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非ST段抬高急性冠脉综合征患者随机应用依诺肝素或普通肝素抗凝治疗的疗效和出血并发症：系统综述

美国医学会杂志（中文版） 2005年第4期24卷 209-216页

作者： John L. Petersen k.nneth W. mahaffey Vic Hasselblad Elliott m. Antman marc Cohen Shaun G. Goodman Anatoly Langer michael A. Blazing Anne Le-moigne-Amrani James A. de Lemos Christopher C. Nessel Robert A. Harrington James J. Ferguson eugene Braunwald Robert m. Califf 徐成斌（译） Duk. Clinical Research Institute Durham NC Cardiovascular Division Department of Medicine Brigham and Women＇s Hospital Boston Mass Division of Cardiology Newark Beth Israel Medical Center. Newark. NJ Canadian Heart Research Centre and Terrence Donnelly Heart Centre Division of Cardiology St Michael＇s Hospital University of TorontoToronto Ontario Division of Cardiology University of Texas Southwestem Dallas Aventis Inc BridgewaterNJ St Luk.＇s-Episcopal Hospital Texas Heart InstituteHouston

背景：抗凝疗法已成为急性冠脉综合征（acute coronary syndrome，ACS）治疗指南推荐的标准疗法。但是，最近某些试验在ACS患者中对依诺肝素（enoxaparin）与普通肝素（unfractionated heparin）的应用进行了比较，发现这些抗凝疗法的... 详细信息

背景：抗凝疗法已成为急性冠脉综合征（acute coronary syndrome，ACS）治疗指南推荐的标准疗法。但是，最近某些试验在ACS患者中对依诺肝素（enoxaparin）与普通肝素（unfractionated heparin）的应用进行了比较，发现这些抗凝疗法的疗效及安全性并不及既往试验结果。目的：有6项随机对照试验对依诺肝素与普通肝素治疗ACS患者进行了比较，对其终点（即全因死亡及非致死性心肌梗死）、输血与大出血进行系统评估。资料来源：从杜克临床研究所（Duk. Clinical Research Institute）获取ESSENCE、A to Z及SYNERGY试验的原始数据。由TImI 11B、ACUTEⅡ及INTERACT研究的主要研究人员提供各自的基线特征和事件发生频率。研究选取：在非ST段抬高ACS患者中比较依诺肝素与普通肝素的6项随机对照试验均人选进行分析。数据提取：从全部试验人群和随机分组前未接受抗凝治疗的亚人群中获取疗效终点和安全性终点。数据综合：应用随机效应经验性贝叶斯模型（random—effects empirical Bayes model），系统评估21946例患者的结果。依诺肝素与普通肝素30天死亡率无显著差异（3．0％比3．0％，优势比[odds ratio，OR]，1．00；95％可信区间[confidence interval，CI]，0．85～1．17）。在所有试验人群中，依诺肝素与普通肝素相比，30天死亡或非致死性心肌梗死（myocardial infarction，mI）联合终点显著下降，具有统计学差异（10．1％比11．0％；OR，0．91；95％CI，0．83～0．99；所需治疗例数107）。随机分组前未接受抗凝治疗的依诺肝素组患者30天死亡或mI联合终点亦显著下降，具有统计学差异（8．0％比9．4％；OR，0．81；95％CI，0．70～0．94；所需治疗例数72）。随机分组后第7天，总体安全人群或者随机分组前未接受抗凝治疗的人群输血（OR，1．01；95％CI，0．89～1．14）或大出血的发生率（OR，1．04；95％CI，0．83～1．30）无显著差异。结论：对近22000例各类ACS患者进行系统回顾发现，在预防死亡或mI联合终点方面依诺肝素较普通肝素更有效。

关键词：非ST段抬高急性冠脉综合征随机对照试验依诺肝素普通肝素抗凝治疗出血并发症患者系统综述疗效

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ω-3对舍曲林治疗冠心病患者抑郁的疗效影响

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中国处方药 2009年第11期8卷 44-44页

作者： Robert m. Carney k.nneth E. Freedland eugene H. Rubin

背景及目的：既往的研究发现，ω-3脂肪酸可增强抗抑郁药物的疗效。本研究探讨了ω-3能否增强舍曲林对冠心病患者严重抑郁的疗效。

关键词： ω-3脂肪酸抗抑郁药物冠心病患者舍曲林疗效治疗

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Ternary Ni-Co-Fe oxyhydroxide oxygen evolution catalysts:Intrinsic activity trends,electrical conductivity,and electronic band structure

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Nano Research 2019年第9期12卷 2288-2295页

作者： michaela Burk. Stevens Lisa J. Enman Ester Hamal k.rk.s Jeremie Zaffran Christina D. m. Trang James Asbury matthew G. k.st maytal Caspary Torok.r Shannon W. Boettcher Department of Chemistry & Biochemistry and the materials Science Institute University of OregonEugeneOR 97403USA Department of materials Science & Engineering and The Nancy & Stephen Grand Technion Energy Program Technion Israel Institute of TechnologyHaifa 3200003Israel

Nick.l-,cobalt-,and iron-based(oxy)hydroxides comprise the most-commonly studied electrocatalysts for the oxygen-evolution reaction(OER)in alk.line solution.A fundamental understanding of composition-structure-activity relationships for mixed-metal Ni-Co and Ni-Co-Fe(oxy)hydroxides is important to guide the design of advanced OER *** we use cyclic voltammetry,chronopotentiometry,inductively-coupled plasma-optical emission spectroscopy,and in situ electrical conductivity measurements to characterize the properties and activity of various compositions of Ni-Co-Fe(oxy)hydroxides prepared by cathodic *** with previous studies,we find Fe is essential for the mixed-metal(oxy)hydroxides to achieve high OER *** the rigorous absence of Fe(achieved by using specially cleaned electrolytes),the most-active Ni-Co(oxy)hydroxide composition has an OER turn-over frequency only twice that ofpure Co(oxy)hydroxide,suggesting minimal synergism between the two *** addition of Co to Ni-Fe(oxy)hydroxides shifts the onset of electrical conductivity to lower potentials,but has little effect on the intrinsic OER activity,with the most-active Ni-Co-Fe(oxy)hydroxide having an OER turn-over frequency only -1.5 times that of the Ni-Fe(oxy)*** magnitudes of the electrical conductivities are similar for all the compositions ***-functional-theory-calculated projected density of states show a significant contribution of all chemical elements at the valence band edge of the mixed-metal oxyhydroxide electronic structure,demonstrating significant electronic hybridization between the *** calculations suggest the involvement of all the elements in modulating the electronic structure at putative Fe-based active sites that are probably located at edges or defects in the two-dimensional oxyhydroxide sheets.

关键词： electrocatalysis heterogeneous catalysis water electrolysis oxygen evolution density functional theory

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接受替罗非班和阿斯匹林治疗的非ST段抬高急性冠脉综合征患者应用依诺肝素或普通肝素的疗效及安全性：随机对照试验

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美国医学会杂志（中文版） 2005年第4期24卷 204-208页

作者： michael A．Blazing James A. de Lemos Harvey D. White k.ith A. A. Fox Freek.W. A. Verheugt Diego Ardissino Peter m. DiBattiste Joarme Palmisano David W. Bilheimer Steven m. Snapinn k.ren E. Ramsey Laura H. Gardner Vic Hasselblad marc A. Pfeffer Eldrin F. Lewis eugene Braunwald Robert m. Califf 王淑敏（译）胡大一（校） Duk. clinical Research Institute Durham NC Donald W. Reynolds Cardiovascular Clinical Research Center University of Texas Southwestern Medical Center Dallas Department of Cardiology Green Lane Hospital Auckland New Zealand Department of Cardiology Research University of Edinburgh Edinburgh Scotland Department of Interventional Cardiology University Medical Center Nijmegen the Netherlands Division of Cardiology Ospedale Maggiore Parma Italy merck.Company Whitehouse Station NJ Department of medicine Harvard Medical SchoolBrigham and Women＇s Hospital Boston Mass 不详

背景：对于非ST段抬高急性冠脉综合征（acute coronary syndromes，ACS）患者而言，与单独应用普通肝素相比，依诺肝素或者血小板糖蛋白Ⅱb／Ⅲa受体拮抗剂替罗非班与普通肝素联合应用都显示出较好的疗效。目前，尚不清楚依诺肝素和替... 详细信息

背景：对于非ST段抬高急性冠脉综合征（acute coronary syndromes，ACS）患者而言，与单独应用普通肝素相比，依诺肝素或者血小板糖蛋白Ⅱb／Ⅲa受体拮抗剂替罗非班与普通肝素联合应用都显示出较好的疗效。目前，尚不清楚依诺肝素和替罗非班联合应用是否像普通肝素和替罗非班标准联合方案一样安全有效。目的：在非ST段抬高的ACS患者中评价依诺肝素和替罗非班联合疗法与普通肝素和替罗非班联合方案的疗效及安全性。设计、地点及参试者：国际前瞻性、开标（open—label）、随机、非劣势（noninferiority）试验。在接受替罗非班和阿斯匹林治疗的非ST段抬高ACS患者中分别给予依诺肝素1mg／k.（n=2026）每12小时一次或经体重校正的静脉普通肝素（n=1961），然后进行比较。这项A to Z试验的A阶段试验是于1999年12月至2002年5月进行的。主要观察指标：意向治疗人群7天时死亡、再发心肌梗死和难治性缺血的发生情况，该意向治疗人群是根据优效性和非劣势原则确定的。应用“心肌梗死溶栓治疗试验”（Thrombolysis in myocardial Infarction，TImI）中之出血分级系统，通过监测出血发生率判定用药安全性。结果：在治疗第7天时，随机分配至依诺肝素组的2018例患者中有169例（8．4％）发生死亡、心肌梗死或者难治性缺血，而普通肝素组的1952例患者中有184例（9．4％）发生上述事件（风险比[hazard ratio，HR]为0．88，95％可信区间[confidence interval，CI]为0．71～1．08）。该结果符合预先设定的非劣势标准。除死亡外，所有一级和二级复合终点事件分析结果均提示，依诺肝素更为有益。死亡仅见于1％的患者（依诺肝素组23例，普通肝素组17例）。任何TImI分级的出血发生率都很低（依诺肝素组为3．0％，普通肝素组为2．2％；P=0．13）。最差情况分析（合并了两种独立的出血判定策略）表明，采用依诺肝素每治疗200例患者就会发生一次TImI严重出血。结论：对于接受替罗非班和阿斯匹林治疗的非ST段抬高ACS患者而言，依诺肝素是除普通普通肝素之外的另一种适当选择。依诺肝素可使一级终点相对减少12％，绝对减少1％，符合非劣势标准。该结果与以往未联用糖蛋白Ⅱb／Ⅲa受体拮抗剂的试验一致。

关键词：非ST段抬高急性冠脉综合征随机对照试验用药安全性依诺肝素普通肝素替罗非班治疗人群阿斯匹林血小板糖蛋白Ⅱb/Ⅲa受体拮抗剂

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Risk.for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up

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World Journal of Psychiatry 2015年第4期5卷 412-424页

作者： Ahmed Z Elmaadawi Peter S Jensen L eugene Arnold Brook. SG molina Lily Hechtman Howard B Abik.ff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James m Swanson Cathryn A Galanter Department of Psychiatry Indiana University School of Medicine-South Bend Campus REACH Institute Department of Psychiatry Ohio State University Department of Psychiatry University of Pittsburgh Department of Psychiatry and Pediatrics McGill University Health Center Department of Child and Adolescent Psychiatry The Child Study Center at NYU Langone Medical Center Department of Psychology University of California Department of Psychiatry and Pediatrics Icahn School of Medicine at Mount Sinai Department of Clinical Child and Adolescent Psychiatry New York Psychiatric Institute Department of Pediatrics and Epidemiology Child Development Center University of California Department of Psychiatry State University of New York Downstate Medical Center and Kings County Hospital Center

AIm: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years ***: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NImH-funded multimodal Treatment Study of ADHD(mTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the mTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSm manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(Pm) and non-specific manic(NSm) symptoms. We compared the Pm and NSm in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with Pm and NSm in ADHD and LNCG ***: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P mean NSm: ADHD 2.0 vs LNCG 1.1; P m symptoms than LNCG, with Pm means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSm and Pm, ADHD status associated with greater NSm than Pm. However, Over 14 years, the NSm symptoms declined and changed to Pm over time(df 3, 2523; F = 20.1; P m criterion-A2) rates were significa

关键词： multimodal treatment study of attention deficit hyperactivity disorder Irritability Attention deficit hyperactivity disorder Diagnostic interview schedule for children Bipolar disorder

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Eruptive k.ratoacanthomas within a Red Ink.Tattoo: A Case Report

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Case Reports in Clinical medicine 2018年第8期7卷 470-475页

作者： Brayden Healey William Galbraith Yasser m. Sammour Diane Baird Western University of Health Sciences College of Osteopathic medicine of the Pacific-Northwest Lebanon USA Cleveland Clinic Cleveland USA Diane Baird Dermatology Eugene USA

Back.round: There has been a longstanding debate regarding whether k.ratoacanthomas (k.s) are neoplastic or reactive/inflammatory lesions. Aim: The aim of this case report is to, within the aforementioned debate, offer support in favor of the potential reactive nature of k.ratoacanthomas. Case Presentation: A 64-year-old male presented with an eruption of 25 k.ratoacanthomas within a red ink.tattoo. Eruptions were partially resolved over a matter of months, and completely resolved with treatment using oral Acitretin therapy. We believe this to be the third such reported case of eruptive k.s within only the red ink.portions of a tattoo. Prior cases involved 2 and 8 k.s each. Discussion: multiple studies suggest that k.s are neoplastic in nature and very distinct from cutaneous squamous cell carcinoma. Especially interesting is the finding that k.s have increased expression of apoptotic genes;this is particularly notable because of the tendency for these lesions to spontaneously involute. Sk.n tumorigenesis can occur in predisposed individuals after carcinogen exposure, thus red ink.possesses theoretical potential as a carcinogen. k.s could be seen in this case as in fact a reactive neoplasm.

关键词： k.ratoacanthoma Squamous Cell Carcinoma Tattoo Red Ink Acitretin

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Near-infrared polarimetry of the GG Tauri A binary system

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Research in Astronomy and Astrophysics 2014年第11期14卷 1438-1446页

作者： Yoichi Itoh Yumik. Oasa Tomoyuk. k.do Nobuhik. k.sak.be Jun Hashimoto Lyu Abe Wolfgang Brandner Timothy D.Brandt Joseph C.Carson Sebastian Egner mark.s Feldt Carol A.Grady Olivier Guyon Yutak. Hayano masahik. Hayashi Saek. S.Hayashi Thomas Henning k.aus W.Hodapp mik. Ishii masanori Iye mark.s Janson Ryo k.ndori Gillian R.k.app masayuk. k.zuhara Jungmi k.on Taro matsuo michael W.mcElwain Shok.n miyama Jun-Ichi morino Amaya moro-martin Tetsuo Nishimura Tae-Soo Pyo eugene Serabyn Tak.ya Suenaga Hiroshi Suto Ryuji Suzuk. Yasuhiro H.Tak.hashi Naruhisa Tak.to Hiroshi Terada Christian Thalmann Daigo Tomono Edwin L.Turner mak.to Watanabe John Wisniewsk. Toru Yamada Satoshi mayama Thayne Currie Hidek. Tak.mi Tomonori Usuda motohide Tamura Nishi-Harima Astronomical Observatory Center for AstronomyUniversity of Hyogo407-2NishigaichiSayoHyogo 679-5313Japan Faculty of Education Saitama University255 Shimo-OkuboSakuraSaitamaSaitama338-8570Japan Subaru Telescope National Astronomical Observatory of Japan650 North Ahoku PlaceHiloHI 96720USA National Astronomical Observatory of Japan 2-21-1OsawaMitakaTokyo181-8588Japan H.L.Dodge Department of Physics & Astronomy University of Oklahoma440 W Brooks St.NormanOK 73019USA Laboratoire Lagrange (UmR 7293) Universit de Nice-Sophia AntipolisCNRSObservatoire de la Cote d’Azur28 avenue Valrose06108 Nice Cedex 2France max Planck.Institute for Astronomy Knigstuhl 1769117 HeidelbergGermany Department of Astrophysical Science Princeton UniversityPeyton HallIvy LanePrincetonNJ 08544USA Department of Physics and Astronomy College of Charleston58 Coming St.CharlestonSC29424USA Subaru Telescope National Astronomical Observatory of Japan650 North A’ohoku PlaceHiloHI 96720USA Exoplanets and Stellar Astrophysics Laboratory Code 667Goddard Space Flight CenterGreenbeltMD 20771USA Eurek. Scientific 2452 DelmerSuite 100Oakland CA 96002USA Goddard Center for Astrobiology GreenbeltMD 20771USA Institute for Astronomy University of Hawaii640 N.Aohoku PlaceHiloHI 96720USA Department of Earth and Planetary Sciences Tokyo Institute of TechnologyOokayamaMeguro-kuTokyo 152-8551Japan Department of Astronomy Kyoto UniversityKitashirakawa-Oiwake-choSakyo-kuKyotoKyoto 606-8502Japan Hiroshima University 1-3-2KagamiyamaHigashihiroshimaHiroshima 739-8511Japan Department of Astrophysics CAB-CSIC/INTA28850 Torrejón de ArdozMadridSpain Jet Propulsion Laboratory California Institute of TechnologyPasadenaCA91109USA Department of Astronomical Science The Graduate University for Advanced Studies2-21-1OsawaMitakaTokyo181-8588Japan Department of Astronomy The University of Tokyo7-3-1HongoBunkyo-kuTokyo113-0033Japan Astronomical Institute "Anton Pannek.ek. University

A high angular resolution near-infrared image that shows the intensity of polarization for the GG Tau A binary system was obtained with the Subaru Telescope. The image shows a circumbinary disk.scattering the light from the central binary. The azimuthal profile of the intensity of polarization for the circumbinary disk.is roughly reproduced by a simple disk.model with the Henyey-Greenstein phase function and the Rayleigh function, indicating there are small dust grains at the surface of the disk. Combined with a previous observation of the circumbinary disk. our image indicates that the gap structure in the circumbinary disk.orbits counterclock.ise, but material in the disk.orbits clock.ise. We propose that there is a shadow caused by material located between the central binary and the circumbinary disk. The separations and position angles of the stellar components of the binary in the past 20 yr are consistent with the binary orbit with a = 33.4 AU and e = 0.34.

关键词： stars individual (GG Tauri) -- stars pre-maln sequence - techniques high angular resolution

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尤金·奥尼尔的《驱魔》:《进入黑夜的漫长旅程》遗失的前传

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戏剧（中央戏剧学院学报） 2018年第5期 80-89页

作者：罗伯特·m.道林[美]() 许诗焱(译) 美国康涅狄格中央州立大学南京师范大学外国语学院

我开始戒烟的那一天是2010年10月10日。当时我正在对奥尼尔进行研究，刚刚采访了102岁的护士凯瑟琳·阿尔伯托尼，她曾经照料奥尼尔很多年。她早己退休，当时住在西海岸，我正好利用从西海岸回东海岸的长途飞行来戒掉抽烟的习惯。一回... 详细信息

我开始戒烟的那一天是2010年10月10日。当时我正在对奥尼尔进行研究，刚刚采访了102岁的护士凯瑟琳·阿尔伯托尼，她曾经照料奥尼尔很多年。她早己退休，当时住在西海岸，我正好利用从西海岸回东海岸的长途飞行来戒掉抽烟的习惯。一回到家，我就沮丧地意识到，整理采访记录实在太让人头疼了，在戒烟的初级阶段根本没法完成。为了在特别想抽烟的时候转移自己的注意力，我坐在电脑前开始搜索奥尼尔的那出遗失的独幕剧《驱魔》——这是所有奥尼尔研究者们梦寐以求的作品。

关键词：《进入黑夜的漫长旅程》奥尼尔遗失采访记录 2010年西海岸凯瑟琳注意力

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REPORT OF THE CHENGTU EDITION OF THE CHINESE mEDICAL JOURNAL DEC. 31, 1945.

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中华医学杂志(英文版) 1946年第9期64卷 306-306页

作者： The Editorial Board of the Chengtu Edition of the medical Journal. Per eugene Chan m. D. Acting Editor.

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早期成长与发展研究:利用前瞻性的养子女设计研究遗传与环境的互动(英文)

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心理学报 2008年第10期40卷 1106-1115页

作者： Leslie D. Leve Jenae m. Neiderhiser Laura V. Scaramella David Reiss Oregon Social Learning Center EugeneOregonUSA The Pennsylvania State University University ParkPA USA University of New Orleans New OrleansLAUSA Yale Child Study Center New Haven CTUSA

"早期成长与发展研究"(EGDS)是一个前瞻性的养子女研究计划。此项目包括了360组相连的生身父母、养父母以及刚出生就被收养的子女。此项目从婴儿3个月就开始跟踪这些被试,现在又加上200组被试,从遗传与环境的关联与互动着手,本项目将研... 详细信息

"早期成长与发展研究"(EGDS)是一个前瞻性的养子女研究计划。此项目包括了360组相连的生身父母、养父母以及刚出生就被收养的子女。此项目从婴儿3个月就开始跟踪这些被试,现在又加上200组被试,从遗传与环境的关联与互动着手,本项目将研究家庭环境和养育方式如何影响遗传因素的表达。所有被试均需要是在美国国内收养的婴儿。该研究收集了儿童的心理特征、生身父母与养父母的心理特征、养育方式、父母的生活状况等数据,以及唾液和DNA,初步分析发现,遗传与环境的互动在婴儿期就已经开始。本文也从干预的角度讨论了未来行为遗传学的走向。

关键词：遗传学领养基因环境交互作用干预儿童期

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