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Biological,pathological,and multifaceted therapeutic functions of exosomes to target cancer

Oncology Research 2024年第1期32卷 73-94页

作者： VIGNESH BALAJI E DIVYA RAMESH manisha chungan shaju AKSHARA KUMAR SAMYAK PANDEY RAKSHA NAYAK V.ALKA SRISHTI MUNJAL AMIR SALIMI K.SREEDHARA RANGANATH PAI SHANKAR M.BAKKANNAVAR Department of Pharmacology Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Forensic Medicine and Toxicology Kasturba Medical CollegeManipal Academy of Higher EducationManipalKarnataka576104India School of Health and Community Services Durham CollegeOshawaOntarioL1G2G5Canada Department of Pharmaceutical Regulatory Affairs and Management Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Clinical Psychology Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Speech and Hearing Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Pharmacy Practice Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India

Exosomes,small tiny vesicle contains a large number of intracellular particles that employ to cause various diseases and prevent several pathological events as well in the human *** is considered a“double-edged sword”,and depending on its biological source,the action of exosomes varies under physiological ***,the isolation and characterization of the exosomes should be performed accurately and the methodology also will vary depending on the exosome ***,the uptake of exosomes from the recipients’cells is a vital and initial step for all the physiological *** are different mechanisms present in the exosomes’cellular uptake to deliver their cargo to acceptor *** the exosomal uptake takes place,it releases the intracellular particles that leads to activate the physiological *** though exosomes have lavish functions,there are some challenges associated with every step of their preparation to bring potential therapeutic ***,overcoming the pitfalls would give a desired quantity of exosomes with high purity.

关键词： Exosomes Physiology Cancer Therapeutics Challenges

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Synthesis of Y3Al5O12∶Eu and Y3Al5O12∶Eu,Si phosphors by combustion method: Comparative investigations on the structural and spectral properties

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Journal of Advanced Ceramics 2016年第4期5卷 248-页

作者： manisha UPASANI Department of Physics Rashtrasant Tukadoji Maharaj Nagpur University Nagpur India

This paper reports the comparative investigations of the structural and spectral properties of Y3Al5O12∶Eu3+ (YAG∶Eu) and Y3Al5O12∶Eu3+,Si4+ (YAG∶Eu,Si) phosphors synthesized by combustion method at low temperature.A pure phase was identified for the YAG∶Eu phosphor with a suitable amount of *** refinement and analytical calculation of different structural parameters were performed to get the idea about the SiO2 substitution in YAG∶*** characteristic red luminescence corresponding to Eu3+ transitions was observed after irradiation with ultra violet (UV) light and enhanced with SiO2 *** formula and nephelauxetic ratio were used to understand the ligand behavior of Eu-O bond in YAG doped *** Judd-Ofelt intensity parameters and color properties of the phosphors were determined in *** efficient synthesis method for YAG∶Eu phosphor,compatible for industrial applications,was proposed.

关键词： yttrium aluminum garnet (Y3Al5O12,YAG) light emitting diode (LED) red phosphor combustion synthesis

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Effect of doping of different rare earth（europium,gadolinium,dysprosium and neodymium） metal ions on structural,optical and photocatalytic properties of LaFeO3 perovskites

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Journal of Rare Earths 2019年第12期37卷 1279-1287页

作者： manisha Dhiman Sonal Singhal Department of Chemistry Panjab University

Different rare earth substituted perovskites LaRExFe1-xO3(where RE=Eu3+,Gd3+,Dy3+,Nd3+and x=0.02,0.04,0.06,0.08,0.1)with orthorhombic structure and narrow band gaps were successfully fabricated via sol-gel autocombustion *** the substituted perovskites are found to exhibit excellent photocatalytic activity towards the oxidative degradation of dye *** excellent increase in the rate constant values of pure perovskite(LaFeO3)photocatalytic reactions is observed with the substitution of rare earth metal *** results are obtained for LaNd0.1Fe0.9O3 which exhibits around 7 times increase in the rate constant values for degradation reaction of SO(1.76×10-1 min-1)and RBY(1.69×10-1 min-1)dyes.

关键词： Rare earth substitution Perovskites Sol-gel autocombustion Structural properties Photocatalysis

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Transformation of Sucrose to Starch and Protein in Rice Leaves and Grains under Two Establishment Methods

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Rice science 2016年第5期23卷 255-265页

作者： manisha KUMARI Bavita ASTHIR Department of Biochemistry Punjab Agricultural University

Six rice varieties, PR120, PR116, Feng Ai Zan, PR115, PAU201 and Punjab Mehak 1 were raised under aerobic and transplanting conditions to assess the effects of planting conditions on sucrose metabolising enzymes in relation to the transformation of free sugars to starch and protein in flag leaves and grains. Activities of sucrose synthase, sucrose phosphate synthase and acid invertase increased till flowering stage in leaves and mid-milky stage（14 d after flowering） in grains and thereafter declined in concomitant with the contents of reducing sugar. Under aerobic conditions, the activities of acid invertase and sucrose synthase（cleavage） significantly decreased in conjunction with the decrease in non-reducing sugars and starch content in all the varieties. Disruption of starch biosynthesis under the influence of aerobic conditions in both leaves and grains and the higher build up of sugars possibly resulted in their favoured utilization in nitrogen metabolism. Feng Ai Zan, PR115 and PR120 maintained higher levels of sucrose synthase enzymes in grains and leaves and contents of metabolites（amino acid, protein and non-reducing sugar） under aerobic conditions, while PR116, Punjab Mehak 1 and PAU201 performed better under transplanting conditions, thus showing their adaptation to environmental stress. Yield gap between aerobic and transplanting rice is attributed primarily to the difference in sink activity and strength. Overall, it appear that up-regulation of sucrose synthase（synthesis） and sucrose phosphate synthase under aerobic conditions might be responsible in enhancing growth and productivity of rice varieties.

关键词： aerobic rice acid invertase protein amino acid starch sucrose synthase sucrose phosphate synthase water soluble carbohydrate sugar

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VLSI scaling methods and low power CMOS buffer circuit

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Journal of Semiconductors 2013年第9期34卷 92-99页

作者： Vijay Kumar Sharma manisha Pattanaik Department of Information Technology ABV-Indian Institute of Information Technology & Management

Device scaling is an important part of the very large scale integration （VLSI） design to boost up the success path of VLSI industry, which results in denser and faster integration of the devices. As technology node moves towards the very deep submicron region, leakage current and circuit reliability become the key issues. Both are increasing with the new technology generation and affecting the performance of the overall logic circuit. The VLSI designers must keep the balance in power dissipation and the circuit＇s performance with scaling of the devices. In this paper, different scaling methods are studied first. These scaling methods are used to identify the effects of those scaling methods on the power dissipation and propagation delay of the CMOS buffer circuit. For mitigating the power dissipation in scaled devices, we have proposed a reliable leakage reduction low power transmission gate （LPTG） approach and tested it on complementary metal oxide semiconductor （CMOS） buffer circuit. All simulation results are taken on HSPICE tool with Berkeley predictive technology model （BPTM） BSIM4 bulk CMOS files. The LPTG CMOS buffer reduces 95.16% power dissipation with 84.20% improvement in figure of merit at 32 nm technology node. Various process, voltage and temperature variations are analyzed for proving the robustness of the proposed approach. Leakage current uncertainty decreases from 0.91 to 0.43 in the CMOS buffer circuit that causes large circuit reliability.

关键词： LPTG buffer power dissipation propagation delay scaling nanoscale CMOS figure of merit

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Adoption of precision agriculture technologies in India and in some developing countries:Scope,present status and strategies

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Progress in Natural Science:Materials International 2009年第6期19卷 659-666页

作者： Pinaki Mondal manisha Basu Department of Agricultural and Food Engineering Indian Institute of Technology International Centre for Automotive Technology 3. National Research Development Corporation

Rapid socio-economic changes in some developing countries, including India, are creating new scopes for application of precision agriculture (PA). The implications of dramatic shifts for economic development, urbanization and energy consumption in some developing countries are immense. High-tech nature of traditional PA technologies developed in advanced countries created a real challenge for engineers to search suitable PA technologies for developing countries. It is expected that application of balanced soft and hard PA technologies based on the need of specific socio-economic condition of a country will make PA suitable for developing countries also. ‘Soft’ PA depends mainly on visual observation of crop and soil and management decision based on experience and intuition, rather than on statistical and scientific analysis. ‘Hard’ PA utilizes all modern technologies such as GPS, RS, and VRT. Three components, namely, ‘single PA technology’, ‘PA technology package’ (for the user to select one or combination) and ‘integrated PA technology’, have been identified as a part of adoption strategies of PA in the developing countries. Therefore, the objective of this paper is to find out the scope, the present status and the strategies for adoption of PA in India and in some developing countries. Application of PA in cash crop, plantation crop, etc. has been discussed. Application of some medium and low-tech PA tools such as chlorophyll meter and leaf colour chart. in small farms has been included. This exhaustive review of the present status of PA in India and in some developing countries is expected to help to find out the adoption trend and direction of future research. Detailed strategy for the adoption of PA in India has also been proposed.

关键词： Precision agriculture Indian agriculture Developing countries Adoption

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Dynamics of a SIR epidemic model with variable recruitment and quadratic treatment

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International Journal of Biomathematics 2023年第7期16卷 219-247页

作者： manisha Mukherjee Biswajit Mondal Department of Mathematics Raja N.L.Khan Women's College Midnapore 721102 West BengalIndia

The dynamical behavior of a variable recruitment SIR model has been investigated with the nonlinear incidence rate and the quadratic treatment function for a horizontally transmitted infectious disease that sustains for a long period(more than one year).For a long duration,we have incorporated human fertility in variable *** societal effort,*** types of medical infrastructures,have a vital role in controlling such a *** this reason,we have considered the quadratic treatment function,which divides the system into two *** have established the existence and stability of different equilibrium points that depend mainly on the societal effort parameter in both subsystems and also global *** rich dynamics such as forward bifurcation,Hopf bifurcation,limit cycle,and Bogdanov-Takens bifurcation of co-dimension 2 have been established by using bifurcation theory and the biological significance of these dynamics has been *** numerical examples have been considered to illustrate the theoretical ***,we have discussed the advantage of our model with the model by Eckalbar and Eckalbar[Nonlinear Anal.:Real World Appl.12(2011)320332].

关键词： Quadratic treatment function endemic equilibrium point Bogdanov-Takens bifurcation disease-free equilibrium point Hopf bifurcation

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Coconut(Cocos nucifera L.:Arecaceae):In health promotion and disease prevention

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Asian Pacific Journal of Tropical Medicine 2011年第3期4卷 241-247页

作者： manisha DebMandal Shyamapada Mandal Department of Physiology and Biophysics KPC Medical College and Hospital1F Raja S C Mallick RoadJadavpurKolkata-700 032India Department of Zoology Gurudas CollegeNarkeldangaKolkata-700 054India

Coconut,Cocos nucifera L.,is a tree that is cultivated for its multiple utilities,mainly for its nutritional and medicinal *** various products of coconut include tender coconut water,copra,coconut oil,raw kernel,coconut cake,coconut toddy,coconut shell and wood based products,coconut leaves,coir pith *** all parts are used in someway or another in the daily life of the people in the traditional coconut growing *** is the unique source of various natural products for the development of medicines against various diseases and also for the development of industrial *** parts of its fruit like coconut kernel and tender coconut water have numerous medicinal properties such as antibacterial,antifungal,antiviral, antiparasitic,antidermatophytic,antioxidant,hypoglycemic,hepatoprotective,immunostimulant. Coconut water and coconut kernel contain microminerals and nutrients,which are essential to human health,and hence coconut is used as food by the peoples in the globe,mainly in the tropical *** coconut palm is,therefore,eulogised as ’Kalpavriksha’(the all giving tree) in Indian classics,and thus the current review describes the facts and phenomena related to its use in health and disease prevention.

关键词： Coconut Medicinal property Nutritional value Disease prevention

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BC driven IoT-based food quality traceability system for dairy product using deep learning model

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High-Confidence Computing 2023年第3期3卷 1-11页

作者： Noothi manisha Madiraju Jagadeeshwar Department of Computer Science Chaitanya Deemed to be UniversityWarangal 506001India

Food traceability is a critical factor that can ensure food safety for enhancing the credibility of the product,thus achieving heightened user satisfaction and *** Perishable Food SC(PFSC)requires paramount care for ensuring quality owing to the limited product *** PFSC comprises of multiple organizations with varied interests and is more likely to be hesitant in sharing the traceability details among one another owing to a lack of trust,which can be overcome by using Blockchain(BC).In this research,an efficient scheme using BC-Deep Residual Network(BC-DRN)is developed to provide food traceability for dairy ***,food traceability is determined by using various modules,like the Internet of Things(IoT),BC data management,Food traceability BC architecture,and DRN-based food quality evaluation *** devised BC-DRN-based food quality traceability system is examined based on its performance metrics,like sensitivity,response time,and testing accuracy,and it has attained better values of 0.939,109.564 s,and 0.931.

关键词： Perishable food SC Blockchain Internet of things Food traceability Deep learning

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Review of Electrochemical Sensors and Biosensors Based on First-Row Transition Metals,Their Oxides,and Noble Metals Nanoparticles

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Journal of Analysis and Testing 2024年第2期8卷 143-159页

作者： Kulveer Singh Kuldeep Kumar Maurya manisha Malviya Department of Chemistry Indian Institute of Technology(Banaras Hindu University)Varanasi221005India

The use of electrochemical sensors for sensitive disease diagnosis and detecting various species with pharmacological,therapeutic,industrial,food-related,and environmental origins is now widely accepted.A catalytic or binding event resulting from the sensor’s electroactive component recognizing its analyte creates an electrical signal proportionate to the analyte concentration,which is then monitored by a *** development of morphologically distinct metal and metal oxide nanoparticles formed from first-row transition elements(Mn,Cr,Fe,Co,Ti,Ni,Cu,Zn)and noble metals(Pt,Au,Ag,Pd)is described in this *** effect of these metal nanoparticles has been studied using Tetracyanoquinodimethane(TCNQ),Ferrocene,and other organic compounds as electroactive species using carbon paste-modified *** sensors,mostly based on ferrocene,are exceedingly sensitive,selective,affordable,and for detecting numerous biomolecules like glucose,dopamine,NADH,ascorbic acid,and a few dyes and are simple to *** recent decades,charge transfer organic species-based chemosensors have become a prominent study *** paper outlines current developments in electrochemical biosensors based on transition metal nanoparticles,covering glucose,ascorbic acid,uric acid,and other inorganic and organic *** importance of transition metal and transition metal oxide nanoparticles as potential electrode modifiers for developing sensors is highlighted.A discussion of the present problem and possible solutions,and plausible future directions marks the review’s conclusion.

关键词： Electrochemical sensing Amperometry Cyclic voltammetry Square wave voltammetry Linear sweep voltammetry

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