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What is the role of adolescent body mass index and physical activity on adult health risk behaviors?

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Open Journal of Preventive medicine 2012年第1期2卷 72-78页

作者： Jennifer A. Pintar Kristi L. Storti vincent C. Arena Robert J. Robertson Elizabeth F. Nagle Andrea m. Kriska Department of Human Performance and Exercise Science Youngstown State University Youngstown USA

Introduction: A high prevalence of modifiable risk factors exists among adolescents that may lead to increased levels of morbidity and mortality in adulthood. This study sought to determine whether higher levels of physical activity (PA) and/or having a healthy body weight in adolescence influences future health risk behaviors (HRB) in young adulthood. methods: Complete data were gathered for 536 participants from a prospective study and a follow-up survey conducted 10 years apart. At both time points, the questionnaires included information about HRB, PA, and health status. Results: males who engaged in HRB during adolescence were more likely to continue these same risk behaviors during adulthood. Using multivariate models, only HRB in adolescence predicted HRB in adulthood for drinking, binge drinking and smoking among males, and for binge drinking and smoking among females. Conclusions: It appears that for males, once a health-risk behavior is initiated, it will likely continue into young adulthood, regardless of the presence of other healthy behaviors such as the proper maintenance of body weight and higher levels of PA. Similarly for females, binge drinking and smoking in adolescence is predictive of the same behavior in adulthood.

关键词： Smoking Drinking Binge Drinking

Impact of body mass index on hepatocellular carcinoma recurrence after liver transplantation through long-term follow-up

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 598-609页

作者： Nada El-Domiaty Faouzi Saliba vincent Karam Rodolphe Sobesky Wafaa Ibrahim Eric Vibert Gabriella Pittau Khaled Amer maysaa ASaeed Jihan AShawky Daniel Cherqui RenéAdam Didier Samuel AP-HP Hôpital Paul Brousse Hepato-Biliary CentreINSERM UMR 1193UniversitéParis SaclayVillejuifFrance Tropical medicine Department Faculty of MedicineZagazig UniversityZagazigEgypt Statistics Department Faculty of Economics and Political ScienceCairo UniversityCairoEgypt Hepato-Biliary and Liver Transplant Department International Medical CenterCairoEgypt

Background:Obesity is associated with increased oncological risk and outcomes but the evidence surrounding the effect of body mass index(BmI)on increased risk of hepatocellular carcinoma(HCC)recurrence after liver transplantation(LT)is still *** purpose of this retrospective study of a large cohort of adult patients transplanted for HCC was to investigate the effect of BmI on the incidence of HCC recurrence and ***:Data from 427 adult recipients transplanted for HCC between 2000 and 2017 were *** were classified at time of LT according to the World Health Organization BmI classification into 3 groups;group 1:BmImI 25-29.9(n=150)and group 3:BmI≥30(n=111).Results:There were no significant changes of mean BmI overtime 26.8±5.0 kg/m2 at time of LT and 28.8±23.1 at 5 *** recurrence rates of HCC after LT in the three groups were 19%,16%and 17%*** 5,10 and 15-year recurrence free survival(RFS)rates were respectively 68.6%,47.3%and 40.8%in group 1,73.3%,66.2%and 49.5%in group 2 and 68.8%,57.5%and 47.7%in group 3(log rank P=0.47).Conclusions:Recipient BmI at time of transplant and during follow-up didn’t impact the incidence of HCC recurrence nor long-term patient survival,irrespective to the status of the patients and their tumor characteristic at time of *** present study clearly confirms that obesity should not be considered,when selecting patients with HCC to LT,as a predictive factor of recurrence.

关键词： Hepatocellular carcinoma(HCC) obesity body mass index(BmI) nutrition liver transplantation(LT) hepatocellular carcinoma recurrence(HCC recurrence)

Effect of Drought Stress on Yield Performance of Parental Chickpea Genotypes in Semi-arid Tropics

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Journal of Life Sciences 2018年第3期12卷 159-168页

作者： Ruth muruiki Paul Kimurto vincent Vandez Rao Gangarao Said Silim moses Siambi Department of Crops Horticulture & Soils Egerton University P.O. Box 536-20115 Egerton Kenya International Crops Research Institute for the Semi-arid Tropics (ICRISAT) P. O. Box 39063-00623 Nairobi Kenya International Crops Research Institute for the Semi-arid Tropics (ICRISAT) Patancheru 502324 Telangana India

Chickpea （Cicer arietinum L.） is an important cool season food legumes with indeterminate growth habit. The crop is valued for its nutritive seeds and used as animal feed in many developing countries. The productivity of the crop is constrained by several abiotic stresses, among which drought stress is one of the key determinants of crop performance aaccounting for 40-50% yield reduction globally. The present study was conducted to screen, evaluate and select chickpea genotypes possessing high yield potential under drought stress condition at ASALs （arid and semi-arid lands） of Kenya. The experiment was conducted at Chemeron dry land and Eco-tourism Research station, Egerton University and Kenya Agricultural and Livestock Research Institute （KALRO）, Pekerra, marigat, Baringo County. The genotypes were planted in RCBD （randomized complete block design） in three replicates at a spacing of 30 cm × 10 cm, giving a plant density of approximately 25 plants/m2. Combined analysis of variance revealed existence of highly significant differences among the tested genotypes for most of the agronomic traits. Overall, the highest grain yield was obtained from ICCV 92944 （1,173 kg/ha）, ICCV 92318 （1,103 kg/ha） and CAVIR （975 kg/ha）, ICCV 92318 （967 kg/ha）, ICCV 00108 （956 kg/ha） and ICC 4958 （921 kg/ha）： possibly due to its comparatively higher drought （and heat） tolerance, and hence could be used as sources of drought tolerance in further breeding programs. This study was carried out in few drought tolerant sites and further more sites need to be evaluated in addition to other drought and heat screening and optimization of protocols, facilities and analytical approaches to identify better genotypes that respond appropriately to climate change.

关键词： Chickpea genotypes drought stress yield performance and tolerance.

Controlling the gelation temperature of biomimetic polyisocyanides

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Chinese Chemical Letters 2018年第2期29卷 281-284页

作者： Paul H.J. Kouwer Paula de Almeida Onno ven den Boomen Zaskia H. Eksteen-Akeroyd Roel Hammink maarten Jaspers Stijn Kragt mathijs F.J. mabesoone RoelandJ.m. Nolte Alan E. Rowan martin G.T.A. Rutten vincent A.A. Le Sage Daniel C. Schoenmakers Chengfen Xing Jialiang xu Institute for molecules and materials Radboud University Nijmegen 6525 A J The Netherlands

Thermosensitive polymers show an entropy-driven transition from a well-solvated to a poorly solvated polymer chain, resulting in a more compact globular conformation. The transition at the lower critical solution temperature（LCST） is often sharp, which allows for a wide range of smart material *** the LCST, oligo（ethylene glycol）-substituted polyisocyanides（PICs） form soft hydrogels, composed of polymer bundles similar to biological gels, such as actin, fibrin and intermediate filaments. Here, we show that the LCST of PICs strongly depends linearly on the length of the ethylene glycol（EG） tails; every EG group increases the LCSTand thus the gelation temperature by nearly 30 ℃. Using a copolymerisation approach, we demonstrate that we can precisely tailor the gelation temperature between 10 ℃ and 60 ℃and, consequently, tune the mechanical properties of the PIC gels.

关键词： Smart materials Lower critical solution temperature Polyisocyanides mechanical properties Biomimetic polymers

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心腔导管电消融治疗顽固性室上性心动过速

西安医科大学学报 1993年第1期14卷 78-80页

作者：丁会文张全发 G.m.vincent 西安医科大学第一附属医院心血管内科西安710061 美国LDS医院

对17例抗心动过速药物治疗无效的顽固性室上性心动过速的患者,经使用心内导管电消融房室交界区,采取R波同步放电200～400J电能2～1次后,其中4例在电消融术后未安置长期心脏起搏器,另13例电消融术后形成完全性房室传导阻滞,安置了长期性... 详细信息

对17例抗心动过速药物治疗无效的顽固性室上性心动过速的患者,经使用心内导管电消融房室交界区,采取R波同步放电200～400J电能2～1次后,其中4例在电消融术后未安置长期心脏起搏器,另13例电消融术后形成完全性房室传导阻滞,安置了长期性心胜起搏器。临床实践证实了使用心腔导管电消融术对治疗顽固性室上性心动过速,可收到较好的效果。

关键词：电消融心脏传导阻滞

Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir Poornima Shaji Ana martinez Bulnes Anupam Dhasmana Swathi Holla Nivesh K.mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni mohammad Sikander Andrew E.massey Bilal B.Hafeez manish K.Tripathi vincent P.Diego meena Jaggi Junming Yue Nadeem Zafar murali m.Yallapu Stephen W.Behrman Sheema Khan Subhash C.Chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of Computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas Center of Excellence in Cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and Cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough Center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory medicine&Pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORm),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORm maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast ***-EXs-ORm effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EmT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-EXs for PDAC tumors,thus imply feasibility of developing a novel personalized medicine for PDAC patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia Extracellular vesicles Exosomes Tumor targeting Ormeloxifene Personalized medicine

基于Cortex-m3的STm32微控制器处理先进电机控制方法

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电子产品世界 2010年第11期17卷 42-44页

作者： vincent Onde 意法半导体

本文将探讨基于ARm的标准微控制器如何在一个被DSP和FPGA长期垄断的市场上打破复杂的控制模式。

关键词：电机控制调速 PmSm Cortex-m3

美国苹果砧木育种历史、现状及其商业化砧木特性

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中国果树 2018年第6期 107-110,113页

作者：王大江 Bus vincent G m 王昆高源赵继荣刘立军李连文朴继成中国农业科学院果树研究所农业部园艺作物种质资源利用重点实验室辽宁兴城125100 新西兰植物与食品研究所

综述美国苹果砧木的育种历史和现状,简介美国选育的苹果砧木特性,以期为我国苹果砧木的选育提供参考。美国从1968年开始苹果砧木育种,早期进行了资源的广泛评价和筛选,随后根据美国具体气候条件,将育种目标主要定为矮化和半矮化、抗火... 详细信息

综述美国苹果砧木的育种历史和现状,简介美国选育的苹果砧木特性,以期为我国苹果砧木的选育提供参考。美国从1968年开始苹果砧木育种,早期进行了资源的广泛评价和筛选,随后根据美国具体气候条件,将育种目标主要定为矮化和半矮化、抗火疫病、抗颈腐病、抗苹果绵蚜、抗重茬、早产丰产等,杂交后代进行深入、多层次的评价和筛选,最终成功选育出目前商业化和科研应用较广泛、已申请专利的14个苹果砧木品种,包括1个极矮化砧木、5个矮化砧木、8个半矮化砧木。主要特性:树体本身为小灌木,抗火疫病和苹果绵蚜,耐颈腐病和重茬,易繁殖;嫁接品种后致矮、早实丰产。可见,美国在矮化砧木选育之前的评价筛选及选育后的鉴定方面都具有系统的手段和方法,为苹果砧木选育的重要部分,可以作为我国苹果砧木育种的参考。

关键词：苹果砧木美国历史现状特性

汶川地震同震滑坡物质在震区的滞留和运移及其对龙门山地形演化的影响

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地球物理学报 2018年第5期61卷 1970-1983页

作者：王伟刘静 vincent Godard 张金玉许冲李志刚徐心悦许强王鹏谢克家中国地震局地质研究所、地震动力学国家重点实验室北京100029 Aix-marseille Universite CNRSIRDCollege de FranceCEREGEAix en Provence 13100France 中国地震局地质研究所活动构造与火山重点实验室北京100029 中山大学地球科学与工程学院、广东省地球动力作用与地质灾害重点实验室广州510275 中国科学院青藏高原研究所北京100101 河南省有色金属矿产探测工程技术研究中心郑州450016

2008年m_W7.9汶川地震导致龙门山断裂发生强烈地壳变形,同时引发的巨量同震滑坡加速了该地区的地表剥蚀和河流侵蚀.然而,目前尚缺少系统的数据定量研究滑坡物质的运移以及河流侵蚀速率随时间的演化规律,这些对理解龙门山前缘物质的再分... 详细信息

2008年m_W7.9汶川地震导致龙门山断裂发生强烈地壳变形,同时引发的巨量同震滑坡加速了该地区的地表剥蚀和河流侵蚀.然而,目前尚缺少系统的数据定量研究滑坡物质的运移以及河流侵蚀速率随时间的演化规律,这些对理解龙门山前缘物质的再分配以及强震对活动造山带地形塑造的作用至关重要.为此,本研究在汶川地震后的6年间,对震区沱江上游3条支流湔江、石亭江、绵远河流域进行了多期次的定点现代河沙采样.通过系统测量河沙中的石英10Be浓度,并与震前已发表的数据进行对比,发现如下基本特点:(1)震后河沙10 Be浓度均有明显降低,表明同震滑坡物质对河沙的稀释作用;(2)震后河流对河沙的运移量增加为震前的1.3~18.5倍,因此震后龙门山地区侵蚀速率短期显著增加;(3)初步估计得到汶川地震产生的滑坡物质被完全运移出造山带所需要的时间至少为100~4000年,接近龙门山地区强震复发周期;(4)震间和同震产生的构造变形和地表剥蚀在空间上具有互补性.考虑到地表剥蚀引起的地壳均衡反弹效应,认为类似汶川地震的强震有利于龙门山的隆升.认识震前、震时和震后的地壳变形及侵蚀过程有助于更好地理解单次强震事件对高原边界龙门山地形演化的作用.

关键词：龙门山汶川地震同震滑坡河流卸载地形演化