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Updated overall survival and circulating tumor DNA analysis of ensartinib for crizotinib-refractory ALK-positive NSCLC from a phase II study

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Cancer Communications 2024年第4期44卷 455-468页

作者： Jing Zheng Tao Wang yunpeng yang Jie Huang Jifeng Feng Wu Zhuang Jianhua Chen Jun Zhao Wei zhong Yanqiu Zhao Yiping Zhang Yong Song Yi Hu Zhuang yu Youling Gong yuan Chen Feng Ye Shucai Zhang Lejie cao yun Fan gang Wu yubiao Guo Chengzhi Zhou Kewei ma Jian Fang Weineng Feng yunpeng liu Zhendong Zheng Gaofeng li Huijie Wang Shundong Cang Ning Wu Wei Song Xiaoqing liu Shijun Zhao lieming ding Giovanni Selvaggi yang Wang Shanshan Xiao Qian Wang Zhilin Shen Jianya Zhou Jianying Zhou li Zhang Department of Respiratory Disease Thoracic Disease CenterThe First Affiliated HospitalCollege of MedicineZhejiang UniversityZhejiang Provincial Clinical Research Center for Respiratory DiseaseHangzhouZhejiangP.R.China Hangzhou Repugene Technology Co. LtdHangzhouZhejiangP.R.China Department of Medical Oncology Sun Yat-sen University Cancer Cen-terState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology Jiangsu Cancer HospitalJiangsu Institute of Cancer ResearchThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingJiangsuP.R.China Department of Thoracic Oncology Fujian Provincial Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianP.R.China Department of Medical Oncology-Chest Hunan Cancer HospitalChangshaHunanP.R.China Department of Thoracic Oncology Beijing Cancer HospitalBeijingP.R.China Department of Pulmonary Medicine Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijingP.R.China Respiratory Department of Internal Medicine Henan Provincial Can-cer HospitalAffiliated Cancer Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Thoracic Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Division of Respiratory Medicine Jinling HospitalNanjing University School of MedicineNanjingJiangsuP.R.China Department of Oncology Chinese People’s Liberation Army(PLA)General HospitalBeijingP.R.China Department of Oncology The Affiliated Hospital of Qingdao UniversityQingdaoShandongP.R.China Department of Thoracic Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuanP.R.China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Medical Oncology Cancer HospitalThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityTeaching Hospital of

Background:The initial phase II stuty(NCT03.15693.demonstrated that ensartinib has shown clinical activity in patients with advanced crizotinib-refractory,anaplastic lymphoma kinase(ALK)-positive non-small cell lung cancer(NSCLC).Herein,we reported the updated data on overall survival(OS)and molecular profiling from the initial phase Ⅱ ***:In this study,180 patients received 225 mg of ensartinib orally once daily until disease progression,death or *** was estimated by Kaplan‒Meier methods with two-sided 95%confidence intervals(CIs).Next-generation sequencing was employed to explore prognostic biomarkers based on plasma samples collected at baseline and after initiating *** tumor DNA(ctDNA)was detected to dynamically monitor the genomic alterna-tions during treatment and indicate the existence of molecular residual disease,facilitating improvement of clinical ***:At the data cut-off date(August 3.,2022),with a median follow-up time of 53.2 months,97 of 180(53.9%)patients had *** median OS was 42.8 months(95%CI:29.3.53.2 months).A total of 3.3.plasma samples from 168 patients were included for ctDNA *** inferior OS correlated sig-nificantly with baseline ALK or tumor protein 53.TP53.*** addition,patients with concurrent TP53.mutations had shorter OS than those without con-current TP53.*** ctDNA levels evaluated by variant allele frequency(VAF)and haploid genome equivalents per milliliter of plasma(hGE/mL)at baseline were associated with poor ***,patients with ctDNA clear-ance at 6 weeks and slow ascent growth had dramatically longer OS than those with ctDNA residual and fast ascent growth,***,patients who had a lower tumor burden,as evaluated by the diameter of target lesions,had a longer *** Cox regression analysis further uncovered the independent prognostic values of bone metastases,higher hGE,and elevated ALK mutation abundance at 6 we

关键词： anaplastic lymphoma kinase ctDNA ensartinib non-small cell lung cancer overall survival

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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科学通报 2024年

作者： Shuai liu Wen-Qiang Xu Ying-Tong Di man-Cheng Tang ding-Kang Chen Ming-Ming {3. Yao-Wen Chang Hong-yu Tang Chun-mao yuan Jun-Bo yang Zhi-li Zuo Han Guo Zi-Fei Xu Ying Zeng yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase SpeF and P450 monooxygenase SpeG, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, SpeF/SpeG metabolon can control the stereoselectivity of its 2,3.epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-ma with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词：

Fully Self-Consistency in Relativistic Random Phase Approximation

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Chinese Physics Letters 2012年第11期29卷 40-42页

作者： yang ding cao {3.-gang ma zhong-yu School of Science Communication University of ChinaBeijing 100024 institute of Modern Physics Chinese Academy of SciencesLanzhou 730000 Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator of LanzhouLanzhou 730000 China institute of atomic energy P.O.Box 275(18)Beijing 102413

Fully self-consistent relativistic random phase approximation(RRPA)is built on the relativistic mean field ground state with a non-linear relativistic *** consistency requires that the same effective interaction is adopted to simultaneously describe both the ground states and the excited states of the *** and accurate numerical results of the nuclear giant resonances obtained in the RRPA require fully consistent *** some excitation modes they are extremely sensitive to consistent treatment,e.g.,such as isoscalar giant monopole and dipole resonances(ISGMR and ISGDR).In this work we perform the numerical calculations in the case of ISGDR for ^(208)Pb and check the *** spurious state in the ISGDR vanishes once the full self-consistency is achieved.

关键词： relativistic consistency Approximation

The Nuclear Incompressibility and Isoscalar Giant Dipole Resonance in Relativistic Continuum Random Phase Approximation

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Chinese Physics Letters 2013年第5期30卷 40-43页

作者： yang ding cao {3.-gang ma zhong-yu School of Science Communication University of ChinaBeijing 100024 China institute of atomic energy Beijing 102413 Center of Theoretical Nuclear Physics National Laboratory of Heavy CollisionLanzhou 730000 institute of Modern Physics Chinese Academy of SciencesLanzhou 730000

The isoscalar giant dipole resonance(ISGDR)in nuclei is studied in the framework of a fully self-consistent relativistic continuum random phase approximation(RCRPA).In this method the contribution of the continuum spectrum to nuclear excitations is treated exactly by the single particle Green's function *** employ different type interactions(NL1,NL3.NL3.(*),NL4,TM1,NLSH and PK1)corresponding to incompressibilities in the range 200–3.0 *** results are discussed in comparison with the existing experimental *** is found that the termη=5/3.r^(2)>can remove spurious components from the admixture of the center of mass state *** ISGDR distribution has two components,the lower-energy component and the higher-energy *** is a large amount of very sharp peaks in the lower-energy region in RCRPA *** the higher-energy component is sensitive to the value of nuclear incompressibility employed in the calculations;the position of the lower-energy component is completely independent of the nuclear incompressibility Knm.

关键词： technique scalar Approximation

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2024年

关键词：

Emerging contaminants:A One Health perspective

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The Innovation 2024年第4期5卷 140-170,139页

作者： Fang Wang Leilei Xiang Kelvin Sze-Yin Leung martin Elsner Ying Zhang yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo Ying Bryan WBrooks Deyi Hou Damian EHelbling Jianqiang Sun Hao Qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott XChang Guanyong Su Bryan MWong Tzung-may Fu Dong Zhu Karl JJobst Chengjun Ge Frederic Coulon Jean Damascene Harindintwali Xiankui Zeng Haijun Wang yuhao Fu zhong Wei Rainer Lohmann Changer Chen yang Song Concepcion Sanchez-Cid yu Wang Ali El-Naggar Yiming Yao Yanran Huang Japhet Cheuk-Fung Law Chenggang Gu Huizhong Shen Yanpeng Gao Chao Qin Hao li Tong Zhang Natàlia Corcoll Min liu Daniel SAlessi Hui li Kristian KBrandt Yolanda Pico Cheng Gu Jianhua Guo Jianqiang Su Philippe Corvini mao Ye Teresa Rocha-Santos Huan He Yi yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu Wang Syed AHashsham marko Virta Qingbin yuan Gaofei Jiang Louis A.Tremblay Qingwei Bu Jichun Wu Willie Peijnenburg Edward Topp Xinde cao Xin Jiang Minghui Zheng Taolin Zhang Yongming Luo lizhong Zhu Xiangdong li DamiàBarceló Jianmin Chen Baoshan Xing Wulf Amelung Zongwei Cai Ravi Naidu Qirong Shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer matthias C.Rillig Fengchang Wu gang yu James M.Tiedje State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Hong Kong Baptist UniversityHong KongChina HKBU institute of Research and Continuing Education Shenzhen Virtual University ParkShenzhenChina Technical University of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany School of Resources&Environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory of Environmental Theoretical Chemistry South China Normal UniversityGuangzhouGuangdong 510006China Department of Environmental Science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic Systems Research(CRASR) Baylor UniversityWacoTXUSA School of Environment Tsinghua UniversityBeijing 100084China School of Civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance Department of Pla

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to estab{3.sh the UN’s Intergovernmental Science-Po{3.cy Panel on Chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental po{3.cies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

低轨倾斜轨道卫星太阳电池阵防遮挡设计与分析

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航天器工程 2024年第1期33卷 36-41页

作者：苏宝法仇恒抗王凯宋园李沐昀丁丕满马聚沙曹程上海空间电源研究所上海200245 上海卫星工程研究所上海200245

低轨倾斜轨道卫星轨道面光照角周期变化,太阳电池阵受照情况复杂,其输出电流呈现波动。为此,文章分析卫星各种工况下的本体遮挡面积,结合太阳电池阵遮挡工作特性分析及阴影遮挡试验结果,开展太阳电池阵防阴影遮挡设计,并采用投影法进行... 详细信息

低轨倾斜轨道卫星轨道面光照角周期变化,太阳电池阵受照情况复杂,其输出电流呈现波动。为此,文章分析卫星各种工况下的本体遮挡面积,结合太阳电池阵遮挡工作特性分析及阴影遮挡试验结果,开展太阳电池阵防阴影遮挡设计,并采用投影法进行卫星本体遮挡影响分析。结果表明:卫星本体遮挡时,电流损失预计值与在轨遥测电流损失值基本一致,分析误差小于2%。上述分析结果可为卫星复杂遮挡工况下电源系统能量平衡设计提供参考。

关键词：低轨倾斜轨道卫星卫星本体遮挡太阳电池阵输出电流

An in-situ spectroscopy investigation of alkali metal interaction mechanism with the imide functional group

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Nano Research 2020年第12期13卷 3224-3229页

作者： Xu lian Zhirui ma zhonghan Zhang Jinlin yang Shuo Sun Chengding Gu yuan liu Honghe ding Jun Hu Xu cao Junfa Zhu Shuzhou li Wei Chen Department of Chemistry National University of SingaporeSingapore117543Singapore Centre for Advanced 2D materials National University of SingaporeSingapore117546Singapore School of materials Science and Engineering Nanyang Technological UniversitySingapore639798Singapore National University of Singapore(Suzhou)Research institute Suzhou215123China Joint School of National University of Singapore and tianjin University International Campus of Tianjin UniversityFuzhou350207China National Synchrotron Radiation Laboratory Department of Chemical PhysicsUniversity of Science and Technology of ChinaHefei230029China Department of Physics National University of SingaporeSingapore117542Singapore

Organic anode materials have attracted considerable interest owing to their high tunability by adopting various active functional ***,the interaction mechanisms between the alkali metals and the active functional groups in host materials have been rarely studied ***,a widely used organic semiconductor of perylene-3.4,9,10-tetracarboxylic diimide(PTCDI)was selected as a model system to investigate how alkali metals interact with imide functional groups and induce changes in chemical and electronic structures of *** interaction at the alkali/PTCDI interface was probed by in-situ X-ray photoelectron spectroscopy(XPS),ultraviolet photoelectron spectroscopy(UPS),synchrotron-based near edge X-ray absorption fine structure(NEXAFS),and corroborated by density functional theory(DFT)*** results indicate that the alkali metal replaces the hydrogen atoms in the imide group and interact with the imide nitrogen of *** transfer induced gap states and downward band-bending like effects are identified on the alkali-deposited PTCDI *** was found that Na shows a stronger electron transfer effect than *** a model study of alkali insertion/intercalation in PTCDI gives insights for the exploration of the potential host materials for alkali storage applications.

关键词： perylene-3.4,9,10-tetracarboxylic diimide(PTCDI) lithium storage organic anode imide electron transfer

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai {3. Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi yuanjie Bi tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert maarten Boonekamp marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai {3.chen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu cao Jianshe cao Antoine Chance Xuejun Chang {3.e Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che {3.zhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-yuan Chen Kai Chen mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen tianlu Chen Wei Chen Xiang Chen Xiao{3. Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen {3.kai Chen Zelin Chen Zilin Chen gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng {3.nlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-{3.n Dai Xinchen Dai Xuwen Dai Antonio De maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran ding Siqin dingl Yadong ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing beijing Computational Science Research Center Beijing beijing Conveyi LTD Beijing beijing Glass Research institute Co. LtdBeijing beijing institute of Technology Beijing beijing Normal University Beijing Brown University ProvidenceRI Budker institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China institute of atomic energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 3. GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying {3. modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 3. MW per beam,it can achieve a luminosity of 5×10^(3.)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13.ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3.million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-203.s.

关键词： initiated exceeding precise