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Leishmaniasis in the Argentine Republic: Temporal and geographical distribution from 2013 to 2017

Asian pacific Journal of Tropical Medicine 2019年第7期12卷 300-305页

作者： GermanóMaría J Salomón María C Neira Gisela Lozano Esteban mackern-oberti juan p Cargnelutti Diego E Consejo Nacional de Investigaciones Científicas y Técnicas Centro Científico y Tecnológico de MendozaInstituto de Medicina y Biología Experimental de CuyoMendozaArgentina Universidad Nacional de Cuyo Facultad de Ciencias Médicasárea de ParasitologíaMendozaArgentina Universidad juan Agustín Maza Facultad de Ciencias Veterinarias y AmbientalesCentro de Investigación en Parasitología RegionalMendozaArgentina Universidad Nacional de Cuyo Facultad de Ciencias MédicasInstituto de FisiologíaMendozaArgentina

Objective: To assess the temporal and geographical distribution of confirmed cases of cutaneous, mucocutaneous and visceral leishmaniasis in the Argentine Republic from 2013 to 2017. Methods: A retrospective study was carried out using data collected from the Integrated Surveillance Bulletin database of the National System of Health Surveillance. Confirmed cases of cutaneous, mucocutaneous and visceral leishmaniasis up to the 52 nd epidemiological week of each year was included. Results: In the 5 years period, 1 295 confirmed leishmaniasis cases were reported in the Argentine Republic. One thousand twenty-eight(1 028) cases corresponded to cutaneous leishmaniasis(87.10%), being the most common type of leishmaniasis. Mucocutaneous leishmaniasis was in the second place in the country with 115 cases reported, mostly in the Northwest and Northeast regions. A total of 52 individuals with visceral leishmaniasis were identified and Misiones province was the most affected. Conclusions: It is important to analyze the temporal and geographical distribution of leishmaniasis in order to provide an adequate management and surveillance.

关键词： Leishmaniasis Epidemiology Argentine Republic Temporal distribution Geographical distribution

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The impact of endocrine-disrupting chemicals on stem cells:Mechanisms and implications for human health

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Journal of Environmental Sciences 2025年第1期147卷 294-309页

作者： juan p.Munoz Laboratorio de Bioquímica Departamento de QuímicaFacultad de CienciasUniversidad de TarapacáArica 1000007Chile

Endocrine-disrupting chemicals(EDCs)are compounds,either natural or man-made,that interferewith the normal functioning of the endocrine *** is increasing evidence that exposure to EDCs can have profound adverse effects on reproduction,metabolic disorders,neurological alterations,and increased risk of hormone-dependent *** cells(SCs)are integral to these pathological processes,and it is therefore crucial to understand how EDCs may influence SC *** review examines the literature on different types of EDCs and their effects on various types of SCs,including embryonic,adult,and cancer *** mechanisms through which EDCs may influence the phenotype of SCs are also ***,the possible implications of these effects on human health are *** available literature demonstrates that EDCs can influence the biology of SCs in a variety of ways,including by altering hormonal pathways,DNA damage,epigenetic changes,reactive oxygen species production and alterations in the gene expression *** disruptions may lead to a variety of cell fates and diseases later in adulthood including increased risk of endocrine disorders,obesity,infertility,reproductive abnormalities,and ***,the review emphasizes the importance of raising broader awareness regarding the intricate impact of EDCs on human health.

关键词： Endocrine-disrupting chemicals Stem cells Cancer stem cells Epigenetic Hormones

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Unraveling the link between lipid oxidation and off-flavor development in grass carp fillets(Ctenopharyngodon idellus) during cold storage: A non-targeted lipidomics approach

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Food Science and Human Wellness 2025年

作者： Huifang Yang Ramy M.Khoder Shanbai Xiong juan You Yueqi An Key Laboratory of Environment Correlative Dietology， Ministry of Education， College of Food Science and Technology， Huazhong Agricultural University Faculty of Agriculture， Benha University College of Health Science and Engineering， Hubei University

Grass carp fillets were susceptible to unpleasant fishiness during cold storage. To clarify the mechanism of fishy odor formation and achieve targeted regulation， volatile compounds， and lipid oxidation were investigated in grass carp fillets during cold storage （0-7d）. The lipid oxidation degree increased continually during cold storage， as evidenced by the change of AV， pOV， TBARS， and Hp. The activities of related enzymes (LOX， LpS， pLA[2]， and HpL) maintained a high level， reaching their maximums after 3-5 days. Free fatty acids exhibited a great downtrend， especially linoleic acid （18:2） and arachidonic acid （20:4）. Forty-five volatile compounds were identified by solvent-assisted flavor evaporation-gas chromatography-mass spectrometer， and the total contents of volatile compounds increased from 706.55 μg/kg （0d） to 1370.65 μg/kg （7d）. （Z）-4-heptenal，（E，E）-2，4-hexadienal， 1-penten-3-ol， nonanal， and （E）-2-heptenal were the key volatile compounds. The pearson correlation showed a strong correlation between 47 differentially abundant lipids （variables important in projection > 1， p value 2） and volatile compounds. During cold storage， lyso-phosphatidylcholine （20:4） and lyso-phosphatidylcholine （18:2） were selected as the main precursors of volatile compounds’ formation in grass carp fillets.

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Conjunctival microbiota variations in a subset of middleaged and elderly individuals from Beijing,China

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 237-243页

作者： Tian-Yao Zhao Yu-Chen Wang Ying-juan Sun Jun-Yue Wang Xiao-Dan Jiang Xue-Min Li Ai-Hua Deng Department of Ophthalmology Peking University Third HospitalBeijing Key Laboratory of Restoration of Damaged Ocular NerveBeijing 100191China Fangshan Hospital Beijing University of Chinese Medicine Beijing 102400China CAS Key Laboratory of pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Animal Nutrition and Feeding Ministry of Agriculture and Rural Affairs Feed Industry CentreAgricultural UniversityBeijing 100193China

AIM:To isolate and identify the conjunctival microbiota of cataract patients and analyze the associated influencing ***:This study recruited 216 participants(216 eyes)from April 2022 to July *** the condition of no antibiotic use prior to cataract surgery,sterile swabs were used to collect samples from the lower conjunctival *** cultures were then conducted,followed by species identification through 16S rDNA gene *** factors associated with positive or negative bacterial isolation rates were analyzed,including age,gender,meibomian gland dysfunction(MGD),history of hypertension,history of diabetes,history of cancer,history of infectious diseases and the habit of wearing ***:Among the 216 eyes,78 eyes yielded isolates,with an isolation rate of 36.11%,detecting a total of 122 ***-positive rods accounted for 49.18%(60 strains),gram-positive cocci accounted for 45.08%(55 strains),gram-negative bacteria accounted for 4.92%(6 strains),and fungi accounted for 0.82%(1 strain).This study found that the most abundant genera in the conjunctival sac were Corynebacterium(42.62%),Staphylococcus(31.15%),Micrococcus(9.84%),Acinetobacter(4.10%),and Bacillus(3.28%).Furthermore,age(p=0.006),gender(p=0.039),diabetes(p=0.003),history of infectious diseases(p=0.02),and duration of mask replacement(pportant factors influencing the positive bacterial culture of the conjunctival *** hypertensive patients exhibited a higher isolation rate of conjunctival bacteria,it did not reach statistical significance,and the history of cancer did not affect the isolation rate of the conjunctival microbial community in cataract patients before ***:potential changes are observed in the conjunctival microbiota among a sample of middleaged and elderly individuals from Beijing,***,an increased isolation rate of Corynebacterium and Micrococcus is detected,suggesting a possible change in the mic

关键词： conjunctival microbiota 16S rDNA middle-aged and elderly population mask cataract surgery

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Multiple Chemical Sensitivity: A Sickness of Suffering, Not of Dying. Descriptive Study of 33 Cases

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Health 2025年第1期17卷 65-81页

作者： Blanca Navas-Soler Aarón Gutiérrez-pastor Antonio palazón-Bru Jorge Vallejo-Ortega Álex Méndez-Jover Celia Santano-pérez Carmen Seguí-pérez Marc Seguí-pérez Sonia Cascant-pérez juan Carlos López-Corbalán Míriam pérez-Cardona Ramón pérez-Doménech Antonio Hernández-García patricia Lorca-Amorrich Ana Belén Llinares-Llinares Cristina Valverde-Cámara Rosa María Bustos-Martínez juan Manuel Núñez-Cruz Isidro Hernández-Isasi José juan Martínez-pérez José Manuel Santano-López María Dolores Jover-Ríos juan Méndez-Mora José Miguel Seguí-Ripoll Internal Medicine Service University Hospital of San Juan de Alicante Alicante Spain Family and Community Medicine Service University Hospital of San Juan de Alicante Alicante Spain Foundation for the promotion of Health and Biomedical Research of the Valencian Community (FISABIO) University Hospital of San Juan de Alicante Alicante Spain Faculty of physics University of Alicante Alicante Spain Department of Clinical Medicine Medical School University Miguel Hernandez de Elche Alicante Spain CEU Veterinary School University Cardenal Herrera Alfara del Patriarca Campus Valencia Spain Secondary School Marist Brothers High School Alicante Spain primary Medicine Hospital Francesc Borgia of Gandia Valencia Spain Faculty of Medicine CEU Cardenal Herrera University Alfara del Patriarca Campus Valencia Spain Faculty of Economics University of Alicante Alicante Spain Department of Internal Medicine Hospital La Vega Baja of Orihuela Alicante Spain

Objective: We describe patients with MCS, the evolution of the Quick Environmental Exposure and Sensitivity Inventory (QEESI) score with a special focus on people whose fillings were removed. Methods: We have conducted a retrospective longitudinal cohort study in patients diagnosed with MCS and attended in the outpatient Internal Medicine department of the University Hospital of San juan de Alicante, from January 1, 2008 to January 1, 2021. Sociodemographic, clinical, QEESI and treatment-related variables were collected. We performed descriptive and inferential analyses. Mixed linear models were used to analyze the QEESI. Calculations were carried out with an α error of 5%. Results: Thirty-three patients were included (72.7% women, mean age 56.2). MCS was mainly triggered by mercury (N = 20) and food intolerance (N = 22). The mean interval from symptoms onset was 120 months (SD 81.6). 114 QEESIs were analyzed: 82 (N = 17 without amalgams) and 32 (N = 16 with amalgams). In patients without amalgams, severity scores increased across all subscales except the masking index (vs. with amalgams). Mean scores for the group without amalgams (vs. with amalgams) were: chemical intolerance, 62.8 points (vs. 63.4 and 46.7);other intolerances, 52.7 points (vs. 62.8 and 50.3);symptom severity, 63.2 (vs. 76.7 and 63.3);masking index, 3.9 (vs. 3.2 and 2.8);and life impacts, 63.1 (vs. 58.4 and 49.8). Conclusion: The profile of patient with MCS is a middle-aged woman who is a frequent user of healthcare services, presents a long diagnostic delay and has borne a great personal, work and socioeconomic impact. The QEESI is useful for the clinical follow-up of patients, including the optimal treatment response in the case of amalgams. Clinical Significance: people affected by Multiple Chemical Sensitivity deserve the attention, understanding and help of health professionals and family members, to face an invisible illness for those who do not suffer from it. Support is needed and doctors

关键词： Chemical Sensitivity Electromagnetic Sensitivity Mercury poisoning Amalgams QEESI

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protein@AuNps Synthesized by Microfluidic Droplet System and Application in Cu(II)and L-Cysteine Sensing

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Chemical Research in Chinese Universities 2025年第1期41卷 131-137页

作者： ZHU Xiaotong LI Xinyu QI Li ZHANG Rongyue LI Nan HE Xiaonan QIAO juan College of New Materials and Chemical Engineering Beijing Institute of Petrochemical TechnologyBeijing102617P.R.China Beijing National Laboratory for Molecular Sciences Key Lab of Analytical Chemistry for Living BiosystemsInstitute of ChemistryChinese Academy of SciencesBeijing100190P.R.China

In this study,pepsin@AuNps(pep@AuNps)and Trypsin@AuNps(Try@AuNps)were synthesized by a microfluidic droplet system using pepsin and Trypsin as protection reagents and NaOH as reducing *** to the synthesis method in a flask,the AuNps synthesized by the microfluidic droplet system demonstrated uniform nucleation,superior ultraviolet absorption performance,high stability and short preparation cycles(15 min).The detection range of Cu(II)by pep@AuNps was 1.0–100.0µmol/L and the detection limit was 0.3µmol/*** detection range of L-Cysteine by Try@AuNps was 0.3–250.0 mmol/L and the detection limit was 0.1 mmol/*** universal method provides an effective strategy for the detection of bioactive molecules,such as metal ions and amino acids by AuNps with protein as a protective agent.

关键词： Microfluidic droplet system AuNps Trypsin pepsin

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Longitudinal assessment of measured and estimated glomerular filtration-rate in autosomal dominant polycystic kidney disease:Real practice experience

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World Journal of Nephrology 2025年第1期14卷 99-109页

作者： juan M Fernandez JoséC Rodriguez-pérez M Mercedes Lorenzo-Medina Fancisco Rodriguez-Esparragon juan C Quevedo-Reina Carmen R Hernandez-Socorro Medical Manager Southern Europe Baxter Healthcare Ltd.Madrid 28830Spain Escuela de Doctorado Universidad De Las Palmas De Gran CanariaLas Palmas 35001Canary IslandsSpain Department of Research Universidad Fernando Pessoa CanariasLas Palmas 35450Canary IslandsSpain Department of Clinical Chemistry Hospital Universitario De Gran Canaria Doctor NegrínLas Palmas 35010Canary IslandsSpain Department of Research Hospital Universitario De Gran Canaria Doctor NegrínLas Palmas 35010Canary IslandsSpain Department of Nephrology Hospital Universitario De Gran Canaria Doctor NegrínLas Palmas 35010Canary IslandsSpain Department of Radiology Hospital Universitario De Gran Canaria Doctor NegrínLas Palmas 35010Canary IslandsSpain

BACKGROUND Equations for estimation glomerular filtration rate(eGFR)have been associated with poor clinical performance and their clinical accuracy and reliability have been called into *** To assess the longitudinal changes in measured glomerular filtration rate(mGFR)in patients with autosomal dominant polycystic kidney disease(ADpKD).METHODS Analysis of an ambispective data base conducted on consecutive patients diagnosed with *** mGFR was assessed by iohexol clearance;while eGFR was calculated by three different formulas:(1)The chronic kidney disease epidemiology collaboration(CKD-EpI);(2)Modification of diet in renal disease(MDRD);and(3)The 24-hour urine creatinine clearance(CrCl).The primary end-points were the mean change in mGFR between the baseline and final visit,as well as the comparison of the mean change in mGFR with the change estimated by the different *** Thirty-seven patients were included in the *** compared to baseline,month-6 mGFR was significantly decrease by-4.4 mL/minute±10.3 mL/minute(p=0.0132).However,the CKD-EpI,MDRD,and CrCl formulas underestimated this change by 48.3%,89.0%,and 45.8%respectively,though none of these differences reached statistical significance(p=0.3647;p=0.0505;and p=0.736,respectively).The discrepancies between measured and estimated glomerular filtration rate values,as evaluated by CKD-EpI(r=0.29,p=0.086);MDRD(r=0.19,p=0.272);and CrCl(r=0.09,p=0.683),were not correlated with baseline mGFR *** This study indicated that eGFR inaccurately reflects the decline in mGFR and cannot reliably track changes over *** poses significant challenges for clinical decision-making,particularly in treatment strategies.

关键词： Autosomal dominant polycystic kidney disease Glomerular filtration rate End-stage kidney disease Iohexol Chronic kidney disease epidemiology collaboration Modification of diet in renal disease

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Serologic parameters in young patients with retinal vein occlusion treated with anti-vascular endothelial growth factor

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International Journal of Ophthalmology(English edition) 2025年第3期18卷 424-434页

作者： Tong-Tong Niu Yun Xiao Wen-juan Lyu Hao Zhou Department of Ophthalmology Xinjiang 474 HospitalUrumchi 830000Xinjiang Uygur Autonomous RegionChina

AIM:To assess the relationship between serological parameters and the prognosis of young patients with retinal vein occlusion(RVO)after intravitreal conbercept injection(IVC).METHODS:This study enrolled 100 young patients(≤50 years old)diagnosed with RVO-related macular edema(RVO-ME)who had been undergoing IVC at the 474 Hospital in Xinjiang between January 2022 and October *** were categorized into two groups:70 eyes in the effective group and 30 eyes in the ineffective *** effective group comprised patients exhibiting a visual acuity improvement of≥2 lines at the last follow-up,with resolved ME and central macular thickness(CMT)p included patients with visual acuity improvement ofpersistent ME,and CMT≥300μm at the last *** parameters,including white blood cell count,neutrophil count,lymphocyte count,monocyte count,and mean platelet volume were assessed before *** correlation between bestcorrected visual acuity(BCVA)and neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(pLR),systemic immune inflammation index(SII),and systemic immune response index(SIRI)was ***,the association between these serological parameters and the efficacy of IVC was ***:Three months after treatment,the effective group demonstrated a significant improvement in BCVA from 0.82±0.20 to 0.36±0.10,with a concurrent decrease in CMT from 661.28±163.90 to 200.61±82.45μm(pp exhibited minimal changes in BCVA(0.86±0.25 to 0.82±0.14)and CMT(669.84±164.95 to 492.13±138.67μm,pps were statistically significant(pp analysis,in patients with central RVO(CRVO),BCVA improved from 0.82±0.23 to 0.49±0.12 in the effective group and from 0.80±0.18 to 0.76±0.22 in the ineffective group(ppatients with branc

关键词： retinal vein occlusion anti-vascular endothelial growth factor systemic immune-inflammatory index neutrophil-to-lymphocyte ratio

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Efficacy and safety of combined Kahook Dual Blade goniotomy with phacoemulsification in Chinese patients with primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 268-274页

作者： Lin Fu Jiang-Tao Lou Yue Guo pei-juan Wang Rong-Rong Le Shu-Xia Xu Guo-Xing Li Yuan-Bo Liang National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325003Zhejiang ProvinceChina

AIM:To report the one-year surgical outcome Kahook Dual Blade goniotomy combined with phacoemulsification(KDB-phaco)in Chinese patients with primary open angle glaucoma(pOAG).METHODS:This is a retrospective study included 43 eyes of 28 Chinese pOAG patients with cataract who accepted KDB-phaco and followed-up for *** pressure(IOp),glaucoma medications and surgical complications were *** 1 and success 2 was defined as 5-21 mm Hg and 5-18 mm Hg,and success plus was determined if additional criteria of IOp reduction≥20%from baseline was reached.A corrected IOp by adding 3 mm Hg for each medication was used to do correlation ***’s proportional hazards regression model was used to test the hazard ratio for factors associated with surgical ***:After a 12-month follow up,the IOp decreased from 28.1±6.3 to 13.8±3.0 mm Hg(47.92%reduction,ppp of all postoperative visits were lower than preoperative IOp(all ppplete success 1 and qualified success 1 were 87.80%and 100.00%*** complete success 1 plus and qualified success 1 plus were 85.37%and 97.56%,*** 82.93%and 90.24%of patients got complete success 2 and qualified success 2 while 80.49%and 87.80%of patients satisfied complete success 2 plus and qualified success 2 ***(r=-0.511,p=0.001)and visual acuity(VA;r=-0.321,p=0.041)were negatively correlated with postoperative corrected IOp at 12mo,while anterior chamber depth(r=0.432,p=0.005),mean deviation(r=0.617,pppositively correlated with *** VA(OR=33.092,p=0.004)and MD(OR=1.481,p=0.018)were hazard factors associated with failure based on qualified success as 18 mm *** main complications of KDB were hyphema(9.30%),IOp spike(11.63%)and peripheral anterior synechia(6.98%).CONCLUSI

关键词： Kahook Dual Blade goniotomy primary open angle glaucoma success rate risk factors

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Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li Hua Zhang Lian-Lian Wang Wen-Wen Liu Xin Yang Ming-Zhao Xiao Hao-Ling Zhang juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(Fop),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,Fop,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,Fop,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(pper capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(pprofessionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

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