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Postoperative Radiotherapy in Bladder Cancer Patients: 5-Year Institutional Experience of National Cancer Institute, Cairo University

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Journal of Cancer Therapy 2015年第7期6卷 579-593页

作者： Azza M. Nasr magda el mongi Mamdouh Hagag Manar M. Moneer Hisham el Hossieny Azza Taher Sherif Magdy Radiation Oncology Department National Cancer Institute Cairo University Giza Egypt Clinical Oncology Department Faculty of Medicine Cairo University Giza Egypt Cancer Epidemiology and Biostatistics Department National Cancer Institute Cairo University Giza Egypt

Purpose: Adjuvant radiation therapy could reduce loco regional failure, but currently has no defined role because of previously reported morbidity. NCI-Cairo routine work is to give adjuvant PORT for locally advanced bladder carcinoma patients. The aim of this work is to re-evaluate this protocol regarding its effect on prognosis and complications. Patients and Method: A retrospective study included 208 patients with pathologically proven bladder cancer who presented to the NCI, Cairo University from 2007-2011. All of them underwent RC with bilateral PLND followed by conventional post-operative radiotherapy in 2 - 6 weeks after surgery for 5000 cGy in 25 fractions, over 5 weeks using 2D technique. Analysis of data from their files was done for the treatment results, prognostic factors and complications. Results: Three years overall survival (OS) and disease free survival (DFS) for the whole group was ~60%, and 54% respectively in favour of the female gender, non-smokers, Squamous cell carcinoma patients, low grade tumours (grade 1 and 2) negative margins, N0, pT2b and early stage group showed the best prognoses. The 3 years metastases free survival (MFS) was ~71%. Only four factors showed a significant relation with the MFS which were the grade, LN status, T-stage and group staging. The local recurrence rate (LRC) at 2 years for the whole group was ~95% and 94% at 3 years. Only surgical margin status and extent of LN dissection had a significant impact on the LRC. Conclusions: Adjuvant radiotherapy shows sustained improvement in the loco regional control, and should be recommended for patients with locally advanced disease especially those with less than 10 dissected lymph nodes and those with positive margins.

关键词： Bladder Cancer Radiotherapy Pelvic Irradiation

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Salt response of the freshwater microalga Scenedesmus obliquus(Turp.)Kutz is modulated by the algal growth phase

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Journal of Oceanology and Limnology 2020年第3期38卷 802-815页

作者： Taha Mohamed el-KATONY magda Faiz el-ADL Department of Botany and Microbiology Faculty of ScienceDamietta UniversityNew Damietta City 34517Egypt

Growth and biochemical responses of the coenobial green alga Scenedesmus obliquus to salinity stress were monitored across different phases of *** alga was cultured on BG11 growth medium and subjected to 0,30,100,and 200 mmol/L NaCl for a period of 20 d,during which algal cultures were harvested at 4-d *** salinity-induced inhibition of algal growth was accompanied with prolongation of timing of the different growth *** sharp and progressive salinity-induced inhibition of algal growth rate during the early phase of growth points to salt shock but moderation of inhibition at the subsequent stages of growth means algal acclimation to *** concentrations of chlorophylls a and b,soluble sugars,proteins as well as those of K+and Na+in the alga exhibited peaks at the initiation of the exponential phase of growth,with increasing magnitude in proportion to the increase in the level of ***,whereas soluble sugars of the alga peaked at initiation of the exponential phase,starch concentration progressively increased with culture age,reaching saturation towards the stationary *** the salinity-induced increase in soluble sugars was most evident at the early stages of growth the reverse was true for *** present results point to fast acclimation of *** to salt stress post a brief salt shock,utilizing soluble sugars,K+and Na+for osmotic *** salinity from 0 to 200 mmol/L NaCl led to progressive increase in soluble sugars,proteins,K+and Na+concentrations of the algal cells,particularly at the early stages of ***,the salinity-induced increase in chlorophyll concentration approached a limit at 100 mmol/L NaCl whereas that in starch concentration was more evident at the later stages of growth.

关键词： carbohydrates growth phase minerals protein salt stress Scenedesmus obliquus

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Proposal for a cross layer scheme for real-time wireless video

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第10期7卷 1690-1694页

作者： JEYARAJ Arulsaravana CHENG Liang el ZARKI magda EECS Department the Henry Samueli School of Engineering University of California Irvine CA-92697 USA NVIDIA Corporation Santa Clara California CA-95050 USA CS Department DonaM Bren School of lnformation ＆ Computer Sciences University of California Irvine CA-92697 USA

This paper focuses on the design of the cross layer between the video application layer and the MIMO physical layer. MIMO physical layer research has promised an enormous increase in the capacity of wireless communication systems. Also MIMO wireless systems operate under fading conditions where the channel faces arbitrary fluctuations. Since the wireless channel changes over each coherence period, the capacity of the wireless channel, given the power constraints, changes. Hence to make efficient use of the available capacity one needs to adapt the video bit rate. However it is impossible to adapt at the application layer as changing the parameters of the video takes more time than the coherence period of the channel. In this paper we address this problem through a novel solution and also investigate its performance through a simulation study.

关键词： MIMO V-BLAST Adaptive modulation Diversity Constant bit rate (CBR) Cross layer design Power control Fine granular scalability (FGS)

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In vitro efficacy of new synthetic benzimidazole-related compounds against Schistosoma mansoni adult worms

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Asian Pacific Journal of Tropical Medicine 2020年第12期13卷 566-572页

作者： Amira Taman Samia el-Bardicy Menerva Tadros magda Ayoub Basem Mansour Fouad el-Shehabi Samar Nel-Beshbishi Department of Medical Parasitology Faculty of MedicineMansoura UniversityMansoura 35516Egypt Department of Medical Malacology Theodor Bilharz Research InstituteImbabaCairoEgypt Department of Pharmaceutical Chemistry Faculty of PharmacyDelta University for Science and TechnologyGamasa CityMansouraEgypt Department of Biological Sciences and Biotechnology Faculty of ScienceThe Hashemite UniversityZarqa 13115Jordan

Objective:To evaluate the in vitro antischistosomal activity of two new synthetic benzimidazole-related compounds:NBTP-OH and ***:Schistosoma adult worms were recovered from mice infected with Schistosoma mansoni cercaria,washed and then incubated in the culture media with different concentrations of compounds NBTP-OH and NBTP-F up to 72 *** electron microscopy was conducted to report morphological ***:Incubation of adult Schistosoma mansoni with 10 μg/mL of NBTP-OH for 48 h killed 81.25% of *** calculated LC50and LC90 72 h post-incubation were 6.8 μg/mL and 9.8 μg/mL,*** of worms to 10 μg/mL of NBTP-F killed89.5% of worms after 48 h,mostly males(83.3%),the LC50 and LC90 after 72 h of incubation were 4.8 μg/mL and 6.9 μg/mL,*** incubated for 72 h with these compounds revealed swelling and deformity of oral sucker,disorganization and erosion of the tegument when examined with scanning electron ***:NBTP-OH and NBTP-F possess in vitro antischistosomal activities;however,in vivo studies should be conducted to examine their antischistosomal effects..

关键词： Schistosoma synthetic swelling

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Preservability of rabbit semen after chilled storage in tris based extender enriched with different concentrations of Propolis ethanolic extract (PEE)

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Asian pacific Journal of Reproduction 2017年第2期6卷 68-76页

作者： Islam el-Sayed el-Seadawy Walid Said el-Nattat magda Mohamed el-Tohamy Samy Ali Hussein Aziza Yakot Abdelfattah el-Senosy Ahmed Said Hussein Animal Reproduction and A I Dept.Veterinary Research DivisionNational Research CentreGizaEgypt Biochemistry and Clinical Biochemistry Dept. Faculty of Veterinary MedicineBenha UniversityEgypt Food Industry Dept Food Industry and Nutrition Research DivisionNational Research CenterGizaEgypt

Objective:To maintain semen quality of male rabbits during chilled storage by enrichment the tris based diluent with different concentrations of propolis ethanolic ***: Total phenolic and total flavonoid contents, as well as antioxidant activity was determined in propolis ethanolic extract (PEE). The extract was analysed by HPLC for separation and identification of target metabolites. Semen was collected from 10 rabbit bucks, pooled, then divided into five aliquots (each of 500 μL) and diluted each in 5 mL Tris-citric acid-glucose-egg yolk extender (TCGY). The 1st aliquot served as control while PEE was added at concentration of 0.8, 1.2, 1.6 and 2.0 mg/5 mL tris extender in the aliquot 2, 3, 4 and 5 respectively. Diluted semen samples were subjected to cooling at 4℃ for 72 h. Sperm motility, sperm viability, sperm abnormality, sperm membrane integrity and acrosome integrity were evaluated in chilled semen allover the chilling ***:The resluts revealed presence of a considerable amount of total phenolic compounds (98.67 mg GAE/g extract) and total flavonoids (70.16 mg CE/g extract) which were parallel to an antioxidant activity assessed as ABTS, DPPH and FRAP (198.65, 180.18 and 306.17 mM TE/g extract respectively). The dominant phenolic acid was chlorogenic acids (3.959 mg/g extract). Other compounds were found in less amounts rosmarinic acid (3.959 mg/g extract), myrcetin (1.946 mg/g extract), kaempferol (1.089 mg/g extract) and apeginin-7-glucoside (1.113 mg/g extract). Obtained results clearly demonstrated that the addition of (1.2-1.6) mg PEE in the chilled extended rabbit semen proved to be beneficial for maintaining semen characteristics compared to control and the addition of 0.8 and 2 mg ***: The enrichment of rabbit semen tris-basic extender with (1.2-1.6) mg PEE/5 mL tris-extender (as the best and safe concentrations) maintain the sperm characteristics in good condition all over 72 h of chilling.

关键词： Male rabbits Semen extender Propolis extract Antioxidants HPLC

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Effect of Molybdate Ions on the Corrosion Behaviour of Ti Alloys

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Journal of Materials Science & Technology 2000年第1期16卷 45-49页

作者： magda.M.A.Gad, Kamal.E.Mohamed and Abdelwahab A.el-Sayed (Metallurgy Dept., Materials Division, Atomic Energy Authority, Cairo, Egypt) Metallurgy Dept. Materials Division Atomic Energy Authority Cairo Egypt

Titanium alloys are extensively used in power, chemical and petroleum industries as constructional materials for vessels and heat transfer tubes. Moreover they are candidate materials for nuclear waste disposal. These alloys have superior resistance to localized forms of corrosion compared to stainless steels and Ni-base alloys. However, this resistance is not as remarkable in crevice corrosion conditions in some aggressive media. electrochemical corrosion tests were conducted on two ASTM Ti grades namely, Ti-2 and Ti-12 in extremely low pH acidic environment. Results indicated that Ti-2 has less resistance to both general and crevice corrosion attack than Ti-12. Both alloys possess better resistance to general corrosion than to crevice corrosion. Also, results showed that the molybdate addition improves remarkably the resistance of Ti-2 to both types of attack. The increase of molybdate ions concentration from 0.03 mol/L to 0.15 mol/L made Ti-2 to be as resistant as, or somewhat higher than, Ti-12. The elecrochemical findings were further supplemented by optical examination of the corroded surface.

关键词： Ti Mo Effect of Molybdate Ions on the Corrosion Behaviour of Ti Alloys

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Fast photocurable thiol-ene elastomers with tunable biodegradability,mechanical and surface properties enhance myoblast differentiation and contractile function

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Bioactive Materials 2021年第7期6卷 2120-2133页

作者： Mohamed Alaa Mohamed Aref Shahini Nika Rajabian Julia Caserto Ahmed M.A.el-Sokkary magda A.Akl Stelios T.Andreadis Chong Cheng Department of Chemical and Biological Engineering University at BuffaloThe State University of New YorkBuffaloNY14260USA Chemistry Department College of ScienceMansoura UniversityMansoura35516Egypt Department of Biomedical Engineering University at BuffaloThe State University of New YorkBuffaloNY14260USA Center of Excellence in Bioinformatics and Life Sciences BuffaloNY14263USA

Biodegradable elastomers are important emerging biomaterials for biomedical applications,particularly in the area of soft-tissue engineering in which scaffolds need to match the physicochemical properties of native ***,we report novel fast photocurable elastomers with readily tunable mechanical properties,surface wettability,and *** elastomers are prepared by a 5-min UV-irradiation of thiol-ene reaction systems of glycerol tripentenoate(GTP;a triene)or the combination of GTP and 4-pentenyl 4-pentenoate(PP;a diene)with a carefully chosen series of di-or *** the subsequent application study,these elastomers were found to be capable of overcoming delamination of myotubes,a technical bottleneck limiting the in vitro growth of mature functional *** glycerol-based elastomers supported the proliferation of mouse and human myoblasts,as well as myogenic differentiation into contractile *** notably,while beating mouse myotubes detached from conventional tissue culture plates,they remain adherent on the elastomer *** results suggest that these elastomers as novel biomaterials may provide a promising platform for engineering functional soft tissues with potential applications in regenerative medicine or pharmacological testing.

关键词： Biodegradable elastomers Cell culture substrate Skeletal muscle regeneration Thiol-ene synthesis Tissue engineering

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Clinico-pathological study and treatment results of 1009 operable breast cancer cases:Experience of NCI Cairo University,Egypt

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The Chinese-German Journal of Clinical Oncology 2010年第7期9卷 409-415页

作者： magda el Mongy Hesham el Hossieny Farouk Haggag Rania Fathy Department of Radiation Oncology National Cancer InstituteCairo University Department of Clinical Oncology Kasr El-Aini Centre Cairo University

Objective： This retrospective study was designed to evaluate ciinico-pathological data including stage, results of treatment, and prognostic factors which affect the overall survival ＆ disease free survival. Methods： This was a retrospective study carried out at the Radiotherapy Department, National Cancer Institute, Cairo University, Egypt on 1009 patients treated for primary breast cancer between 1999-2003. Results： The median follow-up was 68 months. Loco regional relapse occurred in 23 patients （2.3%） and distant relapse occurred in 203 patients （20.1%）. Both Ioco regional and distant relapse were reported in 32 patients （3.2%）. The disease free survival （DFS） at 3 and 5 years were 87% and 78% respectively, while OAS at 3 and 5 years were 96.4% and 91.4% respectively. Multivariate analysis of different prognostic factors showed that the independent bad prognostic factors in the study for disease relapse were positive lymph nodes （LNs, more than 10）, tumor size T3, T4 with significance of 0.0001 for each, and pathologic grade with significance of 0.003. Conclusion： The most important independent bad prognostic factors for relapse are positive LNs more than 10, tumor size T3, T4 and pathologic grade. The timing of radiotherapy affects the disease free survival significantly also it is recommended to analyze the group of patients with LNs negative using well designed randomized trials.

关键词： Clinico-pathological study breast cancer retrospective

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Plastic Deformation Evaluation of 6201 Alloy by Using Positron Annihilation Lifetime Technique

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材料科学与工程（中英文A版） 2013年第1期3卷 14-21页

作者： Amira.Nassar magda Abd el-Wahab Eman Abd el Hamid Zeinab Yousef Metal Physics Lab. Solid State Physics Department National Research Center Dokki Cairo P.O. 1231 I Egypt Physics Department Faculty of Women for Arts Science and Education A in Shams University Heliopolis Cairo 1175 7 Egypt

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Natural radioactivity levels and radiation hazards for gypsum materials used in Egypt

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Natural Science 2014年第1期6卷 5-13页

作者： Ahmed Hassan Korna Soad Saad Fares magda Abd el-Rahman Department of Physics Faculty of Science Al Baha University Al Bahah KSA Department of Radiation Physics National Center of Radiation Research and Technology NCRRT Atomic Energy Authority Cairo Egypt

Radionuclides naturally occurring in building materials may significantly contribute to the annual doses to the public. For instance, familiar building materials such as the concrete and gypsum board have been reported to produce a dose of about 0.04 mSv per year for a typical person (NCRP 1987c). External as well as internal exposures are two pathways of radiation dose imparted to human beings from the building materials. As information on the radioactivity of such materials is lacking, the study of gypsum materials used in Egypt was carried out in order to estimate the annual dose to the Egyptian population due to natural radionuclides in building materials. During the study, 18 samples of commonly used gypsum raw materials were collected and measured. The activity concentrations were determined by gamma ray spectrometry. Their mean values were in the ranges of 499.29 ± 11.53 Bq·kg-1 for 40K, 91.97 ± 2.61 Bq·kg-1 for 226Ra, 37.62 ± 1.67 Bq·kg-1 for 238U and 42.27 ± 2.22 Bq·kg-1 for 232Th. The activity indexed Iγ for 18, different gypsum samples varied from 0.31 ± 0.03 to 2.3 ± 0.19 and the radium equivalent activity (Raeq), from 38.81 ± 1.68 to 324.7 ± 9.42. These values are lower than the limit of 370 Bq·kg-1 adopted by the Organization for Economic Cooperation and Development (OECD). The average indoor annual effective gamma dose rate (DE) in (mSv/y) for the people, caused by the building materials of dwellings, was assessed for most commonly gypsum materials. It was estimated to be in the range from 0.10 ± 0.003 mSv/y to 0.74 ± 0.08 mSv/y. The internal and external hazard indices (Hin, Hex) and the absorbed dose rate in air D in each sample were evaluated to assess the radiation hazard for people living in dwelling made of the studied materials. The absorbed dose rate of indoor air in samples G1, G2, G11, G17 and G18 is less than the international recommended value which is 55 nGyh-1. While the absorbed dose rate for samples G3, G4, G5, G6, G7, G8, G9, G10, G12

关键词： Gypsum Gamma Spectrometer Hazard Indices NORM Building Materials

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