检索结果-南通市图书馆

MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui Xiaokuang ma Jing Wei Chang Chen Neha Shakir Hitesch Guirram Zhiyu Dai Trent Anderson Deveroux Ferguson Shenfeng qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses

Heavy metal (Pb,Zn) uptake and chemical changes in rhizosphere soils of four wetland plants with different radial oxygen loss

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2010年第5期22卷 696-702页

作者： Junxing Yang Zuoluo ma zhihong Ye Xueyan Guo Rongliang qiu State Key Laboratory for Bio-control and School of Life Sciences Sun Yat-sen University Guangzhou 510006 China Ministry of Agriculture Key Laboratory of Plant Nutrition and Nutrient Cycling Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences Beijing 100081 China School of Enviromnental Sciences and Engineering Sun Yat-sen University Guangzhou 510275 China

Lead and Zn uptake and chemical changes in rhizosphere soils of four emergent-rooted wetland plants;Aneilema bracteatum,Cyperus alternifolius,Ludwigia hyssopifolia and Veronica serpyllifolia were investigated by two experiments：（1） rhizobag filled with ＂clean＂ or metal-contaminated soil for analysis of Pb and Zn in plants and rhizosphere soils;and （2） applied deoxygenated solution for analyzing their rates of radial oxygen loss （ROL）.The results showed that the wetland plants with different ROL rates had significant effects on the mobility and chemical forms of Pb and Zn in rhizosphere under flooded *** effects were varied with different metal elements and metal concentrations in the *** mobility in rhizosphere of the four plants both in the ＂clean＂ and contaminated soils was decreased,while Zn mobility was increased in the rhizosphere of the ＂clean＂ soil,but decreased in the contaminated *** the four plants,***,with the highest ROL,formed the highest degree of Fe plaque on the root surface,immobilized more Zn in Fe plaque,and has the highest effects on the changes of Zn form （EXC-Zn） in rhizosphere under both ＂clean＂ and contaminated soil *** results suggested that ROL of wetland plants could play an important role in Fe plaque formation and mobility and chemical changes of metals in rhizosphere soil under flood conditions.

关键词： lead zinc rhizosphere wetland plant radial oxygen loss

在线全文

学校读者我要写书评

暂无评论

煤矿提升机天轮安全运维在线监测系统研究

煤矿现代化 2025年第1期34卷 91-96,101页

作者：马智宏晋能控股集团煤峪口矿山西大同037000

为解决矿井提升机天轮传统运维方式存在的效率较低、运行监控难度较大、安全运维成本较高、智能化不足等问题,本文对煤矿提升机天轮结构组成进行分析,研究了煤矿提升机天轮常见故障机理的基础上,搭建出天轮平台音视频协同安全运维在线... 详细信息

为解决矿井提升机天轮传统运维方式存在的效率较低、运行监控难度较大、安全运维成本较高、智能化不足等问题,本文对煤矿提升机天轮结构组成进行分析,研究了煤矿提升机天轮常见故障机理的基础上,搭建出天轮平台音视频协同安全运维在线监测系统,对硬件系统和软件控制系统进行研究,实现了对天轮振动、偏振、音频信号的全方位采集和实时远程监控运维,搭建出天轮监控评价指标体系。经试验和现场调试后表明,测试得到的天轮端面圆跳动≤9 mm,设备异常识别精度达0.01,响应时间仅为1.97 s,取得了满意的实验和应用结果。

关键词：煤矿提升机天轮安全运维在线监测多传感器

Solvents incubatedπ-πstacking in hole transport layer for perovskite-silicon 2-terminal tandem solar cells with 27.21%efficiency

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2023年第7期82卷 25-30,I0002页

作者： Qiaoyan ma jufeng qiu Yuzhao Yang Fei Tang Yilin Zeng Nanxi ma Bohao Yu Feiping Lu Chong Liu Andreas Lambertz Weiyuan Duan Kaining Ding Yaohua mai Institute of New Energy Technology College of Information Science and TechnologyJinan UniversityGuangzhou 510632GuangdongChina School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006GuangdongChina IEK-5 Photovoltaik Forschungszentrum Jülich GmbH52425 JülichGermany Department of Physics Tianshui Normal UniversityTianshui 741000GansuChina Guangdong Mellow Energy Co. LimitedHuajing RoadGuangzhou 510630GuangdongChina

Room temperature sputtered inorganic nickel oxide(NiO_(x))is one of the most promising hole transport layers(HTL)for perovskite-sillion 2-terminal tandem solar cells with the aid of ultrathin and compact organic layers to passivate the surface *** this study,the aromatic solvent with different substituent groups was used to regulate the conformation of poly[bis(4-phenyl)(2,4,6-trimethylphenyl)am ine](PTAA)*** a result,the single-junction perovskite solar cell(PSC)gained a power conversion efficiency(PCE)of 20.63%,contributing to a 27.21%efficiency for monolithic perovskite/silicon(double-side polished)2-terminal tandem solar cell,by applying the alkyl aromatic solvent to enhance theπ-πstacking of PTAA molecular *** tandem solar cell can maintain 95%initial efficiency after aging over 1000 *** study provides a universal approach for improving the photovoltaic performance of NiO_(x)/polymer-based perovskite/silicon tandem solar cells and other single junction inverted PSCs.

关键词： Tandem solar cells Low temperature deposition Hole transporting property π-πstacking Alkyl aromatic solvent

Recent advances in the development of activatable multifunctional probes for in vivo imaging of caspase-3

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2021年第1期32卷 168-178页

作者： Pengzhan Wang Huocheng Yang Chang Liu Mingqiang qiu Xin ma Zhiqiang mao Yao Sun zhihong Liu Hubei Collaborative Innovation Center for Advanced Organic Chemical materials Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules&College of Chemistry and Chemical EngineeringHubei UniversityWuhan 430062China State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaXinjiang Medical UniversityXinjiang 830011China International Joint Research Center for Intelligent Biosensor Technology and Health Key Laboratory of Pesticides and Chemical BiologyMinistry of EducationCollege of ChemistryCentral China Normal UniversityWuhan 430079China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

Caspases are a family of proteases that play critical roles in controlling inflammation and cell *** is a caspase-3 mainly controlled behavior to avoid inflammation and damage to surrounding cells,whereas anomalistic cell apoptosis may be associated with many *** detection and imaging of caspase-3 will be of great significance in evaluating the early therapeutic effect of *** smart fluorescent probes may be helpful for the visualization of the rapeutic effect compared with "always on" ***,more and more works toward activatable fluorescent probes for caspase-3 imaging have been *** addition,multifunctional probes have also been designed to further improve the imaging of ***,this review systematically summarized the representative wo rk of caspase-3 from the perspective of molecular design that it will play a guiding role in the design of probes that respond to ***,challenges and perspectives toward the field for imaging of cell apoptosis(caspase-3) are also discussed.

关键词： Fluorescence imaging Multi-functional Activatable probe Caspase-3

Fluid structure interaction of supersonic parachute with material failure

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2023年第10期36卷 90-100页

作者： Shunchen NIE Li YU Yanjun LI zhihong SUN Bowen qiu College of Aerospace Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Key Laboratory of Aircraft Environment Control and Life Support MIITNanjing University of Aeronautics and AstronauticsNanjing 210016China

The material damage of parachute may occur in parachutes at high speeds,and the growth of tearing may finally lead to failure of aerospace *** order to study the damage mechanism of parachute,a material failure model is proposed to simulate the failure of canopy *** inflation process of supersonic parachute is studied numerically based on Arbitrary Lagrange Euler(ALE)*** ALE method with material failure can predict the transient parachute shape with damage propagation as well as the flow characteristics in the parachute inflation process,and the simulated dynamic opening load is consistent with the flight *** damage propagation mechanism of parachute is then investigated,and the effect of parachute velocity on the damage process is *** results show that the canopy tears apart by the fast flow from the initial damaged area and the damaged canopy shape leads to the asymmetric change of the flow *** the increase of mach number,the canopy tearing speed increases,and the tearing directions become uncertain at high mach *** dynamic load when damage occurs increases with the mach number,and is proportional to the dynamic pressure above the critical mach number.

关键词： Arbitrary Lagrange Euler method Dynamic loads Fluid structure interaction material failure model Parachute damage

Unsupervised robust adaptive filtering against impulsive noise

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2012年第1期23卷 32-39页

作者： Tao ma Jie Chen Wenjie Chen zhihong Peng School of Automation Beijing Institute of Technology Beijing 100081 R R. China Key Laboratory of Complex System Intelligent Control and Decision （Ministry of Education） Beijing Institute of Technology Beijing 100081 P. R. China

An implementation of adaptive filtering, composed of an unsupervised adaptive filter （UAF）, a multi-step forward linear predictor （FLP）, and an unsupervised multi-step adaptive predictor （UmaP）, is built for suppressing impulsive noise in unknown circumstances. This filtering scheme, called unsupervised robust adaptive filter （URAF）, possesses a switching structure, which ensures the robustness against impulsive noise. The FLP is used to detect the possible impulsive noise added to the signal, if the signal is ＂impulse-free＂, the filter UAF can estimate the clean sig- nal. If there exists impulsive noise, the impulse corrupted samples are replaced by predicted ones from the FLP, and then the UmaP estimates the clean signal. Both the simulation and experimental results show that the URAF has a better rate of convergence than the most recent universal filter, and is effective to restrict large disturbance like impulsive noise when the universal filter fails.

关键词： adaptive filtering unsupervised form impulse insen- sitive switching structure.

Heat treatment effect on electrochemical properties of spinel Li_4Ti_5O_(12)

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2008年第2期27卷 165-169页

作者： LI Yue ZHAO Hailei TIAN zhihong qiu Weihua LI Xue School of materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

Anode material Li4Ti5O12 was prepared at 800℃ by a solid-state reaction, followed by heat-treatment at 600℃ for different times （0, 2, 8, and 12 h）. The effects of heat-treatment time on the particle morphology, rate-capability, and electrode kinetic process of the Li4Ti5O12 electrode, and on the lithium ion diffusion coefficient inside the Li4Ti5O12 electrode were investigated. Proper heat treatment could smoothen the particle surface of Li4Ti5O12 particles and increase the rate-capability of the electrode. Overlong heat treatment might cause particle aggregation and hence result in a poor electrode kinetic process. A sample with 8 h of heat treatment showed the best rate-capability and the lowest electrode reaction resistance. Heat treatment for 2-8 h does not significantly change the lithium ion diffusion coefficient inside the Li4Ti5O12 electrode, whereas, 12-h treatment results in a lower lithium ion diffusion coefficient.

关键词： lithium titanate heat treatment electrochemical property lithium ion battery

Filamin B:The next hotspot in skeletal research?

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2017年第7期44卷 335-342页

作者： Qiming xu Nan Wu Lijia Cui zhihong Wu Guixing qiu Department of Orthopaedic Surgery Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeiiing 100730China Beijing Key Laboratory for Genetic Research of Skeletal Deformity Beijing 100730China Medical Research Center of Orthopaedics Chinese Academy of Medical SciencesBeijing 100730China Peking Union Medical College Hospital Beijing 100730China School of Medicine Tsinghua UniversityBeijing 100084China Department of Central Laboratory Peking UnionMedical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

Filamin B （FLNB） is a large dimeric actin-binding protein which crosslinks actin cytoskeleton filaments into a dynamic structure. Lip to present, pathogenic mutations in FLNB are solely found to cause skeletal deformities, indicating the important role of FLNB in skeletal development. FLNB-related disorders are classified as spondylocarpotarsal synostosis （SCT）, Larsen syndrome （LS）, atelosteogenesis （AO）, boomerang dysplasia （BD）, and isolated congenital talipes equinovarus, presenting with scoliosis, short- limbed dwarfism, clubfoot, joint dislocation and other unique skeletal abnormalities. Several mecha- nisms of FLNB mutations causing skeletal malformations have been proposed, including delay of ossi- fication in long bone growth plate, reduction of bone mineral density （BMD）, dysregulation of muscle differentiation, ossification of intervertebral disc （IVD）, disturbance of proliferation, differentiation and apoptosis in chondrocytes, impairment of angiogenesis, and hypomotility of osteoblast, chondrocyte and fibroblast. Interventions on FLNB-related diseases require prenatal surveillance by sonography, gene testing in high-risk carriers, and proper orthosis or orthopedic surgeries to correct malformations including scoliosis, cervical spine instability, large joint dislocation, and clubfoot. Gene and cell therapies for FLNB-related diseases are also promising but require further studies.

关键词： Filamin B Spondylocarpotarsal synostosis Larsen syndrome Scoliosis Skeletal development