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Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression

Genes & Diseases 2024年第2期11卷 921-934页

作者： Hui-Qing Zhang Fanyang Kong Xiangyu Kong Tingting Jiang Muyuan ma Shaojiang zheng Junli Guo Keping Xie The Third Department of Medical Oncology Jiangxi Cancer HospitalNanchangJiangxi 330006China Departments of Gastroenterology Changhai HospitalSecond Military Medical UniversityShanghai 200433China Center for Pancreatic Cancer Research The South China University of Technology School of MedicineGuangzhouGuangdong 510006China Hainan Clinical Medical Research Center of the First Affiliated Hospital Hainan Women and Children's Medical CenterHainan Medical UniversityHaikouHainan 570102China Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province Key Laboratory of Emergency and Trauma of Ministry of EducationHainan Medical UniversityHaikouHainan 571199China

Ubiquitously transcribed tetratricopeptide repeat on chromosome X(UTX),also known as lysine(K)-specific demethylase 6A(KDM6A),functions as a tumor suppressor gene or oncogene depending on the tumor type and ***,its tumor-suppressive mechanisms remain largely ***,we investigated the clinical significance and biological effects of UTX expression in pancreatic ductal adenocarcinoma(PDA)and determined the potential mechanisms of its *** expression and its association with clinicopathologic characteristics of PDA patients were analyzed using *** mRNA and protein expression and their regulation in PDA cell lines were measured using quantitative polymerase chain reaction and Western blot *** biological functions of UTX in PDA cell growth,migration,and invasion were determined using gain-and loss-of-function assays with both in vitro and in vivo animal *** expression was reduced in human PDA cell lines and *** UTX expression was associated with poor differentiation and prognosis in *** UTX expression inhibited PDA proliferation,migration,and invasion in vitro and PDA growth and metastasis in vivo,whereas knockdown of UTX expression did the ***,UTX expression was trans-activated by GATA6 ***6-mediated PDA progression could be blocked,at least partially,by silencing UTX *** conclusion,loss of GATA6-mediated UTX expression was evident in human PDA and restored UTX expression suppressed PDA growth and ***,UTX is a tumor suppressor in PDA and may serve as a prognostic biomarker and therapeutic target.

关键词： Growth Invasion Metastasis Pancreatic cancer UTX

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Existence of long-range magnetic order in Heisenberg spin nanoribbons with edge modification

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Communications in Theoretical Physics 2024年第7期76卷 134-144页

作者： Da-cheng ma Ling-yi Cui Chu-xiao Sun Xiao-dan Chi zheng-Nan XianYu An Du College of Science Northeastern UniversityShenyang 110819China Department of Basic Science Dalian Naval AcademyDalian 116018China Department of Physics College of SciencesShenyang University of Chemical TechnologyShenyang 110142China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern UniversityChina Key Laboratory of Data Analytics and Optimization for Smart Industry(Northeastern University) Ministry of EducationChina

Long-range magnetic order appears on a side decorated Heisenberg spin nanoribbon at nonzero temperature,although no spontaneous magnetization exists in a one-or two-dimensional isotropic Heisenberg model at any nonzero temperature according to the Mermin-Wagner *** use of the spin Green's function method,we calculated the magnetizations of Heisenberg nanoribbons decorated by side spins with single-ion anisotropy and found that the system exhibits a nonzero transition temperature,whether the decorated edge spins of the system link together or separate from each *** the width of the nanoribbon achieves infinite limit,the transition temperatures of the system tend to the same finite constant eventually whether one edge or both edges are decorated by side spins in the *** results reveal that the magnetism of a low-dimensional spin system is different from that of a threedimensional spin *** the single-ion anisotropy of edge spins in a Heisenberg spin nanoribbon can be modulated by an electric field experimentally,various useful long-range magnetic orders of the system can be *** work can provide a detailed theoretical basis for designing and fabricating next-generation low-dimensional magnetic random-access memory.

关键词： Nanoribbon magnetic anisotropy long-range magnetic order Heisenberg model transition temperature

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Micelle-directed self-assembly of single-crystal-like mesoporous stoichiometric oxides for high-performance lithium storage

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National Science Review 2024年第4期11卷 195-205页

作者： Yanhua Wan Changyao Wang Xingmiao Zhang Yang Yin Mengmeng Liu Bing ma Linlin Duan Yuzhu ma Wei Zhang Changlin zheng Dongliang Chao Fei Wang Yongyao Xia Wei Li Department of Chemistry Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials State Key Laboratory of Molecular Engineering of Polymers College of Chemistry and Materials ScienceFudan University State Key Laboratory of Surface Physics and Department of Physics Fudan University

Due to their uncontrollable assembly and crystallization process,the synthesis of mesoporous metal oxide single crystals remains a formidable ***,we report the synthesis of single-crystal-like mesoporous Li2TiSiO5by using soft micelles as *** key lies in the atomic-scale self-assembly and step-crystallization processes,which ensure the formation of single-crystal-like mesoporous Li2TiSiO5microparticles via an oriented attachment growth mechanism under the confinement of an in-situ formed carbon *** mesoporous Li2TiSiO5anode achieves a superior rate capability(148 mah g-1at5.0 A g-1) and outstanding long-term cycling stability(138 mah g-1after 3000 cycles at 2.0 A g-1) for lithium storage as a result of the ultrafast Li+diffusion caused by penetrating mesochannels and nanosized crystal frameworks（5-10 nm）.In comparison,bulk Li2TiSiO5exhibits poor rate capability and cycle performance due to micron-scale diffusion *** method is very simple and reproducible,heralding a new way of designing and synthesizing mesoporous single crystals with controllable frameworks and chemical functionalities.

关键词： mesoporous materials micelles single-crystal-like Li2TiSiO5 lithium-ion batteries

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A tectono-thermal perspective on the petroleum generation,accumulation and preservation in the southern Ordos Basin, North China

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Petroleum Science 2024年第3期21卷 1459-1473页

作者： Peng Yang Zhan-Li Ren Jin-Hua Fu Hong-Ping Bao Hui Xiao zheng Shi kun Wang Yuan-Yuan Zhang Wen-Hui Liu Wen-Hou Li State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi'an710069ShanxiChina National Engineering Laboratory for Exploration and Development of Low-Permeability Oil and Gas Fields Exploration and Development Research Institute of PetroChina Changqing Oilfield CompanyXi'an710018ShaanxiChina Shaanxi Key Lab of Petroleum Accumulation Geology School of Earth Science and EngineeringXi'an Shiyou UniversityXian710065ShaanxiChina Wuxi Research Institute of Petroleum Geology Petroleum Exploration and Production Research InstituteSINOPECWuxi214126JiangsuChina

The southern Ordos Basin has excellent petroleum exploration ***,the tectono-thermal history and the controls on petroleum generation,accumulation and preservation conditions in southern basin are *** this study,we analyzed the present geothermal field,paleo-geothermal gradient,maturity of the hydrocarbon source rocks,uplift and cooling process and tectono-thermal evolution *** the study area,for the Ordovician,Permain and the Triassic strata,the present temperature is low(3070℃)in the southeastern area but high(80140℃)in the northwestern *** paleogeothermal gradient varied from 24℃/km to 30℃/km with a heat flow of 58—69 m W/m^(2)(i.e.,a medium-temperature basin).The paleo-temperatures are higher than the present temperatures and the maximum paleo-temperatures controlled the thermal maturity of the source *** vitrinite reflectance(Ro)values of the Triassic strata are>0.7%and the thermal maturity reached the middlemature oil generation *** Rovalues of the Permian-Ordovician strata are>1.8%and the thermal maturity reached the over-mature gas generation *** southern Ordos Basin has experienced the multiple tectonic events at the Late Ordovician Caledonian(452 ma),Late Triassic(215 ma),Late Jurassic(165160 ma),End-Early Cretaceous(110100 ma)and Cenozoic(since 40 ma).A large-scale tectonothermal event occurred at the End-Early Cretaceous(110100 ma),which was controlled by lithospheric extension,destruction and *** event led to the highest paleo-temperatures and thermal maturities and coeval with the peak period of petroleum generation and *** southern Ordos Basin has undergone rapid and large-scale uplift since the Late Cretaceous due to expansion of the northeastern margin of the Tibetan Plateau,uplift of the Qinling orogenic belt and thrust faulting in the Liupanshan tectonic *** southern Ordos Basin experienced tectonic overprinting that was strong in the south and weak in the *** str

关键词： Fission-track dating Vitrinitereflectance Geothermal field Tectono-thermal evolution Petroleum geology Ordos Basin

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Low-dimensional van der Waals materials for linear-polarization-sensitive photodetection: materials, polarizing strategies and applications

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materials Futures 2024年第1期3卷 95-127页

作者： Yuhang ma Huaxin Yi Huanrong Liang Wan Wang Zhaoqiang zheng Jiandong Yao Guowei Yang State Key Laboratory of Optoelectronic materials and Technologies Nanotechnology Research CenterSchool of Materials Science&EngineeringSun Yat-sen UniversityGuangzhou 510275GuangdongPeople’s Republic of China Guangzhou Key Laboratory of Flexible Electronic materials and Wearable Devices Sun Yat-sen UniversityGuangzhou 510275GuangdongPeople’s Republic of China School of materials and Energy Guangdong University of TechnologyGuangzhou 510006GuangdongPeople’s Republic of China

Detecting light from a wealth of physical degrees of freedom(***,intensity,polarization state,phase,etc)enables the acquirement of more comprehensive *** the past two decades,low-dimensional van der Waals materials(vdWMs)have established themselves as transformative building blocks toward lensless polarization optoelectronics,which is highly beneficial for optoelectronic system *** review provides a comprehensive overview on the recent development of low-dimensional vdWM polarized *** begin with,the exploitation of pristine 1D/2D vdWMs with immanent in-plane anisotropy and related heterostructures for filterless polarization-sensitive photodetectors is ***,we have systematically epitomized the various strategies to induce polarization photosensitivity and enhance the degree of anisotropy for low-dimensional vdWM photodetectors,including quantum tailoring,construction of core–shell structures,rolling engineering,ferroelectric regulation,strain engineering,etc,with emphasis on the fundamental physical *** that,the ingenious optoelectronic applications based on the low-dimensional vdWM polarized photodetectors,including multiplexing optical communications and enhanced-contrast imaging,have been *** the end,the current challenges along with the future prospects of this burgeoning research field have been *** the whole,the review depicts a fascinating landscape for the next-generation high-integration multifunctional optoelectronic systems.

关键词： polarization-discriminating photodetectors 1D van der Waals materials

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One-Step Scalable Fabrication of Nitrogen and Chlorine Co-doped Graphene by Electrochemical Exfoliation for High-Performance Supercapacitors

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Transactions of Tianjin University 2024年第5期30卷 448-458页

作者： Qian Li Hu zheng Binbin Liu Tianzhen Jian Wenqing ma Caixia Xu Kai Wang Institute for Advanced Interdisciplinary Research(iAIR) School of Chemistry and Chemical Engineering University of Jinan Institute of Electrical Engineering Chinese Academy of Sciences

The stacking and aggregation of graphene nanosheets have been obstacles to their application as electrode materials for microelectronic devices. This study deploys a one-step, scalable, facile electrochemical exfoliation technique to fabricate nitrogen（N） and chlorine（Cl） co-doped graphene nanosheets（i.e., N–Cl–G） via the application of constant voltage on graphite in a mixture of 0.1 mol/L H2SO4and 0.1 mol/L NH4Cl without using dangerous and exhaustive operation. The introduction of Cl（with its large radius） and N, both with high electrical negativity, facilitates the modulation of the electronic structure of graphene and creation of rich structural defects in it. Consequently, in the as-constructed supercapacitors, N–Cl–G exhibits a high specific capacitance of 77 F/g at 0.2 A/g and remarkable cycling stability with 91.7% retention of initial capacitance after 20,000 cycles at 10 A/g. Furthermore, a symmetrical supercapacitor assembled with N–Cl–G as the positive and negative electrodes（denoted as N–Cl–G//N–Cl–G） exhibits an energy density of 3.38 Wh/kg at a power density of 600 W/kg and superior cycling stability with almost no capacitance loss after 5000 cycles at 5 A/g. This study provides a scalable protocol for the facile fabrication of high-performance co-doped graphene as an electrode material candidate for supercapacitors.

关键词： Chlorine Electrochemical exfoliation Graphene Nitrogen Supercapacitor

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Ultrathin ternary PtNiGa nanowires for enhanced oxygen reduction reaction

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Chinese Chemical Letters 2024年第2期35卷 599-603页

作者： Giday Fisseha Yiping Hu Yanan Yu Shaojie Lu Dongsheng ma Pei Nian zheng Wang Qin Yue Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering School of Chemistry and Chemical EngineeringNingxia UniversityYinchuan 750021China

Achieving high activity and durability for the oxygen reduction reaction(ORR)with an ultra-low amount of platinum is significant to promote the widespread application of proton exchange membrane fuel cells(PEMFCs).Here we report a new ultrathin(∼1 nm)ternary PtNiGa alloy nanowires(PtNiGa NWs)electrocatalyst,in which the presence of gallium(Ga)enhances the oxidation resistance of platinum(Pt)and nickel(Ni)and suppresses the dissolution of *** mass and specific activities of PtNiGa NWs are about 11.2 and 7.6 times higher than those of commercial Pt/C catalysts for ***,the mass activity of PtNiGa/C NWs nanocatalyst decreased only by 12.8%and largely retained its electrochemical surface area(ECSA)after 10,000 potential cycles,compared with 38%loss of ECSA for commercial Pt/C ***,this work provides a general guideline for preparing ternary alloy electrocatalysts and enhancing the activity and stability of the cathode ORR reaction of PEMFCs.

关键词： Ultrathin nanowires Gallium Oxygen reduction reaction Ternary alloy Durability

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Proposing a machine learning approach to analyze and predict basic high-temperature properties of iron ore fines and its factors

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Journal of Iron and Steel Research International 2024年第5期31卷 1082-1094页

作者： Qing-ke Sun Yao-zu Wang Jian-liang Zhang zheng-jian Liu Le-le Niu Chang-dong Shan Yun-fei ma Institute of Artificial Intelligence University of Science and Technology BeijingBeijing100083China School of Intelligence Science and Technology University of Science and Technology BeijingBeijing100083China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China

The basic high-temperature properties of iron ore play a crucial role in optimizing sintering and ore blending,but the testing process for these properties is complex and has significant lag time,which cannot meet the actual needs of ore blending.A prediction model for the basic high-temperature properties of iron ore fines was thus proposed based on a combination of machine learning algorithms and genetic ***,the prediction accuracy of different machine learning models for the basic high-temperature properties of iron ore fines was ***,a random forest model optimized by genetic algorithms was built,further improving the prediction accuracy of the *** test results show that the random forest model optimized by genetic algorithms has the highest prediction accuracy for the lowest assimilation temperature and liquid phase fluidity of iron ore,with a determination coefficient of 0.903 for the lowest assimilation temperature and 0.927 for the liquid phase fluidity after *** trained model meets the fluctuation requirements of on-site testing and has been successfully applied to actual production on site.

关键词： Iron ore Basic high-temperature property machine learning Random forest Genetic algorithm

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Lightweight,Strong and High Heat-Resistant Poly(lactide acid)Foams via Microcellular Injection Molding with Self-Assembly Nucleating Agent

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Chinese Journal of Polymer Science 2024年第6期42卷 739-750页

作者： Xiao-Hu Bing Wen-Yu ma Ming-Hui Wu Peng Gao Xiao Zhou Hai-Bin Luo Long Wang Wen-Ge zheng School of materials Science and Engineering Shanghai UniversityShanghai200444China Ningbo Key Lab of Polymer materials Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo315201China University of Chinese Academy of Sciences Beijing100049China

Poly(lactide acid)(PLA)foams have shown considerable promise as eco-friendly alternatives to nondegradable plastic foams,such as polystyrene(PS)***,PLA foam typically suffers from low heat-resistance and poor cellular structure stemming from its inherent slow crystallization rate and low melt *** this study,a high-performance PLA foam with well-defined cell morphology,exceptional strength and enhanced heat-resistance was successfully fabricated via a core-back microcellular injection molding(MIM)*** scanning calorimetry(DSC)results revealed that the added hydrazine-based nucleating agent(HNA)significantly increased the crystallization temperature and accelerated the crystallization process of ***,the addition of a 1.5 wt%of HNA led to a significant reduction in PLA’s cell size,from 43.5µm to 2.87µm,and a remarkable increase in cell density,from 1.08×10^(7)cells/cm^(3)to 2.15×10^(10)cells/cm^(3).This enhancement resulted in a final crystallinity of approximately 55.7%for the PLA blend foam,a marked improvement compared to the pure PLA ***,at 1.5 wt%HNA concentration,the tensile strength and tensile toughness of PLA blend foams demonstrated remarkable improvements of 136%and 463%,***,the Vicat softening temperature of PLA blend foam increased significantly to 134.8°C,whereas the pure PLA foam exhibited only about 59.7℃.These findings underscore the potential for the preparation of lightweight injection-molded PLA foam with enhanced toughness and heat-resistance,which offers a viable approach for the production of high-performance PLA foams suitable for large-scale applications.

关键词： Poly(lactide acid) Nucleating agent Microcellular injection molding Heat-resistance Toughness

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Interfacial Reaction of Ti6Al4V Lattice Structure-Reinforced VW92 Alloy matrix Composites

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 570-576页

作者： Haijun Wang Renju Cheng Xianhua Chen Mingbo Yang Daiyi Deng Lirui Liu Yongfeng Zhou Yanlong ma Kaihong zheng Fusheng Pan College of materials Science and Engineering Chongqing University of TechnologyChongqing 400054China College of materials Science and Engineering Chongqing UniversityChongqing 400044China Institute of New materials Guangdong Academy of SciencesGuangzhou 510650China

A novel melting infiltration by ultrasonic vibration was investigated and applied to fabricate Ti6Al4V(TC4)lattice structure-reinforced Mg-10Gd-2Y-1Zn-xZr(refer to VW92 hereafter,x=0,0.5 wt%)alloy matrix *** edge-to-edge matching model indicates that the well-matching and possible orientation relationships(ORs)between theα-Mg andα-Ti,[10-10]_(α-Mg)//[11-23]_(α-Ti) in(0002)_(α-Mg)//(10-10)_(α-Ti) possesses the smallest misfit of 0.4%(f_(r)),and thus theα-Mg grains can nucleate on the TC4 lattice *** reaction occurred in the TC4/VW92+0.5 wt%Zr composites,and the reaction product was confirmed to be Al_(2)Zr_(3),AlZr_(2) andα-Ti(Zr)particles formed by continuous solution of *** the interfacial products,the AlZr_(2) phase is a brittle phase with high-volume fraction,which is not conducive to the load *** generally speaking,theα-Ti(Zr)and theα-Mg tend to form a coherent interface,which is beneficial for improving the interfacial bonding strength of composites.

关键词： TC4 VW92 composites TC4 lattice structure Interfacial reaction Mismatch

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