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Retrospective study evaluating association of colorectal tumors and hepatitis C virus

World Journal of Virology 2024年第3期13卷 56-64页

作者： maya Gogtay Lekha Yadukumar Yuvaraj Singh m.thil gowda suresh Aakriti Soni Anuroop Yekula Asha Bullappa George m Abraham Department of Hematology and Oncology Internal MedicineUniversity of Nebraska Medical CenterOmahaNE 68198United States Department of Internal medicine The Wright Center for Graduate Medical EducationScrantonPA 18505United States Department of Gastroenterology and Hepatology University of Massachusetts Chan Medical SchoolWorcesterMA 01605United States Department of Internal medicine Saint Vincent HospitalWorcesterMA 01608United States Department of Internal medicine St.Vincent HospitalWorcesterMA 01608United States Department of Community medicine SS Institute of Medical Sciences and Research CentreDavangere 577003KarnatakaIndia

BACKGROUND Chronic hepatitis C virus(HCV)has been associated with hepatic and extrahe-patic *** studies have shown an association between colorectal adenomas and HCV *** To study the prevalence of colorectal adenomas in patients with HCV compared to the general population and to evaluate if it is an independent risk factor for colorectal *** Patients were divided into HCV and non-HCV based on their HCV RNA *** with alcoholic liver disease,hepatitis B infection,and inflammatory bowel disease were *** variables were analyzed using the mann-Whitney U test,and categorical variables usingχ^(2) with Pmatched in both groups by propensity score matching,followed by multivariate regression *** Of the 415 patients screened,109 HCV patients and 97 non-HCV patients with colonoscopy results were included in the *** patients were older,had a smoking history,had less frequent aspirin use,and had a lower body mass index(BmI)(Pmber of patients with adenomas(adenoma detection rate of 53.2%vs 34%.P=0.006).We performed a propensity-matched multivariate analysis where HCV infection was significantly associated with colorectal adenoma(OR:2.070,P=0.019).CONCLUSION Our study shows a significantly higher rate of adenomas in HCV patients compared to the general *** studies would help determine if the increase in adenoma detection lowers the risk for colorectal cancer.

关键词： Hepatitis C Colon cancer Adenoma Polyps Colonoscopy

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Case-control analysis of venous thromboembolism risk in nonalcoholic steatohepatitis diagnosed by transient elastography

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World Journal of Clinical Cases 2023年第34期11卷 8126-8138页

作者： m.thil gowda suresh maya Gogtay Yuvaraj Singh Lekha Yadukumar Ajay Kumar mishra George m Abraham Department of Internal medicine Saint Vincent HospitalWorcesterMA 01608United States Department of Hematology and Oncology University of Nebraska Medical CenterOmahaNE 68198United States Department of Gastroenterology and Hepatology University of MassachusettsWorcesterMA 01605United States Internal medicine The Wright Center for Graduate Medical EducationScrantonPA 18505United States Division of Cardiology Saint Vincent HospitalWorcesterMA 01608United States Internal medicine Saint Vincent HospitalWorcesterMA 01608United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is the most common cause of chronic liver disease *** have shown a strong association between nonalcoholic steatohepatitis(NASH)cirrhosis and portal vein ***,there is paucity of data on the association of NASH and venous thromboembolism(VTE),with one such study predicting a 2.5-fold increased risk for VTE compared to other liver diseases in hospitalized *** mechanism is believed to be a hepatocellular injury,which causes a chronic inflammatory state leading to the unregulated activation of procoagulant *** has been no prior analysis of the degree of steatosis and fibrosis(measured using transient elastography,commonly known as FibroScan)in NASH and its association with *** To examine the association between the degree of hepatic steatosis and fibrosis,quantified by transient elastography,and the incidence of VTE in patients with *** In our case-control study,we included patients with a documented diagnosis of *** excluded patients with inherited thrombophilia,hemoglobinopathy,malignancy,alcohol use disorder,autoimmune hepatitis,and primary biliary *** collected data included age,demographics,tobacco use,recreational drug use,medical history,and vibration controlled transient elastography ***-specific data included the location,type of anticoagulant,need for hospital stay,and history of VTE *** was categorized as S0-S1(mild)and S2-S3(moderate to severe)based on the controlled attenuation parameter *** was classified based on the kilopascal score and graded as F0-F1(metavir stage),F2,F3,and F4(cirrhosis).χ^(2) and mann-Whitney U tests were used for the qualitative and quantitative variable analyses,***,we performed a logistic regression using VTE as the dependent *** A total of 415 patients were analyzed,and 386 met the inclusion criteria.51 and 335 patients were included

关键词： Nonalcoholic fatty liver disease Venous thromboembolism Non-alcoholic steatohepatitis Diabetes mellitus Liver fibrosis Steatosis Deep vein thrombosis Anticoagulation management

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