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Serum nitrite levels in Sri Lankan patients with leptospirosis

Asian Pacific Journal of Tropical Medicine 2012年第1期5卷 75-78页

作者： Rohini I Gunaratna Shiroma M Handunnetti mrc bulathsinghalage Pranitha Somaratne Ananda Jayanaga HJ de Silva Senaka Rajapakse Institute of Biochemistry Molecular Biology and Biotechnology(IBMBB)University of ColomboSri Lanka Department of Microbiology Medical Research InstituteColomboSri Lanka Base Hospital HomagamaSri Lanka Department of Medicine Faculty of MedicineUniversity of KelaniyaSri Lanka Department of Clinical Medicine Faculty of MedicineUniversity of ColomboSri Lanka

Objective:To determine whether blood nitrite levels are elevated in patients with leptospirosis. Methods:Male patients Fulfilling clinical and epidemiological criteria for a diagnosis of leptospirosis were *** with MAT title of≥400 together with those seroconverting to a titer of≥200 were included in the *** nitrite levels were measured in these patients and *** matched healthy ***:Patients from 3 hospitals(n=75) were screened during a 3 month period from 28th June to 3rd September 2009,of whom 20 were eligible for the *** nilrile levels were found to be significantly higher in patients with acute leptospirosis[n=20.(0.359±0.229)μM]compared to controls[(n= 13.(0.216±0.051)μM] (P=0.014).A significant correlation was also observed between the MAT titre and the day of illness (r = 0.547;P<0.0001).Conclusions:Serum nitrite levels are higher in patients with acute leptospirosis compared to age and sex matched *** correlation could be assessed with severity of illness,as sample size was inadequate to determine this.

关键词： Leptospirosis Nitrite Nitric oxide Sri Lanka

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