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Identification of blaIMI-mediated carbapenem-resistant Enterobacter from a duck farm in China

Journal of Integrative Agriculture 2023年第8期22卷 2500-2508页

作者： HUANG Hong-hao LU Yi-xing WU Su-juan ma zhen-bao ZENG Dong-ping ZENG zhen-ling National Laboratory of Safety Evaluation(Environmental Assessment)of Veterinary Drugs College of Veterinary Medicine/China National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria/Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety EvaluationCollege of Veterinary MedicineSouth China Agricultural University Guangdong Haid Group Co. Ltd.Guangzhou 511400P.R.China

Carbapenem-and colistin-resistant Enterobacter has been a clinical and therapy problem in recent ***,we report the carbapenem-and colistin-resistant Enterobacter harboring bla_(IMI) isolated from intestinal samples and the environment of a duck farm in *** bla_(IMI)-positive Enterobacter isolates were resistant to carbapenem and *** bla_(IMI) subtypes were detected in different molecular categories of *** detection of the various IMI producers highlights the diversity of carbapenemases in a duck ***-genome sequencing demonstrated the bla_(IMI) genes were present in chromosomes or plasmids in these *** conjugation experiment demonstrated the ability of bla_(IMI)-carrying plasmid to transmit *** molecular evolution characteristics were examined through comparative genetic *** study demonstrated the presence of chromosomal and plasmid bla_(IMI) and the bla_(IMI)-carrying plasmid exhibits a horizontal transmission between Enterobacter and Escherichia coli *** similar genetic content was discovered between two bla_(IMI-16)-positive Enterobacter *** addition,a bla_(IMI-16)-carrying plasmid is an IncFII(Yp)plasmid,and a substantial amount of mobile genetic elements were identified around bla_(IMI-16).The IS-like elements and IncFII(Yp)plasmid are significant in the propagation of bla_(IMI).Our study provides evidence for the transmission of diverse bla_(IMI) genes in China and supplies additional reference data for bla_(IMI)-positive antimicrobialresistant *** surveys of bla_(IMI)-positive Enterobacter from animal-raising environments must be given more focus.

关键词： Enterobacter antimicrobial resistance carbapenemases colistin

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Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 188-197页

作者： Shuai Li zhen ma Jin-Hua Gao School of Science Hebei University of Science and TechnologyShijiazhuang 050018China School of Electronics and Information Zhengzhou University of Light IndustryZhengzhou 450002China School of Physics and Wuhan National High magnetic Field Center Huazhong University of Science and TechnologyWuhan 430074China

We theoretically investigate the spin resolved Friedel oscillation(FO)and quasiparticle interference(QPI)in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r^(-2) in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as r^(-3).Such spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment(***ález-Herrero et al.,Science 352,437(2016)).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states(FT-LDOS).Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

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微弱直接序列扩频信号Duffing振子检测方法研究

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电子科技大学学报 2012年第5期41卷 693-696页

作者：盛广铭马德保解放军信息工程大学信息技术学院郑州450002

Duffing系统对特定信号敏感及对噪声免疫的特性,使其在微弱信号检测中具有潜在应用。该文针对Duffing振子的分岔问题,通过对Duffing系统Feigenbaum行为的分析,导出了在微弱直接序列扩频信号检测中Duffing系统所表现出的间歇性混沌行为,... 详细信息

Duffing系统对特定信号敏感及对噪声免疫的特性,使其在微弱信号检测中具有潜在应用。该文针对Duffing振子的分岔问题,通过对Duffing系统Feigenbaum行为的分析,导出了在微弱直接序列扩频信号检测中Duffing系统所表现出的间歇性混沌行为,提出了一种新的基于间歇性混沌行为的微弱直扩信号检测方法。通过仿真实验,验证了该方法的有效性。

关键词：混沌系统直接序列扩频信号 Duffing振子大尺度周期信号检测

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A fast amplitude preserving three-parameter 3D parabolic Radon transform and its application on multiple attenuation

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Petroleum Science 2025年第1期22卷 163-177页

作者： Ji-Tao ma Kai-Ge Zhao zhen Liao College of Geophysics China University of Petroleum (Beijing) State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum (Beijing) CNPC Key Laboratory of Geophysical Prospecting China University of Petroleum (Beijing)

Seismic wavefields propagate through three-dimensional(3D) space, and their precise characterization is crucial for understanding subsurface structures. Traditional 2D algorithms, due to their limitations, are insufficient to fully represent three-dimensional wavefields. The classic 3D Radon transform algorithm assumes that the wavefield's propagation characteristics are consistent in all directions, which often does not hold true in complex underground media. To address this issue, we present an improved 3D threeparameter Radon algorithm that considers the wavefield variation with azimuth and provides a more accurate wavefield description. However, introducing new parameters to describe the azimuthal variation also poses computational challenges. The new Radon transform operator involves five variables and cannot be simply decomposed into small matrices for efficient computation; instead, it requires large matrix multiplication and inversion operations, significantly increasing the computational load. To overcome this challenge, we have integrated the curvature and frequency parameters, simplifying all frequency operators to the same, thereby significantly improving computation efficiency. Furthermore,existing transform algorithms neglect the lateral variation of seismic amplitudes, leading to discrepancies between the estimated multiples and those in the data. To enhance the amplitude preservation of the algorithm, we employ orthogonal polynomial fitting to capture the amplitude spatial variation in 3D seismic data. Combining these improvements, we propose a fast, amplitude-preserving, 3D threeparameter Radon transform algorithm. This algorithm not only enhances computational efficiency while maintaining the original wavefield characteristics, but also improves the representation of seismic data by increasing amplitude fidelity. We validated the algorithm in multiple attenuation using both synthetic and real seismic data. The results demonstrate that the new algor

关键词： Three-parameter 3D Radon Orthogonal polynomial Amplitude-preserving Multiple attenuation

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Compound heterozygous mutation of AFG3L2 causes autosomal recessive spinocerebellar ataxia through mitochondrial impairment and MICU1 mediated Ca2+overload

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Science China(Life Sciences) 2025年第2期68卷 484-501页

作者： Hongyu Li Qingwen ma Yan Xue Linlin Cai Liwen bao Lei Hong Yitao Zeng Shu-zhen Huang Richard H.Finnell Fanyi Zeng Shanghai Institute of Medical Genetics Shanghai Children’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200040China Department of Histo-Embryology Genetics and Developmental BiologyShanghai Jiao Tong University School of MedicineShanghai 200025China NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology Shanghai Key Laboratory of Embryo and Reproduction EngineeringShanghai 200040China Center for Precision Environmental Health Baylor College of MedicineHouston 77030USA School of Pharmacy Macao University of Science and TechnologyMacao 999078China

Autosomal recessive spinocerebellar ataxias(SCARs)are one of the most common neurodegenerative diseases characterized by progressive *** SCARs are known to be caused by mutations in multiple genes,there are still many cases that go undiagnosed or are *** this study,we presented a SCAR patient,and identified a probable novel pathogenic mutation(c.1A>G,p.M1V)in the AFG3L2 start *** proband's genotype included heterozygous mutations of the compound AFG3L2(p.[M1V];[R632X](c.[1A>G];[1894.C>T])),which were inherited from the father(c.1A>G,p.M1V)and mother(c.1894C>T,p.R632X).Functional studies performed on hi PSCs(human induced pluripotent stem cells)generated from the patients and HEK293T cells showed that the mutations impair mitochondrial function and the unbalanced expression of AFG3L2 mRNA and protein ***,this novel mutation resulted in the degradation of the protein and the reduction of the stability of the AFG3L2 protein,and MCU(mitochondrial calcium uniporter)complex mediated Ca2+overload.

关键词： AFG3L2 gene autosomal recessive spinocerebellar ataxia mitochondrial impairment Ca2+overload

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Effect of Cu/HZSM-5 sorbents with different Si/Al ratios on the adsorption and oxidation performance of H_(2)S

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Journal of Environmental Sciences 2025年第5期151卷 161-173页

作者： Kaini ma Kai Li Ping Ning Jiayu Feng Jiacheng bao Lei Shi Xiangyu Wang Xin Sun Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming 650500China National-Regional Engineering Center for Recovery of Waste Gases from Metallurgical and Chemical Industries Kunming University of Science and TechnologyKunming 650500China

This study employed a wet impregnation method to synthesize five types of Cu/HZSM-5 adsorbents with Si/Al ratios of 25,50,85,200,and 300,used for the removal of H_(2)S in lowtemperature,low-oxygen *** impact of different Si/Al ratios on the adsorption oxidative performance of Cu_(30)/HZSM-5–85 adsorbents was *** to the performance test results,Cu_(30)/HZSM-5–85 exhibited the highest breakthrough capacity,reaching 231.75 mg H_(2)S/g_(sorbent).Cu/HZSM-5 sorbent maintains a strong ability to remove H_(2)S even under humid conditions and shows excellent water ***,BET,and XPS results revealed that CuO is the primary active species,with Cu_(30)/HZSM-5–85 having the largest surface area and highest CuO content,providing more active sites for H_(2)S adsorption.H_(2)-TPR and O_(2)-TPD results confirmed that Cu_(30)/HZSM-5–85 sorbent exhibits outstanding redox properties and oxygen storage capacity,contributing to excellent oxygen transferability in the molecular sieve adsorption-oxidation *** notable characteristics such as a large surface area,high desulfurization efficiency,and water resistance,Cu_(30)/HZSM-5–85 sorbents hold significant importance for industrial applications.

关键词： H_(2)S Si/Al ratio Adoration-oxidation Cu/HZSM-5-85(HZSM-5 with Si/Al ratio of 85 loaded Cu)

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Optimizing electronic structure through point defect engineering for enhanced electrocatalytic energy conversion

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Green Energy & Environment 2025年第1期10卷 109-131页

作者： Wei ma Jiahao Yao Fang Xie Xinqi Wang Hao Wan Xiangjian Shen Lili Zhang Menggai Jiao zhen Zhou Interdisciplinary Research Center for Sustainable Energy Science and Engineering(IRC4SE2) School of Chemical EngineeringZhengzhou UniversityHenan450001China

Point defect engineering endows catalysts with novel physical and chemical properties,elevating their electrocatalytic *** introduction of defects emerges as a promising strategy,effectively modifying the electronic structure of active *** optimization influences the adsorption energy of intermediates,thereby mitigating reaction energy barriers,altering paths,enhancing selectivity,and ultimately improving the catalytic efficiency of *** elucidate the impact of defects on the electrocatalytic process,we comprehensively outline the roles of various point defects,their synthetic methodologies,and characterization ***,we consolidate insights into the relationship between point defects and catalytic activity for hydrogen/oxygen evolution and CO_(2)/O_(2)/N_(2) reduction reactions by integrating mechanisms from diverse *** underscores the pivotal role of point defects in enhancing catalytic *** last,the principal challenges and prospects associated with point defects in current electrocatalysts are proposed,emphasizing their role in advancing the efficiency of electrochemical energy storage and conversion materials.

关键词： Point defect engineering Doping Vacancy Electrocatalysis Electronic structure

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Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin ma Yang Qu Jiaxin Ren Yingying Sun zhen-Ni Guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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Positive effect of Mo on mechanical properties of a Ni-42W-10Co-xMo medium heavy alloy

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China Foundry 2025年第1期22卷 108-116页

作者： Guo-xin Cao Jian-xin Dong Yong-sheng He He Jiang Fang Hao Zhi-hua Nie Teng-fei ma bao-quan Fu School of materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Xi'an Superalloy Technology Co. Ltd.Xi’an 710299China School of materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou UniversityQuzhou 324000ZhejiangChina

In this study,a novel Ni-W-Co-Mo medium heavy alloy(MHA)was designed to improve its mechanical strength via Mo *** the Ni-42W-10Co-x Mo alloy series,where x represents the weight percent of Mo and varies between 0,1,2,5,and 10,the microstructure transitions from a dendritic structure to a hypo-eutectic structure as the Mo content increases from 0 to 5wt.%.Moreover,as the Mo content increases from 0 to 10wt.%,the distribution of theμ-phase shifts from being individually dispersed to forming aggregates,and its volume fraction rises from 0.5%to 7.9%.Notably,theμ-phase evolves into an eutectic microstructure,which helps in minimizing the segregation of *** change is accompanied by a substantial enhancement in mechanical properties;specifically,the compressive yield strength at room temperature increases from 350 MPa to 646 MPa,indicating a significant 85%***,the microhardness increases from 230 HV to 304 *** dynamics simulations further reveal that the strengthening mechanism of Ni-42W-10Co-x Mo alloys is Mo-induced solid solution strengthening and precipitation strengthening.

关键词： medium-heavy alloys Ni-based alloy mechanical properties solid solution strengthening precipitation strengthening

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快速检测小孔类零件的同轴度误差

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煤矿机械 2007年第8期28卷 110-113页

作者：武双杰马保振河北工业职业技术学院石家庄050091

因小孔类零件检测比较困难,使用快速检测装置有助于小孔类零件同轴度误差的检测速度和精度的提高。列举实例采用2种方法进行对比分析,解决了在批量生产条件下小型孔类零件的同轴度误差测量。

关键词：小孔同轴度误差快速检测

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