthma risk based on fetal lung *** model development and validation,study participants were randomly divided into a training and a testing group,respectively,by the employed *** Enhanced fetal lung growth throughout pregnancy predicted a lower early-life respiratory infection *** sex was associated with a higher risk for respiratory infections in *** lung growth could also predict the risk of asthma at five years of *** designed three machine-learning models to predict the risk and number of infections in infancy as well as the risk of early-onset *** models’R2 values were 0.92,0.90 and 0.93,respectively,underscoring a high accuracy and agreement between the actual and predicted *** variables included known risk factors and novel predictors,such as ultrasound-monitored fetal lung *** Sonographic monitoring of fetal lung growth allows to predict the risk for early-life respiratory infections and asthma.

关键词： Asthma Child risk Early-life respiratory infections Prenatal lung development Sexual dimorphism

Paramutation： A Heritable Change in Gene Expression by Allelic Interactions In Trans

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2009年第4期2卷 578-588页

作者： maike Stam Swammerdarn Institute for Life Sciences Universiteit van Amsterdam Science Park 904 1098 XH Amsterdam The Netherlands

Epigenetic gene regulation involves the stable propagation of gene activity states through mitotic, and sometimes even meiotic, cell divisions without changes in DNA sequence. Paramutation is an epigenetic phenomenon involving changes in gene expression that are stably transmitted through mitosis as well as meiosis. These heritable changes are mediated by in trans interactions between homologous DNA sequences on different chromosomes. During these in trans interactions, epigenetic information is transferred from one allele of a gene to another allele of the same gene, resulting in a change in gene expression. Although paramutation was initially discovered in plants, it has recently been observed in mammals as well, suggesting that the mechanisms underlying paramutation might be evolutionarily conserved. Recent findings point to a crucial role for small RNAs in the paramutation process. In mice, small RNAs appear sufficient to induce paramutation, whereas in maize, it seems not to be the only player in the process. In this review, potential mechanisms are discussed in relation to the various paramutation phenomena.

关键词： Paramutation in trans interactions epigenetics epigenetic memory RNAi RdDM physical pairing silencing.

大气NO_(2)短期暴露与不同体重年轻个体凝血功能相关指标的关联及气温的修饰作用

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

环境与职业医学 2024年第7期41卷 721-727页

作者：陈迈克张文楼李陆一郭新彪邓芙蓉北京大学公共卫生学院劳动卫生与环境卫生学系北京100191

[背景]二氧化氮(NO_(2))是主要的大气污染物之一,我国大气NO_(2)污染水平逐年改善,但仍处于较高水平,威胁人群健康。[目的]探讨大气NO_(2)短期暴露对正常体重和肥胖年轻个体凝血功能相关指标的影响及气温的修饰作用。[方法]采用平行对... 详细信息

[背景]二氧化氮(NO_(2))是主要的大气污染物之一,我国大气NO_(2)污染水平逐年改善,但仍处于较高水平,威胁人群健康。[目的]探讨大气NO_(2)短期暴露对正常体重和肥胖年轻个体凝血功能相关指标的影响及气温的修饰作用。[方法]采用平行对照定组研究设计,招募53名正常体重和44名肥胖年轻个体作为研究对象,进行三次前瞻性随访。选择距离研究对象住所最近的固定监测站数据,结合时间活动日志与渗透系数计算研究对象每次随访前一周的污染物个体暴露水平,从中国气象数据服务中心获取气温数据。每次随访时,采集研究对象空腹静脉血以检测血小板(PLT)计数、平均血小板体积(MPV)、可溶性CD40配体(sCD40L)、可溶性P-选择素(sP-selectin)、血小板聚集率(PAgT)和纤溶酶原激活物抑制剂-1(PAI-1)等。采用线性混合效应模型分析大气NO_(2)短期暴露与不同体重年轻个体凝血功能相关指标间的关联,采用分层分析探讨气温的修饰作用。[结果]本研究中个体大气NO_(2)暴露水平的中位数[四分位数间距(IQR)]为21.47(8.01)μg·m^(-3)。大气NO_(2)短期暴露与肥胖个体sCD40L、PAgT升高的关联有统计学意义,关联程度最高出现在累积滞后5 d,大气NO_(2)累积滞后5 d的滑动平均暴露浓度每增加一个IQR,sCD40L升高27.4%(95%CI:4.2%~56.6%),PAgT升高37.5%(95%CI:12.2%~68.6%);大气NO_(2)短期暴露与正常体重个体PLT、PAgT下降的关联有统计学意义,关联程度最高的分别出现在累积滞后5 d和累积滞后7 d,大气NO_(2)累积滞后5 d的滑动平均暴露浓度每增加一个IQR,PLT下降11.8%(95%CI:–17.8%~–5.3%),累积滞后7 d的滑动平均暴露浓度每增加一个IQR,PAgT下降16.8%(95%CI:–30.6%~–0.4%)。未观察到大气NO_(2)短期暴露与肥胖个体PLT和正常体重个体sCD40L间的关联。未发现大气NO_(2)短期暴露与不同体重个体PAI-1、MPV和sP-selectin间的关联。分层分析发现,大气NO_(2)短期暴露与正常体重组的PAgT以及肥胖组的PLT、sCD40L和sP-selectin间的关联仅在高温时具有统计学意义。[结论]大气NO_(2)短期暴露可对不同体重年轻个体凝血功能相关指标产生不良影响,与正常体重个体相比,肥胖个体对大气NO_(2)短期暴露更为敏感。高温可增强大气NO_(2)短期暴露的不良健康影响。

关键词：二氧化氮肥胖凝血功能相关指标气温修饰作用

Evaluation of the use of surrogate Laminaria digitata in eco-hydraulic laboratory experiments

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2014年第3期26卷 374-383页

作者： PAUL maike HENRY Pierre-Yves T. Forschungszentrum Küste Leibniz Universit?t Hannover Department of Marine Technology Norwegian University of Science and Technology

Inert surrogates can avoid husbandry and adaptation problems of live vegetation in laboratories. Surrogates are generally used for experiments on vegetation-hydrodynamics interactions, but it is unclear how well they replicate field conditions. Here, surrogates for the brown macroalgae Laminaria digitata were developed to reproduce its hydraulic roughness. Plant shape, stiffness and buoyancy of L. digitata were evaluated and compared to the properties of inert materials. Different surrogate materials and shapes were exposed to unidirectional flow. It is concluded that buoyancy is an important factor in low flow conditions and a basic shape might be sufficient to model complex shaped plants resulting in the same streamlined shape.

关键词： bending modulus buoyancy hydraulic forcing Laminaria digitata plant surrogate

A Review of Testing Object‑Based Environment Perception for Safe Automated Driving

在线全文

学校读者我要写书评

暂无评论

Automotive Innovation 2022年第3期5卷 223-250页

作者： Michael Hoss maike Scholtes Lutz Eckstein Institute for Automotive Engineering RWTH Aachen UniversitySteinbachstr.752074 AachenGermany

Safety assurance of automated driving systems must consider uncertain environment *** paper reviews litera-ture addressing how perception testing is realized as part of safety *** paper focuses on testing for verification and validation purposes at the interface between perception and planning,and structures the analysis along the three axes(1)test criteria and metrics,(2)test scenarios,and(3)reference ***,the analyzed literature includes related safety standards,safety-independent perception algorithm benchmarking,and sensor *** is found that the realiza-tion of safety-oriented perception testing remains an open issue since challenges concerning the three testing axes and their interdependencies currently do not appear to be sufficiently solved.

关键词： Automated driving Environment perception Safety assurance Testing

Detrimental role of hydrogen evolution and its temperature-dependent impact on the performance of vanadium redox flow batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2019年第5期28卷 57-62页

作者： Abdulmonem Fetyan Gumaa A. El-Nagar Iver Lauermann maike Schnucklake Jonathan Schneider Christina Roth Institute for Chemistry and Biochemistry Freie Universitat BerlinTakustr.3D-14195 BerlinGermany Chemistry Department Faculty of ScienceCairo UniversityCairo 12613Egypt Helmholtz-Zentrum Berlin fur Materialien und Energie Hahn-Meitner-Platz 114109 BerlinGermany

This paper addresses the damaging role of the parasitic hydrogen evolution reaction (HER) in the negative half-cell of a vanadium redox flow battery (VRFB) on state-of-the-art carbon felt electrodes at different temperatures. It was found that increasing the temperature resulted in a better catalytic performance for both the positive and negative half-cell reactions. In addition, increasing the temperature significantly enhanced the undesired HER at the negative side. Operating the VRFB cell at higher temperature led to a decrease in the coulombic efficiency attributed to the higher hydrogen production. More pronounced hydrogen production caused an oxidation on the surface of the carb on fibers and a degradation of the electrode as indicated from scanning electron microscopy and X-ray photoelectron spectroscopy measurements. This observed degradation results in fading of the overall performance of the vanadium redox flow battery over time.

关键词： Hydrogen evolution Carbon felt Degradation Electrode Redox flow batteries

Physiochemical Properties of Resistant Starch and Its Enhancement Approaches in Rice

在线全文

学校读者我要写书评

暂无评论

Rice science 2021年第1期28卷 31-42页

作者： Ding Yi Wang maike Shen Yi Shu Xiaoli Wu Dianxing Song Wenjian State Key Laboratory of Rice Biology/Key Laboratory of the Ministry of Agriculture for the Nuclear Agricultural Sciences Zhejiang UniversityHangzhou 310058China Agricultural Technology Extension Center Zhejiang UniversityHangzhou 310058China

With changes in food preferences and life styles,more and more attentions have been focused on healthier ***,resistant starch(RS)which can resist digestion in the human intestine has been recognized and *** RS diet shows great benefit for the human health,and breeding high RS rice variety is a great target for realizing dietary *** provide guidance for RS improvement in rice,this review summarized the unique physiochemical properties of RS and the possible approaches,*** regulation,for enhancing RS content in rice,and proposed the potential ways to obtain rice variety with high RS content.

关键词： rice resistant starch starch modification physiochemical property

重症肺结核患者病原学阳性率及利福平耐药结果分析

在线全文

学校读者我要写书评

暂无评论

中国防痨杂志 2024年第9期46卷 1050-1055页

作者：耿子妹王潮虹龙嗣博郑迈克施亦衡孙勇赵艳王桂荣首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所检验科北京101149

目的:分析重症肺结核患者病原学阳性率及利福平耐药情况,为临床治疗重症肺结核提供参考。方法:选取2023年1—12月首都医科大学附属北京胸科医院收治的临床诊断为肺结核的369例患者为研究对象,其中145例为重症肺结核,224例为轻症肺结核... 详细信息

目的:分析重症肺结核患者病原学阳性率及利福平耐药情况,为临床治疗重症肺结核提供参考。方法:选取2023年1—12月首都医科大学附属北京胸科医院收治的临床诊断为肺结核的369例患者为研究对象,其中145例为重症肺结核,224例为轻症肺结核。分析患者痰液抗酸杆菌染色涂片法(涂片法)、BACTEC MGIT 960液体培养法(MGIT 960法)和GeneXpert MTB/RIF(Xpert法)的阳性率及对利福平的耐药情况。结果:重症肺结核患者中,涂片法、培养法和Xpert法的阳性率及病原学总阳性率分别为47.41%(55/116)、68.75%(77/112)、85.82%(115/134)和80.69%(117/145),明显高于轻症患者[29.44%(63/214)、53.17%(109/205)、68.35%(149/218)、71.43%(160/224)],差异均有统计学意义(χ^(2)=10.580,P=0.001;χ^(2)=7.250,P=0.007;χ^(2)=12.512,P<0.001;χ^(2)=4.034,P=0.045)。Xpert法检测阳性的重症与轻症肺结核患者利福平耐药率分别为11.30%(13/115)和8.05%(12/149),差异无统计学意义(χ^(2)=0.800,P=0.371)。Xpert法阳性的重症肺结核中,复治患者利福平耐药率为24.24%(8/33),高于初治患者[6.10%(5/82)],差异有统计学意义(χ^(2)=7.727,P=0.005)。结论:相较于轻症患者,重症肺结核患者的病原学阳性率较高,且Xpert法阳性率最高。重症与轻症肺结核间利福平耐药情况无差异,而重症肺结核复治患者利福平耐药率明显高于初治患者。

关键词：结核肺微生物学技术抗药性细菌

维普期刊数据库博看期刊

Barriers and Facilitators in Interorganizational Disaster Response: Identifying Examples Across Europe

在线全文

学校读者我要写书评

暂无评论

International Journal of Disaster Risk Science 2020年第1期11卷 46-58页

作者： Claudia Berchtold maike Vollmer Philip Sendrowski Florian Neisser Larissa Müller Sonja Grigoleit Department for Technology Analysis and Strategic Planning(TASP) Fraunhofer Institute for Technological Trend Analysis53879 EuskirchenGermany

Disaster response actors are facing new challenges, which encompass not only new and ever more complex threats but also the need to collaborate across organizational boundaries and even state *** on scale, these interactions have to work across governance setups, political and legal conditions, organizational cultures, as well as personal preferences and experiences that vary among actors, organizations, and countries. But which concrete measures are taken by crisis management actors at different scales to bridge these challenges and which of these could serve others as example to address comparable challenges in their contexts? This study made attempts to analyze whether certain solutions across organizations and states exist that facilitate effective interorganizational crisis management in the member states of the European Union(EU). It is based on selected expert interviews with representatives of different types of disaster response organizations(health services,police services, fire services, and other crisis management organizations) from seven EU member states(Germany,Netherlands, United Kingdom, Ireland, Italy, Austria, and Greece).

关键词： Disaster response European union Interorganizational crisis management Transboundary cooperation