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Prostaglandin E2 receptor EP3 regulates both adipogenesis and lipolysis in mouse white adipose tissue

Journal of Molecular Cell Biology 2016年第6期8卷 518-529页

作者： Hu Xu Jia-Lin Fu Yi-Fei Miao Chun-Jiong Wang Qi-Fei Han Sha Li Shi-Zheng Huang Sheng-Nan Du Yu-Xiang Qiu Ji-Chun Yang Jan-Ake gustafsson Richard MBreyer Feng Zheng Nan-Ping Wang Xiao-Yan Zhang You-Fei Guan Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Center for Nuclear Receptors and Cell Signaling Department of Biology and BiochemistryUniversity of HoustonHoustonTX 77204USA Department of Veterans Affairs Tennessee Valley Health Authorityand Department of MedicineVanderbilt University Medical CenterNashvilleTN 37232USA Advanced Institute for Medical Sciences Dalian Medical UniversityDalian 116044China Department of Physiology AstraZeneca–Shenzhen University Joint Institute of NephrologyShenzhen University Health Science CenterShenzhen 518060China

Among the four prostaglandin E2 receptors,EP3 receptor is the one most abundantly expressed in white adipose tissue(WAT).The mouse EP3 gene gives rise to three isoforms,namely EP3α,EP3β,and EP3γ,which differ only at their C-terminal *** date,functions of EP3 receptor and its isoforms in WAT remain incompletely *** this study,we found that the expression of all EP3 isoforms were downregulated in WAT of both db/db and high-fat diet-induced obese *** ablation of three EP3 receptor isoforms(EP3^(−/−)mice)or EP3αand EP3γisoforms with EP3βintact(EP3βmice)led to an obese phenotype with increased food intake,decreased motor activity,reduced insulin sensitivity,and elevated serum *** the differentiation of preadipocytes and mouse embryonic fibroblasts to adipocytes was markedly facilitated by either pharmacological blockade or genetic deletion/inhibition of EP3 receptor via the cAMP/PKA/PPARγpathway,increased adipogenesis may contribute to obesity in EP3^(−/−)and EP3β***,both EP3^(−/−)and EP3βmice had increased lipolysis in WAT mainly due to the activated cAMP/PKA/hormone-sensitive lipase *** together,our findings suggest that EP3 receptor and itsαandγisoforms are involved in both adipogenesis and lipolysis and influence food intake,serum lipid levels,and insulin sensitivity.

关键词： arachidonic acid EP3 receptor isoform PKA PPARγ insulin resistance obesity

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先天性耳聋患儿肺呼吸量测定与肺功能状况

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世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 31-32页

作者： Jonsson. gustafsson D. 李开 Department of Paediatrics rebro Un iversity Hospital SE-701 85rebro Sweden

Aim: Deaf children do not develop a verbal language and will therefore not exp erience normal changes in airway pressure produced by speech. The impact on lung development of factors such as talking and screaming has not previously been in vestigated. Method: We performed spirometry in 51 children with congenital deafn ess without other medical problems and compared the results with 82 healthy hear ing controls. Results: The deaf children had poorer spirometry results. They par ticipated in the spirometry manoeuvre with less enthusiasm than the controls. Th is was due to difficulty in giving non-verbal instructions in an enthusiastic w ay. When comparing only those in the two groups whose participation in the spiro metry testing was evaluated as very good, poorer results were never the less obt ained by the deaf group. Conclusion: We conclude that spirometry instructions fo r deaf children must be improved. Furthermore, a positive effect on lung develop ment through use of the lungs for speech and screaming cannot be excluded.

关键词：先天性耳聋耳聋儿童功能状况量测操作说明发育不良语言性语言方式语言表达能力压力变化

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时尚达人的呼声：改造我的宜家

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商业周刊（中文版） 2014年第6期 29-30页

作者： Katarina gustafsson 一毫

初创家具公司通过生产宜家家私附属产品获利“我们买宜家沙发的唯一原因”是它可以上特制沙发支脚在宜家家居（IKEA），你有9000多种商品可以选择，它们价位不一，可以满足不同消费档次的需求，将你的家打造成完美的北欧风格。但是，你... 详细信息

初创家具公司通过生产宜家家私附属产品获利“我们买宜家沙发的唯一原因”是它可以上特制沙发支脚在宜家家居（IKEA），你有9000多种商品可以选择，它们价位不一，可以满足不同消费档次的需求，将你的家打造成完美的北欧风格。但是，你却无法找到你的邻居不曾见过的东西。

关键词：宜家家居改造时尚家具公司消费档次沙发商品价位

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这款雨衣很忧郁

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商业周刊（中文版） 2015年第6期 20-21页

作者： Katarina gustafsson 任文科

5年前，亚历山大·斯塔特海姆（Alexander Stutterheim）决定在他的斯德哥尔摩公寓出售雨衣，他想创设一个忧郁的场景。这位时年38岁的文案撰稿人随即将导演英格玛·伯格曼（Ingmar Bergman）的电影海报挂在墙上，并播放了一曲忧伤的瑞... 详细信息

5年前，亚历山大·斯塔特海姆（Alexander Stutterheim）决定在他的斯德哥尔摩公寓出售雨衣，他想创设一个忧郁的场景。这位时年38岁的文案撰稿人随即将导演英格玛·伯格曼（Ingmar Bergman）的电影海报挂在墙上，并播放了一曲忧伤的瑞典爵士乐。

关键词：忧郁雨衣斯德哥尔摩亚历山大电影海报撰稿人爵士乐忧伤

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非抗生素药物在大家畜子宫病治疗上的应用

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动物医学进展 1987年第1期 20-22页

作者： B、K、gustafsson 刘智喜

刚分娩后,当循环中高水平雌激素使子宫致敏时,催产素的子宫收缩作用即增强。当在6—10小时期间静脉滴注催产素或每日肌注催产素3—4次,连续2—3天时,催产素的效果最佳。当把麦角新碱用于产犊后的母牛时,总是无益的。在产后头10天,一次... 详细信息

刚分娩后,当循环中高水平雌激素使子宫致敏时,催产素的子宫收缩作用即增强。当在6—10小时期间静脉滴注催产素或每日肌注催产素3—4次,连续2—3天时,催产素的效果最佳。当把麦角新碱用于产犊后的母牛时,总是无益的。在产后头10天,一次或多次注射前列腺素F2a(PGF2a),可加速子宫的复旧。单用雌激素类也足以满足对产后轻度至中度子宫感染治疗的需要。对各种消毒剂的宫内灌注是不提倡的。促性腺素释放激素（GnRH）可提高胎衣不下病牛的繁殖力。PGF2a1—2次注射,对具有发情周期母牛的轻度至中度子宫内膜炎是有益的。碘溶液宫内灌注也可以诱发发情。该疗法可替代PGF2a满意地用于轻度至中度子宫内膜炎病例的治疗。几乎没有一种疾病比大家畜子宫感染的疗法多。局部最常应用的抗生素,已普遍作为选择疗法。虽然最初对其疗效主要凭经验判定,而一些对照研究还是探讨了许多疗法的疗效。随着人们对细菌耐药性和组织残留危险的认识,生产肉、乳时,必须有停药时间,必需以非抗生素药物来代替,已日益清楚。本文讨论了有关子宫感染非抗菌疗法的某些重要特征。

关键词：子宫内膜炎疗法胎衣不下胎盘滞留子宫感染母牛雌激素类子宫弛缓发情周期抗生素药物

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电信行业能否拯救地球?

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中国新通信 2008年第17期10卷 5-10页

作者： Anna Kramers Jens Malmodin Matilda Gennvi gustafsson 爱立信

近年来,有关全球变暖的原因开始显得越发明显,特别是对温室效应来说。四大商业因素——建筑,履行,交通,以及食物(肉制品极其重要)——占据了全球能源消耗以及二氧化碳排放的四分之三。通讯技术无力独自改变现状,但ICT却是未来低碳世界... 详细信息

近年来,有关全球变暖的原因开始显得越发明显,特别是对温室效应来说。四大商业因素——建筑,履行,交通,以及食物(肉制品极其重要)——占据了全球能源消耗以及二氧化碳排放的四分之三。通讯技术无力独自改变现状,但ICT却是未来低碳世界的一个关键。就中短期而言,我们相信ICT可以提供5%-20%的削减量。最近的研究表明,在全球变暖中,ICT的直接二氧化碳排放量大概占据2%的份额。其中移动通讯占了0.2%,而固定电话(包括宽带)则是0.3%。就全球变暖而言,ICT领域中,电脑以及互联网(特别是数据中心)才是最大最重要的肇事者。

关键词： ICT 二氧化碳排放电信措施环保

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用标准金属栅CMOS工艺设计和制造低噪声运放

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微纳电子技术 1985年第6期 27-30页

作者： S.gustafsson 王晓民

设计了两种低噪声运算放大器。它们都采用双极晶体管作为输入级。因此,对照常规的 CMOS 放大器,它们具有低噪声和低失调的优点,而与其它的双极型放大器相比,又有输入电流低的特点。

关键词：双极晶体管输入级运放金属栅低噪声 CMOS 工艺设计

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Climate shapes the spatiotemporal variation in color morph diversity and composition across the distribution range of Chrysomela lapponica leaf beetle

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Insect Science 2022年第3期29卷 942-955页

作者： Mikhail V.Kozlov Zowi Oudendijk Anders Forsman Vojtech Lanta Maxwell V.L.Barclay Vladimir I.Gusarov Bert gustafsson Zheng-Zhong Huang Oksana Y.Kruglova Yuri M.Marusik Yuri E.Mikhailov Marko Mutanen Alexander Schneider Lukas Sekerka Maksim E.Sergeev Vitali Zverev Elena L.Zvereva Department of Biology University of TurkuTurkuFinland Department of Animal Ecology and Physiology Radboud UniversityNijmegenThe Netherlands Department of Biology and Environmental Science Linnaeus UniversityKalmarSweden Institute of Botany The Czech Academy of SciencesDukelskaTrebohCzech Republic Department of Life Sciences Natural History MuseumLondonUnited Kingdom Natural History Museum University of OsloOsloNorway Departmant of Zoology Swedish Museum of Natural HistoryStockholmSweden elnsititute of Zoology Chinese Academy of SciencesBeijingChina Faculty of Biology Belarusian State UniversityMinskBelarus Department of Biocenology Institute for Biological Problems of the NorthFar East Branch of the Russian Academy of SciencesMagadanRussia Department of Zoology&Entomology University of the Free StateBloemfonteinSouth Africa Department of Ecology&Nature Management Ural State Forest Engineering UniversityYekaterinburgRussia Ecology and Genetics Research Unit University of OuluOuluFinland Department of Terrestrial Zoology Senckenberg Research Institute and Natural History MuseumFrankfurt am MainGermany Department of Entomology National MuseumPrague 9CirkusovaCzech Republic Federal Scientific Center of the East Asia Terrestrial Biodiversity Far East Branch of the Russian Academy of SciencesVladivostokRussia

Color polymorphism offers rich opportunities for studying the eco-evolutionary mechanisms that drive the adaptations of local populations to heterogeneous and changing *** explored the color morph diversity and composition in a Chrysomela lapponica leaf beetle across its entire distribution range to test the hypothesis that environmental and climatic variables shape spatiotemporal variation in the phenotypic structure of a polymorphic *** obtained information on 13617 specimens of this beetle from museums,private collections,and *** specimens(collected from 1830-2020)originated from 959 localities spanning 33°latitude,178°longitude,and 4200 m *** classified the beetles into five color morphs and searched for environmental factors that could explain the variation in the level of polymorphism(quantified by the Shannon diversity index)and in the relative frequencies of individual color *** highest level of polymorphism was found at high latitudes and *** color morphs differed in their climatic requirements;composition of colour morphs was independent of the geographic distance that separated populations but changed with collection year,longitude,mean July temperature and betweenyear temperature *** proportion of melanic beetles,in line with the thermal melanism hypothesis,increased with increasing latitude and altitude and decreased with increasing climate *** morph frequencies also declined during the past century,but only at high latitudes and altitudes where recent climate warming was especially *** observed patterns suggest that color polymorphism is especially advantageous for populations inhabiting unpredictable environments,presumably due to the different climatic requirements of coexisting color morphs.

关键词： adaptive polymorphism color morphs evolutionary dynamics geographic variation phenotypic diversity thermal melanism

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