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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-Dong Qian Qiao Gao Sheng-Lan Xu hua ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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ResNet的大学图书馆信息素养评价系统构建

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信息技术 2025年第2期49卷 136-143页

作者：马骅咸阳师范学院图书馆陕西咸阳712000

随着信息技术的持续发展,大学图书馆在信息服务能力方面面临着挑战。为了客观评价大学图书馆的信息服务能力,文中提出一种基于深度学习的评价模型。该研究采用残差网络进行特征提取,结合模型参数优化,以克服传统评价方法存在的主观性强... 详细信息

随着信息技术的持续发展,大学图书馆在信息服务能力方面面临着挑战。为了客观评价大学图书馆的信息服务能力,文中提出一种基于深度学习的评价模型。该研究采用残差网络进行特征提取,结合模型参数优化,以克服传统评价方法存在的主观性强、准确性不高等问题。研究结果表明,基于残差网络特征提取与模型优化的评价模型准确率达到90%,且计算效率较高。该研究为图书馆信息服务能力评价提供了一个更准确高效的技术方案,使评价结果更具客观性和参考价值。

关键词： ResNet 信息服务能力深度学习模型训练信息素养

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ma huang Tang ameliorates asthma though modulation of Th1/Th2 cytokines and inhibition of Th17 cells in ovalbumin-sensitized mice

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Chinese Journal of Natural Medicines 2014年第5期12卷 361-366页

作者： ma Chun-hua ma Zhan-Qiang FU Qiang ma Shi-Ping Department of Pharmacology of Chinese materia Medica China Pharmaceutical University

AIM： ma huang Tang （Ephedra decoction, MHT） is a famous classical formula from Shang Han Lun by Zhang Zhongjing in the Han Dynasty. The anti-asthmatic effects of MHT and the possible mechanisms were tested. METHOD： An asthma model was established by ovalbumin （OVA）-induction in mice. A total of forty-eight mice were randomly assigned to six experimental groups： control, model, dexamethasone （2 mg·kg^-1） and MHT （5, 10, and 20 mg·kg^-1）. Airway resistance （Raw） was measured by the forced oscillation technique, histological studies were evaluated by hematoxylin and eosin （HE） staining, Thl/Th2 and Th17 cytokines were evaluated by enzyme-linked immunosorbent assay （ELISA）, and Thl7 cells were evaluated by flow cytometry （FCM）.RESULTS： This study demonstrated that MHT inhibited OVA-induced increases in Raw and eosinophil cotmt; interleukin （IL）-4 and IL-17 levels were recovered in bronchoalveolar lavage fluid, increased IFN-γ level in bronchoalveolar lavage fluid. Histological studies demonstrated that MHT substantially inhibited OVA-induced eosinophilia in lung tissue. Flow cytometry studies demonstrated that MHT substantially inhibited Thl 7 ***： These findings suggest that MHT may effectively ameliorate the progression of asthma, and could be further investigated for potential use as a therapy for patients with allergic asthma,

关键词： ma huang Tang Asthma Thl/Th2 Thl7 cells

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学科实践的感性活动基础与育人价值实现

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内蒙古社会科学 2025年第1期46卷 175-182,F0003页

作者：郭元祥马晓华华中师范大学教育学院湖北武汉430079

感性关涉人对外部世界的反映以及人的活动和存在方式,它既指感性认识,也指人的主观感受能力,更指实践的感性活动。人的完整性在于其实践性,形成于实践的感性活动,实践体现了感性的核心要义。学科实践是感性学习活动与理性学习活动的深... 详细信息

感性关涉人对外部世界的反映以及人的活动和存在方式,它既指感性认识,也指人的主观感受能力,更指实践的感性活动。人的完整性在于其实践性,形成于实践的感性活动,实践体现了感性的核心要义。学科实践是感性学习活动与理性学习活动的深度融合,它在本质上是以学科为载体、面向感性的现实世界、运用学科知识解决真实问题的实践活动。学科实践具有深刻的感性活动基础:其一,学科实践是认识性实践与改造性实践的统一;其二,作为学科实践主体的学生是具有感性意识和感性需要的感性存在;其三,学科实践是学生以外部世界和自我为对象的感性活动。深化实践育人,要求回应学科实践的感性活动基础。由感性直观到感性实践,确立学科实践的感性表达;超越知识符号,促进学生面向现实世界的学习;发展思维,实现感性认识向理性认识的转化;设计多样化的学科或跨学科的感性活动,丰富学生的主体经验。

关键词：学科实践感性活动感性与理性教学改革

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银发数字鸿沟:影响因素、类型及跨越之策

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成人教育 2025年第3期45卷 34-41页

作者：陈杰马丽华黄悦琦上海开放大学静安分校上海200040 华东师范大学上海200062 上海市静安区业余大学上海200040

助力老年人跨越数字鸿沟,事关民生。通过半结构访谈发现,银发数字鸿沟存在机能、安全、支持和意愿四个影响因素,其外在表现为不同程度的技能沟。通过问卷调查,采用聚类分析法,归纳出老年人智能手机运用基本类型和每一类型的主要特点,确... 详细信息

助力老年人跨越数字鸿沟,事关民生。通过半结构访谈发现,银发数字鸿沟存在机能、安全、支持和意愿四个影响因素,其外在表现为不同程度的技能沟。通过问卷调查,采用聚类分析法,归纳出老年人智能手机运用基本类型和每一类型的主要特点,确定游离型、激进型、谨慎型为银发数字鸿沟的三个基本类型,其分别揭示了银发数字鸿沟的程度之深、跨越之险及跨越之难。在此基础上,提出推进数字安全教育、老年学习团队活动、互联网无障碍改造及居委教育资源下沉等四项建议,以优化老年数字教育,促进老年人融入数字社会。

关键词：老年人数字鸿沟影响因素类型

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Recommend trustworthy services using interval numbers of four parameters via cloud model for potential users

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Frontiers of Computer Science 2015年第6期9卷 887-903页

作者： hua ma Zhigang HU School of Software Central South University Changsha 410075 China School of Information Science and Engineering Hunan International Economics University Changsha 410205 China

How to discover the trustworthy services is a challenge for potential users because of the deficiency of us- age experiences and the information overload of QoE （qual- ity of experience） evaluations from consumers. Aiming to the limitations of traditional interval numbers in measuring the trustworthiness of service, this paper proposed a novel ser- vice recommendation approach using the interval numbers of four parameters （INF） for potential users. In this approach, a trustworthiness cloud model was established to identify the eigenvalue of INF via backward cloud generator, and a new formula of INF possibility degree based on geometrical anal- ysis was presented to ensure the high calculation precision. In order to select the highly valuable QoE evaluations, the similarity of client-side feature between potential user and consumers was calculated, and the multi-attributes trustwor- thiness values were aggregated into INF by the fuzzy ana- lytic hierarchy process method. On the basis of ranking INF, the sort values of trustworthiness of candidate services were obtained, and the trustworthy services were chosen to recommend to potential user. The experiments based on a real-world dataset showed that it can improve the recommendation accuracy of trustworthy services compared to other approaches, which contributes to solving cold start and information overload problem in service recommendation.

关键词： service recommendation trustworthiness interval numbers of four parameters cloud model potential users

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Evaluation of Ambient Light Display for High Information Capacity

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Journal of Beijing Institute of Technology 2018年第4期27卷 637-644页

作者： hua ma Suzhou Art and Design Technology Institute Suzhou 215000China

Ambient light display presents peripheral information unobtrusively,and it can be context aware and aesthetically enhance specific ***,since the abstract characteristic of light,people should attentively keep agood balance between unobtrusiveness and effectiveness,when designing an ambient light ***,in the condition of high information capacity,ambient light display need a mechanism to portray information *** this paper,a framework with an overlay mechanism is evaluated for high information *** on the framework,two ambient light displays are designed to support the evaluation *** evaluation questions are related with three aspects including information understanding,transition and encoding,special output *** the perception level,interpretation level and experience level,the process of evaluation is *** results indicate that the framework with the overlay mechanism can effectively support varied and specific communicating *** transitions and information encoding benefit from the proper mapping of states and notification levels in the framework.

关键词： evaluation ambient display light information capacity

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New Active Organic Substance in Oyster Shell Capable of Scavenging Oxygen Free Radicals with High Efficiency

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Chemical Research in Chinese Universities 2008年第2期24卷 171-174页

作者： ma Jian-hua College of Biology Engineering Jimei University Xiamen 361021 P. R. China

A light purple organic active substance capable of scavenging hydroxyl radical（OH） with a high efficiency was extracted from Oyster shell at an extraction rate of 2.49%. It was found for the first time that this active substance may scavenge OH with the efficiency far higher than that of vitamin C. This active substance may scavenge also superoxide radical（O2） although the scavenging efficiency is far lower than that of vitamin C. Infrared spectrometry and routine chemical analysis primarily reveal that this active substance belongs to glycoprotein.

关键词： Oyster shell Glycoprotein Scavenging Hydroxyl radical Superoxide radical

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Trustworthy Service Selection Integrating Cloud Model and Possibility Degree Ranking of Interval Numbers

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Chinese Journal of Electronics 2017年第6期26卷 1177-1183页

作者： ma hua HU Zhigang CAI Meiling School of Software Central South University Computer Education Department Hunan Normal University

It has been challenging to select suitable services from abundant candidates in cloud *** to the characteristics of batch computing mode and stream computing mode, a novel trustworthy service selection approach is proposed integrating cloud model and interval numbers theory. To facilitate potential users to understand the quality of service, the trustworthiness of service is described with interval number using reverse cloud generator, and the services with poor performance are filtered out by employing deviation degree or proximity degree. Two formulas of possibility degree of interval numbers are designed to compare the trustworthiness values between cloud services by utilizing probability zone analysis and geometrical analysis respectively, and the ranking method for possibility degree of interval numbers is exploited to select the most trustworthy service. The experiments show that this approach is effective to improve the accuracy of service selection and select trustworthy service for potential users in cloud paradigm.

关键词： Service selection Trustworthiness Cloud model Possibility degree ranking Interval numbers

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Premixed insulin: Advantages, disadvantages, and future

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World Journal of Diabetes 2025年第3期16卷 8-13页

作者： Yan Xia Yun Hu Jian-hua ma Department of Endocrinology The Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi People’s HospitalWuxi Medical CenterNanjing Medical UniversityWuxi 214000Jiangsu ProvinceChina Department of Endocrinology Nanjing First HospitalNanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina

Premixed insulin combines two types of insulin in a single *** combination streamlines dosing for patients with type 1 or type 2 diabetes,thereby enhancing ***,patients receiving premixed insulin commonly have less satisfactory blood glucose *** fixed ratio of insulin in these formulations frequently fails to account for the nuanced demands of individualized glucose-lowering ***,local absorption of mixed insulin and potential systemic autoimmune responses may further compromise glycaemic *** co-formulation of insulin degludec and insulin aspart introduces a new combination of the two insulin types within a single injection,offering a promising solution for mitigating the limitations inherent in premixed insulin.

关键词： Premixed insulin Blood glucose control Insulin antibodies Diabetes Glucose-lowering therapy

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