检索结果-南通市图书馆

Dendritic cell co-stimulatory and co-inhibitory markers in chronic HCV: An Egyptian study

World Journal of Gastroenterology 2013年第43期19卷 7711-7718页

作者： Hanan Fouad Maissa Saeed El Raziky Rasha Ahmed abdel aziz Dina Sabry Ghada mahmoud abdel aziz Manal Ewais Ahmed Reda Sayed Medical Biochemistry Department Faculty of MedicineCairo University11562 CairoEgypt Gastroenterology and Tropical Department Faculty of MedicineCairo University11562 CairoEgypt Medical Biochemistry Department Faculty of MedicineBeni Sueif University19206 Kornish Al NileBani SweifEgypt

AIM:To assess co-stimulatory and co-inhibitory markers of dendritic cells(DCs)in hepatitis C virus(HCV)infected subjects with and without ***:Three subject groups were included in the study:group 1 involved 50 control subjects,group2 involved 50 patients with chronic HCV infection and group 3 involved 50 HCV uremic subjects undergoing ***83,CD86 and CD40 as co-stimulatory markers and PD-L1 as a co-inhibitory marker were assessed in peripheral blood mononuclear cells by realtime polymerase chain ***-10(IL-10)and hyaluronic acid(HA)levels were also *** findings were correlated with disease activity,viral load and ***:There was a significant decrease in costimulatory markers;CD83,CD86 and CD40 in groups2 and 3 vs the control ***-stimulatory markers were significantly higher in group 3 vs group *** was a significant elevation in PD-L1 in both HCV groups vs the control ***-L1 was significantly lower in group 3 vs group *** was a significant elevation in IL-10 and HA levels in groups 2 and 3,where IL-10was higher in group 3 and HA was lower in group 3 vs group *** level was significantly correlated with disease activity and fibrosis grade in group ***-10 was significantly correlated with fibrosis grade in group *** were significant negative correlations between co-stimulatory markers and viral load in groups 2 and3,except CD83 in dialysis *** was a significant positive correlation between PD-L1 and viral load in both HCV ***:A significant decrease in DC co-stimulatory markers and a significant increase in a DC coinhibitory marker were observed in HCV subjects and to a lesser extent in dialysis patients.

关键词： Hepatitis C virus Uremia Hemodialysis Dendritic cells CD83 CD86,CD40 PD-L1 Interleukin-10 Hyaluronic acid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Spontaneous bacterial peritonitis:risk factors and causative organisms

引用

Asian Pacific Journal of Tropical Medicine 2009年第6期2卷 52-58页

作者： mahmoud M Al-Bendary mahmoud abdel-aziz Waleed A Al-Sherbeeny Raghda El-Sayed Farag abdel-Hady El-Gilany Mohammad Hosam Eldeen Zaghloul Tropical Medicine Unit Community Medicine DepartmentCollege of MedicineMansoura UniversityEgypt Clinical Pathology Department College of MedicineMansoura UniversityEgypt

Objective:To determine the prevalent pathogens responsible for spontaneous bacterial peritonitis(SBP) and their sensitivity pattern,to test the efficiency of different culture techniques in microbial isolation,and to study the diagnostic predictors of such ***:One hundred eight SBP episodes from 92 adult patients were compared to 88 cirrhotic ascites patients cross - matched with age and sex without *** fluid was subjected to cytological,biochemical examination and culture on both conventional and blood culture bottles at the bedside for bacterial identification and antimicrobial susceptibility ***:The prevalence of SBP was 25.02%.Logistic regression analysis revealed that;previous SBP episode,low ascitic fluid protein levels, high serum creatinine and low serum albumin levels were the independent significant predictors of *** forty - five per cent of SBP episodes were detected by conventional culture compared to 73.15%by modified technique with a significant *** - negative bacteria were the cause of SBP in 46(58.23%) culture positive *** coli and Staphylococcus aureus were the most commonly detected organisms. Resistance to different antibiotics was ***:Culture of ascitic fluid in blood culture bottles at bedside increases the sensitivity of SBP *** is a recent increase in Gram - positive pathogen with emergence of multidrug *** recent changes may have an impact on guidelines for management and treatment of SBP in our locality.

关键词： Spontaneous bacterial peritonitis Paracentesis Bedside inoculation Blood bottle culture

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regulatory and activated effector T cells in chronic hepatitis C virus: Relation to autoimmunity

引用

World Journal of Hepatology 2016年第30期8卷 1287-1294页

作者： Hanan Fouad Maissa El Raziky Eman Medhat Hassan Ghada mahmoud abdel aziz Samar K Darweesh Ahmed Reda Sayed Department of Medical Biochemistry Faculty of Medicine Cairo University Department of Pharmacology and Toxicology Faculty of Pharmacy Hail University Department of Hepato-gastroenterology and Tropical Medicine Faculty of Medicine Cairo University Department of Medical Biochemistry Faculty of Medicine Beni Suef University

AIMTo investigate how Tregs are regulated in chronic hepatitis C virus (HCV) patients via assessment of Tregs markers (granzyme 2, CD69 and FoxP3), Teffs markers [TNFRSF4 (OX40), INFG] and CD4, CD25 genes. METHODSA prospective study was conducted on 120 subjects divided into 4 groups: Group I (n = 30) treatment naïve chronic HCV patients; Group II (n = 30) chronic HCV treated with Peg/Riba; Group III (n = 30) chronic HCV associated with non-organ specific autoantibody and Group IV (n = 30) healthy persons as a control group. Tregs and Teffs markers were assessed in peripheral blood mononuclear cells by quantitative real time reverse transcriptase-polymerase chain reaction. RESULTSChronic HCV patients exhibited significant higher levels of both Teffs and Tregs in comparison to healthy control group. Tregs markers were significantly decreased in Peg/Riba treated HCV patients in comparison to treatment naïve HCV group. In HCV patients with antinuclear antibody (ANA) +ve, Tregs markers were significantly decreased in comparison to all other studied groups. Teffs markers were significantly elevated in all HCV groups in comparison to control and in HCV group with ANA +ve in comparison to treatment naïve HCV group. CONCLUSIONElevated Tregs cells in chronic HCV patients dampen both CD4+ and CD8+ autologous T cell immune response. Interferon-α and ribavirin therapy suppress proliferation of Tregs. More significant suppression of Tregs was observed in HCV patients with autoantibodies favoring pathological autoimmune response.

关键词： Autoimmunity T regulatory cells Hepatitis C virus T activator cells Interferon

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical-based phenotypes in children with pediatric post-COVID-19 condition

引用

World Journal of Pediatrics 2024年第7期20卷 682-691页

作者： Lieke C.E.Noij Jelle M.Blankestijn Coen R.Lap Marlies A.van Houten Giske Biesbroek Anke-Hilse Maitland-van der Zee mahmoud I.abdel-aziz Johannes B.van Goudoever Mattijs W.Alsem Caroline L.H.Brackel Kim J.Oostrom Simone Hashimoto Suzanne W.J.Terheggen-Lagro Department of Pediatric Pulmonology and Allergy Amsterdam UMCLocation AMCEmma Children’s HospitalAmsterdam University Medical CenterRoom G2-222Meibergdreef 91105AZAmsterdamThe Netherlands Department of Pulmonary Medicine Amsterdam UMCAmsterdamThe Netherlands Department of Pediatrics Spaarne GasthuisHoofddorpThe Netherlands Department of Pediatrics Emma Children’s HospitalAmsterdam University Medical CenterAmsterdamThe Netherlands Department of Rehabilitation Medicine Amsterdam Movement SciencesMeibergdreef 9AmsterdamThe Netherlands Department of Paediatric Pulmonology Department of PaediatricsTergooi MCHilversumThe Netherlands Department of Child and Adolescent Psychiatry and Psychosocial Care Amsterdam UMCAmsterdam Reproduction and DevelopmentAmsterdamThe Netherlands

Background Pediatric post coronavirus disease 2019(COVID-19)condition(PPCC)is a heterogeneous syndrome,which can significantly affect the daily lives of *** study aimed to identify clinically meaningful phenotypes in children with PPCC,to better characterize and treat this *** Participants were children with physician-diagnosed PPCC,referred to the academic hospital Amsterdam UMC in the Netherlands between November 2021 and March *** factors and information on post-COVID symptoms,comorbidities,and impact on daily life were *** clusters were identified using an unsupervised and unbiased approach for mixed data *** Analysis of 111 patients(aged 3–18 years)revealed three distinct clusters within *** 1(n=62,median age=15 years)predominantly consisted of girls(74.2%).These patients suffered relatively more from exercise intolerance,dyspnea,and smell *** 2(n=33,median age=13 years)contained patients with an even gender distribution(51.5%girls).They suffered from relatively more sleep problems,memory loss,gastrointestinal symptoms,and *** 3(n=16,median age=11 years)had a higher proportion of boys(75.0%),suffered relatively more from fever,had significantly fewer symptoms(median of 5 symptoms compared to 8 and 10 for clusters 1 and 2 respectively),and experienced a lower impact on daily *** This study identified three distinct clinical PPCC phenotypes,with variations in sex,age,symptom patterns,and impact on daily *** findings highlight the need for further research to understand the potentially diverse underlying mechanisms contributing to post-COVID symptoms in children.

关键词： Adolescents Clusters Long COVID Pediatric Phenotypes Post-COVID syndrome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Crosstalk between androgen signaling and the chemokine receptor CXCR4:a novel strategy to promote myelin regeneration

引用

Neural Regeneration Research 2025年第9期20卷 2581-2582页

作者： Marianne Bardy-Lagarde Narimène Asbelaoui abdel Mouman Ghoumari UMR1195 “Diseases and Hormones of the Nervous System”Inserm and University Paris-SaclayKremlin-BicêtreFrance

Multiple sclerosis(MS)is the most common chronic disease of the central nervous system(CNS)in young adults and represents the first cause of severe handicap,originally non-traumatic(Oh et al.,2018).MS is chara cterized by the infiltration of auto reactive lymphocytes specific to myelin through the blood-brain barrier,which results in the appearance of inflammatory demyelinating lesions caused by the death of the central nervous system myelinating cells,oligodendrocytes(Oh et al.,2018).There is a prevalence sexual with a ratio of three times more affected women than men.

关键词： myelin CXCR4

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Two paths, one goal: mechanism of calcium homeostasis to balance plant growth and immunity

引用

Science China Life Sciences 2025年第1期 306-308页

作者： aziz Ul Ikram Yanping Jing Huan Chen Jian Chen International Genome Center Jiangsu University Joint Center for Single Cell Biology School of Agriculture and BiologyShanghai Jiao Tong University

Calcium(Ca2+) is an essential nutrient and a cellular signal in plants. The level of free Ca2+in the apoplast is ～10,000-fold higher than that in the cytoplasm at the resting state. This large Ca2+level gradient across the membrane between the interior and exterior can cause Ca2+overload and toxicity. Plants have evolved mechanisms to export Ca2+out of the cytoplasm or store it in intracellular organelles, such as endoplasmic reticulum（ER）, mitochondria, and vacuole.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Role of zinc as an antioxidant and anti-inflammatory to relieve cadmium oxidative stress induced testicular damage in rats

引用

Asian Pacific Journal of Tropical Biomedicine 2016年第12期6卷 1056-1064页

作者： Samir Abd El-Monem Bashandy Enayat abdel aziz Omara Hossam Ebaid Mohamed mahmoud Amin mahmoud Sanad Soliman Department of Pharmacology Medical DivisionNational Research Centre Department of Pathology National Research Centre Department of Zoology College of ScienceKing Saud University Department of Zoology Faculty of ScienceEl-Minia University Department of Therapeutic Chemistry National Research Centre

Objective:To investigate the role of zinc in reducing the deleterious effects of cadmium on male ***:Rats were injected subcutaneously with CdCl_2 and ZnCl_2 at dose level of2.2 mg/kg(1/40 of LD50 of cadmium per day).Results:The rats treated with cadmium exhibited a significant increase in levels of testicular malondialdehyde,tumor necrosis factor-alpha,nitrogen oxide and inducible nitrogen oxide synthase immunostaining reaction,as well as an elevation of blood hydroperoxide and follicle stimulating *** addition,a significant decrease in testicular ascorbic acid,zinc,reduced glutathione,catalase,superoxide dismutase,sex organ weight,plasma testosterone and luteinizing hormone were observed in the cadmium *** motility and count were decreased with cadmium treatment,while sperm abnormalities elevated *** treatment was found to mitigate the toxic effects of cadmium on oxidative stress,spermatogenesis,sex hormones,and inflammatory *** injected with cadmium showed intense histopathological *** manifested protective role and markedly reduced tissues damage induced by ***:The protective effect of zinc can be attributed to its antioxidant and antiinflammatory properties.

关键词： Zinc Cadmium Oxidative stress Immunohistochemistry Sperms Inflammatory markers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geometric Phase of a Coupled System

引用

Communications in Theoretical Physics 2004年第5X期42卷 672-674页

作者： H.S.abdel-aziz MathematicsDepartment FacultyofScienceSouthValleyUniversitySohagEgypt

In this contribution, my main attention is paid to the study of the geometric phase ora two-level *** expansion of the eigenvalue and analytic information are obtained. The results are illustrated with an application ... 详细信息

关键词：几何相位二平面偏微分方程量子论

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Attitude dynamics and control of spacecraft using geomagnetic Lorentz force

引用

Research in Astronomy and Astrophysics 2015年第1期15卷 127-144页

作者： Yehia A.abdel-aziz Muhammad Shoaib National Research Institute of Astronomy and Geophysics (NRIAG) Helwan Cairo 11721Egypt University of Hail Department of Mathematics PO BOX 2440 Kingdom of Saudi Arabia

Attitude stabilization of a charged rigid spacecraft in Low Earth Orbit using torques due to Lorentz force in pitch and roll directions is considered. A spacecraft that generates an electrostatic charge on its surface in the Earth’s magnetic field will be subject to perturbations from the Lorentz force. The Lorentz force acting on an electrostatically charged spacecraft may provide a useful thrust for controlling a spacecraft’s orientation. We assume that the spacecraft is moving in the Earth’s magnetic field in an elliptical orbit under the effects of gravitational, geomagnetic and Lorentz torques. The magnetic field of the Earth is modeled as a non-tilted dipole.A model incorporating all Lorentz torques as a function of orbital elements has been developed on the basis of electric and magnetic fields. The stability of the spacecraft orientation is investigated both analytically and numerically. The existence and stability of equilibrium positions is investigated for different values of the charge to mass ratio（α＊）. Stable orbits are identified for various values of α＊. The main parameters for stabilization of the spacecraft are α＊and the difference between the components of the moment of inertia for the spacecraft.

关键词： space vehicles atmospheric effects celestial mechanics kinematics and dynamics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Equilibria of a charged artificial satellite subject to gravitational and Lorentz torques

引用

Research in Astronomy and Astrophysics 2014年第7期14卷 891-902页

作者： Yehia A.abdel-aziz Muhammad Shoaib National Research Institute of Astronomy and Geophysics (NRIAG) HelwanCairo 11721Egypt University of Hail Department of MathematicsPO Box 2440Kingdom of Saudi Arabia

The attitude dynamics of a rigid artificial satellite subject to a gravity gradient and Lorentz torques in a circular orbit are considered. Lorentz torque is developed on the basis of the electrodynamic effects of the Lorentz force acting on the charged satellite＇s surface. We assume that the satellite is moving in a Low Earth Orbit in the geomagnetic field, which is considered to be a dipole. Our model of torque due to the Lorentz force is developed for an artificial satellite with a general shape, and the nonlinear differential equations of Euler are used to describe its attitude orientation. All equilibrium positions are determined and conditions for their existence are *** numerical results show that the charge q and radius ρ0of the center of charge for the satellite provide a certain type of semi-passive control for the attitude of the satellite. The technique for this kind of control would be to increase or decrease the electrostatic screening on the satellite. The results obtained confirm that the change in charge can affect the magnitude of the Lorentz torque, which can also affect control of the satellite. Moreover, the relationship between magnitude of the Lorentz torque and inclination of the orbit is investigated.

关键词： space vehicles -- atmospheric effects -- celestial mechanics -- kine-matics and dynamics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：