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Chemotherapeutic nanomaterials in tumor boundary delineation:Prospects for effective tumor treatment

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Acta Pharmaceutica Sinica B 2022年第6期12卷 2640-2657页

作者： Ozioma Udochukwu Akakuru Zhoujing Zhang m.zubair iqbal Chengjie Zhu Yewei Zhang Aiguo Wu Cixi Institute of Biomedical Engineering International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringCASNingbo 315201China School of medicine Southeast UniversityNanjing 210009China School of materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China

Accurately delineating tumor boundaries is key to predicting survival rates of cancer patients and assessing response of tumor microenvironment to various therapeutic techniques such as chemotherapy and *** review discusses various strategies that have been deployed to accurately delineate tumor boundaries with particular emphasis on the potential of chemotherapeutic nanomaterials in tumor boundary *** also compiles the types of tumors that have been successfully delineated by currently available ***,the challenges that still abound in accurate tumor boundary delineation are presented alongside possible perspective strategies to either ameliorate or solve the *** is expected that the information communicated herein will form the first compendious baseline information on tumor boundary delineation with chemotherapeutic nanomaterials and provide useful insights into future possible paths to advancing current available tumor boundary delineation approaches to achieve efficacious tumor therapy.

关键词： Bioimaging Boundary delineation Tumor Tumor imaging Tumor therapy Surgery

Canted antiferromagnetic and optical properties of nanostructures of mn_2O_3 prepared by hydrothermal synthesis

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Chinese Physics B 2012年第11期21卷 441-447页

作者： Qurat-ul-ain Javed Wang Feng-Ping m.Yasir Rafique Arbab mohammad toufiq m.zubair iqbal Department of Physics School of Mathematics and PhysicsUniversity of Science and Technology Beijing

We have reported new magnetic and optical properties of mn2O3 nanostructures. The nanostructures have been synthesized by the hydrothermal method combined with the adjustment of pH values in the reaction system. The particular characteristics of the nanostructures have been analyzed by employing X-Ray diffraction （XRD）, scanning electron microscopy （SEm）, energy dispersive X-ray （EDX） analysis, transmission electron microscopy （TEm）, high resolution transmission electron microscopy （HRTEm）, Raman spectroscopy （RS）, UV-visible spectroscopy, and the vibrating sample magnetometer （VSm）. Structural investigation manifests that the synthesized mn2O3 nanostructures are orthorhombic crystal. magnetic investigation indicates that the mn2O3 nanostructures are antiferromagnetic and the antiferromagnetic transition temperature is at TN = 83 K. Furthermore, the mn2O3 nanostructures possess canted antiferromagnetic order below the Neel temperature due to spin frustration, resulting in hysteresis with large coercivity （1580 Oe） and remnant magnetization （1.52 emu/g）. The UV-visible spectrophotometry was used to determine the transmittance behaviour of mn203 nanostructures. A direct optical band gap of 1.2 eV was acquired by using the Davis-mott model. The UV-visible spectrum indicates that the absorption is prominent in the visible region, and transparency is more than 80% in the UV region.

关键词： mn2O3 orthorhombic nanocrystals UV transparency canted antiferromagnetic property

Growth of monodisperse nanospheres of mnFe_2O_4 with enhanced magnetic and optical properties

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Chinese Physics B 2013年第10期22卷 453-459页

作者： m.Yasir Rafique 潘礼庆 Qurat-ul-ain Javed m.zubair iqbal 邱红梅 m.Hassan Farooq 郭振刚 m.Tanveer College of Science and Research Institute for New Energy China Three Gorges University Department of Physics University of Science and Technology of Beijing School of material Science and Engineering University of Science and Technology of Beijing Research Center of materials Science Beijing Institute of Technology

Highly dispersive nanospheres of mnFe204 are prepared by template free hydrothermal method. The nanospheres have 47.3-nm average diameter, narrow size distribution, and good crystallinity with average crystallite size about 22 nm. The reaction temperature strongly affects the morphology, and high temperature is found to be responsible for growth of uniform nanospheres. Raman spectroscopy reveals high purity of prepared nanospheres. High saturation magnetization （78.3 emu/g）, low coercivity （45 Oe, 10e = 79.5775 ***-1）, low remanence （5.32 emu/g）, and high anisotropy constant 2.84 × 10^4 J/m3 （10 times larger than bulk） are observed at room temperatures. The nearly snperparamagnetic behavior is ~ spin due to comparable size of nanospheres with superparamagnetic critical thameter Dcr spm The high value of Keff may be due to coupling between the pinned moment in the amorphous shell and the magnetic moment in the core of the nanospheres. The nanospheres show prominent optical absorption in the visible region, and the indirect band gap is estimated to be 0.98 eV from the transmission spectrum. The prepared mn ferrite has potential applications in biomedicine and photocatalysis.

关键词： mn ferrite magnetic materials hydrothermal method superparamagnetic Raman spectroscopy

Ovalbumin-loaded paramagnetic nano-triangles for enhanced dendritic cell stimulation,T_(1)-mR imaging,and antitumor immunity

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Journal of materials Science & Technology 2023年第17期148卷 123-137页

作者： Yike Hou Zhe Tang Jabeen Farheen madiha Saeed Lijia Luo Wenzi Ren Dandan Luo Asim mushtaq Ruibo Zhao Jian Ge Zhangsen Yu Yao Li m.zubair iqbal Xiangdong Kong Institute of Smart Biomedical materials School of Materials Science and EngineeringZhejiang Sci-Tech UniversityHangzhou 310018China State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Cixi Institute of Biomedical Engineering CAS Key Laboratory of Magnetic Materials and DevicesKey Laboratory of Additive Manufacturing Materials of Zhejiang ProvinceNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Department of materials Imperial College LondonLondon SW72AZUK College of Life Sciences China Jiliang UniversityHangzhou 310018China Laboratory of Nanomedicine Medical Science Research CenterSchool of MedicineShaoxing UniversityShaoxing 312000China

Vaccine-based cancer immunotherapy has demonstrated a significant potential for cancer treatment in *** the efficiencies of vaccines are limited,they can be enhanced by a well-designed antigen delivery system that promotes sufficient antigen presentation of dendritic cells(DCs)for initiating high T cell ***,antigen-loaded manganese oxide(mn_(3)O_(4))triangular-shaped ultrasmall nanoparti-cles were prepared to stimulate DC-based immunotherapy under the guidance of T_(1)magnetic resonance *** FDA-approved triblock copolymer Pluronic^(■)F-68 wasused not onlyto transferthe phase from hydrophobic to hydrophilic but also to enrich antigen loading and improve the biocompatibility of the prepared ***(OVA),a model antigen,was adsorbed on the surface of polymer-coated nanoparticles through electrostatic interaction to form mn_(3)O_(4)@PF68-OVA nanoparticle-antigen complexes to stimulate DC-based immunization and antigen-specific T cell *** mn_(3)O_(4)@PF68-OVA nanovaccine(NV)induces negligible toxicity effects against 4T1 and bone marrow-derived dendritic cells(BmDCs)by conventional methods supports the proliferation of intestine organoids,which are an innovative three-dimensional cytotoxicity evaluation system,thereby indicating their potential safety for in vivo cancer *** designed paramagnetic nanovaccine possessed excellent OVA delivery to dendritic-regulated antigen-specific T cells in vitro by stimulating the maturation level of *** ad-dition,mn_(3)O_(4)@PF68-OVA NVs enhance immunity in vivo by increasing the T-cells and m1 macrophages,which suggests improved ***,vaccination with mn_(3)O_(4)@PF68-OVA offer complete pro-tection in the prophylactic group and significant tumor inhibition in the therapeutic group against B16-OVA *** addition,the designed nanovaccine demonstrated high T_(1)-mR imaging in the tumor,fur-ther justifying enhanced tumor accumulation and capability to

关键词： Ovalbumin Nanovaccine Antigen delivery magnetic resonance imaging Contrast agent Cancer immunotherapy

Physical aspects of anisotropic compact stars in f(T,T) gravity with off diagonal tetrad

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Chinese Physics C 2021年第8期45卷 190-205页

作者： m.zubair Allah Ditta G.Abbas Rabia Saleem Department of mathematics COMSATS University IslamabadLahore CampusLahorePakistan Department of mathematics The Islamia University of BahawalpurBahawalpurPakistan

This study addresses the formation of anisotropic compact star models in the background of f(T,T)gravity(where T and T represent the torsion and trace of the energy momentum tensor,respectively).f(T,T)gravity is an extension of the f(T)theory,and it allows a general non-minimal coupling between T and *** this setup,we apply Krori and Barua's solution to the static spacetime with the components ξ=Br^(2)+c and ψ=Ar^(2).To develop viable solutions,we select a well-known model f(T,T)=αT^(m)+βT+Ф(where α and β are coupling parameters,and Ф indicates the cosmological constant).We adopt the conventional matching of interior and exterior space time to evaluate the unknowns,which are employed in the stellar *** present a comprehensive discussion on the stellar properties to elaborate the anisotropic nature of compact stars corresponding to well-known models:PSRJ1416-2230,4U1608-52,CenX-3,EXO1785-248,and *** physical analysis,it is observed that the solution of compact spheres satisfy the acceptability criteria,and its models behave optimally and depict stability and consistency,in accordance with f(T,T)gravity.

关键词： f(T,T)gravity compact stars stellar models

Hydrodynamics and Sensitivity Analysis of a Williamson Fluid in Porous-Walled Wavy Channel

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Computers, materials & Continua 2021年第9期68卷 3877-3893页

作者： A.Shahzad W.A.Khan R.Gul B.Dayyan m.zubair Department of mathematics COMSATS University IslamabadAbbottabad Campus22060Pakistan Department of mechanical Engineering College of Engineering Prince Mohammad Bin Fahd UniversityAl Khobar31952Kingdom of Saudi Arabia

In this work,a steady,incompressible Williamson fluid model is investigated in a porous wavy *** situation arises in the reabsorption of useful substances from the glomerular filtrate in the *** 80%reabsorption,urine is left,which behaves like a thinning *** laws of conservation of mass and momentum are used to model the physical *** analytical solution of the problem in terms of stream function is obtained by a regular perturbation expansion *** asymptotic integration method for small wave amplitudes and the RK-Fehlberg method for pressure distribution has been used inside the *** is demonstrated that the forward flow becomes fast in the narrow region(at x=0.75),which dominates the upward flow inside the *** study the impact of model parameters on outputs,we applied normalized local sensitivity analysis and noticed that the most influential parameter for the longitudinal velocity profile is the dimensionless wave *** reabsorption parameter is sensitive for transverse velocity in the narrow region,and the Weissenberg number has a strong effect on the pressure inside the ***,the least sensitive parameters for the velocity components and pressure have been identified.

关键词： Sensitivity analysis Williamson fluid regular perturbation method asymptotic approximation RK-Fehlberg method kidney flow

不同通风策略下大规模鸭粪堆肥的腐熟和光谱特征

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植物营养与肥料学报 2024年第3期30卷 575-586页

作者： zubair muhammad 柳夏艳李兆君王建才朱荣生山东省农业科学院畜牧兽医研究所山东济南250100 北京林业大学/水体污染源控制技术重点实验室北京100083 中国农业科学院农业资源与农业区划研究所北京100081

[目的]鉴于鸭粪处理的固有挑战,有效的通风措施是鸭粪工业堆肥过程成功的关键。这项开创性的研究旨在评估来自鸭粪和蘑菇废弃物堆肥的腐熟度和稳定性。本研究进一步探讨了各种通风策略在促进堆肥过程中有机物分解和转化方面的有效性和... 详细信息

[目的]鉴于鸭粪处理的固有挑战,有效的通风措施是鸭粪工业堆肥过程成功的关键。这项开创性的研究旨在评估来自鸭粪和蘑菇废弃物堆肥的腐熟度和稳定性。本研究进一步探讨了各种通风策略在促进堆肥过程中有机物分解和转化方面的有效性和效率。[方法]将鸭肥和蘑菇废弃物按干重比为2∶1(C/N约为21.15)混合进行堆肥试验。堆肥采用梯形桩,每桩体积5.6 m^(3),采用管道通风。堆肥试验包括4个通气时间处理,分别为10、20、30、60 min/d(分别记作C1、C2、C3和C4处理)。主要研究了堆肥过程中物理化学特性、紫外-可见光谱、X射线衍射(XRD)和红外光谱(IR)的变化特征。[结果]在堆肥第5天和第6天,堆肥进入嗜热期,持续17天,第15天达到50℃。在堆肥前5天,堆肥pH从8.5迅速上升到12.3,可能是由于鸭粪蛋白质的分解,然后在接下来的20天里逐渐下降,在28~30天急剧下降,之后逐渐下降。在高温期(第17天)后,堆肥C1、C2、C3和C4处理的含水量较堆肥初期分别减少了45.9%、46%、44.7%和43%。C3和C4处理的TC值远低于C1和C2。所有堆肥处理的紫外吸收均随波长的增加而降低。在X射线衍射图中存在部分纤维素特征峰(2θ=26.56°)。这些样品含有更多的结晶和“无定形”纤维素、木聚糖和其他多糖。在200~220 nm光谱范围内,硝酸盐和羧基类化学物质的吸收速度比芳香族或不饱和分子快。堆肥的吸收率随初始碳氮比和堆肥过程的持续时间而变化。相反,在460~480 nm处的吸光度表明有机材料的腐殖质化。Q2/6或Q4/6值越低,表明有机物腐殖化程度越高和越多的有机物缩合成芳香族化合物。在红外光谱中,整个堆肥过程中与有机或无机官能团相关的所有条带的强度都有明显的变化。红外光谱显示出一个宽峰,中心波数为3400 cm^(-1),表明存在与羟基(OH)基团和水分子相关的拉伸振动。在3000~2800 cm^(-1)的光谱范围内,可以观察到一个与有机化合物所表现出的疏水特性相关的现象。在2900~2850 cm^(-1)处存在的条带可以归因于C-H脂肪族基团和醛基基团(CHO)的伸缩振动。初始堆肥样品和C1、C2、C3、C4的红外光谱在堆肥过程中发生了显著变化。由于这些变化,红外光谱吸收带发生了显著的变化,表明相关的物质结构发生了变化。因此,C3和C4在堆肥过程中表现出较高程度的稳定性。[结论]65天的堆肥试验显示,在整个堆肥过程中,温度发生变化,通风60 min/d的堆肥最高温度高于通风10 min/d的堆肥。在堆肥过程中,随着通气量的增加,pH呈下降趋势,因此,日通风30~60 min的堆肥pH较低。堆肥过程中,堆料C/N逐渐降低,表明纤维素活性增加。XRD光谱显示峰值强度降低,反映了纤维素的分解。日通风30~60 min堆肥表现出较高的成熟度,突出了通风对成功堆肥的重要性。

关键词：鸭粪蘑菇废弃物堆肥通风成熟度

Physical aspects of anisotropic compact stars in f(T,■) gravity with off diagonal tetrad

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Chinese Physics C 2021年第8期 195-210页

作者： m.zubair Allah Ditta G.Abbas Rabia Saleem Department of mathematics COMSATS University Islamabad Department of mathematics The Islamia University of Bahawalpur

This study addresses the formation of anisotropic compact star models in the background of f(T,■)gravity(where T and ■ represent the torsion and trace of the energy momentum tensor,respectively).f(T,■) gravity is an extension of the f(T) theory,and it allows a general non-minimal coupling between T and ■.In this setup,we apply Krori and Barua’s solution to the static spacetime with the components ξ=Br~2+c and Ψ=Ar~*** develop viable solutions,we select a well-known model f(T,■)=aT~m+β■+φ(where α and β are coupling parameters,and φ indicates the cosmological constant).We adopt the conventional matching of interior and exterior space time to evaluate the unknowns,which are employed in the stellar *** present a comprehensive discussion on the stellar properties to elaborate the anisotropic nature of compact stars corresponding to well-known models:PSRJ1416-2230,4U1608-52,CenX-3,EX01785-248,and *** physical analysis,it is observed that the solution of compact spheres satisfy the acceptability criteria,and its models behave optimally and depict stability and consistency,in accordance with f(T,■) gravity.

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Strong gravitational lensing for photon coupled to Weyl tensor in Kiselev black hole

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Chinese Physics C 2020年第9期44卷 210-223页

作者： G.Abbas Asif mahmood m.zubair Departmentof mathematics The Islamia University of BahwalpurPakistan Department of mathematics COMSATS UniversityIslamabadLahore CampusPakistan

The objective of the present work is to highlight the phenomena of strong gravitational lensing and deflection angle for the photon coupling with the Weyl tensor in a Kiselev black ***,we have extended the prior work of Chen and Jing(*** and ***,JCAP,10:002(2015))for a Schwarzschild black hole to a Kiselev black *** this purpose,the equation of motion for the photons coupled to the Weyl tensor,null geodesic,and equation of photon sphere in a Kiselev black hole spacetime have been *** is found that the equation of motion of the photons depends not only on the coupling between the photons and the Weyl tensor,but also on the polarization direction of the *** is a critical value of the coupling parameter,α,for the existence of the marginally circular photon orbit outside the event horizon,which depends on the parameters of the black hole and the polarization direction of the ***,the polarization directions of the coupled photons and the coupling parameter,α;both modify the features of the photon sphere,angle of deflection,and functions(^ˉa and^ˉb)owing to the strong gravitational lensing in the Kiselev black hole *** addition to this,the observable gravitational lensing quantities and the shadows of the Kiselev black hole spacetime are presented in detail.

关键词： relativity and gravitation gravitational lensing classical black holes deflection angle