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Overestimate of Fibrosis by FIBROSpect(R) Ⅱ in African Americans Complicates the Management of their Chronic Hepatitis C

引用

Journal of Clinical and Translational Hepatology 2016年第1期4卷 12-19页

作者： maher tama Paul Naylor Suhag Patel Johnny Altawil Dhiraj Gulati Fadi Antaki Milton G.Mutchnick Murray Ehrinpreis Wayne State University School of Medicine Department of Internal Medicine Division of Gastroenterology Detroit MI USA

Background:Evaluation of advanced fibrosis in patients with hepatitis C virus (HCV) infection is used to facilitate decisions on treatment strategy and to initiate additional screening ***,most studies have predominately Caucasian (Cau) patients and may not be as relevant for African Americans (AA).Aims:This study specifically addresses the issue of defining minimal *** fibrosis in African Americans (AA) with chronic hepatitis C (CHC) using noninvasive ***:All patients (n =319) seen between 1 January 2008 and 30 June 2013 for whom a FibroSpect II(R) (FSII) assay was performed and had data for calculation of aspartate aminotransferase (AST)platelet ratio index (APRI) and Fibrosis-4 (FIB-4) were identified using the medical ***:When liver biopsy score and FSII assay results for the AA patients with CHC were compared,31% of AA had advanced FSII fibrosis scores (F2-F4) despite a biopsy score of *** contrast,10% of Cau *** AA false positive rate was 14% for APRI and 34% for *** FSII with either APRI (7% false positive) or FIB-4 (10% false positive) improved the false positive rate in AA to 7% (FSII + APRI) and 10%(FSII + FIB-4) but reduced the sensitivity for significant ***:The FSII assay overestimates fibrosis in AA and should be used with caution since these patients may not have significant *** the APRI or FIB-4 assay is combined with the FSII assay,minimal fibrosis in AA can be defined without subjecting the patients to a subsequent biopsy.

关键词： Hepatitis c Fibrosis African Americans Fibrospect

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