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High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation:Role of endoplasmic-reticulum-stress

World Journal of Diabetes 2017年第2期8卷 56-65页

作者： maha coucha Islam N Mohamed Sally L Elshaer Osinakachuk Mbata Megan L Bartasis Azza B El-Remessy Clinical and Experimental Therapeutics College of PharmacyUniversity of GeorgiaAugustaGA 30912United States

AIM To elucidate how high diet-induced endoplasmic reticulum-stress upregulates thioredoxin interacting protein expression in Müller cells leading to retinal inflammation. METHODS Male C57Bl/J mice were fed either normal diet or 60% high fat diet for 4-8 wk. During the 4 wk study, mice received phenyl-butyric acid(PBA); endoplasmic reticulum-stress inhibitor; for 2 wk. Insulin resistance was assessed by oral glucose tolerance. Effects of palmitate-bovine serum albumin(BSA)(400 μmol/L) were examined in retinal Müller glial cell line and primary Müller cells isolated from wild type and thioredoxin interacting protein knock-out mice. Expression of thioredoxin interacting protein, endoplasmic reticulum-stress markers, mi R-17-5p m RNA, as well as nucleotide-binding oligomerization domain-like receptor protein(NLRP3) and IL1β protein was *** High fat diet for 8 wk induced obesity and insulin resistance evident by increases in body weight and impaired glucose tolerance. By performing quantitative real-time polymerase chain reaction, we found that high fat diet triggered the expression of retinal endoplasmic reticulum-stress markers(P < 0.05). These effects were associated with increased thioredoxin interacting protein and decreased mi R-17-5p expression, whichwere restored by inhibiting endoplasmic reticulumstress with PBA(P < 0.05). In vitro, palmitate-BSA triggered endoplasmic reticulum-stress markers, which was accompanied with reduced mi R-17-5p and induced thioredoxin interacting protein m RNA in retinal Müller glial cell line(P < 0.05). Palmitate upregulated NLRP3 and IL1β expression in primary Müller cells isolated from wild type. However, using primary Müller cells isolated from thioredoxin interacting protein knock-out mice abolished palmitate-mediated increase in NLRP3 and IL1β.CONCLUSION Our work suggests that targeting endoplasmic reticulumstress or thioredoxin interacting protein are potential therapeutic strategies for early intervention of ob

关键词： High fat diet Palmitate Endoplasmic-reticulum-stress Inflammation Thioredoxin-interacting protein Micro-RNA 17-5p

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Spatial dynamics and Palestinian resilience:The lifestyle of Al-Kurshan Bedouins in Bethlehem District

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Frontiers of Architectural Research 2024年第3期13卷 439-458页

作者： maha Samman Sarah Mitwassi Abdel Rahman Kaloti Department of Architecture Faculty of EngineeringAl-Quds UniversityJerusalemPalestine

This study explores the role of Bedouins in preserving Palestinian land through their own means of community resilience through the concept of“Art of being”and its entailed“Arts of presence and persistence”.This is examined through the correlation between Bedouin lifestyle and the spatial distribution of structures within“Al-Kurshan”Bedouin clan in Area C in the West *** on a mixed qualitative and spatial methodologies,information was gathered through semi-structured interviews with Al-Kurshan Bedouins and employees of organizations supporting Bedouins,on-site observation,and analyses of maps and photos,in addition to drawings and *** spatial distribution of Bedouin built structures is analyzed in relation to landscape and climate,social aspects within the families,and available service and sectorial *** analyses give insight on how Bedouins struggle against adopting other *** study shows that the Bedouins are slowly forced to negotiate their semi-nomadic lifestyle,but resist giving up their right to exist against the threat of forced *** maintain their“Art of being”which partly represents their own way of safeguarding Palestinian lands from *** study contributes to the wider discussion of spatial dynamics of Bedouins and their community resilience within the Palestinian geopolitical context.

关键词： Bedouin everyday life Spatial distribution Community resilience Art of being Palestine Area C

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Stock Markets,Financial Depth,and Economic Growth in China:Evidence from ARDLModel

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China Finance and Economic Review 2024年第1期13卷 88-111页

作者： Afef Bouattour maha Kalai Kamel Helali Higher Institute of Business Administration of Sfax University of Sfax Faculty of Economics and Management of Sfax University of Sfax

The relationship between financial development and economic growth in China is *** this perspective,this article aims to identify this relationship using both capital market and banking intermediation indicators,which were rarely considered in the previous *** autoregressive model with staggered lags(ARDL)examines the long-run cointegration relationship between 1980 and *** results suggest that the contribution of different subsectors of the Chinese financial system to economic growth *** development of the money market has a negative impact,whereas market capitalization has a positive impact on economic growth in *** the contribution of the banking system to China's economic growth,the two variables measuring the depth of financial institutions showed opposite impacts in both the short and long *** important policy implications,regulators need to ensure a pro-growth environment,effectively regulate the informal banking system,and prevent potential financial risks by revising policies.

关键词： stock markets financial depth economic growth China ARDL

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Improved Dynamic Johnson Sequencing Algorithm(DJS)in Cloud Computing Environment for Efficient Resource Scheduling for Distributed Overloading

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Journal of Systems Science and Systems Engineering 2024年第4期33卷 391-424页

作者： Anurag Sinha Pallab Banerjee Sharmistha Roy Nitasha Rathore Narendra Pratap Singh Mueen Uddin maha Abdelhaq Raed Alsaqour Department of Computer Science Engineering ICFAI Tech SchoolICFAI UniversityJharkhandRanchi834004India Department of Computer Science Engineering Amity UniversityJharkhandRanchi835303India Department of Computing and Information Technology Usha Martin UniversityRanchi835103India Department of Information Technology Bharti Vidyapeeth’s College of EngineeringPaschim ViharNew DelhiIndia Department of CSE Delhi UniversityNew DelhiIndia College of Computing and Information Technology University of Doha for Science and TechnologyDoha24449Qatar Department of Information Technology College of Computer and Information SciencesPrincess Nourah Bint Abdurrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Information Technology College of Computing and InformaticsSaudi Electronic University93499RiyadhSaudi Arabia

This study introduces an innovative approach to optimize cloud computing job distribution using the Improved Dynamic Johnson Sequencing Algorithm(DJS).Emphasizing on-demand resource sharing,typical to Cloud Service Providers(CSPs),the research focuses on minimizing job completion delays through efficient task *** Johnson’s rule from operations research,the study addresses the challenge of resource availability post-task *** advocates for queuing models with multiple servers and finite capacity to improve job scheduling models,subsequently reducing wait times and queue *** Dynamic Johnson Sequencing Algorithm and the M/M/c/K queuing model are applied to optimize task sequences,showcasing their efficacy through comparative *** research evaluates the impact of makespan calculation on data file transfer times and assesses vital performance indicators,ultimately positioning the proposed technique as superior to existing approaches,offering a robust framework for enhanced task scheduling and resource allocation in cloud computing.

关键词： First come first served(FCFS)scheduling round robin task scheduling queuing model Johnson scheduling algorithm

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Risk factors for long COVID in children and adolescents:a systematic review and meta-analysis

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World Journal of Pediatrics 2024年第2期20卷 133-142页

作者： Daniel G.Rayner Elaine Wang Cloris Su Om D.Patel Stephanie Aleluya Alessandra Giglia Evelyn Zhu maha Siddique Department of Health Research Methods Evidenceand ImpactFaculty of Health SciencesMcMaster University1280 Main St WHamiltonONL8S 4K1Canada Faculty of Health Sciences McMaster University1280 Main St WHamiltonON L8S 4K1Canada Faculty of Science McMaster University1280 Main St WHamiltonONL8S 4K1Canada

Background The long-term sequelae of COVID-19 in children and adolescents remain poorly understood and *** systematic review and meta-analysis sought to summarize the risk factors for long COVID in the pediatric *** We searched six databases from January 2020 to May 2023 for observational studies reporting on risk factors for long COVID or persistent symptoms those were present 12 or more weeks post-infection using multivariable regression *** registries,reference lists of included studies,and preprint servers were hand-searched for relevant ***-effects meta-analyses were conducted to pool odds ratios for each risk *** study risk of bias was rated using QUIPS,and the GRADE framework was used to assess the certainty of evidence for each unique *** Sixteen observational studies(N=46,262)were included,and 19 risk factors were amenable to *** moderate certainty in the evidence,age(per 2-year increase),allergic rhinitis,obesity,previous respiratory diseases,hospitalization,severe acute COVID-19,and symptomatic acute COVID-19 are probably associated with an increased risk of long *** sex,asthma,comorbidity,and heart diseases may be associated with an increased risk of long COVID,and Asian and Black races may be associated with a decreased risk of long *** did not observe any credible subgroup effects for any risk *** The current body of literature presents several compelling risk factors for the development of long COVID in the pediatric *** research is necessary to elucidate the pathophysiology of long COVID.

关键词： COVID-19 Long COVID Post-acute COVID-19 syndrome Pediatrics Risk factors

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Solving the Generalized Traveling Salesman Problem Using Sequential Constructive Crossover Operator in Genetic Algorithm

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Computer Systems Science & Engineering 2024年第5期48卷 1113-1131页

作者： Zakir Hussain Ahmed maha Ata Al-Furhood Abdul Khader Jilani Saudagar Shakir Khan Department of Mathematics and Statistics College of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia Department of Computer Science College of Computer and Information SciencesJouf UniversitySakakah42421Saudi Arabia Information Systems Department Imam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia College of Computer and Information Sciences Imam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia

The generalized travelling salesman problem(GTSP),a generalization of the well-known travelling salesman problem(TSP),is considered for our *** the GTSP is NP-hard and very complex,finding exact solutions is highly expensive,we will develop genetic algorithms(GAs)to obtain heuristic solutions to the *** GAs,as the crossover is a very important process,the crossovermethods proposed for the traditional TSP could be adapted for the *** sequential constructive crossover(SCX)and three other operators are adapted to use in GAs to solve the *** effectiveness of GA using SCX is verified on some GTSP Library(GTSPLIB)instances first and then compared against GAs using the other crossover *** computational results show the success of the GA using SCX for this *** proposed GA using SCX,and swap mutation could find average solutions whose average percentage of excesses fromthe best-known solutions is between 0.00 and 14.07 for our investigated instances.

关键词： Generalized travelling salesman problem NP-hard genetic algorithms sequential constructive crossover swap mutation

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A comparative in vitro study on the effect of SGLT2 inhibitors on chemosensitivity to doxorubicin in MCF-7 breast cancer cells

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Oncology Research 2024年第5期32卷 817-830页

作者： SHAHID KARIM ALANOUD NAHER ALGHANMI maha JAMAL HUDA ALKREATHY ALAM JAMAL HIND A.ALKHATABI MOHAMMED BAZUHAIR AFTAB AHMAD Department of Clinical Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Biochemistry Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Department of Biochemistry College of ScienceUniversity of JeddahJeddah21959Saudi Arabia Health Information Technology Department The Applied CollegeKing Abdulaziz UniversityJeddahSaudi Arabia Pharmacovigilance and Medication Safety Unit Center of Research Excellence for Drug Research and Pharmaceutical IndustriesKing Abdulaziz UniversityJeddahSaudi Arabia

Cancer frequently develops resistance to the majority of chemotherapy *** study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors,specifically Canagliflozin(CAN),Dapagliflozin(DAP),Empagliflozin(EMP),and Doxorubicin(DOX),using in vitro *** precise combination of CAN+DOX has been found to greatly enhance the cytotoxic effects of doxorubicin(DOX)in MCF-7 ***,it was shown that cancer cells exhibit an increased demand for glucose and ATP in order to support their ***,when these medications were combined with DOX,there was a considerable inhibition of glucose consumption,as well as reductions in intracellular ATP and lactate ***,this effect was found to be dependent on the dosages of the *** addition to effectively inhibiting the cell cycle,the combination of CAN+DOX induces substantial modifications in both cell cycle and apoptotic gene *** work represents the initial report on the beneficial impact of SGLT2 inhibitor medications,namely CAN,DAP,and EMP,on the responsiveness to the anticancer properties of *** underlying molecular mechanisms potentially involve the suppression of the function of SGLT2.

关键词： SGLT2 Cancer Cytotoxicity ATP Cell cycle

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A novel medical image data protection scheme for smart healthcare system

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CAAI Transactions on Intelligence Technology 2024年第4期9卷 821-836页

作者： Mujeeb Ur Rehman Arslan Shafique Muhammad Shahbaz Khan maha Driss Wadii Boulila Yazeed Yasin Ghadi Suresh Babu Changalasetty Majed Alhaisoni Jawad Ahmad School of Computer Science and Informatics Cyber Technology InstituteDe Montfort UniversityLeicesterUK Department of Biomedical Engineering University of GlasgowGlasgowUK School of Computing Engineering and the Built EnvironmentEdinburgh Napier UniversityEdinburghUK Robotics and Internet‐of‐Things Laboratory Prince Sultan UniversityRiyadhSaudi Arabia Department of Computer Science Al Ain UniversityAl AinUnited Arab Emirates Department of Computer Engineering College of Computer Science King Khalid UniversityAbhaSaudi Arabia Computer Sciences Department College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityRiyadhSaudi Arabia

The Internet of Multimedia Things(IoMT)refers to a network of interconnected multimedia devices that communicate with each other over the ***,smart healthcare has emerged as a significant application of the IoMT,particularly in the context of knowledge‐based learning *** healthcare systems leverage knowledge‐based learning to become more context‐aware,adaptable,and auditable while maintain-ing the ability to learn from historical *** smart healthcare systems,devices capture images,such as X‐rays,Magnetic Resonance *** security and integrity of these images are crucial for the databases used in knowledge‐based learning systems to foster structured decision‐making and enhance the learning abilities of ***,in knowledge‐driven systems,the storage and transmission of HD medical images exert a burden on the limited bandwidth of the communication channel,leading to data trans-mission *** address the security and latency concerns,this paper presents a lightweight medical image encryption scheme utilising bit‐plane decomposition and chaos *** results of the experiment yield entropy,energy,and correlation values of 7.999,0.0156,and 0.0001,*** validates the effectiveness of the encryption system proposed in this paper,which offers high‐quality encryption,a large key space,key sensitivity,and resistance to statistical attacks.

关键词： data analysis medical image processing security

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Prevalence of post-traumatic stress disorder and depressive symptoms among civilians residing in armed conflict-affected regions:a systematic review and meta-analysis

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General Psychiatry 2024年第3期37卷 324-334页

作者： Syed Hassan Ahmed Aabia Zakai maha Zahi Muhammad Youshay Jawad Rui Fu Michael Chaiton Dow University of Health Sciences KarachiPakistan Department of Psychiatry and Behavioral Health Penn State College of MedicineHersheyPennsylvaniaUSA Dalla Lana School of Public Health University of TorontoTorontoOntarioCanada institute of Mental Health Policy Research The Center of Addiction and Mental HealthTorontoOntarioCanada

Background Globally,populations afflicted by armed conflict are known to have high rates of mental health *** This meta-analysis aims to estimate the prevalence of post-traumatic stress disorder(PTSD)and depressive symptoms among civilians residing in armed conflictaffected *** This meta-analysis was conducted in accordance with the Preferred Reporting Items forSystematic Reviews and Meta-Analyses.A literature search employing MEDLINE(R),Embase Classic+Embase,APA PsyclNFO,Ovid Healthstar,Journal@Ovid Full Text,Cochrane,PTSDpubs and CINAHL was conducted from inception until 19 March 2024 to identify relevant *** assessment was performed using the Joanna Briggs Institute Critical Appraisal Checklist for Prevalence Studies,and a Comprehensive Meta-Analysiswas usedto conduct the statistical *** The search yielded 38595 articles,of which 57 were considered eligible for *** included studies comprised data from 64596 *** estimated a prevalence of 23.70%(95%CI 19.50%to28.40%)forPTSD symptomsand 25.60%(95%Cl 20.70%to 31.10%)for depressive features among war-afflicted *** subgroup analysis based on time since the war and the country's economic status revealed the highest prevalence for both PTSD and depressive symptoms was present during the years of war and in low/*** The results of this study provide conclusive evidence of the detrimental impacts of armed conflict on mental health ***,it is crucial to emphasise the significance of both physical and mental health in the aftermath of war and take appropriate humanistic measures to overcome challenges in the management of psychiatric illnesses.

关键词： analysis stress armed

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Micro-Computed Tomography Applications in Dentistry

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Open Journal of Stomatology 2024年第1期14卷 32-41页

作者： Ahmad Assari maha Al Bukairi Reema Al Saif Oral Maxillofacial Surgery & Diagnostic Sciences Department College of Medicine and Dentistry Riyadh Elm University Ri-yadh Saudi Arabia Orthodontist Ministry of Health First Health Cluster Riyadh Saudi Arabia Periodontist Ministry of Health Third Health Cluster Riyadh Saudi Arabia

Micro-computed tomography (MCT) encompasses two primary scanning options: ex-vivo and in-vivo imaging. Ex-vivo scanning involves the examination of extracted teeth or dental specimens, allowing for detailed analyses of the microarchitecture of mineralized tissue. By analyzing the microarchitecture of dental tissues, MCT can provide valuable information about bone density, porosity, and microstructural changes, contributing to a better understanding of disease progression and treatment outcomes. Moreover, MCT facilitates the quantification of dental parameters, such as bone volume, trabecular thickness, and connectivity density, which are crucial for evaluating the efficacy of dental interventions. This present study aims to comprehensively review and explore the applications of MCT in dentistry and highlight its potential in advancing research and clinical practice. The results depicted that the quantitative approach of MCT enhances the precision and reliability of dental research. Researchers and clinicians can make evidence-based decisions regarding treatment strategies and patient management, relying on quantifiable data provided by MCT. The applications of MCT in dentistry extend beyond research, with potential clinical implications in fields such as dental implantology and endodontics. MCT is expected to play an increasingly significant role in enhancing our understanding of dental pathologies, improving treatment outcomes, and ultimately, benefiting patient care in the field of dentistry.

关键词： Clinical Practice Dentistry Ex-Vivo Scanning Micro-Computed Tomography

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