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Treatment refractory mast cell leukemia with dominant gastrointestinal manifestation and concomitant skin symptoms:A case report

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World Journal of Clinical Cases 2024年第20期12卷 4317-4324页

作者： maciej Tomasz Wysocki maciej gonciarz Bartosz Puła Department of Gastroenterology and Internal Medicine Military Institute of Medicine-National Research InstituteWarsaw 04-141Poland Department of Hematology Institute of Hematology and Transfusion MedicineWarsaw 02-776Poland

BACKGROUND Mast cell leukemia(MCL),a subtype of systemic mastocytosis(SM),is an extremely rare clinical entity characterized by a very poor ***,tyrosine kinase inhibitors,and allogeneic hematopoietic cell transplantation are the only treatment options,but they cannot provide the desired outcomes in most cases of ***,other types of SM can be successfully *** disease has no specific manifestation,but gastroenterological symptoms are present in most *** SUMMARY The authors,hereby,report a case of a 46-year-old female patient diagnosed with MCL-the rarest subtype of *** patient presented to the gastroenterology clinic with multiple,various,and unspecific gastroenterological *** of skin lesions significantly contributed to a relatively prompt *** serum tryptase level was extremely high and bone the marrow aspirate showed an infiltration of atypical mast *** disease was rapidly progressive and primary refractory to chemotherapy and the patient succumbed to the illness about a month after the initiation of *** Despite its“hematological nature”,MCL,in most cases presents dominantly with unspecific gastroenterological ***,a high disease awareness among physicians other than hematologists is necessary to improve treatment *** tryptase level,due to its non-invasive nature and easy access,may serve as an initial step to estimate the probability of mastocytosis.

关键词： Mastocytosis Systemic mastocytosis Mast cell leukemia Tryptase Case report

Electroluminescence from pure resonant states in hBN-based vertical tunneling junctions

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Light(Science & Applications) 2024年第8期13卷 1557-1564页

作者： Magdalena Grzeszczyk Kristina Vaklinova Kenji Watanabe Takashi Taniguchi Konstantin SNovoselov maciej Koperski Institute for Functional Intelligent Materials National University of SingaporeSingapore 117544Singapore Research Center for Functional Materials National Institute for Materials ScienceTsukuba 305-0044Japan International Center for Materials Nanoarchitectonics National Institute for Materials ScienceTsukuba 305-0044Japan Department of Materials Science and Engineering National University of SingaporeSingapore 117575Singapore

Defect centers in wide-band-gap crystals have garnered interest for their potential in applications among optoelectronic and sensor ***,defects embedded in highly insulating crystals,like diamond,silicon carbide,or aluminum oxide,have been notoriously difficult to excite electrically due to their large internal *** address this challenge,we realized a new paradigm of exciting defects in vertical tunneling junctions based on carbon centers in hexagonal boron nitride(hBN).The rational design of the devices via van der Waals technology enabled us to raise and control optical processes related to defect-to-band and intradefect *** fundamental understanding of the tunneling events was based on the transfer of the electronic wave function amplitude between resonant defect states in hBN to the metallic state in graphene,which leads to dramatic changes in the characteristics of electrons due to different band structures of constituent *** our devices,the decay of electrons via tunneling pathways competed with radiative recombination,resulting in an unprecedented degree of tuneability of carrier dynamics due to the significant sensitivity of the characteristic tunneling times on the thickness and structure of the *** enabled us to achieve a high-efficiency electrical excitation of intradefect transitions,exceeding by several orders of magnitude the efficiency of optical excitation in the sub-band-gap *** work represents a significant advancement towards a universal and scalable platform for electrically driven devices utilizing defect centers in wide-band-gap crystals with properties modulated via activation of different tunneling mechanisms at a level of device engineering.

关键词： carbide tunneling defect

The g-factor measurement as an ultimate test for nuclear chirality

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Frontiers of physics 2024年第3期19卷 1-10页

作者： Ernest Grodner Michał Kowalczyk Julian Srebrny Leszek Próchniak Chrystian Droste Jan Kownacki maciej Kisieliński Krzysztof Starosta Takeshi Koike National Centre for Nuclear Research 05-540ŚwierkPoland Heavy Ion Laboratory University of WarsawPasteura 5a02-093 WarsawPoland Faculty of Physics University of WarsawPasteura 502-093 WarsawPoland Simon Fraser University 8888 University Drive BurnabyB.C.Canada V5A 1S6 Department of Physics Tohoku UniversitySendaiMiyagi 980-8577Japan

We present results of a series of experiments aimed at finding the most direct fingerprints of a phenomenon of nuclear chirality. These experiments brought a detailed knowledge of the so called partner bands in 132La, 128Cs and 126Cs including absolute values of E2 and M1 transition probabilities obtained through the DSA (Doppler Shift Attenuation) method. Considering the indirect character of observables such as energies and transition rates we proposed measurement of the g-factor of a chosen state as a direct, ultimate test of chirality. Our experiment on the bandhead of partner bands in 128Cs showed feasibility of this approach. Measured value of the g-factor which suggests non-chiral character of this state leads to another puzzle in the chirality studies — how the chirality emerges with increasing spin of levels along a partner band.

关键词： nuclear chirality electromagnetic transitions electromagnetic moments level lifetimes

激励参数对Q235钢增量磁导率蝶形图的影响研究

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机械工程学报 2024年第2期60卷 27-35页

作者：涂洪铭伍剑波柯瑞夏慧陈笑天 maciej Roskosz 四川大学机械工程学院成都610065 AGH科技大学机械工程与机器人学院波兰克拉科夫30-059

增量磁导率检测法是一种新型电磁无损检测方法,能够实现对铁磁性材料多种特性的定量或定性检测与评估。由于增量磁导率信号特征值容易受电磁影响,不同的激励条件会影响其最终评价的结果,且尚未有研究分析激励参数对增量磁导率蝶形图的... 详细信息

增量磁导率检测法是一种新型电磁无损检测方法,能够实现对铁磁性材料多种特性的定量或定性检测与评估。由于增量磁导率信号特征值容易受电磁影响,不同的激励条件会影响其最终评价的结果,且尚未有研究分析激励参数对增量磁导率蝶形图的影响。通过多种激励参数变化下的增量磁导率检测方法试验,分析高频/低频磁化的频率、强度、叠加方向以及提离效应带来的影响,探究不同激励参数下增量磁导率的变化规律,结果表明高频/低频磁场强度、频率、方向以及提离对增量磁导率信号及其蝶形图的特征值影响程度各不相同,为增量磁导率检测法的信号分析和工业应用奠定理论基础。

关键词：无损检测增量磁导率激励参数矫顽力

Molecular mimicry in Helicobacter pylori infections

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World Journal of Gastroenterology 2017年第22期23卷 3964-3977页

作者： magdalena chmiela weronika gonciarz department of immunology and infectious biology institute of microbiology biotechnology and immunology faculty of biology and environmental protection university of lodz

Gram-negative bacteria Helicobacter pylori(H. pylori) colonize gastric mucosa in humans and increase the risk of serious diseases such as gastric and duodenal ulcers, stomach cancers and mucosa associated lymphoid tissue lymphoma. The role of H. pylori infection in the pathogenesis of several extragastric diseases has been suggested including immune thrombocytopenic purpura, iron deficiency anemia, vitamin D deficiency, cardiovascular diseases,diabetes mellitus and dermatological disorders. Also neurological diseases and even lung cancer have attracted researchers concern. The relation between H. pylori infection and a growth retardation in children has also been suggested. Many mechanisms of molecular mimicry between H. pylori and the host have been proposed as a pathogen strategy to manipulate the immune system of the host in order to remain unrecognized and avoid eradication. A lot of effort has been put into the demonstration of homologous sequences between H. pylori and host compounds. However, knowledge about how often autoantibodies or autoreactive T lymphocytes induced during H. pylori infections cause pathological disorders is insufficient. This review provides data on H. pylori antigenic mimicry and possible deleterious effects due to the induction of immune response to the components common to these bacteria and the host.

关键词： Helicobacter pylori Molecular mimicry Anti-self response Extragastric effects

Gadolinium-modified titanium oxide materials for photoenergy applications:a review

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Journal of Rare Earths 2014年第6期32卷 487-495页

作者： maciej Zalas Faculty of Chemistry Adam Mickiewicz University in Poznań

Gadolinium doped titania materials were explored for application in photoenergy production. Incorporation of gadolinium into titania permitted improvement of photocatalytic or photovoltaic performance of the latter. This review provided a deep analysis of gadolinium applications in photoenergy processes and devices with the main focus on explanation of gadolinium doping effect on physicochemical properties of titania.

关键词： gadolinium doped titania Gd-TiO2 photocatalysis dye-sensitized solar cells photoenergy rare earths

Host pathogen interactions in Helicobacter pylori related gastric cancer

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World Journal of Gastroenterology 2017年第9期23卷 1521-1540页

作者： Magdalena Chmiela Zuzanna Karwowska Weronika gonciarz Bujana Allushi Pawel Staczek Department of Immunology and Infectious Biology Institute of MicrobiologyBiotechnology and ImmunologyFaculty of Biology and Environmental ProtectionUniversity of Lodz Department of Genetics of Bacteria Institute of MicrobiologyBiotechnology and ImmunologyFaculty of Biology and Environmental ProtectionUniversity of Lodz

Helicobacter pylori (H. pylori), discovered in 1982, is a microaerophilic, spiral-shaped gram-negative bacterium that is able to colonize the human stomach. Nearly half of the world’s population is infected by this pathogen. Its ability to induce gastritis, peptic ulcers, gastric cancer and mucosa-associated lymphoid tissue lymphoma has been confirmed. The susceptibility of an individual to these clinical outcomes is multifactorial and depends on H. pylori virulence, environmental factors, the genetic susceptibility of the host and the reactivity of the host immune system. Despite the host immune response, H. pylori infection can be difficult to eradicate. H. pylori is categorized as a group I carcinogen since this bacterium is responsible for the highest rate of cancer-related deaths worldwide. Early detection of cancer can be lifesaving. The 5-year survival rate for gastric cancer patients diagnosed in the early stages is nearly 90%. Gastric cancer is asymptomatic in the early stages but always progresses over time and begins to cause symptoms when untreated. In 97% of stomach cancer cases, cancer cells metastasize to other organs. H. pylori infection is responsible for nearly 60% of the intestinal-type gastric cancer cases but also influences the development of diffuse gastric cancer. The host genetic susceptibility depends on polymorphisms of genes involved in H. pylori-related inflammation and the cytokine response of gastric epithelial and immune cells. H. pylori strains differ in their ability to induce a deleterious inflammatory response. H. pylori-driven cytokines accelerate the inflammatory response and promote malignancy. Chronic H. pylori infection induces genetic instability in gastric epithelial cells and affects the DNA damage repair systems. Therefore, H. pylori infection should always be considered a pro-cancerous factor.

关键词： Helicobacter pylori Host susceptibility Carcinogenesis Bacterial diversity

Statistical variation of characteristics of random packed beds of Raschig rings:The influence of the sample size

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Particuology 2021年第3期19卷 50-61页

作者： PawełNiegodajew maciej Marek Czestochowa University of Technology Department of Thermal Machineryal.Armii Krajowej 2142-200 CzestochowaPoland

Many studies on random packed beds have been dedicated to local porosity(void fraction)or orientation distribution of ***,despite the random nature of the considered packings,very little attention has been devoted to examination whether the number of particles used in experiments/simulations is sufficiently large to get reproducible *** reproducibility of the key packing parameters depends on the size of the population of particles(sample size)and ordering effects induced by the confining *** work investigates quantitatively the influence of the sample size on the statistical variation of the packed bed *** beds of Raschig rings were generated with a sequential algorithm and three column diameters were *** has been found that in the case of the orientation distribution the results depend strongly on the sample size,especially for slender columns,while the porosity profiles are well-reproducible characteristics even for relatively small packings of *** complementary results for full cylinders are also included.

关键词： Random packing Raschig rings Full cylinders Particle orientation Porosity Reproducibility

Modeling of Propagation and Transformation of Transient Nonlinear Waves on A Current

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China Ocean Engineering 2013年第5期27卷 579-592页

作者： Wojciech Sulisz maciej Paprota Institute of Hydroengineering Polish Academy of Sciencies

A novel theoretical approach is applied to predict the propagation and transformation of transient nonlinear waves on a current. The problem was solved by applying an eigenfunction expansion method and the derived semi-analytical solution was employed to study the transformation of wave profile and the evolution of wave spectrum arising from the nonlinear interactions of wave components in a wave train which may lead to the formation of very large waves. The results show that the propagation of wave trains is significantly affected by a current. A relatively small current may substantially affect wave train components and the wave train shape. This is observed for both opposing and following current. The results demonstrate that the application of the nonlinear model has a substantial effect on the shape of a wave spectrum. A train of originally linear and very narrow-banded waves changes its one-peak spectrum to a multi-peak one in a fairly short distance from an initial position. The discrepancies between the wave trains predicted by applying the linear and nonlinear models increase with the increasing wavelength and become significant in shallow water even for waves with low steepness. Laboratory experiments were conducted in a wave flume to verify theoretical results. The free-surface elevations recorded by a system of wave gauges are compared with the results provided by the nonlinear model. Additional verification was achieved by applying a Fourier analysis and comparing wave amplitude spectra obtained from theoretical results with experimental data. A reasonable agreement between theoretical results and experimental data is observed for both amplitudes and phases. The model predicts fairly well multi-peak spectra, including wave spectra with significant nonlinear wave components.

关键词： numerical modeling transient waves current boundary conditions initial conditions