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Energy and Built Environment 2024年第2期5卷 194-210页

作者： Patrick Facelli Sanchez Lisset mercado Hancco Department of Civil Engineering Faculty of Architecture and Civil EngineeringUniversidad Nacional de San Antonio Abad del Cusco08003 CuscoPeru

The Trombe wall is a passive indirect heating system which should be used in Cusco,Peru to improve thermal conditions against the typical frosts and low temperatures during winter in the high Andean *** to this problem,the use of a modified Trombe wall with insertion of porous medium is proposed to improve thermal comfort in flat buildings in *** research aims to analyse and compare the performance of dwellings without Trombe wall,with traditional Trombe wall,and with Trombe wall with glass and plastic pellets insertion in thermal comfort ***■CFD was used to simulate and analyse the *** simulation was performed with three prototype flats(55 m^(2),75 m^(2) and 95 m^(2))for six months of the *** the results obtained,the level of thermal comfort in the traditional scenarios is low with an average PMV of-1.86,in the scenarios with Trombe wall is good and in the scenarios with Trombe wall with insertion of porous medium is slightly better than the previous one,reaching an average PMV of+0.10 and a temperature of 21.90℃.The study carried out is important because it represents an efficient eco-sustainable heating alternative that improves the thermal comfort sensation in houses during the coldest months of the year.

关键词： Trombe wall thermal comfort porous medium residential buildings computational fluid dynamics

Diet variability of snappers(Teleostei:Lutjanidae)in a bay-to-reef ecosystem of the Mexican Caribbean

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Water Biology and Security 2024年第1期3卷 53-59页

作者： Leon Felipe Martínez-Juarez Juan J.Schmitter-Soto Nancy Cabanillas-Teran Norman mercado-Silva El Colegio de la Frontera Sur 77014ChetumalQuintana RooMexico Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de Morelos62209CuernavacaMorelosMexico

Fishes use environmental resources *** ontogenic movements among coastal habitats lead to diverse *** investigated the diets of seven snapper species(Lutjanus apodus,***,***,***,***,***,and Ocyurus chrysurus)in three interconnected coastal environments in the western Caribbean:Río Huach channel,Chetumal/Corozal bay,and the adjacent Xcalak reef *** three encompass all habitats used by the seven species in the study *** diets were mostly composed of fish and crustaceans,but dominance of either group varied among the studied habitats;for example,fish were the main prey for *** from the reef lagoon zone,but second in the *** are piscivorous-invertivorous mesopredators;the species that relied the most on fishes were *** and ***,whereas *** preferred *** content results revealed a high degree of dietary overlap among *** findings suggested a tradeoff in relative weight between fish and crustaceans as the main food source of snappers at these connected areas,supporting the hypothesis of niche *** results can be used as a baseline to further our understanding of the ecology and differences in resource use by snapper species in an area undergoing important anthropogenic changes.

关键词： Resource partitioning Chetumal/Corozal bay Quintana Roo Trophic ecology

Periodontal disease:A silent factor in the development and progression of diabetic retinopathy

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World Journal of Diabetes 2024年第8期15卷 1672-1676页

作者： Sarah Monserrat LomelíMartínez Irán Cortés Trujillo Melissa Martínez Nieto Ana Esther mercado González Department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Master of Public Health Department of Wellbeing and SustainableCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico Periodontics Program Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Antiguo Hospital Civil de Guadalajara“Fray Antonio Alcalde” Guadalajara 44280Mexico

The global increase in the prevalence of type 2 diabetes mellitus(T2DM)and its complications presents significant challenges to public ***,periodontal disease(PD)was recognized as a factor that is likely to influence the progression of T2DM and its complications due to its potential to exacerbate systemic inflammation and oxidative *** this editorial,we comment on the article published by Thazhe Poyil et al in the very recent issue of the World Journal of Diabetes in 2024,which investigated the correlation between PD and diabetic retinopathy(DR)in T2DM patients,with emphasis on the association between periodontal swollen surface area,glycated hemoglobin(HbA1c),interleukin-6(IL-6),and lipoprotein(a).The findings by Thazhe Poyil et al are significant as they demonstrate a strong link between PD and DR in T2DM *** correlation highlights the importance of addressing periodontal health in diabetes management to potentially reduce the risk and severity of DR,a complication of *** integration of periodontal evaluation and treatment into diabetes care protocols may lead to improved glycemic control and better overall outcomes for T2DM patients.A few studies have established an interconnection between PD and diabetic complication,specifically DR,in T2DM patients,which we aim to highlight in this *** was placed on the different mechanisms that suggest a bidirectional relationship between PD and T2DM,where the presence of periodontal inflammation negatively influenced glycemic control and contributed to the development and progression of DR through shared inflammatory and vascular *** article highlights the importance of collaboration amongst diabetes specialists,ophthalmologists,periodontists,and public health professionals to advance the prevention,early detection,and treatment of PD and *** will improve the health and quality of life of T2DM ***,the editorial highlights the need for further re

关键词： Type 2 diabetes mellitus Periodontal disease Periodontitis Diabetic retinopathy Editorial

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客车制造企业供应链JIT优化策略研究

中小企业管理与科技 2024年第3期 103-105页

作者：张浩 Cecilia mercado 圣路易斯大学菲律宾碧瑶2600 广安职业技术学院四川广安638500

随着市场经济的发展,客车制造企业面临日益激烈的市场竞争和客户需求变化,供应链管理成为其核心竞争力提升的关键。论文旨在探讨和优化客车制造企业中供应链管理中的JIT(即时生产)运作策略,确保企业生产效率和响应速度的同步提升。论文... 详细信息

随着市场经济的发展,客车制造企业面临日益激烈的市场竞争和客户需求变化,供应链管理成为其核心竞争力提升的关键。论文旨在探讨和优化客车制造企业中供应链管理中的JIT(即时生产)运作策略,确保企业生产效率和响应速度的同步提升。论文通过数据分析和现场问题调研,确定了影响企业供应链JIT运作的关键因素,并在此基础上构建了一套完整的优化策略框架。研究结果表明,通过优化原材料采购、生产流程、库存控制及物流配送等环节,显著提高了整个供应链的效率和灵活性。论文提出的JIT优化措施可为同行业内其他企业提供借鉴,具有良好的理论价值与实际应用意义。

关键词：客车制造供应链管理即时生产(JIT) 优化策略效率提升

Wernicke-Korsakoff Syndrome From Hyperemesis Gravidarum

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Maternal-Fetal Medicine 2024年第1期6卷 54-56页

作者： Vaishnavi Jagat Patel Jennifer Vu Gisela mercado Sreenivas Avula Shad Deering University of the Incarnate Word School of Osteopathic Medicine San AntonioTX 78235USA Department of Pediatrics Children’s Hospital of San AntonioSan AntonioTX 78207USA Baylor College of Medicine HoustonTX 77030USA Department of Radiology Children’s Hospital of San AntonioSan AntonioTX 78207USA Department of Radiology Baylor College of MedicineHoustonTX 77030USA Department of OB/GYN Children’s Hospital of San AntonioSan AntonioTX 78207USA Department of OB/GYN Baylor College of MedicineHoustonTX 77030USA

To editor:Wernicke encephalopathy(WE)is an acute neurological disorder caused by a deficiency of vitamin B1(thiamine),with a prevalence of 1.3%in autopsy studies.1 Eighty-four percent of patients with WE will develop Korsakoff syndrome,which is characterized by amnesia and confusion.2 Although WE is more common in alcoholics,it can also be caused by vomiting,malnourishment,and other situations.

关键词： Hyperemesis gravidarum Wernicke's encephalopathy Pregnancy complication Wernicke-korsakoff

Empowering Rice Farmers in Nueva Ecija, Philippines: A Strategic Approach to Boosting Income through Special Purpose Rice Production

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Open Journal of Ecology 2024年第3期14卷 199-214页

作者： Armando C. Lagasca Eugenia G. Baltazar Johnah Jefferson S. mercado Randy L. Kwan Erwin M. Valiente Jerski Jarzen C. Duria University Extension Program Office Central Luzon State University Science City of Mu&#241oz Philippines Department of Agri-Management College of Agriculture Central Luzon State University Science City of Mu&#241oz Philippines Department of Social Science College of Arts and Social Sciences Central Luzon State University Science City of Mu&#241oz Philippines

Low income is the main problem of millions of farmers who are cultivating 4.81 million hectares in the Philippines. This problem is attributed to challenges specifically low yield, low quality of produce, and significant post-harvest losses, particularly in a resource-scarce setting. This study aimed to help increase the farmers’ income in selected towns of Nueva Ecija through the promotion and use of special purpose rice production technology. Twenty (20) farmer-cooperators in three towns of Nueva Ecija were selected to demonstrate the production technology covering a total area of 4.75 hectares during the dry season, and 3.3 hectares during the wet season, both in 2023. Extension modalities such as training, techno-demo establishment, information material and technical assistance provision, and market linkage were undertaken to enhance their knowledge, attitude, and skills on special rice production and enterprise. The study utilized the descriptive quantitative method wherein the data were gathered through surveys, specifically personal interviews. Results showed that 70% of the farmer-cooperators were male and 60% were living below the poverty threshold. The farmers were 53 years old on average and engaged in farming as their primary source of income. The average yield of special purpose rice particularly the CLS-2 variety was higher (6.46 MT/ha and 6.22 MT/ha during dry and wet seasons, respectively) than that of inbred or non-special rice. The income per hectare from special purpose rice production per hectare was Php 75,420.00, which is higher than that of regular rice at Php 29,389.00, giving a higher benefit of Php 46,031.00. The technology adopters and area planted increased (from 6 to 9 and from 1.4 hectares to 2.75 hectares, respectively) in Licab, Nueva Ecija. The opposite was true in Sto. Domingo and Guimba, Nueva Ecija where farmers were discouraged by the marketing issues that arose.

关键词： Special Purpose Rice Technology Promotion Extension Modality

Treasures in insect collections:the future of the bomb-radiocarbon analysis

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Insect Science 2018年第6期25卷 1128-1131页

作者： Norbert Kunert Alida mercado Cárdenas Biogeochemical Processes Max-Planck-lnsUtute for BiogeochemistryHans-Knoll-Str.10JenaGermany Chair of Silviculture Universitɑt FreiburgTennenbacherstr.4FreiburgGermany

Dear Editor, Bomb-radiocarbon analysis of modern carbon has been applied in many fields of *** method allows de- terrnining the residence time of carbon in photosynthetic products and thus aU organic matter in *** atmospheric 14C signature will soon drop below the pre- bomb level due to fixation of atmospheric carbon in ter- restrial and marine ecosystems and high rates of lac-free fossil fuel ***,the time is running out for bomb-radiocarbon *** collections shelter an immense quantity of specimens stored in *** show how those specimens can be used for exploring the trophic structure of food webs by comparing their isotopic radiocarbon signature.

关键词： ATMOSPHERIC RADIOCARBON CARBON

Gene therapy in Parkinson's disease: targeting the endplasmic reticulum proteostasis network

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Neural Regeneration Research 2015年第7期10卷 1053-1054页

作者： Valentina Castillo Gabriela mercado Claudio Hetz Biomedical Neuroscience Institute Faculty of MedicineUniversity of Chile Program of Cellular and Molecular Biology Center for Molecular Studies of the Cell Institute of Biomedical SciencesUniversity of Chile Department of Immunology and Infectious Diseases Harvard School of Public Health

Parkinson’s disease（PD）is the second most common neurodegenerative disease affecting 1%of the population over 60 years of *** progressive degeneration of dopaminergic neurons at the substantia nigra pars compacta（SNpc）results in a severe and gradual depletion of dopamine content in the striatum,a phenomena that is responsible for the characteristic motor symptoms of this disease.

关键词： gene Gene therapy in Parkinson’s disease targeting the endplasmic reticulum proteostasis network

A Novel and Functional Artificial Bruch’s Membrane Made of Poly (ε-Caprolactone)/Gelatin for Retinal Pigment Epithelium Restoration

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Advances in Bioscience and Biotechnology 2024年第8期15卷 443-461页

作者： López Edith Silva-Bermudez Phaedra Gonzalez-Salinas Roberto Velasquillo Cristina Torres-Romero Abigail López-Colomé Ana María Pérez Armando Gina Prado-Prone Edgar Ramos-Martínez Iván Ramos-Martínez Quiroz-mercado Hugo Hernández-Zimbrón Luis Fernando Instituto de Fisiologa Celular Universidad Nacional Autnoma de Mxico Ciudad de Mxico City Mxico Unidad de Ingeniería de Tejidos Terapia Celular y Medicina Regenerativa Instituto Nacional de Rehabilitación Luis Guiller-mo Ibarra Ibarra Ciudad de México México Departamento de Investigacin Asociacin Para Evitar la Ceguera Ciudad de Mxico Mxico Subdireccin de Investigacin Tecnolgica Instituto Nacional de Rehabilitacin Luis Guillermo Ibarra Ibarra Ciudad de Mxico Mxico Departamento de Biologa Celular y Tisular Facultad de Medicina Universidad Nacional Autnoma de Mxico Ciudad de Mxico Mxico Escuela de Ciencias Universidad Autnoma Benito Jurez de Oaxaca Oaxaca Mxico Departamento de Medicina y Zootecnia de Cerdos Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional utnoma de Mxico Mxico Laboratorio de Investigacion Interdisciplinaria rea de Optometria Escuela Nacional de Estudios Superiores Unidad Len Universidad Nacional Autnoma de Mxico Len Guanajuato Mxico Laboratorio Nacional de ptica de la Visin-Centro de Investigaciones en ptica Len Guanajuato Mxico

Purpose: The primary aim of this paper is to design, create, and improve functional and artificial Bruch’s membranes (BM) using bioengineering techniques, which can be applied in the treatment of maculopathies by supporting the growth and maintenance of retinal pigment epithelium (RPE) cells, thereby potentially enabling subretinal implantation in patients. Methods: We fabricated by electrospinning ultrathin 3D nanofibrous membranes from Polycaprolactone (PCL), and different concentrations of gelatin (5%, 15% and 30%). ARPE-19 cells were seeded onto these artificial membranes. MTT assays were performed in order to evaluate ARPE-19 cell viability and cytotoxicity. IF assays were realized to observe the ARPE-19 cells onto each membrane. Ultrastructure of the modified Bruch’s membrane and ARPE-19 morphology after 25 days of culture were studied with transmission and scanning electron microscopy. To evaluate expression changes in markers of ARPE-19 (RPE65 and ZO-1) qRT-PCR assays were realized. Data from three independent experiments were pooled and expressed as the mean SD. A confidence level of P 0.05 was considered to be statistically significant. Results ARPE-19 cells grew on PCL/Gelatin membranes mainly in PCL/30% gelatin combination, which had not cytotoxic effect. RPE65/cytokeratin-18/ and actin-positive ARPE-19 cells formed a correctly orientated monolayer of polygonal cells with morphological polarity. The apical cell surfaces exhibited abundant protruding microfolds. Moreover, zones of polygonal border look as if ARPE-19 cells fused among, suggesting the presence of tight junctions. The expression of RPE65 and ZO-1 was unchanged. Conclusions: PCL/30% Gelatine membranes may imitate the natural BM to such extent that they support RPE-cells and exhibited RPE-like morphology. The engineering of a human RPE monolayer with these artificial BM, emulating the in vivo retina, arouse their potential subretinal implantation in patients with wet age-related macular degene

关键词： Artificial Bruch’s Membrane Electrospinning ARPE-19 Cells Age-Related Macular Degeneration