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Journal of Harbin Institute of Technology(New Series) 2024年第1期31卷 26-37页

作者： Kamasamudram Bhavya Sai Rishi raghu Sai Surya Varshith Nukala Jayashree Jayaraman Vijayashree Jayaraman School of Computer Science and Engineering Vellore Institute of TechnologyVellore 632014India

For years,foot ulcers linked with diabetes mellitus and neuropathy have significantly impacted diabetic patients’ health-related quality of life(HRQoL). Diabetes foot ulcers impact15% of all diabetic patients at some point in their lives. The facilities and resources used for DFU detection and treatment are only available at hospitals and clinics,which results in the unavailability of feasible and timely detection at an early stage. This necessitates the development of an at-home DFU detection system that enables timely predictions and seamless communication with users,thereby preventing amputations due to neglect and severity. This paper proposes a feasible system consisting of three major modules:an IoT device that works to sense foot nodes to send vibrations onto a foot sole,a machine learning model based on supervised learning which predicts the level of severity of the DFU using four different classification techniques including XGBoost,K-SVM,Random Forest,and Decision tree,and a mobile application that acts as an interface between the sensors and the patient. Based on the severity levels,necessary steps for prevention,treatment,and medications are recommended via the application.

关键词： diabetic foot ulcer podiatry diabetes mellitus healthcare footcare internet of things machine learning human⁃computer interaction

Recognition and Anticipation of Diabetic Foot Ulcer in Type Ⅱ Diabetic Patients using Multi-layered Fuzzy Model

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Journal of Harbin Institute of Technology(New Series) 2024年第4期31卷 13-23页

作者： Sai Surya Varshith Nukala Jayashree Jayaraman Vijayashree Jayaraman Rishi raghu School of Computer Science and Engineering Vellore Institute of TechnologyVellore 632014Tamil NaduIndia

Diabetes mellitus is associated with foot ulcers,which frequently pave the way to lower-extremity ***,trauma,deformity,high plantar pressures,and peripheral vascular disease are the most common underlying *** 15%of diabetic patients are affected by diabetic foot ulcer in their lifetime.64 million people are affected by diabetics in India and 40000 amputations are done every *** ulcers are evaluated and classified in a systematic and thorough manner to assist in determining the best course of *** paper proposes a novel model which predicts the threat of diabetic foot ulcer using independent agents for various input values and a combination of fuzzy expert *** proposed model uses a classification system to distinguish between each fuzzy framework and its *** on the severity levels necessary prevention,treatment,and medication are *** the results of all the fuzzy frameworks derived from its constituent parameters,a risk-specific medication is *** work also has higher accuracy when compared to other related models.

关键词： diabetic ulcer typeⅡdiabetic fuzzy model

Discrete Wavelet Transmission and Modified PSO with ACO Based Feed Forward Neural Network Model for Brain Tumour Detection

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Computers, Materials & Continua 2020年第11期65卷 1081-1096页

作者： machiraju Jayalakshmi S.Nagaraja Rao Department of Electrical&Computer Engineering JNTUA AnantapuramuAndhra PradeshIndia Department of ECE G.Pulla Reddy Engineering College(Autonomous)KurnoolAndhra PradeshIndia

In recent years,the development in the field of computer-aided diagnosis(CAD)has increased *** traditional machine learning algorithms have been proposed for identifying the pathological brain using magnetic resonance *** existing algorithms have drawbacks with respect to their accuracy,efficiency,and limited learning *** address these issues,we propose a pathological brain tumour detection method that utilizes the Weiner filter to improve the image contrast,2D-discrete wavelet transformation(2D-DWT)to extract the features,probabilistic principal component analysis(PPCA)and linear discriminant analysis(LDA)to normalize and reduce the features,and a feed-forward neural network(FNN)and modified particle swarm optimization(MPSO)with ant colony optimization(ACO)to improve the accuracy,stability,and overcome fitting issues in the classification of brain magnetic resonance *** proposed method achieves better results than other existing algorithms.

关键词： Discrete wavelet transformation ant colony optimization feed-forward neural network linear discriminant analysis

Current methods for the maturation of induced pluripotent stem cellderived cardiomyocytes

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World Journal of Stem Cells 2019年第1期11卷 33-43页

作者： Pranav machiraju Steven C Greenway Departments of Pediatrics and Cardiac Sciences Alberta Children’s Hospital Research Institute Libin Cardiovascular Institute of Alberta Cumming School of MedicineUniversity of Calgary Departments of Pediatrics Cardiac Sciences Biochemistry & Molecular Biology Alberta Children’s Hospital Research Institute Libin Cardiovascular Institute of Alberta Cumming School of Medicine University of Calgary

Induced pluripotent stem cells(iPSCs) were first generated by Yamanaka and colleagues over a decade ago. Since then, iPSCs have been successfully differentiated into many distinct cell types, enabling tissue-, disease-, and patientspecific in vitro modelling. Cardiovascular disease is the greatest cause of mortality worldwide but encompasses rarer disorders of conduction and myocardial function for which a cellular model of study is ideal. Although methods to differentiate iPSCs into beating cardiomyocytes(iPSC-CMs) have recently been adequately optimized and commercialized, the resulting cells remain largely immature with regards to their structure and function,demonstrating fetal gene expression, disorganized morphology, reliance on predominantly glycolytic metabolism and contractile characteristics that differ from those of adult cardiomyocytes. As such, disease modelling using iPSC-CMs may be inaccurate and of limited utility. However, this limitation is widely recognized, and numerous groups have made substantial progress in addressing this problem. This review highlights successful methods that have been developed for the maturation of human iPSC-CMs using small molecules,environmental manipulation and 3-dimensional(3 D) growth approaches.

关键词： Induced pluripotent stem cells Induced pluripotent stem cell-derived cardiomyocytes Regenerative medicine Stem cell biology Translational research

Bismuth Modified Porous Silica Preparation,Characterization and Photocatalytic Activity Evaluation for Degradation of Isoproturon

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Journal of Materials Science & Technology 2013年第7期29卷 639-646页

作者： Anil Kumar Reddy Police Srinivas Basavaraju Durga Kumari Valluri Subrahmanyam machiraju Inorganic and Physical Chemistry Division Indian Institute of Chemical TechnologyHyderabad 500607India

Porous silica prepared by using an acrylic emulsion has been impregnated with bismuth ion resulting in Bi2Si05 species containing surface. The as-prepared materials have been characterized by X-ray diffraction spectroscopy （XRD）, X-ray photoelectron spectroscopy （XPS）, UV-Vis diffuse reflectance spectroscopy （UV-Vis DRS）, scanning electron microscopy （SEM）, energy dispersive analysis of X-ray （EDAX）, transmission electron microscopy （TEM）, Fourier transform infrared spectroscopy （FTIR） and N2 adsorption/desorption techniques. EDAX analysis confirms the penetration of bismuth ions into the framework of silica to form Bi2SiO5, which is substantiated by XRD. The UV-Vis DRS shows that the catalysts are optically active and XPS confirms the inclusion of bismuth into the framework of silica. FTIR spectra illustrate the formation of Bi-O-Si linkages in the porous silica framework. SEM and TEM show the spherical morphology, whereas N2 adsorption/desorption study confirms the porosity of the prepared materials. The photocatalytic activity of the material is evaluated for the degradation of isoproturon herbicide and it is found that the material is active as compared to the commercial P-25 Degussa TiO2.

关键词： Acrylic emulsion Emulsion polymerization technique Porous silica Bi2SiO5 Photocatalyfic degradation lsoproturon

Catalytic decomposition of CH_4 over Ni-Al_2O_3-SiO_2 catalysts:Influence of pretreatment conditions for the production of H_2

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Journal of Natural Gas Chemistry 2008年第2期17卷 113-119页

作者： Jangam Ashok Gangadhara Raju Padigapati Shiva Reddy machiraju Subrahmanyam Akula Venugopal Catalysis and Physical Chemistry Division Indian Institute of Chemical TechnologyTarnakaHyderabadIndia-500 607

This article reports the production of COx free hydrogen and carbon nanofibers by the catalytic decomposition of methane over Ni-Al2O3-SiO2 catalysts. The influence of reaction temperature, pretreatment temperature, and effect of reductive pretreatment on the decomposition of methane activity is investigated. The physico-chemical characteristics of fresh and deactivated samples were characterized using BET-SA, XRD, TPR, SEM/TEM, CHNS analyses and correlated with the methane decomposition results obtained. The Ni-Al-Si （4 ： 0.5 ： 1.5） catalyst reduced with hydrazine hydrate produced better H2 yields of ca. 1815 mol H2/mol Ni than the catalyst reduced with 5% H2/N2.

关键词： in situ reduction Ni-Al2O3-SiO2 catalyst methane decomposition hydrogen production carbon nanofibers

Spray Characteristics of Biodiesel Fuel in Constant Volume Chamber using Multi-response Optimization Technique

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Journal of Thermal Science 2016年第6期25卷 581-588页

作者： P.raghu N.Nallusamy Sri Venkateswara College of Engineering Department of Mechanical Engineering SSN College of Engineering Department of Mechanical Engineering

This study discusses about the optimization of spray characteristics of biodiesel fuel in a spray *** factors namely,fuel injection pressure,fuel temperature and fuel blends were chosen as the influencing factor for the set *** levels were chosen in each factor and spray tip penetration,spray cone angle and Sauter mean diameter(SMD) were taken as the response *** were designed by employing design of experiments method and Taguchi full factorial array was used to conduct the tests with different levels of the chosen *** Response Signal to Noise ratio(MRSN) was calculated for the response variables and the optimum combination level of factors was obtained simultaneously using Taguchi's parametric *** experiments were conducted for the obtained optimum combination level of factors and the results were compared with the normal operating conditions and significant improvement were observed in the response variables.

关键词： spray penetration factorial weighting chosen conduct chamber parametric normalized blends

Enhancement of current density using effective membranes electrode assemblies for water electrolyser system

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Journal of Energy Chemistry 2016年第1期25卷 77-84页

作者： Swaminathan Seetharaman Subash Chandrabose raghu Kambiz Ansari Mahabadi Institute of Materials Research & Engineering A*STAR (Agency for Science Technology and Research) 3 Research Link Singapore 117 602 Singapore School of Civil and Environmental Engineering Nanyang Technological University Block N1 Nanyang Avenue Singapore 639 798 Singapore

The goal of this study was to develop and design a composite proton exchange membrane（PEM） and membrane electrode assembly（MEA） that are suitable for the PEM based water electrolysis system. In particular,it focuses on the development of sulphonated polyether ether ketone（SPEEK） based membranes and caesium salt of silico-tungstic acid（Cs Si WA） matrix compared with one of the transition metal oxides such as titanium dioxide（TiO2）, silicon dioxide（SiO2） and zirconium dioxide（ZrO2）. The resultant membranes have been characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, ion exchange capacity（IEC）, water uptake and atomic force microscopy. Comparative studies on the performance of MEAs were also conducted utilizing impregnation-reduction and conventional brush coating methods. The PEM electrolysis performance of SPEEK-Cs Si WA-ZrO2 composite membrane was more superior than that of other membranes involved in this study. Electrochemical characterization shows that a maximum current density of 1.4 A/cm^2 was achieved at 60 °C, explained by an increased concentration of protonic sites available at the interface.

关键词： Composite membrane Membrane electrode assembly Impregnation reduction method Brush coating method Electrolysis

Cerium(Ⅳ) ammonium nitrate catalysed facile and efficient synthesis of polyhydroquinoline derivatives through Hantzsch multicomponent condensation

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Chinese Chemical Letters 2008年第7期19卷 775-779页

作者： Cherkupally Sanjeeva Reddy Mekala raghu Department of Chemistry Kakatiya UniversityWarangal 506009India

A general and convenient practical approach for the synthesis of polyhydroquinoline derivatives has been achieved via one-pot four-component Hantzsch condensation of aromatic aldehydes, dimedone, ethyl acetoacetate and ammonium acetate in the presence of a catalytic amount of cerium（IV） ammonium nitrate （CAN）, in ethanol solvent at ambient temperature. Simple work-up, mild reaction conditions, inexpensive and non-toxic catalyst, and excellent product yields are the advantageous features of this method.

关键词： Aldehydes Dimedone Ethyl acetoacetate Ammonium acetate CAN Polyhydroquinolines