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原发性皮肤B细胞淋巴瘤的局部光动力学治疗:一项先导性研究

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世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 7-7页

作者： mori m. Campolmi P. mavilia L. n. Pimpinelli 党倩丽 Department of Dermatological Sciences University of Florence Via della Pergola 58/64 50121 Florence Italy Dr.

Photodynamic therapy (PDt) is a treatment based on the accumulation of a photosensitizer in the target cells and their selective destruction by irradiation with visible light. In the past 10 years, several patients with cutaneous t cell lymphoma have been successfully treated. the use of PDt in cutaneous B cell lymphoma has not been reported to date. We report the successful PDt treatment of 3 patients with early primary cutaneousBcell lymphoma.

关键词：光动力学治疗 B细胞淋巴瘤选择性破坏光敏剂可见光辐射

Effects of Fixation Drying Conditions on Fixation Rate and Leachability in CCA-C treated Red Pine and Southern Pine

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Forestry Studies in China 2001年第1期3卷 50-57页

作者：郭爱龙 P.A.Cooper t.Y.Ung 内蒙古农业大学呼和浩特010019 加拿大多伦多大学林学院

the effects of fixation drying conditions on fixation rates and chemical leachab ility were investigated with CCA-C treated red pine (Pinus koraiensis Sieb. )and southern pine specimens at a retention of 6 4 kg·m -3 , and under 11 post-treatment schedules ra ng ing from 50～70℃ and 5 different relative humidity conditions. these samples w e re monitored by expressing residual liquid and analyzing it for hexavatent chrom ium content. Samples were subjected to AWPA E11-97 (AWPA 1997) standard leachi n g tests after fixation. Generally, red pine fixed slightly faster than southern pine for most fixation conditions. High temperature, high humidity, fixation co nditions during the fixation/drying schedules resulted in faster fixation and lo wer leaching of chromium and arsenic elements compared to low humidity condition s. Copper leaching showed no significant difference under 11 fixation /drying co nditions for both species. All of the CCA components were leached significantly more in red pine than southern pine. Further work is needed to examine the effec ts of different fixation/drying conditions on leaching from full\|size samples a n d to optimize dry/wet bulb depression for fixation/drying of CCA treated lumber.

关键词： CCA-C fixation leaching red pine southern pine post-treatment schedule

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损伤性围生期颈椎脱位

世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 38-38页

作者： Haddad-Zebouni S. elia D. Aoun n. Ghossain m. 郭战宏 Service d'Imager ie mêdicale Htel- Dieu de France boulevard Alfred-Naccache Achrafieh Beyrouth Lebanon

We report on a case of cervical dislocation in which the severity of the lesio n contrasts with the paucity of the symptoms. An eight-month-old girl presente d with weakness of the left upper limb. She had a normal cephalic delivery. On t he following days, increased weakness of the limb showed a spontaneous, partial regression. Clinical examination at eightmonths showed a normal physical and psy chical development,a falling neck and an impossibility to maintain the sitting p osition, but a normal mobility of the lower limbs. Cervical radiography performe d showed a complete dislocation. Ct confirmed the diagnosis and eliminated conge nital vertebral anomalies. magnetic resonance imaging showed an important stretc hing and compression of the spinal cord. Cervical spine damage in the newborn ar e scarce and serious. the here reported case is characterized by a complete vert ebral dislocation associated with medullar stretching and compression, but few i nitial symptoms.

关键词：颈椎脱位围生期损伤性临床体检头位分娩上肢肌完全脱位精神发育下肢运动颈段

多发性硬化症患者体内记忆t细胞CD4^+、CD8^+的启动

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世界核心医学期刊文摘（神经病学分册） 2005年第11期1卷 48-48页

作者： Okuda Y. Okuda m. Apatoff B.R. Posnett D.n. 史利利 Department of neurology Tane General Hospital 1-2-31 Sakaigawa Nishi-ku Osaka 550-0024 Japan

to reevaluate whether an association exists between the clinical course of multiple sclerosis (mS) and the activation of memory t cells, we investigated the phenotype of t cells in peripheral blood and cerebrospinal fluid (CSF) of patients with mS using five-color flow cytometry. A cross-sectional study with 39 relapsing-remitting mS patients demonstrated that the percentage of CD25+CD45RO+CD4+CD3+cells was significantly increased in peripheral blood as well as in CSF of active mS patients compared with inactive mS patients. A longitudinal study with 11 relapsing-remitting mS patients also showed a higher percentage of CD25+CD45RO+CD4+CD3+cells in peripheral blood at the phase of exacerbation than during remission. On the other hand, regardless of the disease activity, the percentage of CD25+CD45RO+CD8+CD3+cells in peripheral blood was significantly higher in patients with mS than in healthy control subjects. A lower percentage of CD25+CD45RO+CD8+CD3+cells in CSF was observed in active mS patients compared with inactive mS patients. these results suggest that the activation of memory CD4+t cells is associated with the exacerbation of mS and activation of memory CD8+t cells reflects systemic immunological dysregulation in mS patients. transient as well as continuous activation of t cells by recall antigens may be involved in the disease course of mS.

关键词：多发性硬化症 CD4 CD8 非活动期临床病程免疫功能失调回忆抗原疾病恶化横断面研究纵向研究

慢性HCV感染者IL-2分泌性CD4^+t辅助细胞的选择性缺失

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世界核心医学期刊文摘（胃肠病学分册） 2005年第9期1卷 46-46页

作者： Semmo n. Day C.L. Ward S.m. P. Klenerman 王铮 Department of Clinical medicine University of Oxford Peter Medawar Bldg. for Pathog. Res. South Parks Road Oxford OX1 3SY United Kingdom Dr.

Hepatitis C virus (HCV) becomes persistent in the majority of infected individuals. In doing so, the virus evades host adaptive immune responses, although the mechanisms responsible in this evasion are not clear. Several groups have demonstrated weak or absent HCV-specific CD4+t cell responses during chronic HCV infection using proliferation assays and, more recently, class II tetramers. However, the functional status of HCV-specific CD4+t cells in resolved and persistent infection is poorly understood. Using interferon γ(IFn-γ) and interleukin 2 (IL-2) enzyme-linked immunospot assays, we analyzed cytokine secretion patterns in chronically infected patients and compared them with those with resolved infection. In the spontaneous resolver group, strong IL-2 secretion in relation to IFn-γsecretion was observed. However, in the persistently infected group, a consistent and significant loss of IL-2-secreting cells, compared with IFn-γ-secreting cells, was identified. In vitro addition of IL-2 had a substantial effect in restoring CD4+t cell activity. In conclusion, failure of IL-2 secretion, as opposed to physical deletion or complete functional unresponsiveness, appears to be an important determinant of the status of CD4+t cell populations in chronic HCV infection. Loss of IL-2 secretory capacity may lead to disruption of IFn-γand proliferative function in vivo-a status that characterizes the cellular immune response in both CD4+and CD8+compartments in chronic disease.

关键词：辅助细胞 CD4 丙型肝炎病毒消退期适应性免疫自限性免疫逃避机制干扰素γ 特异性酶联免疫斑点法

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毛发红糠疹

世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 9-9页

作者： Artik S. Kuhn A. neumann n.J. m. megahed 牛新武 Hautklin. der Heinrich -Heine-Univ. Moorenstra.e 5 40225 Dü sseldorf GermanyDr.

Pityriasis rubra pilaris (PRP) is a rare papulosquamous disease with typical onset during the first and fifth decades. the skin disorder normally starts on t he scalp and spreads caudally Within a few weeks. It often results in a generali zed erythroderma with sharply demarcated islands of sparing (“ nappes claires” ). A 65-year-old patient with severe PRP showed good clinical improvement a fter 8 months of treatment when treated with acitretin in combination with photo therapy and systemic glucocorticosteroids.

关键词：毛发红糠疹泛发性红皮病阿维糖皮质激素

雄激素受体共活化物ARA70/elE1在雄激素性脱发皮损中的表达

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世界核心医学期刊文摘（皮肤病学分册） 2006年第1期2卷 11-12页

作者： Lee P Sadick n.S 冯义国 Department of Pathology University of Texas M. D. Anderson Cancer Center Houston TX United States.Dr

Background: Androgens have been implicated in androgenic alopecia as evidenced by the increased cutaneous expression of androgen receptor (AR), 5α-reductase, and decreased aromatase. Abnormalities of the AR-signal transduction pathway probably participate in the development of androgenic alopecia. ARA70/elE1 is an AR coactivator with two isoforms, one full-length form (ARA70α/elE1α), and a n internally deleted form (ARA70β/elE1β). We decided to examine the cutaneous expression of both isoforms in male androgenic alopecia. methods: Formalin-fixe d, paraffin-embedded tissue sections from seven subjects with androgenic alopec ia with matched punch biopsies from non-balding and balding areas were examined by in situ hybridization. Results: Expression of at least one of the two probes for ARA70/elE1 was present in all phases of the hair-growth cycle in all epith elial hair structures except for the inner root sheath. the dermal papilla and h air bulb expressed only the short (β) but not the long (α) form of ARA70/elE1. In situ labeling for ARA70β/elE1βwas weaker in the dermal papilla of balding recipient areas than those from donor ones. Conclusions: Our data further suppor t that the hair growth is regulated by androgens. the differential expression pa ttern of ARA70/elE1 suggests that this key androgen receptor coactivator is invo lved in androgenic alopecia.

关键词：雄激素性脱发 ARA70/elE1 雄激素受体共活化物脱发区雄激素源性脱发真皮乳头原位杂交

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先兆子痫和正常妊娠的神经心理表现

世界核心医学期刊文摘（妇产科学分册） 2006年第10期2卷 7-7页

作者： Rana S. Lindheimer m. Hibbard J. Pliskin n. 张新艳 Departments of Obstetrics and Gynecology Dr.

Objective: the objective of the study was to evaluate neurocognitive function in preeclampsia and normal pregnancy. Study design: three groups(each n=15)were studied before and after delivery using standard neurocognitive test techniques. Group A consisted of normal laboring patients; group B, preeclamptics receiving magnesium; and group C, women in preterm labor receiving mgSO4 tocolysis(mg control). the tests, examining attention, working memory, explicit memory, auditory comprehension, and measures for emotional distress, pain, and fatigue were analyzed via 4-way multivariate analysis of variance and multiple t tests. Results: Preeclamptics receiving mgSO4 had better attention and working memory(P=.05), compared with normal laboring women and the preterm patients. Explicit memory was impaired in all groups, and this could not be accounted for by pain or emotional distress. Conclusion: We could detect no cognitive defects in preeclamptics, compared with normotensive gravidas, at least while the cerebral vasodilator mgSO4 is being infused.

关键词：正常妊娠神经心理先兆子痫保胎治疗神经认知正常分娩工作记忆外显记忆血管舒张认知缺陷

Residual urinary output in high body mass index individuals on chronic hemodialysis:A disregarded life vest?

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World Journal of nephrology 2014年第4期3卷 317-323页

作者： Hernán trimarchi maría S Ra?a Alejandra Karl José Andrews mariana Dicugno Vanesa Pomeranz Pablo Young mariano Forrester mirta Alonso Fernando Lombi Alexis muryan nephrology Hospital Británico de Buenos Aires Biochemistry Hospital Británico de Buenos Aires Internal medicine Services Hospital Británico de Buenos Aires

AIm： to assess residual diuresis and diverse variables according to body mass index （BmI）.mEtHODS： Cross-sectional study （n = 57）, with 3 groups. Group A： BmI 〈 25, n = 22; Group B： BmI 25-30, n = 15; Group C： BmI 〉 30, n = 20. Diuresis, hematocrit, albumin, C-reactive protein, malnutrition infammatory score, Pro-BnP, troponin t, leptin and in-sulin levels are expressed as median and ranges （r）. RESULtS： Albumin （g/dL）： GA vs GC, 3.70 （r2.20-4.90） vs 3.85 （r3.40-4.90）, P = 0.02. Diuresis （mL/d）： GA 690 （r0-1780）; GB 660 （r60-1800）; GC 840 （r40-2840）. Diuresis GA vs GC, P = 0.01. Leptin （ng/mL）： GA vs GC, 3.81 （r0.78-69.60） vs GC, 32.80 （r0.78-124.50）, P 〈 0.001. Insulin （μU/mL）： GA vs GB, 7 （r2-44） vs 11.50 （r4-38）, P = 0.02; GA vs GC, 7 （r2-44） vs 19.5 （r5-155）, P = 0.0001. troponin t and Pro-BnP levels were not different. Significant correlations： GC, Insulin-UF： ρ= 0.53; P = 0.03; troponint-diuresis： ρ = -0.48, P 〈 0.05; Pro-BnP-diuresis： ρ = -0.39, P 〈 0.01; troponin t-ProBnP： ρ = 0.77, P 〈 0.0001; albumin-troponin t： ρ = -0.66, P 〈 0.0001; albumin-ProBnP： ρ = -0.44, P 〈 ***： High BmI associated positively with higher diuresis and albuminemia, and negatively with tropt and Pro-BnP. High BmI-associated better survival may be explained by better urinary output, lowering cardiovascular stress.

关键词： Hemodialysis Residual diuresis Body mass index troponin t Pro-BnP Insulin