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Nanoparticles induce the biosynthesis and activity of the new possible therapeutic proteinase source,Talaromyces purpureogenus KJ584844

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BIOCelL 2021年第1期45卷 119-127页

作者： SALLY NEGM mohammad el-metwally WESAM elDIN SABER SAHAR ABO-NEIMA MAHMOUD MOUSTAFA ATTALLA el-KOTT Life Sciences Department College of Science and literature Mahyel AseerKing Khalid UniversityAbhaSaudi Arabia Unit of Food Bacteriology Central Laboratory of Food HygieneMinistry of HealthSharkiaEgypt Department of Botany and Microbiology Faculty of ScienceDamanhour UniversityEl-BeheraEgypt Microbial Activity Unit Department of MicrobiologySoilsWater and Environment Research InstituteAgricultural Research CenterGizaEgypt Physics Department Faculty of ScienceDamanhour UniversityDamanhourEgypt Department of Biology College of ScienceKing Khalid University9004AbhaSaudi Arabia Department of Botany and Microbiology Faculty of ScienceSouth Valley UniversityQenaEgypt Zoology Department Faculty of ScienceDamanhour UniversityEl-BeheraEgypt

The need for the bacterial proteinase is rapidly growing,urging to catch a lowcost medium for the microbial fermentation,nanoparticles can play a vital role in this *** proteinase of Talaromyces purpureogenus was produced on the tubers of Helianthus tuberosus that also operated as solid support for the fermentation *** interface amongst nitrogen sources(NH_(4)Cl and yeast extract)was investigated,applying the statistical modeling of central composite design under solid-state *** optimum medium for proteinase secretion was stimulated by 979.82 mg NH_(4)Cl and 437.68 mg yeast extract per 100 g substrate,yielding 108.15 U/g *** Plackett-Burman experimental design,the nanoparticles Co,Ni and Fe were assessed as inducers for proteinase *** nanoparticles(5 ppm)were the greatest in both proteinase production by the fungus as well as an inducer of the proteolysis process by the enzyme when using faba bean straw as a proteinaceous substrate in the reaction mixture,liberating the extreme quantity of amino acids,compared with the lack of the *** findings suggest the incorporation of Co nanoparticles in both the proteinase fabrication process and during the degradation of proteinaceous materials induce proteinase *** approach could be extended to modulate the productivity and activity of similar biomolecules.

关键词： Experimental design Helianthus tuberosus proteolysis solid-state fermentation

Secondary antiviral metabolites from fungi with special reference to coronaviruses

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BIOCelL 2022年第8期46卷 1979-1988页

作者： MOHAMED SALEM mohammad el-metwally WESAMelDIN SABER SALLY NEGM ATTALLA el-KOTT YASSER MAZROUA ABEER MAKHLOUF MAHMOUD MOUSTAFA Department of Chemistry Faculty of Science and ArtKing Khalid UniversityMohailAssirSaudi Arabia Department of Chemistry Faculty of ScienceAl-Azhar UniversityCairoEgypt Botany and Microbiology Department Faculty of ScienceDamanhour UniversityEl-BeheraEgypt Microbial Activity Unit Department of MicrobiologySoilsWater and Environment Research InstituteAgricultural Research CenterGizaEgypt Life Sciences Department College of Science and ArtKing Khalid UniversityMohailAseerSaudi Arabia Unit of Food Bacteriology Central Laboratory of Food HygieneMinistry of HealthSharkiaEgypt Department of Biology College of ScienceKing Khalid UniversityAbhaSaudi Arabia Zoology Department Faculty of ScienceDamanhour UniversityEl-BeheraEgypt Department of Business Administration Community CollegeKing Khalid UniversityAbhaSaudi Arabia Department of Agricultural Economics Faculty of AgricultureTanta UniversityTantaEgypt Department of Botany Faculty of AgricultureMenoufia UniversitySheben El-KomMenoufiaEgypt Botany and Microbiology Department Faculty of ScienceSouth Valley UniversityQenaEgypt

Profound inspection of the life forms on the earth teaches how to be the complexity of interrelationships among the various *** of the emergence of novel viruses all the time and the inadequate of vaccines and antivirals,viral contagions are amongst the most causative diseases affecting people *** exemplify a massive source of bioactive molecules as,many fungal secondary metabolities like Oxoglyantrypine,Carneic acid F,Scedapin C,Asteltoxin E,Phomanolide,Norquinadoline A and Quinadoline B have antiviral *** review deals with how secondary metabolites of fungi can help in the war against viruses in general and especially Coronaviruses moreover several pieces of literature pointed out that many clusters of fungi in different biotopes are waiting to be exploited.

关键词： COVID-19 SARS-CoV-2 Antibiotics Virus Fungi

Isolation, purification and structure elucidation of three newbioactive secondary metabolites from Streptomyces lividans AM

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BIOCelL 2021年第5期45卷 1263-1271页

作者： mohammad el-metwally MAMDOUH ABDel-MOGIB MANAL elFEDAWY GAAD SOHSAH AHMED REZK MAHMOUD MOUSTAFA MOHAMED SHAABAN Botany and Microbiology Department Faculty of ScienceDamanhour UniversityDamanhour22511Egypt Chemistry Department Faculty of ScienceMansoura UniversityEl-Mansoura35516Egypt Bioprocess Development Department Genetic Engineering and Biotechnology Research InstituteCity of Scientific Research and Technological Applications(SRTA-City)New Borg El-Arab CityAlexandria21934Egypt Biology Department College of ScienceKing Khalid UniversityAbha9004Saudi Arabia Chemistry of Natural Compounds Department Division of Pharmaceutical IndustriesNational Research CentreDokki-Cairo12622Egypt Organic and Bioorganic Chemistry Department of ChemistryBielefeld UniversityBielefeld33615Germany

Microorganisms are a huge mine of bioactive metabolites,and actinomycetes are one of the very active groups in this *** this article,we are concerned about the full taxonomical characterization of Streptomyces lividans AM,isolated from Egyptian *** isolate produced three new bioactive metabolites,namely:1-Nona-decanoyl,4-oleyl disuccinate(1),filoboletic acid;(9Z,11E)-8,13-dihydroxy octadeca-9,11-dienoic acid(2),and sitosteryl-3β-D-glucoside(3).Extensive 1D and 2D NMR and HR-mass spectrometry were used to elucidate the structures of the three ***,ten known compounds were also *** antimicrobial activity of the producing organism and newly reported compounds(1–3)was investigated against a selected group of pathogenic microorganisms.A full taxonomical characterization of the strain was described as well.

关键词： Bioactive metabolites Streptomyces sp. Taxonomy Biological activity

Suitability of SDN and MEC to facilitate digital twin communication over LTE-A

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Digital Communications and Networks 2024年第2期10卷 347-354页

作者： Hikmat Adhami mohammad Alja’afreh Mohamed Hoda Jiaqi Zhao Yong Zhou Abdulmotaleb el Saddik Mohamed bin Zayed University of Artificial Intelligence Masdar CityAbu DhabiUnited Arab Emirates School of Computer Science and Technology China University of Mining and TechnologyXuzhou221116China School of electrical Engineering and Computer Science University of OttawaOttawaONK1N 6N5Canada

Haptic is the modality that complements traditional multimedia,i.e.,audiovisual,to evolve the next wave of innovation at which the Internet data stream can be exchanged to enable remote skills and control *** will require ultra-low latency and ultra-high reliability to evolve the mobile experience into the era of Digital Twin and Tactile *** the 5th generation of mobile networks is not yet widely deployed,Long-Term Evolution(LTE-A)latency remains much higher than the 1 ms requirement for the Tactile Internet and therefore the Digital *** work investigates an interesting solution based on the incorporation of Software-defined networking(SDN)and Multi-access Mobile Edge Computing(MEC)technologies in an LTE-A network,to deliver future multimedia applications over the Tactile Internet while overcoming the QoS *** network scenarios were designed and simulated using Riverbed modeler and the performance was evaluated using several time-related Key Performance Indicators(KPIs)such as throughput,End-2-End(E2E)delay,and *** best scenario possible is clearly the one integrating MEC and SDN approaches,where the overall delay,jitter,and throughput for haptics-attained 2 ms,0.01 ms,and 1000 packets per *** results obtained give clear evidence that the integration of,both SDN and MEC,in LTE-A indicates performance improvement,and fulfills the standard requirements in terms of the above KPIs,for realizing a Digital Twin/Tactile Internet-based system.

关键词： LTE-A 5G Digital twin Tactile Internet KPIs SDN MEC NFV Haptic

Phosphoric Acid Pretreatment and Saccharification of Paper Sludge as a Renewable Material for Cellulosic Fibers

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Journal of Renewable Materials 2024年第9期12卷 1573-1591页

作者： Samar el-Mekkawi Wafaa Abou-elseoud Shaimaa Fadel Enas Hassan mohammad Hassan Chemical Engineering and Pilot Plant Department National Research CentreDokkiGiza12622Egypt Cellulose and Paper Department National Research CentreDokkiGiza12622Egypt

Recycling of paper sludge waste is crucial for establishing a sustainable green *** waste contains valuable sugars that can be converted into important chemicals such as ethanol,poly hydroxybutyrate,and lactic ***,the main challenge in obtaining sugars in high yield from paper sludge is the high crystallinity of cellulose,which hinders *** address this,pretreatment using phosphoric acid was optimized using response surface methodology to facilitate cellulose hydrolysis with minimal energy and *** created prediction model using the response surface method considered factors such as acid concentration(ranging from 60%to 85%),consistency(ranging from 4%to 10%),temperature(ranging from 25℃to 80℃),and time(ranging from 0.5 to 4 h).The results revealed that the model’s significant factors affecting the yield were acid concentration,reaction time,temperature,and the product of acid concentration and temperature,while the model’s significant factors affecting the crystallinity were the consistency,the temperature,and their *** results showed that the optimum conditions for pretreatment were using an acid concentration of 64%,temperature of 25℃,consistency of 10%,and time of 30 *** hydrolysis of the conditionally pretreated paper sludge resulted in a weight loss of 42%,compared to only 18%weight loss in non-pretreated paper ***,the optimized conditions led to low levels of furfurals and acetic acid,which are undesirable by-products that can interfere with sugar *** total sugar obtained under the optimized conditions was 0.43 g glucose/g sample(10.46 g/L),while the contents of methyl furfural,furfural,and acetic acid were 21.65,235.7,and 4.57 mg/L,*** study demonstrates the potential of phosphoric acid for pretreatment and hydrolysis of paper sludge,enabling efficient saccharification and the production of sugars with minimal undesired by-products.

关键词： Waste valorization fermentable sugars response surface methodology acid hydrolysis cellulose crystallinity

Thermodynamic Performance Analysis of Geothermal Power Plant Based on Organic Rankine Cycle (ORC) Using Mixture of Pure Working Fluids

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Energy Engineering 2024年第8期121卷 2023-2038页

作者： Abdul Sattar Laghari mohammad Waqas Chandio Laveet Kumar Mamdouh el Haj Assad Department of Mechanical Engineering Mehran University of Engineering and TechnologyJamshoro76062Pakistan Department of Mechanical and Industrial Engineering College of EngineeringQatar UniversityDoha00000Qatar Sustainable&Renewable Energy Engineering Department University of SharjahSharjah00000United Arab Emirates

The selection of working fluid significantly impacts the geothermal ORC’s *** a mixture as a working fluid is a strategy to improve the output of geothermal *** the current study,modelling and thermodynamic analysis of ORC,using geothermal as a heat source,is carried out at fixed operating *** model is simulated in the Engineering Equation Solver(EES).An environment-friendly mixture of fluids,i.e.,R245fa/R600a,with a suitable mole fraction,is used as the operating *** mixture provided the most convenient results compared to the pure working fluid under fixed operating *** impact of varying the evaporator pressure on the performance parameters,including energy efficiency,exergy efficiency and net power output is *** system provided the optimal performance once the evaporator pressure reached the maximum *** efficiencies:Energy and Exergy,and Net Power output of the system are 16.62%,64.08%and 2199 kW for the basic cycle and 20.72%,67.76%and 2326 kW respectively for the regenerative cycle.

关键词： Organic rankine cycle internal heat exchanger moderate-temperature geothermal source mixture of the fluid exergy

Gut microbiota predicts the diagnosis of ulcerative colitis in Saudi children

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World Journal of Clinical Pediatrics 2024年第1期13卷 118-124页

作者： mohammad el Mouzan Ahmed Al Sarkhy Asaad Assiri Department of Pediatrics Gastroenterology UnitKing Saud UniversityRiyadh 11461Saudi Arabia

BACKGROUND Ulcerative colitis(UC)is an immune-mediated chronic inflammatory condition with a worldwide *** the etiology of this disease is still unknown,the understanding of the role of the microbiota is becoming increasingly *** To investigate the predictive power of the gut microbiota for the diagnosis of UC in a cohort of newly diagnosed treatment-naïve Saudi children with *** The study population included 20 children with a confirmed diagnosis of UC and 20 healthy *** DNA was extracted and sequenced,and shotgun metagenomic analysis was performed for bacteria and *** and bioinformatics demonstrated significant dysbiosis in the form of reduced alpha diversity,beta diversity,and significant difference of abundance of taxa between children with UC and control *** receiver operating characteristic curve,a probability curve,was used to determine the difference between the UC and control *** area under the curve(AUC)represents the degree of separability between the UC group and the control *** AUC was calculated for all identified bacterial species and for bacterial species identified by the random forest classification algorithm as important potential biomarkers of UC.A similar method of AUC calculation for all bacteriophages and important species was *** The median age and range were 14(0.5-21)and 12.9(6.8-16.3)years for children with UC and controls,respectively,and 40%and 35%were male for children with UC and controls,*** AUC for all identified bacterial species was 89.5%.However,when using the bacterial species identified as important by random forest classification algorithm analysis, the accuracy increased to 97.6%. Similarly, the AUC for all theidentified bacteriophages was 87.4%, but this value increased to 94.5% when the important bacteriophagebiomarkers were *** very high to excellent AUCs of fecal bacterial and viral species sugge

关键词： Ulcerative colitis Microbiota Area under the curve Children Saudi Arabia

Modern Mobile Malware Detection Framework Using Machine Learning and Random Forest Algorithm

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Computer Systems Science & Engineering 2024年第5期48卷 1171-1191页

作者： mohammad Ababneh Ayat Al-Droos Ammar el-Hassan School of Computing Sciences Princess Sumaya University for TechnologyAmman11941Jordan

With the high level of proliferation of connected mobile devices,the risk of intrusion becomes *** Intelligence(AI)and Machine Learning(ML)algorithms started to feature in protection software and showed effective *** algorithms are nonetheless hindered by the lack of rich datasets and compounded by the appearance of new categories of malware such that the race between attackers’malware,especially with the assistance of Artificial Intelligence tools and protection solutions makes these systems and frameworks lose effectiveness *** this article,we present a framework for mobile malware detection based on a new dataset containing new categories of mobile *** focus on categories of malware that were not tested before by Machine Learning algorithms proven effective in malware *** carefully select an optimal number of features,do necessary preprocessing,and then apply Machine Learning algorithms to discover malicious code *** our experiments,we have found that the Random Forest algorithm is the best-performing algorithm with such mobile malware with detection rates of around 99%.We compared our results from this work and found that they are aligned well with our previous *** also compared our work with State-of-the-Art works of others and found that the results are very close and competitive.

关键词： Android malware detect prevent artificial intelligence machine learning mobile CICMalDroid2020 CCCSCIC-AndMal-2020

Impact of auditory stimulation nursing protocol on auditory response in cerebrovascular stroke patients

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Journal of Integrative Nursing 2024年第2期6卷 111-116页

作者： Mohammed elSayed ZAKY Hanan Ahmed AL SEBAEE Nagat el Morsy IBRAHIEM Heba Ahmed MOHAMMED mohammad Edrees mohammad Department of Medical Surgical Nursing Faculty of NursingCairo UniversityCairoEgypt Department of Neurology Faculty of MedicineCairo UniversityCairoEgypt

Objectives:The objective of the study was to explore the impact of auditory stimulation protocol on auditory response in cerebrovascular stroke(CVS)*** and Methods:A pre-posttest nonequivalent control group quasi-experimental study was conducted at Al Mainal Hospital at Al Kars Einy Hospital,Cairo University,among 60 CVS patients,and the sample was randomly assigned through a coin to allocate subjects to study or control group(30 for each group).Auditory stimulation techniques were applied three times per week for the study group for two consecutive *** in the control group received only routine hospital care during the study *** Glasgow Coma Scale(GCS)score for assessing the neurological function and level of arousal and the auditory subscale score of Western Neuro Sensory Stimulation Profile(WNSSP)for assessing auditory response were recorded and compared between the two groups before and after the ***:There were statistically significant differences between the study group and the control group regarding third reading of GCS score(11.5±0.3 vs.10.6±0.9,t=4.676,P=0.000).The scores of all auditory subscales of WNSSP in the study groups increased after implementing the auditory stimulation protocol(P<0.05).Conclusion:Utilizing the auditory stimulation protocol by nurse proves to be an effective method for enhancing hearing responses in individuals with CVS.

关键词： Auditory stimulation techniques hearing response nursing management stroke