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Toxicity of the disinfectant benzalkonium chloride(C_(14))towards cyanobacterium Microcystis results from its impact on the photosynthetic apparatus and cell metabolism

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Journal of Environmental Sciences 2024年第1期135卷 198-209页

作者： Yunlu Jia Yi Huang jin ma Shangwei Zhang jin Liu Tianli Li Lirong Song Institute of Hydrobiology Chinese Academy of SciencesWuhan 430072China School of Environmental Studies China University of GeosciencesWuhan 430074China Advanced Interdisciplinary Institute of Environment and Ecology Beijing Normal UniversityZhuhai 519087China

Quaternary ammonium compounds(QACs)are commonly used in a variety of consumer and commercial products,typically as a component of *** the COVID-19 pandemic,QACs became one of the primary agents utilized to inactivate the SARS CoV-2 virus on ***,the ecotoxicological effects of QACs upon aquatic organisms have not been fully *** this study,we examined the effects of a widely used QAC(benzalkonium chloride-C_(14),BAC-14)on two toxigenic Microcystis strains and one non-toxigenic freshwater Microcystis strain and carried out an analysis focused on primary,adaptive and compensatory stress responses at apical(growth and photosynthesis)and metabolic *** analysis revealed that the two toxic Microcystis strains were more tolerant than the non-toxic strain,with 96 hr-EC_(50)values of 0.70,0.76,and 0.38 mg/L BAC-14 for toxigenic *** FACHB-905,toxigenic *** FACHB-469,and non-toxigenic *** FACHB-908,*** photosynthetic activities of the Microcystis,assessed via F_(v)/F_(m) values,were significantly suppressed under 0.4 mg/L ***,this analysis revealed that BAC-14 altered 14,12,and 8 metabolic pathways in *** FACHB-905,*** FACHB-469,and *** FACHB-908,*** is noteworthy that BAC-14 enhanced the level of extracellular microcystin production in the toxigenic Microcystis strains,although cell growth was not significantly ***,these data show that BAC-14 disrupted the physiological and metabolic status of Microcystis cells and stimulated the production and release of microcystin,which could result in damage to aquatic systems.

关键词： Disinfectants Quaternary ammonium compounds Microcystis Cyanotoxin Metabolomics Chlorophyll fluorescence

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Direct enantioselective reduction of C=C bond of β-polyfluoro-alkylated enones via asymmetric photoredox catalysis

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Science China Chemistry 2024年第6期67卷 2016-2021页

作者： Linghong Zhang jin ma Xu Ban Xiaowei Zhao Yanli Yin Zhiyong Jiang Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province Henan UniversityKaifeng475004China School of Chemistry and Chemical Engineering Henan Normal UniversityPingyuan LaboratoryXinxiang453007China College of Advanced Interdisciplinary Science and Technology Henan University of TechnologyZhengzhou450001China

Direct enantioselective reduction of the C=C bond ofβ-polyfluoro-alkylated enones is an important but long-pending subject in asymmetric ***,we report on the viability of visible light-driven cooperative photoredox and chiral hydrogenbonding catalysis to effectively address this challenge,as a variety of products are obtained in high yields(up to 85%)with good to excellent enantioselectivities(up to 98%ee).The formation of thermodynamically favorable enol intermediates after double single-electron reduction represents the center of the ***,the utility of the current method is validated by the convenient regio-specific and-diverse synthesis of various deuterated derivatives for these products using inexpensive D_(2)O as the deuterium source.

关键词： photoredox catalysis Br?nsted acids asymmetric reduction enantioselective protonation azaarenes

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Effect of Sonic hedgehog gene-modified bone marrow mesenchymal stem cells on graft-induced retinal gliosis and retinal ganglion cells survival in diabetic mice

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 34-41页

作者： Tong Wang Hai-Chun Li jin ma Xi-Ling Yu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina

AIM:To investigate the effects of Sonic hedgehog(Shh)gene-modified bone marrow mesenchymal stem cells(MSCs)on graft-induced retinal gliosis and retinal ganglion cells(RGCs)survival in diabetic ***:Bone marrow-derived MSCs were genetically modified with the Shh gene to generate a stably transfected cell line of Shh-modified MSCs(MSC-Shh).Intravitreal injections of MSC-Shh and green fluorescent protein-modified MSCs(MSC-Gfp;control)were administered in diabetic *** 4wk,the effects of MSC-Shh on retinal gliosis were evaluated using fundus photography,and markers of gliosis were examined by immunofluorescence and Western *** neurotrophic factors expression and RGCs survival in the host retina were evaluated using Western blotting and *** mechanisms underlying the effects of MSC-Shh was ***:A significant reduction of proliferative vitreoretinopathy(PVR)was observed after intravitreal injection of MSC-Shh compared to *** downregulation of glial fibrillary acidic protein(GFAP)was demonstrated in the host retina after MSC-Shh administration compared to *** extracellular signal-regulated kinase 1/2(ERK1/2),protein kinase B(AKT)and phosphatidylin-ositol-3-kinase(PI3K)pathways were significantly downregulated after MSC-Shh administration compared to ***-derived neurotrophic factor(BDNF)and ciliary neurotrophic factor(CNTF)levels were significantly increased in the host retina,and RGCs loss was significantly prevented after MSC-Shh ***:MSC-Shh administration reduces graft-induced reactive gliosis following intravitreal injection in diabetic *** ERK1/2,AKT and PI3K pathways are involved in this ***-Shh also increases the levels of neurotrophic factors in the host retina and promoted RGCs survival in diabetic mice.

关键词： mesenchymal stem cells Sonic hedgehog signaling reactive gliosis diabetic retinopathy retinal ganglion cells

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Simulation Analysis of Deformation Control for magnetic Soft Medical Robots

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 794-796页

作者： jingxi Wang Baoyu Liu Edmond Q.Wu jin ma Ping Li Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of Education Beijing Advanced Innovation Center for Biomedical Engineeringthe School of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China IEEE the Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China the Department of Aerospace Medicine Air Force Medical UniversityXi’an 710032China

Dear Editor,This letter presents a biocompatible cross-shaped magnetic soft robot and investigates its deformation mode control strategy through COMSOL modeling and *** soft robots offer novel avenues for precise trea... 详细信息

关键词： robot simulation COMSOL

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magnetocaloric effect and phase transition critical behavior of La0.75Sr0.25Mn0.9Co0.1O3 compound synthesized under the high pressure

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Tungsten 2024年第03期6卷 621-632页

作者： jing Zhao Lei Gao Jian-Jun Zhao Wei Wei Hui-Qin Yun Ru Xing Huai-jin ma Xiang jin Luo-Meng Chao School of Physical Science and Technology Key Laboratory of Magnetism and Magnetic Materials for Higher Education in Inner Mongolia Autonomous Region Baotou Teachers' College National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths School of Physics and Electronic Information Inner Mongolia Normal University College of Science Inner Mongolia University of Science and Technology

In this study,a novel method is proposed for producing perovskite rare-earth manganese oxide magnetic refrigeration materials that exhibit superior properties compared to similar *** maximum magnetic entropy change values for this sample are 1.44 and 3.75 J·kg-1·K-1for magnetic fields of 2 and 7 T,***,its relative cooling power has been calculated to be 101.96 and 404.78 J·kg-1,indicating good *** results were obtained using the sample synthesized under a pressure of 4 GPa,and the sample has undergone a second phase *** critical behavior of the sample fits well with the mean field *** different magnetic fields,there is a significant overlap between the values of the maximum magnetic entropy change and the temperature-averaged entropy change,indicating that the refrigeration performance of the sample after high pressure can approach its maximum capability.

关键词： High-pressure synthesis magnetocaloric effect Relative cooling power magnetic phase transition

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农业FDI会加剧农业面源污染吗?——基于中国省级面板数据的空间计量

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山东社会科学 2024年第2期 160-168页

作者：马进山东师范大学经济学院

为探究农业FDI对农业环境的影响,采用单元调查法和输出系数法对2005—2020年中国27个省份的单位面积农业面源污染等标排放量进行核算,通过空间杜宾模型分析农业FDI数量和质量对农业面源污染的直接影响和空间效应。研究结果表明:农业FDI... 详细信息

为探究农业FDI对农业环境的影响,采用单元调查法和输出系数法对2005—2020年中国27个省份的单位面积农业面源污染等标排放量进行核算,通过空间杜宾模型分析农业FDI数量和质量对农业面源污染的直接影响和空间效应。研究结果表明:农业FDI数量和质量均能显著增加本地农业面源污染排放量,并通过空间溢出效应破坏邻地农业环境;经济规模、人口密度、技术水平、环境规制和生产结构等因素会影响农业面源污染,其中,经济规模的扩大、人口密度的提升和牧业占农业比例的提高会对农业环境产生负面影响,环境规制的加强和技术水平的提升会对农业环境产生正面影响。因此,应优化外资结构,提高引资门槛,加强各地区间的引资合作和治污政策合作,推动农业生产方式绿色化。

关键词：农业FDI数量农业FDI质量农业面源污染空间杜宾模型

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Revisiting the top-quark pair production at future e^(+)e^(−)colliders

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Chinese Physics C 2024年第4期48卷 82-88页

作者：马进王声权孙婷申建明吴兴刚 Department of Physics Guizhou Minzu UniversityGuiyang 550025China School of Physics and Electronics Hunan Provincial Key Laboratory of High-Energy Scale Physics and ApplicationsHunan UniversityChangsha 410082China Department of Physics Chongqing Key Laboratory for Strongly Coupled PhysicsChongqing UniversityChongqing 401331China

In this study,we reanalyze the top-quark pair production at next-to-next-to-leading order(NNLO)in quantum chromodynamics(QCD)at future e^(+)e^(−)colliders using the Principle of maximum Conformality(PMC)*** PMC renormalization scales inαs are determined by absorbing the non-conformalβterms by recursively using the Renormalization Group Equation(RGE).Unlike the conventional scale-setting method of fixing the scale at the center-of-mass energyμ_(r)=√s,the determined PMC scale Q_(⋆)is far smaller than the √sand increases with the √s,yielding the correct physical behavior for the top-quark pair production ***,the convergence of the pQCD series for the top-quark pair production is greatly improved owing to the elimination of the renormalon *** a typical collision energy of √s=500 GeV,the PMC scale is Q_(⋆)=107 GeV;the QCD correction factor K for conventional results is K∼1+0.1244+0.0102+0.0012−0.0087−0.0011+0.0184−0.0086+0.0002+0.0061−0.0003,where the first error is caused by varying the scaleμr∈[√s/2,2√s]and the second error is from the top-quark massΔm_(t)=±0.7 *** applying the PMC,the renormalization scale uncertainty is eliminated,and the QCD correction factor K is improved to K∼1+0.1507_(−0.0015)^(+0.0015)−0.0057_(−0.0000)^(+0.0001),where the error is from the top-quark massΔm_(t)=±0.7 *** PMC improved predictions for the top-quark pair production are helpful for detailed studies of the properties of the top-quark at future e^(+)e^(−)colliders.

关键词： top-quark lepton colliders Renormalization Group Equation QCD correction

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2型糖尿病肾病风险列线图预测模型的建立

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中国基层医药 2024年第5期31卷 734-741页

作者：马瑾马芳琪董小英宁夏医科大学总医院临床医学院银川750003 吴忠市人民医院肾病内科吴忠751199 宁夏医科大学总医院内分泌科银川750003

目的分析2型糖尿病(type 2 diabetes mellitus,T2DM)患者并发糖尿病肾病(diabetic kidney disease,DKD)的危险因素,构建DKD的风险列线图预测模型并进行验证,以期为疾病的早期筛查及预防提供科学依据。方法回顾性收集2018年1月至2022年1... 详细信息

目的分析2型糖尿病(type 2 diabetes mellitus,T2DM)患者并发糖尿病肾病(diabetic kidney disease,DKD)的危险因素,构建DKD的风险列线图预测模型并进行验证,以期为疾病的早期筛查及预防提供科学依据。方法回顾性收集2018年1月至2022年12月在宁夏医科大学总医院内分泌科住院的T2DM患者1223例的临床资料,用RStudio 4.2.1,通过LASSO回归及十折交叉验证筛选最优特征变量,利用多因素logistic回归分析确定最终预测因子并构建风险预测模型后绘制列线图。最后,分别采用C指数、受试者工作特征曲线(ROC曲线)、校准曲线和Hosmer-Lemeshow拟合优度检验验证评价模型的区分度和准确性,决策曲线分析评估模型的临床效能。结果多因素logistic回归分析结果显示,糖尿病病程、糖化血红蛋白(HbA1c)(OR=1.14,95%CI:1.05~1.24)、血肌酐(Scr)(OR=1.02,95%CI:1.01~1.04)、25-羟维生素D[25-(OH)-D](OR=0.97,95%CI:0.95~1.00)均是T2DM患者发生DKD的最佳预测因素(均P<0.05)。依据预测变量绘制列线图,构建预测模型。预测模型预测训练集T2DM患者发生DKD的C指数为0.762(95%CI:0.734~0.790),预测验证集T2DM患者发生DKD的C指数为0.742(95%CI:0.689~0.790),Hosmer-Lemeshow拟合优度检验显示模型拟合度较好(P=0.108),DCA结果显示预测模型在临床上是有益的。结论风险列线图预测模型的建立可早期筛查和防治DKD,为临床工作者提供了更为便捷、科学的方法和手段。

关键词：糖尿病,2型糖尿病肾病列线图 logistic模型 ROC曲线血红蛋白A,糖基化

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基于多源融合的联级网络安全态势感知模型

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信息技术 2024年第3期48卷 164-169页

作者：马晋重庆市气象信息与技术保障中心重庆401147

为实时获取网络安全状态,便于管理员及时采取响应措施,建立基于多源融合的联级网络安全态势感知模型。确立数据分割点,通过分割条件对数据实施连续的自适应离散化处理;采用粒子群算法融合相同类型的感知数据;以资产重要程度、脆弱指数... 详细信息

为实时获取网络安全状态,便于管理员及时采取响应措施,建立基于多源融合的联级网络安全态势感知模型。确立数据分割点,通过分割条件对数据实施连续的自适应离散化处理;采用粒子群算法融合相同类型的感知数据;以资产重要程度、脆弱指数与威胁指数为态势感知一级指标,建立联级网络安全态势感知指标体系;输入融合数据到支持向量机中,将态势感知问题变换为支持向量机分类预测问题,得到最佳分类函数,建立综合感知矩阵,完成感知模型构建。实验结果表明,所建模型提高了多源数据融合效果,感知结果较精确。

关键词：多源融合联级网络安全态势感知模型支持向量机算法

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基于图文多模态融合推理的产品创新方案设计方法研究

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包装工程 2024年第8期45卷 21-28页

作者：马进范明浩马良山胡洁上海交通大学感知科学与工程学院上海200240 上海交通大学设计学院上海200240 上海中软计算机系统工程有限公司上海200001

目的针对当前产品创新设计领域中对基于图像-文本多模态知识支撑创新设计方法研究不足的问题,提出了一套基于图文多模态的产品创新方案设计方法。方法首先,对设计师的设计草图与文本要求进行预处理,然后引入产品设计知识图谱来促进设计... 详细信息

目的针对当前产品创新设计领域中对基于图像-文本多模态知识支撑创新设计方法研究不足的问题,提出了一套基于图文多模态的产品创新方案设计方法。方法首先,对设计师的设计草图与文本要求进行预处理,然后引入产品设计知识图谱来促进设计思维的发散和创新;其次,通过微调的生成式预训练变换器模型和扩散模型生成产品方案及其概念图;最后,利用深度多模态设计评估模型对产品设计方案的可行性和市场潜力进行评估。结果通过产品设计知识图谱,及深度多模态设计评估模型的引入,该设计流程可以生成富有创新性且具备可行性的产品方案。结论基于图文多模态的产品创新方案设计流程结合了最新的深度学习技术,不仅提高了设计的效率,还为设计师提供了更广阔的创新视角和灵感来源。

关键词：图文多模态深度生成模型知识图谱产品创新设计

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