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Behavior of circulating epithelial tumor cells(CETC)and FISH(fluorescence in situ hybridisation)of epidermal growth factor receptor(EGFR)-gene amplification in lung cancer patients during the course of therapy

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Advances in Lung Cancer 2013年第1期2卷 1-8页

作者： May el Sherif Claus Peter Schneider Carola Rabenstein Amina Hessein Hassab magdy mamdouh el bordiny Mona Wagdy Ayad Katharina Pachmann Departement of Experimental Heamatology and Oncology Clinic for Internal Medicine II Friedrich-Schiller-Universität JenaJenaGermany Oncology Departement Bad Berka Central Clinic Bad BerkaGermany Transfusion Center Bayreuth BayreuthGermany Clinical Pathology Department Faculty of MedicineAlexandria UniversityAlexandriaEgypt

Introduction: Monitoring the response of CETC to therapy in lung cancer allows early detection of patients at risk of progression. Analysis of the EGFR-gene amplification in these cells may help to characterize patients who might benefit from tyrosine kinase inhibitors. Methods: CETCs were quantified at least twice during treatment from blood of 52 patients with advanced non small cell lung cancer (NSCLC) using fluorescence labelled anti-EpCAM. EGFR-gene amplification was analysed in these cells with double probe (EGFR/CEP7) using FISH analysis. Results: Progression of the tumor was observed in 30 of the 52 patients (58%). With respect to changes in CETCs during therapy and progression free survival 31 patients showed a decrease in CETCs, 2 developing a single brain metastasis and 12 progressive disease;20 patients showed an increase in CETC more than twofold 16 of which developed progressive disease. The difference was highly significant (p=0.007 Fisher’s exact test) irrespective of age, sex, tumor size, pathological type and therapy. Kaplan-Meier progression free survival was significantly different between patients with decreasing and increaseing CETC (p=0.038). 5/20 patients tested were positive for EGFR amplification with 85-100% of EpCAM positive cells showing this chromosomal abnormality. One patient could be followed during therapy with increasing CETC during therapy with bevacizumab followed by relapse. He subsequently received erlotinib resulting in a decrease in CETC and is still free of progress after 516 days. Conclusions: These results show that peripherally circulating tumor cells in patients with advanced NSCLC are influenced by systemic chemotherapy and an increase in spite of therapy is a marker of aggressiveness of the tumor cells. Determination of the EGFR amplification might help to better treat part of these patients.

关键词： Circulating Epithelial Tumor Cells Lung Cancer EGFR-Gene Mutation Amplification FISH

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The role of polymorphic cytochrome P450 gene(CYP2B6)in B-chronic lymphocytic leukemia(B-CLL)incidence and outcome among Egyptian patients

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Oncology Research 2024年第4期32卷 785-797页

作者： MENNA AL-ADL magdy MYOUSSEF AHMED el-SEBAIE SHERIF REFAAT AFAF el-SAID Division of Biochemistry Department of ChemistryFaculty of ScienceMansoura UniversityMansoura35511Egypt Hematology Unit Department of Clinical PathologyFaculty of MedicineMansoura UniversityMansoura35511Egypt Medical Oncology Unit Oncology Center Mansoura UniversityMansoura35511Egypt Department of Genetics Mansoura University Children’s HospitalMansoura35511Egypt

Cytochromes P450(CYPs)play a prominent role in catalyzing phase I xenobiotic biotransformation and account for about 75%of the total metabolism of commercially available drugs,including *** gene expression and enzyme activity of CYPs are variable between individuals,which subsequently leads to different patterns of susceptibility to carcinogenesis by genotoxic xenobiotics,as well as differences in the efficacy and toxicity of clinically used *** research aimed to examine the presence of the CYP2B6*9 polymorphism and its possible association with the incidence of B-CLL in Egyptian patients,as well as the clinical outcome after receiving cyclophosphamide *** was isolated from whole blood samples of 100 de novo B-CLL cases and also from 100 sex-and age-matched healthy *** presence of the CYP2B6*9(G516T)polymorphism was examined by PCR-based allele specific amplification(ASA).Patients were further indicated for receiving chemotherapy,and then they were followed *** CYP2B6*9 variant indicated a statistically significant higher risk of B-CLL under different genetic models,comprising allelic(T-allele vs.G-allele,OR=4.8,pely to achieve remission compared to those with the wild-type genotype(GG),with a response percentage of(37.5%vs.83%,respectively).In conclusion,our findings showed that the CYP2B6*9(G516T)polymorphism is associated with B-CLL susceptibility among Egyptian *** variant greatly affected the clinical outcome and can serve as a good therapeutic marker in predicting response to cyclophosphamide treatment.

关键词： B-CLL Xenobiotics Cytochromes P450 CYP2B6

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Thermodynamic Performance Analysis of Geothermal Power Plant Based on Organic Rankine Cycle (ORC) Using Mixture of Pure Working Fluids

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Energy Engineering 2024年第8期121卷 2023-2038页

作者： Abdul Sattar Laghari Mohammad Waqas Chandio Laveet Kumar mamdouh el Haj Assad Department of Mechanical Engineering Mehran University of Engineering and TechnologyJamshoro76062Pakistan Department of Mechanical and Industrial Engineering College of EngineeringQatar UniversityDoha00000Qatar Sustainable&Renewable Energy Engineering Department University of SharjahSharjah00000United Arab Emirates

The selection of working fluid significantly impacts the geothermal ORC’s *** a mixture as a working fluid is a strategy to improve the output of geothermal *** the current study,modelling and thermodynamic analysis of ORC,using geothermal as a heat source,is carried out at fixed operating *** model is simulated in the Engineering Equation Solver(EES).An environment-friendly mixture of fluids,i.e.,R245fa/R600a,with a suitable mole fraction,is used as the operating *** mixture provided the most convenient results compared to the pure working fluid under fixed operating *** impact of varying the evaporator pressure on the performance parameters,including energy efficiency,exergy efficiency and net power output is *** system provided the optimal performance once the evaporator pressure reached the maximum *** efficiencies:Energy and Exergy,and Net Power output of the system are 16.62%,64.08%and 2199 kW for the basic cycle and 20.72%,67.76%and 2326 kW respectively for the regenerative cycle.

关键词： Organic rankine cycle internal heat exchanger moderate-temperature geothermal source mixture of the fluid exergy

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Measuring Impact of Lean Manufacturing Tools for Continuous Improvement on Economic Sustainability

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Journal of Systems Science and Systems Engineering 2024年第4期33卷 452-474页

作者： Luis Javier Márquez Figueroa Jorge Luis García-Alcaraz Ahmed I.Osman Alfonso Jesús Gil López Yashar Aryanfar Mika Sillanpää mamdouh el Haj Assad Department of electrical Engineering and Computer Science Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico Department of Industrial Engineering and Manufacturing Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico School of Chemistry and Chemical Engineering Queens UniversityBelfastNorthern IrelandUK Department of Economic and Managerial Sciences University of La RiojaLa RiojaSpain Department of Chemical Engineering University of JohannesburgJohannesburgSouth Africa Department of Sustainable and Renewable Energy Engineering University of SharjahSharjahUAE

Using Lean Manufacturing(LM)tools in production processes is crucial for companies’economic,environmental,and social sustainability *** study shows a structural equation model(SEM)that shows the relationship between LM Tools like Kaizen(KAI),Gemba(GEM),Value Stream Mapping(VSM)and Key Performance Indicator(KPI)with Economic Sustainability(ECS).Seven hypotheses were evaluated with data from 179 responses to a questionnaire about the Mexican maquiladora industry,showing that these variables are *** a 95%confidence level,the model was evaluated using the partial least squares *** findings indicate that the relationships between KAI and GEM and KAI and VSM have the strongest relationship,followed by VSM and ECS;however,VSM has the strongest effect on *** on these findings,it is recommended that managers adopt a continuous improvement(KAI)approach based on working directly on the shop floor(GEM and VSM)to support their decisions regarding economic growth(ECS).

关键词： Lean manufacturing economic sustainability structural equation model quality improvement

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Performance Assessment of a Real PV System Connected to a Low-Voltage Grid

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Energy Engineering 2024年第1期121卷 13-26页

作者： Gaber magdy Mostafa Metwally Adel A.elbaset Esam Zaki electrical Engineering Department Faculty of Energy EngineeringAswan UniversityAswanEgypt `2Faculty of Engineering King Salman International UniversityEl-Tor46511Egypt electrical Engineering Department Faculty of EngineeringMinia UniversityMiniaEgypt Department of electromechanics Engineering Faculty of EngineeringHeliopolis UniversityCairoEgypt Computer Department Faculty of EngineeringModern Academy of Engineering&TechnologyCairoEgypt

The generation of photovoltaic(PV)solar energy is increasing continuously because it is renewable,unlimited,and clean *** the past,generation systems depended on non-renewable sources such as oil,coal,and ***,this paper assesses the performance of a 51 kW PV solar power plant connected to a low-voltage grid to feed an administrative building in the 6th of October City,*** performance analysis of the considered grid-connected PV system is carried out using power system simulator for Engineering(PSS/E)*** the PSS/E program,monitors and uses the power analyzer that displays the parameters and measures some parameters such as current,voltage,total power,power factor,frequency,and current and voltage harmonics,the used inverter from the type of grid inverter for the considered *** results conclude that when the maximum solar radiation is reached,the maximum current can be obtained from the solar panels,thus obtaining the maximum power and power *** total voltage harmonic distortion,a current harmonic distortion within permissible limits using active harmonic distortion because this type is fast in processing up to 300 *** connection between solar stations and the national grid makes the system more efficient.

关键词： Low-voltage grid photovoltaic(PV)system total harmonic distortion grid-connected PV system

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Enhancing Data Analysis and Automation: Integrating Python with Microsoft Excel for Non-Programmers

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Journal of Software Engineering and Applications 2024年第6期17卷 530-540页

作者： Osama magdy Ali Mohamed Breik Tarek Aly Atef Tayh Nour el-Din Raslan Mervat Gheith Software Engineering Department Faculty of Graduate Studies for Statistical Research Cairo University Giza Egypt

Microsoft Excel is essential for the End-User Approach (EUA), offering versatility in data organization, analysis, and visualization, as well as widespread accessibility. It fosters collaboration and informed decision-making across diverse domains. Conversely, Python is indispensable for professional programming due to its versatility, readability, extensive libraries, and robust community support. It enables efficient development, advanced data analysis, data mining, and automation, catering to diverse industries and applications. However, one primary issue when using Microsoft Excel with Python libraries is compatibility and interoperability. While Excel is a widely used tool for data storage and analysis, it may not seamlessly integrate with Python libraries, leading to challenges in reading and writing data, especially in complex or large datasets. Additionally, manipulating Excel files with Python may not always preserve formatting or formulas accurately, potentially affecting data integrity. Moreover, dependency on Excel’s graphical user interface (GUI) for automation can limit scalability and reproducibility compared to Python’s scripting capabilities. This paper covers the integration solution of empowering non-programmers to leverage Python’s capabilities within the familiar Excel environment. This enables users to perform advanced data analysis and automation tasks without requiring extensive programming knowledge. Based on Soliciting feedback from non-programmers who have tested the integration solution, the case study shows how the solution evaluates the ease of implementation, performance, and compatibility of Python with Excel versions.

关键词： Python End-User Approach Microsoft Excel Data Analysis Integration Spreadsheet Programming Data Visualization

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Possible role of intestinal stem cells in the pathophysiology of irritable bowel syndrome

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World Journal of Gastroenterology 2020年第13期26卷 1427-1438页

作者： magdy el-Salhy Section for Gastroenterology Department of MedicineStord HospitalStord 5409Norway Department of Clinical Medicine University of BergenBergen 5021Norway

The pathophysiology of irritable bowel syndrome(IBS)is not completely ***,several factors are known to play a role in pathophysiology of IBS such as genetics,diet,gut microbiota,gut endocrine cells,stress and low-grade *** the pathophysiology of IBS may open the way for new treatment *** density of intestinal stem cells and low differentiation toward enteroendocrine cells has been reported recently in patients with *** abnormalities are believed to be the cause of the low density of enteroendocrine cells seen in patients with *** cells regulate gastrointestinal motility,secretion,absorption and visceral *** dysmotility,abnormal absorption/secretion and visceral hypersensitivity are all seen in patients with IBS and haven been attributed to the low density the intestinal enteroendocrine cells in these *** present review conducted a literature search in Medline(Pub Med)covering the last ten years until November 2019,where articles in English were *** about the intestinal stem cells and their possible role in the pathophysiology of IBS are discussed in the present *** present review discusses the assumption that intestinal stem cells play a central role in the pathophysiology of IBS and that the other factors known to contribute to the pathophysiology of IBS such as genetics,diet gut microbiota,stress,and lowgrade inflammation exert their effects through affecting the intestinal stem *** reports further the data that support this assumption on genetics,diet,gut microbiota,stress with depletion of glutamine,and inflammation.

关键词： Diet Gut enteroendocrine cells Gut microbiota Low grade inflammation Stress

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Recent developments in the pathophysiology of irritable bowel syndrome

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World Journal of Gastroenterology 2015年第25期21卷 7621-7636页

作者： magdy el-Salhy Section for Gastroenterology Department of Medicine Stord Hospital Section of Neuroendocrine Gastroenterology Division of Gastroenterology Department of Clinical MedicineUniversity of Bergen National Centre for Functional Gastrointestinal Disorders Department of Medicine Haukeland University Hospital

Irritable bowel syndrome(IBS) is a common gastrointestinal disorder, the pathophysiology of which is not completely known, although it has been shown that genetic/social learning factors, diet, intestinal microbiota, intestinal low-grade inflammation, and abnormal gastrointestinal endocrine cells play a major role. Studies of familial aggregation and on twins have confirmed the heritability of IBS. However, the proposed IBS risk genes are thus far nonvalidated hits rather than true predisposing factors. There is no convincing evidence that IBS patients suffer from food allergy/intolerance, with the effect exerted by diet seemingly caused by intake of poorly absorbed carbohydrates and fiber. Obesity is a possible comorbidity of IBS. Differences in the microbiota between IBS patients and healthy controls have been reported, but the association between IBS symptoms and specific bacterial species is uncertain. Low-grade inflammation appears to play a role in the pathophysiology of a major subset of IBS, namely postinfectious IBS. The density of intestinal endocrine cells is reduced in patients with IBS, possibly as a result of genetic factors, diet, intestinal microbiota, and low-grade inflammation interfering with the regulatory signals controlling the intestinal stem-cell clonogenic and differentiation activities. Furthermore, there is speculation that this decreased number of endocrine cells is responsible for the visceral hypersensitivity, disturbed gastrointestinal motility, and abnormal gut secretion seen in IBS patients.

关键词： Diet Endocrine cells Genetic factors Low-grade inflammation Microbiota Stem cells

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Martensitic transformation and magnetic properties of aged Ni-Fe-Ga-Ti shape memory alloy

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International Journal of Minerals,Metallurgy and Materials 2013年第9期20卷 867-873页

作者： Nader el-Bagoury Mahmoud Mohamed Hessien magdy Abdel Wahab Kaseem Chemistry Department Faculty of Science TAIF University P.O. Box 888 El-Haweyah El-Taif Saudi Arbia Central Metallurgical Research and Development Institute (CMRDI) P.O. Box 87 Helwan Cairo Egypt Head of National Authority for Quality of Education Assurance and Accreditation Nasr City Cairo P.O. Box 11461 Egypt

This article reports the effect of ageing on the microstructure, martensitic transformation, magnetic properties, and mechanical properties of Ni51FelsGa27Ti4 shape memory alloy. There are five specimens of this alloy aged at 573 up to 973 K for 3 h per each. This range of ageing temperature greatly affects the microstructure of the alloy. As the ageing temperature increased from 573 up to 973 K, the microstructure of Ni51FelsGa27Ti4 alloy gradually changed from the entirely martensitic matrix at 573 K to the fully austenitic microstructure at 973 K. The volume fraction of precipi- tated Ni3Ti particles increased with the ageing temperature increasing from 573 to 773 K. Further increasing the ageing temperature to 973 K decreased the content of Ni3Ti in the microstructure. The martensitic transformation tempera- ture was decreased steadily by increasing the ageing temperature. The magnetization saturation, remnant magnetization, and coercivity increased with the ageing temperature increasing up to 773 K. A further increase in ageing temperature decreased these raagnetic properties. Moreover, the hardness values were gradually increased at first by increasing the ageing temperature to 773 K, and then dramatically decreased to the lowest value at 973 K.

关键词： magnetic materials shape memory effect ageing microstructure martensitic transformations magnetic properties hardness

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Fecal microbiota transplantation for irritable bowel syndrome:An intervention for the 21st century

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World Journal of Gastroenterology 2021年第22期27卷 2921-2943页

作者： magdy el-Salhy Tanisa Patcharatrakul Sutep Gonlachanvit Department of Medicine Stord Helse Fonna Hospital and University of BergenStord 5416Norway Department of Medicine King Chulalongkorn Memorial Hospital and Center of Excellence in Neurogastroenterology and MotilityChulalongkorn UniversityBangkok 10330Thailand

Irritable bowel syndrome(IBS)affects about 12%of the global *** IBS does not develop into a serious disease or increase mortality,it results in a considerable reduction in the quality of *** etiology of IBS is not known,but the intestinal microbiota appears to play a pivotal role in its *** is no effective treatment for IBS,and so the applied treatments clinically focus on symptom *** microbiota transplantation(FMT),an old Chinese treatment,has been applied to IBS patients in seven randomized controlled trials(RCTs).Positive effects on IBS symptoms in various degrees were obtained in four of these RCTs,while there was no effect in the remaining *** the seven RCTs there were marked differences in the selection processes for the donor and treated patients,the transplant dose,the route of administration,and the methods used to measure how the patients responded to *** present frontier discusses these differences and proposes:(1)criteria for selecting an effective donor(superdonor);(2)selection criteria for patients that are suitable for FMT;(3)the optimal FMT dose;and(4)the route of transplant *** appears to be safe,with only mild,self-limiting side effects of abdominal pain,cramping,tenderness,diarrhea,and *** it is early to speculate about the mechanisms underlying the effects of FMT,the available data suggest that changes in the intestinal bacteria accompanied by changes in fermentation patterns and fermentation products(specifically short-chain fatty acids)play an important role in improving the IBS symptoms seen after *** appears to be a promising treatment for IBS,but further studies are needed before it can be applied in everyday clinical practice.

关键词： Butyric acid Enteroendocrine cells Etiology Microbiota Short-chain fatty acids Superdonor Therapy

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