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Inflammatory myofibroblastic tumor from molecular diagnostics to current treatment

Oncology Research 2024年第7期32卷 1141-1162页

作者： PAULINA CHMIEL ALekSANDRA SŁOWIKOWSKA ŁUKASZ BANASZek ANNA SZUMERA-CIEĆKIEWICZ BARTŁOMIEj SZOSTAKOWSKI mateusz j.spałek TOMASZŚWITAj PIOTR RUTKOWSKI ANNA M.CZARNECKA Department of Soft Tissue/Bone Sarcoma and Melanoma Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland Faculty of Medicine Medical University of WarsawWarsaw02-091Poland Department of Pathology Maria Sklodowska Curie National Research Institute of OncologyWarsaw02-781Poland Department of Radiotherapy Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland

Inﬂammatory myoﬁbroblastic tumor(IMT)is a rare neoplasm with intermediate malignancy characterized by a propensity for recurrence but a low metastatic *** challenges arise from the diverse pathological presentation,variable symptomatology,and lack of different imaging ***,IMT is identiﬁed by the fusion of the anaplastic lymphoma kinase(ALK)gene,which is present in approximately 70%of cases,with various fusion partners,including ran-binding protein 2(RANBP2),which allows conﬁrmation of the *** surgery is the preferred approach for localized tumors,the optimal long-term treatment for advanced or metastatic disease is difﬁcult to deﬁ*** therapies are crucial for achieving sustained response to treatment within the context of genetic alteration in ***,an ALK tyrosine kinase inhibitor(TKI),was ofﬁcially approved by the US Food and Drug Administration(FDA)in 2020 to treat IMT with ALK ***,most patients face resistance and disease progression,requiring consideration of sequential *** radiotherapy with targeted therapy appears to be beneﬁcial in this *** promising results have also been achieved with immunotherapy,indicating potential for combined therapy ***,deﬁned recommendations are still *** review analyzes the available research on IMT,including genetic disorders and their impact on the course of the disease,data on the latest targeted therapy regimens and the possibility of developing immunotherapy in this indication,as well as summarizing general knowledge about prognostic and predictive factors,also in terms of resistance to systemic therapy.

关键词： Inﬂammatory myoﬁbroblastic tumor(IMT) Epithelioid inﬂammatory myoﬁbroblastic sarcoma Tyrosine kinase inhibitors(TKI) Anaplastic lymphoma kinase(ALK)

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Relating estimates of wood properties of birch to stem form, age and species

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journal of Forestry Research 2024年第3期35卷 1-11页

作者： Grace jones Maria Ulan mateusz Liziniewicz johan Lindeberg Stergios Adamopoulos Teagasc Forestry Development Department Ashtown Research CentreDublin 15 D15DY05Ireland Research Institutes of Sweden(RISE) GoteborgSweden The Forest Research Institute of Sweden(Skogforsk) Ekebo 225026890SvalovSweden Department of Forestry and Wood Technology Linnaeus University35195VaxjoSweden Department of Forest Biomaterials and Technology Swedish University of Agricultural SciencesBox 700875007 UppsalaSweden

Birch has long suffered from a lack of active forest management,leading many researchers to use mate-rial without a detailed management *** collected from three birch(Betula pendula Roth,*** Ehrh.)sites in southern Sweden were analyzed using regression analysis to detect any trends or differences in wood proper-ties that could be explained by stand history,tree age and stem *** sites were genetics trials established in the same *** of acoustic velocity(AV)from non-destructive testing(NDT)and predicted AV had a higher correlation if data was pooled across sites and other stem form factors were considered.A subsample of stems had radial profiles of X-ray wood density and ring width by year created,and wood density was related to ring number from the pith and ring *** seemed likely that wood density was negatively related to ring width for both birch *** models had slight improvements if site and species were included,but only the youngest site with trees at age 15 had both birch *** paper indicated that NDT values need to be considered separately,and any predictive models will likely be improved if they are specific to the site and birch species measured.

关键词： Acoustic velocity Non-destructive testing Predictive models Regression analysis Wood density

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Liquid superlubricity of lubricants containing hydroxyl groups and their aqueous solution under rolling/sliding conditions

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Friction 2024年第1期12卷 164-173页

作者： Tomáš POLÁČek Petr ŠPERKA Ivan KŘUPKA Faculty of Mechanical Engineering Brno University of TechnologyBrno 61669Czech Republic

Macroscale rolling/sliding conditions are in the superlubricity,a little-studied topic so *** purpose of this paper is to examine the formation of elastohydrodynamic lubrication(EHL)films by water-based lubricants(glycerol and polyethylene glycol(PEG)),providing superlubricous *** were carried out on an optical ball-on-disc tribometer under rolling/sliding *** film thickness was measured by the thin film colorimetric interferometry,and the viscosity of liquids was measured by rotational and high-pressure falling body *** results show that tribochemical reactions are not the mandatory reason for friction to reach the superlubricity level when using the water-based *** studied liquids themselves are almost *** the addition of water,the signs of shear thinning behavior disappear even *** conditions for this type of lubricant can be predicted using the known Hamrock–Dowson *** anomaly in the thickness of the lubricants was observed as an abrupt change at certain *** more PEG there is in the lubricant,the higher the thickness at the beginning of the jump.

关键词： macroscale superlubricity super low traction water-based lubricants elastohydrodynamic lubrication(EHL) film thickness

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High-resolution photogrammetry to measure physical aperture of two separated rock fracture surfaces

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journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 2922-2934页

作者： Masoud Torkan mateusz janiszewski Lauri Uotinen Alireza Baghbanan Mikael Rinne Department of Civil Engineering Aalto UniversityEspooFinland Department of Mining Engineering Isfahan University of TechnologyIsfahanIran

Photogrammetry,reconstructing three-dimensional(3D)models from overlapping two-dimensional(2D)photos,finds application in rock mechanics and rock engineering to extract geometrical details of reconstructed objects,for example rock *** properties are important for determining the mechanical stability,permeability,strength,and shear behavior of the rock *** can be used to reconstruct detailed 3D models of two separated rock fracture surfaces to characterize fracture roughness and physical aperture,which controls the fluid flow,hydromechanical and shear behavior of the rock *** research aimed to determine the optimal number of scale bars required to produce high-precision 3D models of a fracture surface.A workflow has been developed to define the physical aperture of a fracture using *** blocks of Kuru granite(25 cm×25 cm×10 cm)with an artificially induced fracture,were *** scaling 3D models,321 markers were used as ground control points(GCPs)with predefined distances on each *** the samples were wellmatched in their original positions,the entire block was *** data of the GCPs were extracted from the 3D model of the *** half was surveyed separately and georeferenced by GCPs and merged into the same coordinate *** fracture surfaces were extracted from the 3D models and the vertical distance between the two surfaces was digitally calculated as physical *** assessment of the photogrammetric reconstruction showed a 20-30 mm digital control distance accuracy when compared to known distances defined between *** attain this accuracy,the study found that at least 200 scale bars were ***,photogrammetry was employed to measure changes in aperture under normal *** results obtained from this approach were found to be in good agreement with those obtained using linear variable displacement transducers(LVDTs),with differences ran

关键词： Photogrammetry Physical aperture Rock fracture Predefined distances Markers

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Comparative analysis of microstructure,mechanical,and corrosion properties of biodegradable Mg-3Y alloy prepared by selective laser melting and spark plasma sintering

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journal of Magnesium and Alloys 2024年第4期12卷 1496-1510页

作者： P.Minárik M.Zemková S.Šašek j.Dittrich M.Knapek F.Lukáˇc D.Koutný j.jaroš R.Král Faculty of Mathematics and Physics Charles UniversityKe Karlovu 5Praha 12116Czech Republic Research Centre University ofŽilinaUniverzitná8215/1Žilina 01026Slovakia Institute of Plasma Physics of the Czech Academy of Sciences Za Slovankou 1782/318200 Praha 8Czech Republic Institute of Machine and Industrial Design Brno University of TechnologyTechnická2896/2Brno 61669Czech Republic

This work explored possibilities of biodegradable magnesium alloy Mg-3Y preparation by two modern powder metallurgy techniques–spark plasma sintering(SPS)and selective laser melting(SLM).The powder material was consolidated by both methods utilising optimised parameters,which led to very low porosity(∼0.3%)in the SLM material and unmeasurably low porosity in the SPS *** main aim of the study was the thorough microstructure characterisation and interrelation between the microstructure and the functional properties,such as mechanical strength,deformability,and corrosion *** materials showed comparable strength of∼110 MPa in tension and compression and relatively good deformability of∼9%and∼21%for the SLM and SPS materials,*** corrosion resistance of the SPS material in 0.1 M NaCl solution was superior to the SLM one and comparable to the conventional extruded *** digital image correlation during loading and the cross-section analysis of the corrosion layers revealed that the residual porosity and large strained grains have the dominant negative effect on the functional properties of the SLM *** the other hand,one of the primary outcomes of this study is that the SPS consolidation method is very effective in the preparation of the W3 biodegradable alloy,resulting in material with convenient mechanical and degradation properties that might find practical applications.

关键词： Magnesium Yttrium Powder metallurgy Microstructure Mechanical strength Corrosion resistance

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Molecular insights into clinical trials for immune checkpoint inhibitors in colorectal cancer:Unravelling challenges and future directions

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World journal of Gastroenterology 2024年第13期30卷 1815-1835页

作者： Samantha Sharma Naresh Singh Anita Ahmed Turk Isabella Wan Akshay Guttikonda julia Lily Dong Xinna Zhang mateusz Opyrchal Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202United States Division of Hematology/Oncology Department of MedicineIndiana University School of MedicineIndianapolisIN 46202United States Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202United States

Colorectal cancer(CRC)is a complex disease with diverse etiologies and clinical *** considerable progress in development of CRC therapeutics,challenges remain regarding the diagnosis and management of advanced stage metastatic CRC(mCRC).In particular,the five-year survival rate is very low since mCRC is currently rarely *** the past decade,cancer treatment has significantly improved with the introduction of cancer immunotherapies,specifically immune checkpoint *** aimed at blocking immune checkpoints such as PD-1,PD-L1,and CTLA-4 target inhibitory pathways of the immune system,and thereby enhance anti-tumor *** therapies thus have shown promising results in many clinical trials alone or in *** efficacy and safety of immunotherapy,either alone or in combination with CRC,have been investigated in several clinical *** trials,including KEYNOTE-164 and CheckMate 142,have led to Food and Drug Administration approval of the PD-1 inhibitors pembrolizumab and nivolumab,respectively,for the treatment of patients with unresectable or metastatic microsatellite instability-high or deficient mismatch repair ***,these drugs benefit only a small percentage of patients,with the benefits of immunotherapy remaining elusive for the vast majority of CRC *** this end,primary and secondary resistance to immunotherapy remains a significant issue,and further research is necessary to optimize the use of immunotherapy in CRC and identify biomarkers to predict the *** review provides a comprehensive overview of the clinical trials involving immune checkpoint inhibitors in *** underlying rationale,challenges faced,and potential future steps to improve the prognosis and enhance the likelihood of successful trials in this field are discussed.

关键词： Colorectal cancer Immune checkpoint inhibitors Clinical trials Immunotherapy Microsatellite instability Microsatellite stability DNA mismatch repair

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Sex differences in the risk of retinopathy of prematurity:a systematic review,frequentist and Bayesian meta‑analysis,and meta‑regression

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World journal of Pediatrics 2024年第4期20卷 340-352页

作者： Tamara M.Hundscheid Silvia Gulden Mohamad F.Almutairi František Bartoš Giacomo Cavallaro Eduardo Villamor Division of Neonatology Department of PediatricsMosaKids Children’s HospitalMaastricht University Medical Center(MUMC+)School for Oncology and Reproduction(GROW)Maastricht UniversityP.Debyelaan 25.P.O.Box 58006202 AZ MaastrichtThe Netherlands Neonatal Intensive Care Unit Sant’Anna HospitalComoItaly Department of Psychology University of Amsterdam1001 NK AmsterdamThe Netherlands Neonatal Intensive Care Unit Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilanItaly

Background Retinopathy of prematurity(ROP)is generally considered to be more frequent in males than in ***,it is not known whether sex differences in ROP affect all degrees of the condition,are global and have changed as neonatology has *** aimed to conduct a systematic review and meta-analysis of studies addressing sex differences in the risk of developing *** PubMed/MEDLINE and Embase databases were *** frequentist,random-effects risk ratio(RR)and 95%confidence interval(CI)were *** model averaged(BMA)meta-analysis was used to calculate the Bayes factors(BFs).The BF10 is the ratio of the probability of the data under the alternative hypothesis(H1)over the probability of the data under the null hypothesis(H0).Results We included 205 studies(867,252 infants).Frequentist meta-analysis showed a positive association between male sex and severe ROP(113 studies,RR=1.14,95%CI=1.07–1.22)but no association with any ROP(144 studies,RR=1.00,95%CI=0.96–1.03).BMA showed extreme evidence in favor of H1 for severe ROP(BF10=71,174)and strong evidence in favor of H0 for any ROP(BF10=0.05).The association between male sex and severe ROP remained stable over time and was present only in cohorts from countries with a high or high-middle sociodemographic *** Our study confirms the presence of a male disadvantage in severe ROP but not in less severe forms of the *** are variations in the sex differences in ROP,depending on geographical location and sociodemographic level of the countries.

关键词： Oxidative stress Retinopathy of prematurity Sex characteristics

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Endoscopic pancreatogastric anastomosis in the treatment of symptoms associated with inflammatory diseases of the pancreas

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World journal of Gastrointestinal Endoscopy 2024年第7期16卷 406-412页

作者： mateusz jagielski Eryk Bella Marek jackowski Department of General Gastroenterological and Oncological SurgeryNicolaus Copernicus UniversityToruń87-100Poland

BACKGROUND The outflow of pancreatic juice into the duodenum is often impaired in pancreatic inflammatory *** basis of interventional treatment in these cases is anatomical transpapillary access of the main pancreatic duct during endoscopic retrograde cholangiopancreatography(ERCP),which ensures the physiological outflow of pancreatic juice into the lumen of the digestive ***,in some patients,anatomical changes prevent transpapillary drainage of the main pancreatic *** is the treatment of choice in such *** To evaluate the effectiveness and safety of endoscopic pancreaticogastrostomy under endoscopic ultrasound(EUS)*** Retrospective analysis of treatment outcomes of all patients with acute or chronic pancreatitis who underwent endoscopic pancreatogastric anastomosis under EUS guidance in 2018-2023 at the Department of General,Gastroenterological and Oncological Surgery,Ludwik Rydygier Collegium Medicum in Bydgoszcz,Nicolaus Copernicus University in Toruń,*** In 9 patients[7 men,2 women;mean age 53.45(36-66)years],endoscopic pancreatogastric anastomosis under EUS guidance was performed because of the lack of transpapillary access during *** of the main pancreatic duct at the head of the pancreas was observed in 4/9 patients(44.44%).Pancreatic fragmentation(disconnected pancreatic duct syndrome)was diagnosed in 3/9 patients(33.33%).In 2/9 patients(22.22%),narrowing of the pancreatoenteric anastomosis was observed after *** success of endoscopic pancreaticogastrostomy was observed in 8/9 patients(88.89%).Endotherapeutic complications were observed in 2/9 patients(22.22%).Clinical success was achieved in 8/9 patients(88.89%).The mean follow-up period was 451(42-988)***-term success of endoscopic pancreatogastric anastomosis was achieved in 7/9 patients(77.78%).CONCLUSION Endoscopic pancreaticogastrostomy under EUS guidance is an effective and safe treatment method,espec

关键词： Pancreaticogastrostomy Chronic pancreatitis Acute pancreatitis Disconnected pancreatic duct syndrome Endotherapy

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SPEED:an integrated,smartphone-operated,handheld digital PCR Device for point-of-care testing

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Microsystems & Nanoengineering 2024年第3期10卷 149-158页

作者： Haoqing Zhang Xiaocheng Liu Xinlu Wang Zhiqiang Yan Ying Xu Martina Gaňová TomášŘezníček Marie Korabečná Pavel Neuzil Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical University127 West Youyi RoadXi’anShaanxi 710072PR China The Key Laboratory of Biomedical Information Engineering of the Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’anShaanxi 710049PR China Bioinspired Engineering and Biomechanics Center(BEBC) Xi’an Jiaotong UniversityXi’an 710049PR China School of Marine Science and Technology Northwestern Polytechnical UniversityXi’anShaanxi 710072PR China Central European Institute of Technology Brno University of TechnologyPurkyňova 12361300 BrnoCzech Republic ITD Tech S.R.O Osvoboditelu100573581 BohumínCzech Republic Institute of Biology and Medical Genetics First Faculty of MedicineCharles University and General University Hospital of PragueAlbertov 412800 PragueCzech Republic

This study elaborates on the design,fabrication,and data analysis details of SPEED,a recently proposed smartphonebased digital polymerase chain reaction(dPCR)*** dPCR chips incorporate partition diameters ranging from 50μm to 5μm,and these partitions are organized into six distinct blocks to facilitate image *** to the superior thermal conductivity of Si and its potential for mass production,the dPCR chips were fabricated on a Si substrate.A temperature control system based on a high-power density Peltier element and a preheating/cooling PCR protocol user interface shortening the thermal cycle *** optical design employs four 470 nm light-emitting diodes as light sources,with filters and mirrors effectively managing the light emitted during *** algorithm is utilized for image processing and illumination nonuniformity correction including conversion to a monochromatic format,partition identification,skew correction,and the generation of an image correction *** validated the device using a range of deoxyribonucleic acid targets,demonstrating its potential applicability across multiple ***,we provide guidance and verification of the design and testing of the recently proposed SPEED device.

关键词： correction smart testing

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Structural correlation and chemistry of molten NaF-ScF3 with dissolved metal aluminium:TG/DTA,XRD,NMR and molecular dynamics simulations

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Rare Metals 2024年第7期43卷 3356-3369页

作者： Aydar Rakhmatullin Franti?ek ?imko Didier Zanghi Zuzana Netriová Ilya B.Polovov Ayrat Dimiev Konstantin V.Maksimtsev Catherine Bessada Michal Korenko Conditions Extrêmes et Materiaux:Haute Température et Irradiation CEMHTIUPR 3079-CNRS Univ Orleans Department of Molten Systems Institute of Inorganic ChemistrySlovak Academy of Sciences Centre of Excellence for Advanced Materials Application-CEMEA Slovak Academy of Sciences Department of Rare Metals and Nanomaterials Institute of Physics and TechnologyUral Federal University Alexander Butlerov Institute of Chemistry Kazan Federal University

For the first time,the mechanism of metal aluminum dissolution in NaF-ScF3eutectic melts and the chemical interaction between the constituents of this mixture have been thoroughly studied by a combination of differential thermal analysis（DTA）,high temperature and solid-state nuclear magnetic resonance（NMR）,and X-ray diffraction（XRD） coupled with the molecular dynamic *** formation of an insoluble Al3Sc alloy in molten（NaF-ScF3）eutsystem was proven,and the chemical mechanism of this aluminothermic Al3Sc alloy production was *** ex situ examinations bring to light the formation of NaScF4and solid solution of Na3（Al,Sc）F6in cooled *** molecular dynamics calculations of the bath allow us to construct the structural model and to predict viscosity,density and electrical conductivity of the reagent melt to help to optimize the conditions of the alloy synthesis.

关键词： Scandium Alloy Molten salts NMR Molecular dynamics

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