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Comparative study of breast cancer in Mexican and Mexican-American women

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Health 2010年第9期2卷 1040-1048页

作者： maria Elena martinez Luis Enrique Gutierrez-Millan Melissa Bondy Adrian Daneri-Navarro maria Mercedes Meza-Montenegro Ivan Anduro-Corona ma isabel aramburo-rubio Luz maria Adriana Balderas-Pena Jose Adelfo Barragan-Ruiz Abenaa Brewster Graciela Caire-Juvera Juan manuel Castro-Cervantes mario Alberto Chavez Zamudio Giovanna Cruz Alicia Del Toro-Arreola mary EEdgerton maria Rosa Flores-marquez Ramon Antonio Franco-Topete Helga Garcia Susan Andrea Gutierrez-rubio Karin Hahn Luz margarita Jimenez-Perez Ian KKomenaka Zoila Areli Lopez Bujanda Dihui Lu Gilberto Morgan-Villela James LMurray Jesse NNodora Antonio Oceguera-Villanueva Miguel Angel Ortiz martinez Laura Perez Michel Antonio Quintero-Ramos Aysegul Sahin Jeong Yun Shim maureen Stewart Gonzalo Vazquez-Camacho Betsy Wertheim Rachel Zenuk Patricia Thompson Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health University of ArizonaTucsonUSA Departamento de Investigaciones Cientificas y Tecnologicas Universidad de SonoraHermosilloMexico University of Texas M.D.Anderson Cancer Center HoustonUSA Departamento de Fisiologia Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Instituto Tecnologico de Sonora Ciudad ObregónMexico Instituto Mexicano del Seguro Social HermosilloMexico Instituto Mexicano del Seguro Social CMNOGuadalajaraJalisco Centro de Investigacion en Alimentacion y Desarrollo HermosilloMexico Instituto Mexicano del Seguro Social Ciudad ObregonMexico OPD Hospital Civil de Guadalajara GuadalajaraMexico Departamento de Salud Publica Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico maricopa Medical Center Department of SurgeryPhoenixUSA University of North Carolina Lineberger Cancer CenterChapel HillUSA Arizona Cancer Center and Department of Family and Community Medicine University of ArizonaTucsonUSA Instituto Jalisciense de Cancerologia GuadalajaraMexico

Breast cancer is the number one cause of can- cer deaths among Hispanic women in the United States, and in Mexico, it recently became the primary cause of cancer deaths. This malign- nancy represents a poorly understood and un- derstudied disease in Hispanic women. The ELLA Binational Breast Cancer Study was es- tablished in 2006 as a multi-center study to as- sess patterns of breast tumor markers, clinical characteristics, and their risk factors in women of Mexican descent. We describe the design and implementation of the ELLA Study and provide a risk factor comparison between women in the U.S. and those in Mexico based on a sample of 765 patients (364 in the U.S. and 401 in Mexico). Compared to women in Mexico, U.S. women had significantly (p < 0.05) lower parity (3.2 vs. 3.9 mean live births) and breastfeeding rates (57.5% vs. 80.5%), higher use of oral contraceptives (60.7% vs. 50.1%) and hormone replacement therapy (23.3% vs. 7.6%), and higher family history of breast cancer (15.7% vs. 9.0%). Re- sults show that differences in breast cancer risk factor patterns exist between Mexico and U.S. women. We provide lessons learned from the conduct of our study. Binational studies are an important step in understanding disease pat- terns and etiology for women in both countries.

关键词： Binational Study Breast Cancer Hispanics Mexico United States

Biodiversity responses to insular fragmentation in Amazonia: Two decades of research in the Balbina Hydroelectric Reservoir

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Zoological Research(Diversity and Conservation) 2024年第2期1卷 106-116页

作者： Ana Filipa Palmeirim maíra Benchimol Danielle Storck-Tonon Anderson S.Bueno isabel L.Jones Gilmar Klein Carlos A.Peres CIBIO Research Centre of Biodiversity and Genetic ResourcesInBIO Associated LabVairão CampusUniversity of PortoVairão 4485-661Portugal BIOPOLIS Program in Genomics Biodiversity and Land PlanningCIBIOVairão CampusUniversity of PortoVairão 4485-661Portugal Laboratório de Ecologia AplicadaàConservação Universidade Estadual de Santa CruzIlhéusBahia 45662-900Brazil Programa de Pós-Graduação em Ambiente e Sistemas de Produção Agrícola(PPGASP) Universidade do Estado de Mato GrossoTangaráda SerraMato Grosso 78301-532Brazil Instituto Federal de Educação Ciência e Tecnologia FarroupilhaJúlio de CastilhosRio Grande do Sul 98130-000Brazil Biological and Environmental Sciences University of StirlingStirling FK94LAUK REBIO Uatumã/ICMBio Presidente FigueiredoAmazonas 69736-000Brazil Centre for Ecology Evolution and ConservationSchool of Environmental SciencesUniversity of East AngliaNorwich NR47TJUK JuruáInstitute ManausAmazonas 69057-060Brazil

As hydropower development expands across lowland tropical forests,flooding and concomitant insular fragmentation have become important threats to *** created insular landscapes serve as natural laboratories to investigate biodiversity responses to *** of these most iconic landscapes is the Balbina Hydroelectric Reservoir in Brazilian Amazonia,occupying>400000 ha and comprising>3500 forest ***,we synthesise the current knowledge on responses of a wide range of biological groups to insular fragmentation at *** has largely concentrated on a set of 22 islands and three mainland *** total,39 studies were conducted over nearly two decades,covering 17 vertebrate,invertebrate,and plant *** species responses varied according to taxonomic group,island area was consistently included and played a pivotal role in 66.7%of all studies examining patterns of species *** persistence was further affected by species traits,mostly related to species capacity to use/traverse the aquatic matrix or tolerate habitat degradation,as noted for species of vertebrates and orchid *** research is needed to improve our understanding of such effects on wider ecosystem *** Impact Assessments must account for changes in both the remaining habitat amount and configuration,and subsequent long-term species losses.

关键词： Habitat loss Hydropower dams Landbridge Local extinctions Species-area relationships Species diversity Tropical forests

The Digital Indexed Zuozhuan

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The Digital Indexed Zuozhuan

Impact of recipient functional status on 1-year liver transplant outcomes

北京论坛（2004）文明的和谐与共同繁荣

作者： St.John Gerard Page ma.isabel García-Hidalgo El Colegio de México

The Digital Indexed Zuozhuan is conceived as a tool to bring the early reader as well as the experienced scholar of the Zuozhuan text into direct contact with the Chinese original without forcible recourse to dictiona...

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World Journal of Transplantation 2019年第7期9卷 145-157页

作者： Natasha H Dolgin Babak Movahedi Frederick A Anderson isabel ma Brüggenwirth Paulo N martins Adel Bozorgzadeh Department of Surgery Division of Organ TransplantationUMass Memorial Medical CenterUniversity of Massachusetts Medical SchoolWorcesterMA 01605United States Department of Quantitative Health Sciences Clinical and Population Health Research ProgramUniversity of Massachusetts Medical SchoolWorcesterMA 01605United States Department of Surgery Center for Outcomes ResearchUniversity of Massachusetts Medical SchoolWorcesterMA 01655United States Department of Surgery Section of Hepatobiliary Surgery and Liver TransplantationUniversity Medical Center GroningenUniversity of GroningenGroningen 9713GZNetherlands

BACKGROUND The Karnofsky Performance Status(KPS)scale has been widely validated for clinical practice for over 60 *** To examine the extent to which poor pre-transplant functional status,assessed using the KPS scale,is associated with increased risk of mortality and/or graft failure at 1-year *** This study included 38278 United States adults who underwent first,non-urgent,liver-only transplantation from 2005 to 2014(Scientific Registry of Transplant Recipients).Functional impairment/disability was categorized as severe,moderate,or none/*** were conducted using multivariableadjusted Cox survival regression *** The median age was 56 years,31%were women,median pre-transplant Model for End-Stage for Liver Disease score was *** impairment was present in 70%;one-quarter of the sample was severely *** controlling for key recipient and donor factors,moderately and severely disabled patients had a 1-year mortality rate of 1.32[confidence interval(CI):1.21-1.44]and 1.73(95%CI:1.56-1.91)compared to patients with no impairment,*** with moderate and severe disability also had a multivariable-adjusted 1-year graft failure rate of 1.13(CI:1.02-1.24)and 1.16(CI:1.02-1.31),*** Pre-transplant functional status is a useful prognostic indicator for 1-year posttransplant patient and graft survival.

关键词： Patient survival Transplantation Liver disease Clinical decision-making Graft survival Risk assessment/risk stratification

Identification of IL11RA and MELK amplification in gastric cancer by comprehensive genomic profiling of gastric cancer cell lines

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World Journal of Gastroenterology 2016年第43期22卷 9506-9514页

作者： Danielle Queiroz Calcagno Sylvia Santomi Takeno Carolina Oliveira Gigek mariana Ferreira Leal Fernanda Wisnieski Elizabeth Suchi Chen Taíssa maíra Thomaz Araújo Eleonidas Moura Lima maria isabel Melaragno Samia Demachki Paulo Pimentel Assumpcao Rommel Rodriguez Burbano marília Cardoso Smith Disciplina de Genética Departamento de Morfologia e GenéticaUniversidade Federal de Sao Paulo Núcleo de Pesquisas em Oncologia Hospital Universitário Joao de Barros Barreto Departamento de Biologia Molecular Universidade Federal da Paraíba Disciplina de Gastroenterologia Cirúrgica Universidade Federal de Sao Paulo Departamento de Ortopedia e Traumatologia Universidade Federal de Sao Paulo

AIM To identify common copy number alterations on gastric cancer cell *** Four gastric cancer cell lines(ACP02, ACP03, AGP01 and PG100) underwent chromosomal comparative genome hybridization and array comparative genome hybridization. We also confirmed the results by fluorescence in situ hybridization analysis using the bacterial artificial chromosome clone and quantitative real time PCR *** The amplification of 9p13.3 was detected in all cell lines by both methodologies. An increase in the copy number of 9p13.3 was also confirmed by fluorescence in situ hybridization analysis. Moreover, the interleukin 11 receptor alpha(IL11RA) and maternal embryonic leucine zipper kinase(MELK) genes, which are present in the 9p13.3 amplicon, revealed gains of the MELK gene in all the cell lines studied. Additionally, a gain in the copy number of IL11 RA and MELK was observed in 19.1%(13/68) and 55.9%(38/68) of primary gastric adenocarcinoma samples, respectively. CONCLUSION The characterization of a small gain region at 9p13.3 in gastric cancer cell lines and primary gastric adenocarcinoma samples has revealed MELK as a candidate target gene that is possibly related to the development of gastric cancer.

关键词： IL11RA Gastric cancer Genomic profiling MELK 9p13.3

Genome-wide comparison inferred the origin and evolution of B-cell epitopes on the proteins of human influenza A virus

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Health 2012年第10期4卷 946-954页

作者： Edgar E. Lara-Ramírez Aldo Segura-Cabrera ma. isabel Salazar mario A. Rodríguez-Pérez Xianwu Guo Centro de Biotecnología Genómica Instituto Politécnico Nacional Reynosa México Departamento de Inmunología Escuela Nacional de Ciencias Biológicas Unidad Profesional Lázaro Cárdenas Instituto Politécnico Nacional México

The novel strain H1N1 caused the outbreak of first pandemic influenza in 21 century. Now it is a common component of current seasonal influenza viruses. The recent transmission and plentiful genome sequences available provided a good opportunity to study the origin and evolution of epitopes on the proteins of human influenza virus. In the present study, the B-cell epitope compositions in the pandemic strains, circulating traditional seasonal strains, swine strains as well as highly virulent avian strain H5N1 were identified with the aid of the Immune Epitope DataBase (IEDB) and were compared at genomic level. A total of 14210 distinct sequences down-loaded from NCBI database were used for analysis. Some epitopes on proteins HA or NA, not conserved in recent seasonal strains, were found in 2009 pandemic strains but existed in the early human strains (1919-1935). The pandemic strain shared higher conserved epitopes with “bird flu” virus H5N1than classic human seasonal strains. The epitopes that could exist at common antigenic regions of HA protein are needed to further identify. The genetic exchanges between human and swine population by transmission was very active but the princepal side of the transmission could be from swine to human. These results provided valuable information on influenza A virus evolution and transmission by means of epitope analysis at genomic level.

关键词： Influenza A Virus H1N1 Pandemic Epitopes Genome Comparison

Factors That Motivate Undergraduate Students： An Analysis at a University in Mexico

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Journal of Modern Accounting and Auditing 2016年第1期12卷 52-59页

作者： Selene Viridiana Perez Ramirez Paula Ponce Lazaro Silvia Cartujano Escobar Crisoforo Alvarez Violante Roque Lopez Tarango Enrique Pineda Figueroa ma. isabel Morales Rangel Autonomous University of Morelos State Morelos Mexico Mexican Distance Education University Mexico

The objective of this research was to analyze （or characterize） what motivational factors are involved in the continuity of the academic development of students in the Graduate School of Jojutla. The study is quantitative, descriptive, and transversal. The population is composed of 346 students who entered college in 2014. A sample of 52 students out of this population was selected, from the majors of Business management, Accounting, Law, Environmental Sciences, Psychology, and Computer Science. The data collection instrument was developed by Esquivel and Arjona （2003）, which measured the dimensions of security, affiliation or affection, self-fulfillment, achievement, power, recognition, and knowledge. The results showed that 72.7% of new students place a very high value on the knowledge dimension： learning new things, improve study skills, do research, better overall job training, and interest in learning. However, in other dimensions, such as affiliation or affection, the percentage given by students is 9. 1%. While the study consists of a small sample, the results provide important information on motivation as a factor that must be considered and evaluated throughout the academic record of the student in order to prevent dropouts and increase terminal efficiency.

关键词： motivation students upper level

αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model

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Protein & Cell 2020年第3期11卷 219-226页

作者： Paloma martinez-Redondo isabel Guillen-Guillen Noah Davidsohn Chao Wang Javier Prieto masakazu Kurita Fumiyuki Hatanaka Cuiqing Zhong Reyna Hernandez-Benitez Tomoaki Hishida Takashi Lezaki Akihisa Sakamoto Amy NNemeth Yuriko Hishida Concepcion Rodriguez Esteban Kensaku Shojima Ling Huang maxim Shokhirev Estrella Nunez-Delicado Josep MCampistol isabel Guillen-Vicente Elena Rodriguez-Inigo Juan manuel Lopez-Alcorocho marta Guillen-Vicente George Church Pradeep Reddy Pedro Guillen-Garcia Guang-Hui Liu Juan Carlos Izpisua Belmonte Gene Expression Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Wyss Institute for Biologically Inspired Engineering Harvard UniversityCambridgeMA 02115USA Department of Genetics Harvard Medical SchoolBostonMA 02115USA Integrative Genomics and Bioinformatics Core Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Universidad Catolica San Antonio de Murcia(UCAM) Campus de los JeronimosNo 1351230107 GuadalupeSpain Hospital Clinic of Barcelona Career Villarroel17008036 BarcelonaSpain Department of Traumatology and Research Unit Clinica CEMTRO28035 MadridSpain National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem cell and Regeneration Chinese Academy of SciencesBeijing 100101China Translational Medical Center for Stem Cell Therapy Shanghai East HospitalTongji University School of MedicineShanghai 200120China

Dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular *** regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with *** aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016).

关键词： aging treatment critical

Utility of Kinetic and Kinematic Jumping and Landing Variables as Predictors of Injury Risk: A Systematic Review

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Journal of Science in Sport and Exercise 2020年第4期2卷 287-304页

作者： Jason S.Pedley Rhodri S.Lloyd Paul J.Read isabel S.Moore mark De Ste Croix Gregory D.Myer Jon L.Oliver Youth Physical Development Centre Cardiff Metropolitan UniversityCardiffUK Sports Performance Research Institute New Zealand AUT UniversityAucklandNew Zealand Centre for Sport Science and Human Performance Waikato Institute of TechnologyWaikatoNew Zealand Institute of Sport Exercise and HealthUniversity College LondonLondonUK School of Sport and Exercise University of GloucestershireGloucesterUK Cardiff School of Sport and Health Sciences Cardiff Metropolitan UniversityCardiffUK School of Sport and Exercise University of GloucestershireCheltenhamUK The SPORT Center Division of Sports MedicineCincinnati Children’s Hospital Medical CenterCincinnatiOHUSA Departments of Pediatrics and Orthopaedic Surgery College of MedicineUniversity of CincinnatiCincinnatiOHUSA Emory Sport Performance and Research Center Flowery BranchAtlantaGAUSA Emory Sports Medicine Center AtlantaGAUSA Department of Orthopaedics Emory University School of MedicineAtlantaGAUSA The Micheli Center for Sports Injury Prevention WalthamMAUSA

Purpose Jump-landing assessments provide a means to quantify an individual’s ability to attenuate ground reaction forces,generate lower limb explosive power and maintain joint *** order to identify risk factors that can be targeted through appropriate training interventions,it is necessary to establish which(scalar)objective kinetic,kinematic,and performance measures are most associated with lower-extremity *** Online searches of MEDLINE,SCOPUS,EBSCOHost,SPORTDiscus and PubMed databases were completed for all articles published before march 2020 in accordance with PRISma *** 40 articles investigating nine jump-landing assessments were included in this *** 79%of studies using drop jump(n=14)observed an association with future injury,while only 8%of countermovement jump studies(n=13)observed an association with injury *** 57%of studies using unilateral assessments found associations with risk of injury(n=14).Studies using performance measures(jump height/distance)as outcome measure were only associated with injury risk in 30%of ***,those using kinetic and/or kinematic analyses(knee abduction moment,knee valgus angle,knee separation distance,peak ground reaction force)found associations with injury in 89%of *** The landing element of jump-landing assessments appears to be superior for identifying individuals at greater risk of injury;likely due to a closer representation of the injury ***,jump-landing assessments that involve attenuation of impact forces such as the drop jump appear most suited for this purpose but should involve assessment of frontal plane knee motion and ground reaction forces.

关键词： Plyometric Screening Anterior cruciate ligament Lower-extremity