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The Chinese-German Journal of Clinical Oncology 2010年第7期9卷 409-415页

作者： magda El Mongy Hesham El Hossieny Farouk Haggag Rania Fathy Department of Radiation Oncology National Cancer InstituteCairo University Department of Clinical Oncology Kasr El-Aini Centre Cairo University

Objective： This retrospective study was designed to evaluate ciinico-pathological data including stage, results of treatment, and prognostic factors which affect the overall survival ＆ disease free survival. Methods： This was a retrospective study carried out at the Radiotherapy Department, National Cancer Institute, Cairo University, Egypt on 1009 patients treated for primary breast cancer between 1999-2003. Results： The median follow-up was 68 months. Loco regional relapse occurred in 23 patients （2.3%） and distant relapse occurred in 203 patients （20.1%）. Both Ioco regional and distant relapse were reported in 32 patients （3.2%）. The disease free survival （DFS） at 3 and 5 years were 87% and 78% respectively, while OAS at 3 and 5 years were 96.4% and 91.4% respectively. Multivariate analysis of different prognostic factors showed that the independent bad prognostic factors in the study for disease relapse were positive lymph nodes （LNs, more than 10）, tumor size T3, T4 with significance of 0.0001 for each, and pathologic grade with significance of 0.003. Conclusion： The most important independent bad prognostic factors for relapse are positive LNs more than 10, tumor size T3, T4 and pathologic grade. The timing of radiotherapy affects the disease free survival significantly also it is recommended to analyze the group of patients with LNs negative using well designed randomized trials.

关键词： Clinico-pathological study breast cancer retrospective

Preservability of rabbit semen after chilled storage in tris based extender enriched with different concentrations of Propolis ethanolic extract (PEE)

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Asian pacific Journal of Reproduction 2017年第2期6卷 68-76页

作者： Islam El-Sayed El-Seadawy Walid Said El-Nattat magda Mohamed El-Tohamy Samy Ali Hussein Aziza Yakot Abdelfattah El-Senosy Ahmed Said Hussein Animal Reproduction and A I Dept.Veterinary Research DivisionNational Research CentreGizaEgypt Biochemistry and Clinical Biochemistry Dept. Faculty of Veterinary MedicineBenha UniversityEgypt Food Industry Dept Food Industry and Nutrition Research DivisionNational Research CenterGizaEgypt

Objective:To maintain semen quality of male rabbits during chilled storage by enrichment the tris based diluent with different concentrations of propolis ethanolic ***: Total phenolic and total flavonoid contents, as well as antioxidant activity was determined in propolis ethanolic extract (PEE). The extract was analysed by HPLC for separation and identification of target metabolites. Semen was collected from 10 rabbit bucks, pooled, then divided into five aliquots (each of 500 μL) and diluted each in 5 mL Tris-citric acid-glucose-egg yolk extender (TCGY). The 1st aliquot served as control while PEE was added at concentration of 0.8, 1.2, 1.6 and 2.0 mg/5 mL tris extender in the aliquot 2, 3, 4 and 5 respectively. Diluted semen samples were subjected to cooling at 4℃ for 72 h. Sperm motility, sperm viability, sperm abnormality, sperm membrane integrity and acrosome integrity were evaluated in chilled semen allover the chilling ***:The resluts revealed presence of a considerable amount of total phenolic compounds (98.67 mg GAE/g extract) and total flavonoids (70.16 mg CE/g extract) which were parallel to an antioxidant activity assessed as ABTS, DPPH and FRAP (198.65, 180.18 and 306.17 mM TE/g extract respectively). The dominant phenolic acid was chlorogenic acids (3.959 mg/g extract). Other compounds were found in less amounts rosmarinic acid (3.959 mg/g extract), myrcetin (1.946 mg/g extract), kaempferol (1.089 mg/g extract) and apeginin-7-glucoside (1.113 mg/g extract). Obtained results clearly demonstrated that the addition of (1.2-1.6) mg PEE in the chilled extended rabbit semen proved to be beneficial for maintaining semen characteristics compared to control and the addition of 0.8 and 2 mg ***: The enrichment of rabbit semen tris-basic extender with (1.2-1.6) mg PEE/5 mL tris-extender (as the best and safe concentrations) maintain the sperm characteristics in good condition all over 72 h of chilling.

关键词： Male rabbits Semen extender Propolis extract Antioxidants HPLC

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大自然的色彩昆虫和花朵微距摄影

北方人 2019年第12期 2-2,65页

作者： magda Wasiczek 不详

Promising Additives to Protect the Activity of Baculovirus Biocontrol Agent under Field-Sunlight Conditions in Egypt

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Journal of Life Sciences 2013年第5期7卷 495-500页

作者： Alexandra EI-Helaly magda Khattab Said EI-Salamouny Mohammed El-Sheikh Salah Elnagar Department of Economic Entomology and Pesticides Faculty of Agriculture Cairo University Cairo Egypt Cutworm and Mole Cricket Plant Protection Research Institute Agriculture Research Center Giza Egypt

Baculoviruses are effective biocontrol agents except of their short persistence under sunlight conditions. Four promising additives containing different groups of antioxidants were tested on cotton plant foliage. Spodoptera littoralis test insect and its nuclepolyhedrovirus （SpliNPV） are the standard material used in the investigation. Results are based on leaf-bioassays, to test Original Activity Remaining （OAR） and Lethal Infectivity Time to 50% （LIT50）of tested population of the virus after exposure to natural sunlight. The results showed that cacao additive at 10%, sustained 50% of virus activity for five days post application （113.11 hours） and three days and a half （83.33 hours） at 5% concentration. The virus alone treatment sustained 50% of its activity for only 24.07 hours. The obtained results suggested the possibility of prolonging the virus activity on plant foliage under field applications.

关键词： Antioxidants baculovirus activity field-biocontrol application Spodoptera littoralis NPV virus protection.

Revisiting the X-Chromosome Inactivation and Its Impact on Female Longevity

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Advances in Bioscience and Biotechnology 2014年第6期5卷 572-583页

作者： Lilian Chuaire-Noack magda Carolina Sánchez-Corredor María Martínez-Agüero Facultad de Ciencias Naturales y Matemáticas Universidad del Rosario Bogotá Colombia

X-chromosome inactivation is the genetic mechanism by which X-linked gene expression is equalized between the male and female genders of all placental mammal species. Given that the probability of mutant X-linked allele expression decreases as a result of the inactivation, it has been proposed that females have biological advantages relative to males. These advantages have grabbed the attention of the scientific community in recent years and have focused it on this topic and its clinical implications. To shed some new light on this intriguing phenomenon, this article reviews the most relevant molecular events involved in this process. These events include the role of Xist, the selection mechanism for future X-chromosome inactivation, the age-related inactivation skewing, and the relationship between inactivation and the emergence of X-linked diseases, possible treatments, and longevity.

关键词： Sex Chromosomes Epigenetic Inheritance Heterochromatin DNA Methylation Gene Therapy

The Fabrication Method and Tribological Properties of Co-TiC Sintered High-Temperature Alloy

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The Fabrication Method and Tribological Properties of Co-TiC...

Systemic Inflammation Response Index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PANTHEIA-SEOM trial

作者： Oleksandr Tisov Alina Yurchuk magda Wlaz?o-?wiklińska School of Aerospace Engineering Xi'an Jiaotong University

Turbine blades of aircraft gas-turbine engines were always the place to apply novel materials and *** attention was paid to strength,corrosion-oxidation,and tribological *** blade top-shrouds are one of the most vulnerable places from the point of wear *** problem was usually solved by applying coatings(weld-deposition,electrospark coating,gas-spray coatings).The new method proposed here is to use soldering technology:the to-size plate manufactured of wear-resistant material is bonded to the friction surface by the solder with the composition close to the composition of the turbine *** this work,we propose the method and the material for improving the wear resistance of the turbine blade’s top *** cobalt-based materials(Co-15Cr-2.5Fe-2.5Al-36TiC) seem very promising for *** the present work,the manufacturing technology of the alloy by HIP method,microstructure,and high-temperature fretting-wear characteristics(1050℃) are discussed.

关键词： Heat Resistant Alloy High-Temperature Fretting Wear Hot Isostatic Pressing Turbine Blades

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 386-397页

作者： Vilma Pacheco-Barcia Sara Custodio-Cabello Fatima Carrasco-Valero magda Palka-Kotlowska Axel Mariño-Mendez Alberto Carmona-Bayonas Javier Gallego A J Muñoz Martín Paula Jimenez-Fonseca Luis Cabezon-Gutierrez Department of Medical Oncology Hospital Universitario de TorrejonMadrid 28850Spain Department of Internal Medicine Hospital Universitario de TorrejonMadrid 28850Spain Department of Medical Oncology Hospital Universitario Central de AsturiasOviedo 33011Spain Department of Medical Oncology Hospital Universitario Morales MeseguerUniversity of MurciaMurcia 30001Spain Department of Medical Oncology Hospital General Universitario de ElcheElche 03202Spain Department of Medical Oncology Hospital General Universitario Gregorio MarañónUniversidad Complutense MadridMadrid 28007Spain Universidad Francisco de Vitoria Madrid 28223Spain

BACKGROUND The prognostic value of the Systemic Inflammation Response Index(SIRI)in advanced pancreatic cancer is recognized,but its correlation with patients´nutritional status and outcomes remains *** To study the prognostic significance of SIRI and weight loss in metastatic pancreatic *** The PANTHEIA-Spanish Society of Medical Oncology(SEOM)study is a multicentric(16 Spanish hospitals),observational,longitudinal,non-interventional initiative,promoted by the SEOM Real World-Evidence work *** pilot study sought to analyze the association between weight loss and inflammatory status as defined by *** cohort stems from a proof-of-concept pilot study conducted at one of the coordinating *** with pathologically confirmed metastatic pancreatic adenocarcinoma,treated from January 2020 to January 2023,were *** index was calculated using the product of neutrophil and monocyte counts,divided by lymphocyte counts,obtained within 15 days before initiation *** study evaluated associations between overall survival(OS),SIRI and weight *** A total of 50 patients were included.66%of these patients were male and the median age was 66 *** sites:36%liver,12%peritoneal carcinomatosis,10%lung,and 42%multiple *** the first line palliative chemotherapy treatments:50%received gemcitabine plus nab-paclitaxel;28%,modified fluorouracil,leucovorin,irinotecan and oxaliplatin,and 16%were administered gemcitabine.42%had a weight loss>5%in the three months(mo)preceding diagnosis.21 patients with a SIRI≥2.3×10^(3)/L exhibited a trend towards a lower median OS compared to those with a SIRI5%weight loss before diagnosis,the median OS was 6 mo,in contrast to 19 mo for those who did not experience such weight loss(P=0.003).Patients with a weight loss>5%showed higher SIRI *** difference was statistically significant(P<0.000).For pat

关键词： Pancreatic cancer Nutrition Prognostic factor Inflammation Advanced cancer Systemic inflammatory response index Weight loss

Involvement of Autoimmune Diseases in the Pathogenesis of Chronic Immune Thrombocytopenic Purpura

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Journal of Biomedical Science and Engineering 2015年第3期8卷 142-148页

作者： Madalina Mocanu magda Badescu Manuela Ciocoiu Codruta Badescu Cristina Elena Iancu Oana Badulescu Department of Pathophysiology “Grigore T.Popa”University of Medicine and PharmacyIasiRomania Department of Internal Medicine “Grigore T.Popa”University of Medicine and PharmacyIasiRomania Deparment of Pharmaceutical Science Ⅱ “Grigore T.Popa”University of Medicine and PharmacyIasiRomania

Chronic immune thrombocytopenic purpura (ITP) is a condition based on an immune-mediated mechanism that determines the premature hyperdestruction of the thrombocytes in peripheral blood, as well as their deficient synthesis at the level of the bone marrow. The chronic immune purpura could be of primary, idiopathic cause, as well as of secondary cause, occurring in the context of other pathologies. The characteristic of the primary form of the disease is the presence of isolated thrombocytopenia, defined by a platelet count under 100,000/mm3 in peripheral blood, in the absence of supporting causes for thrombocytopenia. In the secondary form of the disease, the decreased platelet count is due to associated pathologies involving an immune mechanism, responsible for the occurrence of thrombocytopenia. This study aims to emphasize the involvement of autoimmune diseases, such as systemic lupus erythematosus (SLE), dermatomyositis, rheumatoid polyarthritis or antiphospholipid syndrome in the pathogenesis of secondary thrombocytopenia. Furthermore, the study was conducted on a sample of 40 patients, divided into two groups: The first group comprising asymptomatic patients diagnosed with thrombocytopenia following routine tests, and the second group comprising patients with hemorrhagiparous symptomatology (petechiae, ecchymoses, epistaxis, gingivorrhagia), who went to the doctor in order to determine the etiology of the hemorrhagiparous syndrome. The average value of the thrombocytopenia of the patients included in the study was of 60.20 ± 19.75 × 103/μL. Laboratory investigations performed in order to establish the etiology of thrombocytopenia showed that 80% of patients presented positive antiplatelet antibodies. Moreover, 20% of the patients in the study showed positive anti-double-stranded DNA, 20% were identified with IgG anticardiolipin antibodies, while antinuclear antibodies were present in 10% of the patients.

关键词： Thrombocytopenic Purpura Antiplatelet Antibodies Systemic Lupus Erythematosus Antiphospholipid Syndrome

Anti-inflammatory effects ofα-humulene andβ-caryophyllene on pterygium fibroblasts

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 1903-1907页

作者： magda Massae Hata Viveiros Márcia Guimarães Silva JoséGalberto Martins da Costa Anselmo Gomes de Oliveira Carolina Rubio Carlos Roberto Padovani Cláudia Aparecida Rainho Silvana Artioli Schellini Department of Ophthalmology School of Medicine of BotucatuSão Paulo State University–UNESPBotucatuSao Paulo 18618-000Brazil Department of Pathology School of Medicine of BotucatuSão Paulo State University–UNESPBotucatuSao Paulo 01049-010Brazil Department of Biological Chemistry Regional University of CaririCratoCeará66100-900Brazil Department of Pharmacology School of Pharmaceutical SciencesSão Paulo State University–UNESPAraraquaraSao Paulo 01049-010Brazil Biological Sciences Institute of Biosciences of BotucatuSão Paulo State University–UNESPBotucatuSao Paulo 01049-010Brazil Department of Biostatistics São Paulo State University–UNESPBotucatuSao Paulo 01049-010Brazil

AIM:To investigate the anti-inflammatory effects of the sesquiterpenesα-humulene andβ-caryophyllene on pterygium ***:Primary cultures of pterygium fibroblasts were *** passage pterygium fibroblasts were exposed toα-humulene andβ-caryophyllene separately and *** cell viability was assessed by 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide(MTT)assay at 12,24,48,and 72h after *** levels of the inflammatory cytokines interleukin(IL)-1β,IL-6,IL-8,tumor necrosis factor(TNF)-αand IL-10 in the conditioned culture medium were assessed by enzymelinked immunosorbent assay(ELISA)at 12,24 and 48h after *** were statistically analyzed using Friedman repeated measures analysis of variances on ***:The 25μmol/Lβ-caryophyllene induced significant decrease in the IL-6 production by pterygium fibroblasts 48h after the exposure(P=0.041).The levels of IL-1β,IL-8,IL-10,and TNF-αwere very low and had no statistically significant variations af ter exposure toα-humulene,β-caryophyllene,or both compounds ***:The exposure to 25μmol/L ofβ-caryophyllene significantly reduce the production of IL-6 by pterygium fibroblasts after *** sesquiterpene may be a potential alternative adjuvant agent for the treatment of pterygium.

关键词： pterygium fibroblasts β-caryophyllene α-humulene cytokines

Plastic Deformation Evaluation of 6201 Alloy by Using Positron Annihilation Lifetime Technique

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材料科学与工程（中英文A版） 2013年第1期3卷 14-21页

作者： Amira.Nassar magda Abd El-Wahab Eman Abd EL Hamid Zeinab Yousef Metal Physics Lab. Solid State Physics Department National Research Center Dokki Cairo P.O. 1231 I Egypt Physics Department Faculty of Women for Arts Science and Education A in Shams University Heliopolis Cairo 1175 7 Egypt