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Tibetan herbal formula Padma Digestin modulates gastrointestinal motility in vitro

World Journal of Gastrointestinal Pharmacology and Therapeutics 2013年第1期4卷 9-15页

作者： Bruno M Balsiger magali krayer Andreas Rickenbacher Beatrice Flogerzi Cecile Vennos Juergen M Gschossmann Department of Clinical Research University of Berne 3001 Bern Switzerland Clinic for Gastroenterology Lindenhofspital (Hochhaus) 3001 Bern Switzerland Department of Gastroenterology University of Berne 3001 BernSwitzerland Department of Visceral and Transplant Surgery University of Zürich 8006 Zürich Switzerland Scientific Division Padma Inc. 8340 Hinwil Switzerland Department of Internal Medicine Klinikum Forchheim/Friedrich-Alexander Universit t ErlangenNürnberg 91301 Forchheim Germany

AIM:To examine the effects of Padma Digestin on the smooth muscle motility of different gastrointestinal segments in vitro . METHODS:The effects of the ethanolic extract of Padma Digestin (at 8.16 mg/mL or 81.6mg/mL) on the contractility and susceptibility to acetylcholine (ACh) of muscle strips from the cardia, antrum, pylorus, duodenum, jejunum, ileum and colon of male Wistar rats were ***:Compared with the control treatment, the Padma Digestin extract had a procontractile effect on the antral smooth muscle strips. Padma Digestin decreased ACh sensitivity in cardia muscle strips and increased it in those from the antrum and pylorus. In the intestinal segments, spontaneous contractility was inhibited in both the duodenal and jejunal strips, whereas reactivity to ACh was inhibited in the jejunal strips only. In the colonic samples, Padma Digestin inhibited spontaneous and ACh-stimulated contractility at a low dose but seems to have increasing effects at a high dose. CONCLUSION:Padma Digestin extract has regionspecific effects on the contractility and excitability of gastrointestinal smooth muscle. Our results support the traditional use of Padma Digestin for maldigestion and functional gastrointestinal disorders.

关键词： Tibetan Medicine System Herbal Gastrointestinal motility Smooth muscle Padma Digestin

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Umbilical Cord Prolapse Managed by Assisted Vacuum Delivery

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Case Reports in Clinical Medicine 2024年第7期13卷 234-240页

作者： Katherine magali Michael Haule Musa Faraay Eltruda Tesha Obstetrics and Gynecology Department Manyara Regional Referral Hospital Babati Tanzania Theatre and Anaesthesia Unit Manyara Regional Referral Hospital Babati Tanzania

G4P3L3 was at 40 weeks of gestation who was admitted in active stage of labor with normal fetal heart rate. At 8 cm cervical dilatation she experienced spontaneous rupture of membrane with clear liquor. Cord prolapse was detected and was prepared for caesarian section meanwhile she was kept in knee chest position and bladder was filled with normal saline 0.9%. 30 min before operation she was fully dilated with signs of Non reassuring fetal status, vacuum extraction was done to assist delivery as soon as possible. The APGAR score was 6 and 10 in the first and fifth minutes respectively. Mother and the baby were discharged the next day in good condition.

关键词： Umbilical Cord Prolapse Operative Vaginal Delivery Vacuum Extraction

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Effects of B[a]P-UVA Co-Exposure on Epigenetic Marks of Isolated Skin Cells and Impact of an Arundo donax L. Extract of These Changes

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第3期14卷 253-269页

作者： Marie M. Dorr magali Favre-Mercuret Katell Vié Richard Fitoussi Laboratoires Clarins Pontoise France

Background: Extrinsic aging results from environmental stressors such as UVR or pollutants. While the effects of single pollutants are better understood, those of their combination remain poorly scrutinized. Objective: Building on a study showing downregulation of several processes upon co-exposure to B[a]P and UVA, we investigated changes induced by epigenetic marks. Materials and Methods: Human primary fibroblasts and HaCaT cells were exposed to B[a]P and UVA. After 24 hours, exposed and unexposed cells were compared to assess DNA methylation. Focusing on HaCaT, multiplex assays enabled quantifying histone H3 modifications and evaluating four splicing factors (SRSF1, SRSF3, SFPQ, and SF3B1) by immunohistochemical labeling. The expression of keratinocyte-/fibroblast-relevant genes was assessed by RT-qPCR. Finally, the impact of an Arundo donax L. extract added 24 hours before B[a]P-UVA co-exposure was analyzed. Results: Exposure to B[a]P-UVA raised DNA methylation (HaCaT: ×3.6, fibroblasts: ×1.9), an increase prevented by the extract. In HaCaT cells, B[a]P-UVA increases the frequency of S10P (+38%). When exposure was preceded by extract treatment, the frequency of several methylations was impacted. B[a]P-UVA only induced the expression of SRSF1 and SFPQ in HaCaT (+46% and +34%). Treatment with the extract abolished this effect. Co-exposure increases the expression of inflammation-related genes (IL-1α, IL-1β) in HaCaT cells and decreases those of AQP3, KRT15, and SOD2. The extract has little effect on these changes. In primary fibroblasts, exposure to B[a]P-UVA lowered the expression of LOXL2, LUM, and TGFBR2 (−38%, −59%, and −51%, respectively), and the extract did not affect these modifications. Conclusion: Within 24 hours, a single B[a]P-UVA co-exposure changes epigenetic marks of skin cells but has only mild effects on gene expression. An Arundo donax L. extract can prevent part of the epigenetic marks’ changes and could stimulate the expression of some genes in

关键词： Extrinsic Aging DNA Methylation Histone H3 Splicing Factors Arundo donax L.

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NONLOCAL CROWD DYNAMICS MODELS FOR SEVERAL POPULATIONS

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Acta Mathematica Scientia 2012年第1期32卷 177-196页

作者： Rinaldo M.Colombo magali Lcureux-Mercier Department of Mathematics Brescia University Department of Mathematics TechnionIsrael Institute of Technology

This paper develops the basic analytical theory related to some recently intro- duced crowd dynamics models. Where well posedness was known only locally in time, it is here extended to all of R＋. The results on the stability with respect to the equations are improved. Moreover, here the case of several populations is considered, obtaining the well posedness of systems of multi-D non-local conservation laws. The basic analytical tools are provided by the classical Kruzkov theory of scalar conservation laws in several space dimensions.

关键词： hyperbolic conservation laws nonlocal flow pedestrian traffic

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Electrochemical reactivity of In-Pb solid solution as a negative electrode for rechargeable Mg-ion batteries

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Journal of Energy Chemistry 2021年第4期30卷 124-128页

作者： Lucie Blondeau Suzy Surble Eddy Foy Hicham Khodja magali Gauthier UniversitéParis-Saclay CEACNRSNIMBELEEL91191Gif-sur-YvetteFrance UniversitéParis-Saclay CEACNRSNIMBELAPA-IRAMAT91191Gif-sur-YvetteFrance

A composite In-Pb:carbon was successfully synthetized by a two-step mechanochemical synthesis in order to obtain an adequate particles size and structure to investigate the electrochemical reactivity of the In-Pb solid solution towards Mg.A potential synergetic coupling of electroactive elements In and Pb was examined using electrochemical and ex situ X-ray diffraction *** potential profile of the solid solution indicates the formation of Mg_(2)Pb and Mg ***,the diffraction study suggests a peculiar electrochemically-driven amorphization of Mg In during the magnesiation,in strong contrast to Mg In crystallization in In-based and In Bi-based electrodes reported in the *** In and Pb favors the amorphization of Mg In and a high first magnesiation capacity of about 550 m Ah g^(-1),but is thereafter detrimental to the material’s *** results emphasize the possible influence of electrochemically-driven amorphization and crystallization processes on electrochemical performance of battery materials.

关键词： Magnesium battery Negative electrode Alloy Amorphization

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An optimized use of limited ground based topographic data for river applications

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International Journal of Sediment Research 2019年第3期34卷 216-225页

作者： Mohamed Jaballah Benoit Camenen ANDré Paquier magali Jodeau Irstea UR River Ly centre de Lyon-Villeurbanne EDF R&D

A prime requirement for hydrological applications, such as sediment budgeting or numerical modelling,is that produced Digital Terrain Models(DTMs) accurately represent the shape of landforms, especially for river reaches where data are not homogeneous. DTM error is a function of data point measurement accuracy and density and also of the field survey strategy when limited amounts of data will be *** paper aims to advance the importance of the field survey strategy for the specific, but common cases, where only limited topographic data will be available. This methodology is based on the idea that any feature can be properly described by a set of cross sections and breaklines describing both main and secondary directions of the flow. Then, a longitudinal linear interpolation can be applied to the defined homogeneous zones. This morphologically oriented(MO) method that includes data acquisition strategy and interpolation, was validated using a reference DTM derived from Li DAR measurements. An estimation of the uncertainties also is suggested based on the distance of the nearest point and the local slope using a geographically weighted regression. The proposed MO method is typically applicable to Alpine river reaches characterized by multiple channels that may always be underwater and not navigable such as an alternate bar system with secondary and transverse channels.

关键词： Digital Terrain Model Survey strategy Interpolation DTM error Gravel bar

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The Sulfate Transporter Family in Wheat： Tissue-Specific Gene Expression in Relation to Nutrition

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Molecular Plant 2010年第2期3卷 374-389页

作者： Peter Buchner Saroj Parmar Anne Kriegel magali Carpentier Malcolm J. Hawkesford Rothamsted Research Plant Science Department West Common Harpenden Hertfordshire AL5 2JQ UK Molecular Plant Nutrition University of Hohenheim Stuttgart Germany

Sulfate uptake and distribution in plants are managed by the differential expression of a family of transporters, developmentally, spatially, and in response to sulfur nutrition. Elucidation of the signaling pathways involved requires a knowledge of the component parts and their interactions. Here, the expression patterns of the full complement of sulfate transporters in wheat, as influenced by development and sulfur nutrition, are described. The 10 wheat sulfate transporters characterized here are compared to the gene families for both rice and Brachypodium, for whom full genome information is available. Expression is reported in young seedlings with a focus on roles in uptake from nutrient solution and differential expression in relation to sulfate deprivation. In addition, patterns of expression in all organs at the grain filling stage are reported and indicate differential responses to nutritional signals of the individual transporters in specific tissues and an overall coordination of uptake, storage, and remobilization to deliver sulfur to the developing grain.

关键词： Sulfate transporter wheat transcriptional regulation sulfur nutrition grain filling.

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Experimental manipulation of reproductive tactics in Seba’s short-tailed bats:consequences on sperm quality and oxidative status

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Current Zoology 2019年第6期65卷 609-616页

作者： magali MENIRI Florence GOHON Ophelie GNING Gaetan GLAUSER Armelle VALLAT Nicolas JFASEL Fabrice HELFENSTEIN Laboratory of Evolutionary Ecophysiology Institute of BiologyUniversity of NeuchatelSwitzerland Neuchatel Platform of Analytical Chemistry University of NeuchatelSwitzerland Leibniz Institute for Zoo and Wildlife Research Germany

To reproduce,males have to fertilize the female’s eggs,sometimes in competition with ejaculates of other *** species where males display alternative reproductive tactics,whereby territorial males secure mating and non-territorial males have to sneak copulations,the latter might be expected to invest relatively more resources towards sperm quality compared with the territorial *** cells are especially vulnerable to oxidative stress,which reduces male ***,antioxidant resources are expected to modulate sperm quality,and might be allocated differently between reproductive *** test the link between reproductive tactics,redox profile and sperm quality,we experimentally induced changes in the reproductive tactics of 39 captive males Seba's short-tailed bats Carollia *** monitored the blood and ejaculate oxidative balance,and the sperm quality before,7 days and 21 days after the manipulation of reproductive *** ejaculates'oxidative damage was negatively related to sperm velocity,males exhibited similar blood and ejaculates redox profiles and similar sperm quality,regardless of their reproductive ***,these results arise as a consequence of some constraints having been lifted during the *** results also suggest that,in Seba's short-tailed bats,the expression of alternative reproductive tactics is not subjected to strong oxidative ***,our results could reflect an absence of trade-off between pre-and post-copulatory traits in harem males,as they could be selected to invest both in female attraction and sperm quality,as a consequence of their inability to fully monopolize females.

关键词： oxidative stress sperm competition alternative reproductive tactics Carollia perspicillata

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Colorectal cancer and immunity:what we know and perspectives

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World Journal of Gastroenterology 2014年第14期20卷 3738-3750页

作者： Simon Pernot magali Terme Thibault Voron Orianne Colussi Elie Marcheteau Eric Tartour Julien Taieb Service d’Hépatogastro-entérologie et d’oncologie digestive H?pital Européen Georges-PompidouUniversité Paris DescartesSorbonne Paris Cité INSERM U970 Paris Cardiovascular Research CenterUniversité Paris-Descartes Service d’Immunologie biologique H?pital Européen Georges-PompidouUniversité Paris Descartes

Strong evidence supports the concept of immunosurveillance and immunoediting in colorectal cancer. In particular, the density of T CD8+ and CD45+ lymphocyte infiltration was recently shown to have a better prognostic value than the classic tumor node metastasis classification factor. Other immune subsets, as macrophages, natural killer cells or unconventionnal lymphocytes, seem to play an important role. Induction of regulatory T cells (Tregs) or immunosuppressive molecules such as PD-1 or CTLA-4 and downregulation of antigen-presenting molecules are major escape mechanisms to antitumor immune response. The development of these mechanisms is a major obstacle to the establishment of an effective immune response, but also to the use of immunotherapy. Although immunotherapy is not yet routinely used in colorectal cancer, we now know that most treatments used (chemotherapy and biotherapy) have immunomodulatory effects, such as induction of immunogenic cell death by chemotherapy, inhibition of immunosuppression by antiangiogenic agents, and antibody-dependent cytotoxicity induced by cetuximab. Finally, many immunotherapy strategies are being developed and tested in phase I to III clinical trials. The most promising strategies are boosting the immune system with cytokines, inhibition of immunoregulatory checkpoints, vaccination with vectorized antigens, and adoptive cell therapy. Comprehension of antitumor immune response and combination of the different approaches of immunotherapy may allow the use of effective immunotherapy for treatment of colorectal cancer in the near future.

关键词： Colorectal cancer Immunotherapy Immunity Immunoregulation Vaccination

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Experimental evidence of Wolbachia introgressive acquisition between terrestrial isopod subspecies

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Current Zoology 2021年第4期67卷 455-464页

作者： Nicolas Bech Sophie Beltran-Bech Cassandre Chupeau Jean Peccoud magali Thierry Roland Raimond Yves Caubet Mathieu Sicard Pierre Greve Laboratoire Ecologie et Biologie des Interactions EBI UMR CNRS 7267Universitéde Poitiers5 rue Albert TurpainTSA *** POITIERSCedex 9France ISEM CNRSIRDEPHEUniversite de MontpellierMontpellierFrance

Wolbachia are the most widespread endosymbiotic bacteria in *** many arthropod host species,they manipulate reproduction via several mechanisms that favor their maternal transmission to *** them,cytoplasmic incompatibility(Cl)promotes the spread of the symbiont by specifically decreasing the fertility of crosses involving infected males and uninfected females,via embryo *** differences in reproductive efficiency may select for the avoidance of incompatible mating,a process called reinforcement,and thus contribute to population *** the terrestrial isopod Porcellio dilatatus,the Wolbachia wPet strain infecting the subspecies *** induces unidirectional Cl with uninfected individuals of the subspecies *** study the consequences of Cl on *** and *** hybridization,mitochondrial haplotypes and Wolbachia infection dynamics,we used population cages seeded with different proportions of the 2 subspecies in which we monitored these genetic parameters 5 and 7 years after the initial *** of microsatellite markers allowed evaluating the degree of hybridization between individuals of the 2 *** markers revealed an increase in *** nuclear genetic signature in all mixed cages,reflecting an asymmetry in *** led to the introgressive acquisition of Wolbachia and mitochondrial haplotype from *** into nuclear genomes dominated by alleles of *** discuss these results with regards to Wolbachia effects on their host(Cl and putative fitness cost),and to a possible reinforcement that may have led to assortative mating,as possible factors contributing to the observed results.

关键词： cytoplasmic incompatibility introgressive acquisition terrestrial isopod Wolbachia

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