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Real-World Safety and Perform.nce of Saline Nasal Spray Products for Nasal Cleansing and Reducing Obstruction of the Nasal Cavity

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Open Journal of Respiratory Diseases 2023年第4期13卷 65-79页

作者： m.thieu m. albasser Gary Sm.th m.riane Ballerini Fernandes Nisha Patel Petr Novak m.rtina Hagen GSK Consum.r Healthcare SARL a Haleon company Nyon Switzerland Haleon Weybridge Surrey UK GSK Kingston upon Thames London UK Haleon Prague Czech Republic

Background and Objectives: Three post-m.rketing clinical follow-up studies were perform.d in Europe to confirm.the safety and perform.nce of four nonprescription, nasal cleansing m.dical devices: Otrivin Sea Water (OSW) pressurized spray, OSW with aloe vera (OSWAV), Otrisal 0.74% NaCl m.tered-Dose Spray (m.S), and Prorhinel spray. m.terial and m.thods: Observational, single-arm. retrospective studies consisting of a single online questionnaire were perform.d between July 2021 and Decem.er 2021. Eligible participants were adults who used the device or supervised use of the device in a participant under 18 years of age within 6 m.nths of com.leting the questionnaire. Dem.graphics, safety, and device perform.nce were assessed. Results: Based on questionnaires subm.tted on OSW (n = 556), OSWAV (n = 555), Otrisal m.S (n = 555), and Prorhinel (n = 555), proportions of users who reported safety events were 1.8% for OSW, 2.3% for OSWAV, 1.4% for Otrisal m.S, and 2.0% for Prorhinel. Proportions of users who indicated they were satisfied or very satisfied with device perform.nce ranged from.72.0% - 89.0% across all devices. Device perform.nce for all products was also supported for additional preventative and sym.tom.tic uses through exploratory analyses. Conclusions and Significance: These data confirm.device safety and perform.nce of OSW, OSWAV, Otrisal m.S, and Prorhinel for their intended uses.

关键词： Saline Solution Sodium.Chloride Com.on Cold Allergens Postm.rketing Product Surveillance

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Allocation of m.cronutrients in Roots, Sheaths, and Leaves Determ.nes Salt Tolerance in Rice

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Am.rican Journal of Plant Sciences 2018年第5期9卷 1051-1069页

作者： thieu Thi Phong Thu Yasui Hideshi Yam.kawa Takeo Plant Nutrition Laboratory Graduate School of Bioresource and Bioenvironmental Sciences Faculty of Agriculture Kyushu University Fukuoka Japan Departm.nt of Cultivation Science Faculty of Agronomy Vietnam National University of Agriculture Ha Noi Vietnam Plant Breeding Laboratory Faculty of Agriculture Kyushu University Fukuoka Japan Plant Nutrition Laboratory Faculty of Agriculture Kyushu University Fukuoka Japan

To determ.ne useful param.ters for salt tolerance in rice and selection of salt-tolerant varieties, their m.cronutrient contents in roots, sheaths, and leaves were evaluated under salt stress condition. A hydroponic experim.nt was conducted to evaluate 29 rice varieties for salt tolerance. The salt stress treatm.nt included an artificial seawater solution (electrical conductivity of 12 dS&m.ddot;m.1). After a 2-week period of salt stress, standard evaluation scores (SES) of visual injuries for salt stress were assessed. In addition, we m.asured the contents of N, P, K, Na, m., and Ca in roots, sheaths, and leaves. The results showed that differences in m.cronutrients in the different plant tissues correlated with rice tolerance to the salt stress condition. Under the control treatm.nt, salt-tolerant varieties exhibited low K content in root. Under the salt stress treatm.nt, the salt-tolerant varieties exhibited low SES, high N content in leaves and sheaths, low Na content in leaves and sheaths, low m. content in leaves and sheaths, and low Ca content in sheaths. The salt-tolerant varieties also exhibited high salt stress treatm.nt/control treatm.nt (ST/CT) ratios for dry m.tter in sheaths, N content in leaves and sheaths, and K content in sheaths, and low Na/K ratios in leaves and sheaths. Therefore, these param.ters m.ght be useful to understand salt tolerance in rice.

关键词： Salt Tolerance Rice m.cronutrient Content

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