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Applied Mathematics and Mechanics(English Edition) 2019年第9期40卷 1285-1300页

作者： M. madhu N. S. SHASHIkumar B. MAHANTHESH B. J. GIREESHA N. KISHAN Department of Studies and Research in Mathematics Kuvempu University Shankaraghatta 577451 India Department of Mathematics Christ Deemed to be University Bangalore 560029 India Department of Mathematics Osmania University Telangana 500007 India

The entropy generation and heat transfer characteristics of magnetohydrodynamic (MHD) third-grade fluid flow through a vertical porous microchannel with a convective boundary condition are analyzed. Entropy generation due to flow of MHD non-Newtonian third-grade fluid within a microchannel and temperature-dependent viscosity is studied using the entropy generation rate and Vogel's model. The equations describing flow and heat transport along with boundary conditions are first made dimensionless using proper non-dimensional transformations and then solved numerically via the finite element method (FEM). An appropriate comparison is made with the previously published results in the literature as a limiting case of the considered problem. The comparison confirms excellent agreement. The effects of the Grashof number, the Hartmann number, the Biot number, the exponential space-and thermal-dependent heat source (ESHS/THS) parameters, and the viscous dissipation parameter on the temperature and velocity are studied and presented graphically. The entropy generation and the Bejan number are also calculated. From the comprehensive parametric study, it is recognized that the production of entropy can be improved with convective heating and viscous dissipation aspects. It is also found that the ESHS aspect dominates the THS aspect.

关键词： microchannel entropy generation Bejan number third-grade fluid magnetic field

Prediction of flow stress of 7017 aluminium alloy under high strain rate compression at elevated temperatures

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Defence Technology（防务技术） 2015年第1期11卷 93-98页

作者： Ravindranadh BOBBILI B.RAMAKRISHNA V.madhu A.K.GOGIA Defence Metallurgical Research Laboratory

An artificial neural network(ANN) constitutive model and JohnsoneC ook(Je C) model were developed for 7017 aluminium alloy based on high strain rate data generated from split Hopkinson pressure bar(SHPB) experiments at various temperatures. A neural network configuration consists of both training and validation, which is effectively employed to predict flow stress. Temperature, strain rate and strain are considered as inputs, whereas flow stress is taken as output of the neural network. A comparative study on Johnsone Cook(Je C) model and neural network model was performed. It was observed that the developed neural network model could predict flow stress under various strain rates and temperatures. The experimental stressestrain data obtained from high strain rate compression tests using SHPB over a range of temperatures(25 e300 C), strains(0.05e0.3) and strain rates(1500e4500 s 1) were employed to formulate JeC model to predict the flow stress behaviour of 7017 aluminium alloy under high strain rate loading. The JeC model and the back-propagation ANN model were developed to predict the flow stress of 7017 aluminium alloy under high strain rates, and their predictability was evaluated in terms of correlation coefficient(R) and average absolute relative error(AARE). R and AARE for the J-C model are found to be 0.8461 and 10.624%, respectively, while R and AARE for the ANN model are 0.9995 and 2.58%, respectively. The predictions of ANN model are observed to be in consistent with the experimental data for all strain rates and temperatures.

关键词： Aluminium alloy Artificial neural network Johnson-Cook model

Madden Julian Oscillations in Total Column Ozone, Air Temperature and Surface Pressure Measured over Cochin during Summer Monsoon 2015

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Open Journal of Marine Science 2016年第2期6卷 270-282页

作者： Vazhathottathil madhu Department of Atmospheric Sciences School of Marine Sciences Cochin University of Science and Technology Cochin India

The intra-seasonal variability plays a major role in the inter-annual variability of weather parameters such as rainfall, temperature and pressure which lead to extreme weather events in certain years. The active (more rainy days) and break (less rainy days) periods of Indian summer monsoon heavily depend on the intra-seasonal variability of weather parameters such as wind, pressure and temperature oscillations during the monsoon season. In the present analysis daily total column ozone, surface temperature and surface pressure measured over Cochin using Microtop II Ozonometer (sun Photometer) were used to study the Intra-Seasonal Variations (ISV) of the above parameters during the monsoon season, 2015. The dominant and significant intra-seasonal oscillations (ISOs) were identified using an advanced statistical method called the Discrete Mayer’s Wavelet (DMW) analysis. Two major ISOs such as Madden Julian Oscillations (MJO, 30 - 60 days) and quasi-bi weekly (12 - 16 days) oscillations were found in TCO, surface temperature and pressure. In TCO an additional mode of ISO with quasi tri-weekly periodicity was also found (16 - 22 day). It is observed that MJO mode is the dominant among all other modes and its positive and negative phases correlate with positive and negative anomalies of the above parameters. The ISO mode in the surface pressure shows an out of phase relation with the Indian summer monsoon rainfall which indicates the active and break periods of Indian summer monsoon. The contribution of MJO mode is dominant in the tropical atmosphere, which modulates the intra-seasonal variability. It is found that for the year 2015 total column ozone, surface pressure and surface temperature show an annual range of 30 DU, 4 hPa and 1°C, respectively.

关键词： Intra-Seasonal Oscillations Total Column Ozone (TCO) Madden Julian Oscillation Wavelet Analysis

Spatial and Temporal Variability of Total Column Ozone over the Indian Subcontinent: A Study Based on Nimbus-7 TOMS Satellite

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Atmospheric and Climate Sciences 2014年第5期4卷 884-898页

作者： Vazhathottathil madhu Department of Atmospheric Sciences Cochin University of Science and Technology Cochin India

The distribution and variability of ozone is very important to the atmospheric thermal structures, and it can exert their greater influence on climate. Present study is based on Nimbus-7 TOMS overpass column ozone for a period of 14 years (1979-1992) over twelve selected Indian stations from south to north latitude and it explores the spatial and temporal variability of Total Column Ozone (TCO). For this investigation an advanced statistical methods such as Factor Analysis and Morlet wavelet transform are employed. Total column ozone variability over these stations is grouped into two clusters (Eigen value greater than 1) by the Multivariate Factor analysis. It is found that the Group I stations shows the same nature of variability mainly due the first factor as the primarily loading and whereas as the Group II stations shows the same nature of variability due to second factor as the primary loading. The correlation value of TCO decreases from 0.9 to 0.32 as we move from south to north stations (lower latitude to higher latitude). The total column ozone over tropical stations is maximum during monsoon season with peak in the month of June and that for the higher latitude stations is during the pre-monsoon season. Annual average of TCO for tropical stations is about 265 DU and that for subtropical stations is about 280 DU and a difference of 15 DU is noted in the annual average of TCO between tropical and subtropical stations. A large reduction in TCO is noted over the Indian subcontinent in the year 1985, the same year in which the ozone hole over Antarctica was discovered. It is also found that two prominent oscillations are present in total column ozone one with a periodicity of 16 to18 months and other with 28 to 32 months (QBO periodicity) apart from the annual oscillations. These oscillations are found to be significant at above 95% level of confidence when tested with Power Spectrum method. Tropical TCO shows high concentration during the westerly phase and lo

关键词： Total Column Ozone Quasi-Biennial Oscillation Interannual Variability Morlet Wavelet

Variation of Zonal Winds in the Upper Troposphere and Lower Stratosphere in Association with Deficient and Excess Indian Summer Monsoon Scenario

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Atmospheric and Climate Sciences 2014年第4期4卷 685-695页

作者： Vazhathottathil madhu Department of Atmospheric Sciences Cochin University of Science and Technology Cochin India

The Indian summer monsoon is one of the most dominant tropical circulation systems in the general circulation of the atmosphere. The country receives more than 80% of the annual rainfall during a short span of four months (June to September) of the southwest monsoon season. Variability in the quantum of rainfall during the monsoon season has profound impacts on water resources, power generation, agriculture, economics and ecosystems in the country. The inter annual variability of Indian Summer Monsoon Rainfall (ISMR) depends on atmospheric and oceanic conditions prevailed during the season. In this study we have made an attempt to understand the variation of the of zonal winds in the tropical Upper Troposphere and Lower Stratosphere (UT/LS) region during deficient and Excess rainfall years of Indian summer monsoon and its relation to Indian Summer Monsoon Rainfall (ISMR). It is found that in the equatorial Upper Troposphere zonal winds have westerly anomalies during deficient rainfall year’s and easterly anomaly during excess rainfall years of Indian summer monsoon and opposite zonal wind anomaly is noted in the equatorial Lower Stratosphere during the deficient and excess rainfall years of Indian summer monsoon. It is also found that the June to September upper troposphere zonal winds averaged between 15°N and 15°S latitudes have a long-term trend during 1960 to 1998. Over this period the tropical easterlies and the tropical jet stream have weakened with time.

关键词： Indian Summer Monsoon Upper Troposphere/Lower Stratosphere Zonal Winds

Suppression of monosodium urate crystal-induced inflammation by inhibiting TGF-β-activated kinase 1-dependent signaling:role of the ubiquitin proteasome system

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Cellular & Molecular Immunology 2021年第1期18卷 162-170页

作者： Anil K.Singh Mahamudul Haque Kayla O'Sullivan Mukesh Chourasia madhu M.Ouseph Salahuddin Ahmed Department of Pharmaceutical Sciences Washington State University College of PharmacySpokaneWAUSA Center for Computational Biology and Bioinformatics Amity Institute of BiotechnologyAmity UniversityNoidaUttar PradeshIndia Department of Pathology Stanford University School of MedicineStanfordCAUSA Division of Rheumatology University of Washington School of MedicineSeattleWAUSA

Monosodium urate(MSU)crystals activate inflammatory pathways that overlap with interleukin-1β(IL-1β)***,the post-translational mechanisms involved and the role of signaling proteins in this activation are *** the present study,we investigated the intracellular signaling mechanisms involved in MSU-induced activation of THP-1 macrophages and human nondiseased synovial fibroblasts(NLSFs)and the in vivo efficacy of an inhibitor of tumor grovArth factor-β(TGF-β)-activated kinase 1(TAK1),5Z-7-oxozeaenoI,in MSU-induced paw inflammation in C57BL76 ***-1 macrophage activation with MSU crystals(25-200 ng/ml)resulted in the rapid and sustained phosphorylation of interleukin-1 receptor-activated kinase 1(IRAK1 Thr^(209))and TAK1(Thr^(184/187))and their association with the E3 ubiquitin ligase *** the cellular level,MSU inhibited the deubiquitinases A20 and UCHL2 and increased 20s proteasomal activity,leading to a global decrease in K^(63)-linked ubiquitination and increase in K^(48)-linked ubiquitination in THP-1 *** MSU did not stimulate cytokine produaion in NLSFs,it significantly amplified IL-1β-induced IL-6,IL-8,and ENA-78/CXCL5 *** studies and MD simulations followed by TAK1 in vitro kinase assays revealed that uric acid molecules are capable of arresting TAK1 in an active-state conformation,resulting in sustained TAK1 kinase ***,MSU-induced proinflammatory cytokine production was completely inhibited by 5Z-7-oxozeaenol but not IRAK1/4 or TRAF6 *** of 5Z-7-oxozeaenol(5 or 15 mg/kg;orally)significantly inhibited MSU-induced paw inflammation in C57BL/6 *** study identifies a novel post-translational mechanism of TAK1 activation by MSU and suggests the therapeutic potential of TAK1 in regulating MSU-induced Inflammation.

关键词： Monosodium urate crystals Gout TAK1 Ubiquitination 5Z-7-oxozeaenol

Artificial Intelligence in hepatology,liver surgery and transplantation:Emerging applications and frontiers of research

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World Journal of Hepatology 2021年第12期13卷 1977-1990页

作者： Fadl H Veerankutty Govind Jayan Manish kumar Yadav Krishnan Sarojam Manoj Abhishek Yadav Sindhu Radha Sadasivan Nair T U Shabeerali Varghese Yeldho madhu Sasidharan Shiraz Ahmad Rather Comprehensive Liver Care VPS Lakeshore HospitalCochin 682040KeralaIndia Hepatobiliary Pancreatic and Liver Transplant Surgery Kerala Institute of Medical SciencesTrivandrum 695029KeralaIndia Department of Radiodiagnosis Kerala Institute of Medical SciencesTrivandrum 695029KeralaIndia Gastroenterology and Hepatology Kerala Institute of Medical SciencesThiruvananthapuram 695029India

The integration of artificial intelligence(AI)and augmented realities into the medical field is being attempted by various researchers across the *** a matter of fact,most of the advanced technologies utilized by medical providers today have been borrowed and extrapolated from other *** introduction of AI into the field of hepatology and liver surgery is relatively a recent *** purpose of this narrative review is to highlight the different AI concepts which are currently being tried to improve the care of patients with liver *** end with summarizing emerging trends and major challenges in the future development of AI in hepatology and liver surgery.

关键词： Liver disease Machine learning Deep learning Artificial neural networks Transplantation Hepatectomy

Non-alcoholic fatty liver and chronic kidney disease:Retrospect,introspect,and prospect

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World Journal of Gastroenterology 2021年第17期27卷 1864-1882页

作者： Rajiv Heda Masahiko Yazawa Michelle Shi madhu Bhaskaran Fuad Zain Aloor Paul J Thuluvath Sanjaya K Satapathy Department of Internal Medicine Tulane University School of MedicineNew OrleansLA 70112United States Department of Nephrology and Hypertension St.Marianna University School of MedicineKawasaki 216-8511Japan Department of Internal Medicine Donald and Barbara Zucker School of MedicineNorthwell HealthManhassetNY 11030United States Department of Nephrology Northwell Health/Zucker School of Medicine at HosftraManhassetNY 11030United States Department of Internal Medicine Baylor College of MedicineHoustonTX 77030United States Institute of Digestive Health&Liver Diseases Mercy Medical CenterBaltimoreMD 21202United States

With the growing prevalence of obesity and diabetes in the United States and across the world,a rise in the overall incidence and prevalence of non-alcoholic fatty liver disease(NAFLD)is *** risk factors for NAFLD are also associated with the development of chronic kidney disease(CKD).We review the epidemiology,risk factors,genetics,implications of gut dysbiosis,and specific pathogenic mechanisms linking NAFLD to *** such as ectopic lipid accumulation,cellular signaling abnormalities,and the interplay between fructose consumption and uric acid accumulation have led to the emergence of potential therapeutic implications for this patient *** evaluation in the setting of both NAFLD and CKD is also *** strategies for surveillance and management include the monitoring of comorbidities,the use of non-invasive fibrosis scoring systems,and the measurement of laboratory ***,we discuss the management of patients with NAFLD and CKD,from preventative measures to experimental interventions.

关键词： Nonalcoholic fatty liver disease Chronic kidney disease Nonalcoholic steatohepatitis Organ transplant genetic Microbiome Pathophysiology

Polyadic Cyclic Codes over a Non-Chain Ring

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Journal of Computer and Communications 2021年第5期9卷 36-57页

作者： Mokshi Goyal madhu Raka Centre for Advanced Study in Mathematics Panjab University Chandigarh India

Let f(u) and g(v) be two polynomials of degree k and l respectively, not both linear which split into distinct linear factors over Fq. Let be a finite commutative non-chain ring. In this paper, we study polyadic codes and their extensions over the ring R. We give examples of some polyadic codes which are optimal with respect to Griesmer type bound for rings. A Gray map is defined from which preserves duality. The Gray images of polyadic codes and their extensions over the ring R lead to construction of self-dual, isodual, self-orthogonal and complementary dual (LCD) codes over Fq. Some examples are also given to illustrate this.

关键词： Polyadic Codes and Their Extensions Griesmer Bound Gray Map Self-Dual and Self-Orthogonal Codes Isodual Codes LCD Codes

Duadic Codes over the Ring F_q[u] /^m- and Their Gray Images

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Journal of Computer and Communications 2016年第12期4卷 50-62页

作者： Mokshi Goyal madhu Raka Centre for Advanced Study in Mathematics Panjab University Chandigarh India

Let m ≥ 2 be any natural number and let be a finite non-chain ring, where and q is a prime power congruent to 1 modulo (m-1). In this paper we study duadic codes over the ring and their extensions. A Gray map from to is defined which preserves self duality of linear codes. As a consequence self-dual, formally self-dual and self-orthogonal codes over are constructed. Some examples are also given to illustrate this.

关键词： Quadratic Residue Codes Duadic Codes Extended Duadic-Codes Gray Map Self-Dual Self-Orthogonal Codes Formally Self-Dual Codes