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Hepatobiliary manifestations following two-stages elective laparoscopic restorative proctocolectomy for patients with ulcerative colitis:A prospective observational study

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World Journal of Gastrointestinal Surgery 2023年第2期15卷 234-248页

作者： Tamer A A M Habeeb Abdulzahra Hussain Mauro Podda Pasquale Cianci Bruce Ramshaw Khaled Safwat Wesam M Amr Tamer Wasefy Alaa A Fiad Mohamed Ibrahim Mansour Adel mahmoud Moursi GamalOsman Anass Qasem Mohamed Fawzy Mohamed Ibrahim Abo Alsaad Abd-Elfattah Kalmoush MohammedShaaban Nassar Fawzy M Mustafa mahmoud hassib morsi badawy Ahmed Hamdy Hamdi Elbelkasi Bassam Mousa Abd-Elrahman M Metwalli Walid A Mawla Mostafa M Elaidy Muhammad Ali Baghdadi Ahmed Raafat Department of General Surgery Faculty of MedicineZagazig UniversityZagazig 44759SharkiaEgypt Homerton University Hospital London E96SRUK Department of Surgical Science University of CagliariCagliari 2432Italy Department of Medical and Surgical Sciences Universitàdegli studi di FoggiaFoggia 546Italy MD CQInsights PBC Co-founder&CEOTennesseeTN 37010United States Department of Internal Medicine Zagazig UniversityZagazig 2355Egypt Department of Internal Medicine Suez UniversitySuez 235Egypt Department of General Surgery Faculty of Medicine-Merit UniversitySohag 82511Egypt Department of General Surgery Al-azhar UniversityCairo 285Egypt Department of Hepato-Bilio-Pancreatic(HBP)Surgery National Hepatology and Tropical Medicine Research InstituteCairo 285Egypt Department of General Surgery Mataryia Teaching HospitalCairo 285Egypt

BACKGROUND Hepatobiliary manifestations occur in ulcerative colitis(UC)*** effect of laparoscopic restorative proctocolectomy(LRP)with ileal pouch anal anastomosis(IPAA)on hepatobiliary manifestations is *** To evaluate hepatobiliary changes after two-stages elective laparoscopic restorative proctocolectomy for patients with *** Between June 2013 and June 2018,167 patients with hepatobiliary symptoms underwent two-stage elective LRP for UC in a prospective observational *** with UC and having at least one hepatobiliary manifestation who underwent LRP with IPAA were included in the *** patients were followed up for four years to assess the outcomes of hepatobiliary *** The patients'mean age was 36±8 years,and males predominated(67.1%).The most common hepatobiliary diagnostic method was liver biopsy(85.6%),followed by Magnetic resonance cholangiopancreatography(63.5%),Antineutrophil cytoplasmic antibodies(62.5%),abdominal ultrasonography(35.9%),and Endoscopic retrograde cholangiopancreatography(6%).The most common hepatobiliary symptom was Primary sclerosing cholangitis(PSC)(62.3%),followed by fatty liver(16.8%)and gallbladder stone(10.2%).66.4%of patients showed a stable course after *** or regressive courses occurred in 16.8%of *** was 6%,and recurrence or progression of symptoms required surgery for 15%.Most PSC patients(87.5%)had a stable course,and only 12.5%became ***-thirds(64.3%)of fatty liver patients showed a regressive course,while one-third(35.7%)showed a stable *** rates were 98.8%,97%,95.8%,and 94%at 12 mo,24 mo,36 mo,and at the end of the *** In patients with UC who had LRP,there is a positive impact on hepatobiliary *** caused an improvement in PSC and fatty liver *** most prevalent unchanged course was PSC,while the most common improvement was fatty liver disease.

关键词： Courses Hepatobiliary manifestations Primary sclerosing cholangitis Restorative proctocolectomy

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Biliary fistula and late recurrence of liver hydatid cyst:Role of cystobiliary communication:A prospective multicenter study

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World Journal of Methodology 2023年第4期13卷 272-286页

作者： Tamer A A M Habeeb Mauro Podda Boris Tadic Vishal G Shelat Yaman Tokat Mohamed Ibrahim Abo Alsaad Abd-Elfattah Kalmoush Mohammed Shaaban Nassar Fawzy Metwally Mustafa mahmoud hassib morsi badawy Mohamed Sobhy Shaaban Tarek Zaghloul Mohamed Mohammed Ibrahim El Sayed Henish Hamdi Elbelkasi mahmoud Abdou Yassin Abdelshafy Mostafa Amr Ibrahim Waleed A-Abdelhady TamerMohamed Elshahidy Mohamed Ibrahim Mansour Adel mahmoud Moursi Mohamed Abdallah Zaitoun EhabShehata Abd-Allah Ashraf Abdelmonem Elsayed Rasha S Elsayed Ahmed M Yehia Amr Abdelghani Mohamed Negm Heba Alhussein Abo-Alella Mostafa M Elaidy Department of General Surgery Faculty of Medicine Zagazig UniversitySharkia 44511Egypt Department of Surgical Science University of CagliariCagliari 09126Italy Clinic for Digestive Surgery–First Surgical Clinic University Clinical Centre of SerbiaBelgrade 11000Serbia Department of General Surgery Tan Tock Seng HospitalSingapore 018971Singapore Department of Liver Transplantation and Hepatobiliary Surgery IstanbulTurkeyInternational Liver Centerand Acibadem Hospital GroupIstanbul 34000Turkey Department of General Surgery Faculty of Medicine-Merit UniversitySohag 82511Egypt Department of General Surgery Faculty of MedicineAl-Azher UniversityCairo 11765Egypt Department of General Surgery Mataryia Teaching HospitalCairo 11765Egypt

BACKGROUND Hydatid cyst disease(HCD)is common in certain *** is associated with postoperative biliary fistula(POBF)and *** primary aim of this study was to identify whether occult cysto-biliary communication(CBC)can predict recurrent *** secondary aim was to assess the role of cystic fluid bilirubin and alkaline phosphatase(ALP)levels in predicting POBF and recurrent *** To identify whether occult CBC can predict recurrent *** secondary aim was to assess the role of cystic fluid bilirubin and ALP levels in predicting POBF and recurrent *** From September 2010 to September 2016,a prospective multicenter study was undertaken involving 244 patients with solitary primary superficial stage cystic echinococcosis 2 and cystic echinococcosis 3b HCD who underwent laparoscopic partial cystectomy with *** logistic regression analysis assessed independent factors determining biliary complications and *** There was a highly statistically significant association(P≤0.001)between cystic fluid biochemical indices and the development of biliary complications(of 16 patients with POBF,15 patients had high cyst fluid bilirubin and ALP levels),where patients with high bilirubin-ALP levels were 3405 times more likely to have biliary *** was a highly statistically significant association(P≤0.001)between biliary complications,biochemical indices,and the occurrence of recurrent HCD(of 30 patients with recurrent HCD,15 patients had high cyst fluid bilirubin and ALP;all 16 patients who had POBF later developed recurrent HCD),where patients who developed biliary complications and high bilirubin-ALP were 244.6 and 214 times more likely to have recurrent hydatid cysts,*** Occult CBC can predict recurrent *** cyst fluid bilirubin and ALP levels predicted POBF and recurrent HCD.

关键词： Cysto-biliary communication Echinococcus granulosus Hydatid disease recurrence Hydatid fluid analysis Laparoscopy

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