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Serological Targeted Analysis of an ITIH4 Peptide Isoform: A Preterm Birth Biomarker and Its Associated SNP Implications

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Journal of Genetics and Genomics 2015年第9期42卷 507-510页

作者： Zhou Tan Zhongkai Hu Emily Y.Cai Cantas Alev Ting Yang Zhen Li Joyce Sung Yasser Yehia El-Sayed Gary m.shaw David K.Stevenson Atul J.Butte Guojun Sheng Karl G.Sylvester Harvey J.Cohen Xuefeng B.Ling Institute of Developmental and Regenerative Biology Hangzhou Normal University Department of Surgery Stanford University Lab for Early Embryogenesis RIKEN Center for Developmental Biology Department of Obstetrics and Gynecology Stanford University Department of Pediatrics Stanford University Stanford

Over 11% of all pregnancies in the US result in preterm birth, greatly contributing to perinatal morbidity and mortality （Goldenberg and Rouse, 1998）. Preterm birth etiologies remain largely unknown, and effective prevention methods have yet to be developed. The use of biofluid （e.g., serum or urine） for the analysis of the naturally occurring peptidome （mW 〈 4000） as a source of biomarkers has been reported for different diseases （Villanueva et al., 2006; Ling et al., 2010a, 2010b, 2010c, 2011）. mass spectrometry-based profiling of naturally occurring peptides can provide an extensive in- ventory of serum peptides derived from either high-abundant endogenous circulating proteins or cell and tissue proteins （Liotta and Petricoin, 2006）.

关键词： Serological Targeted Analysis of an ITIH4 Peptide Isoform A Preterm Birth Biomarker and Its Associated SNP Implications SNP

Evolving technologies for growing,imaging and analyzing 3D root system architecture of crop plants

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Journal of Integrative Plant Biology 2016年第3期58卷 230-241页

作者： miguel A.Pieros Brandon G.Larson Jon E.Shaff David J.Schneider Alexandre Xavier Falcao Lixing Yuan Randy T.Clark Eric J.Craft Tyler W.Davis Pierre-Luc Pradier Nathanael m.shaw Ithipong Assaranurak Susan R.mc Couch Craig Sturrock malcolm Bennett Leon V.Kochian USDA-ARS Robert Holley Center for Agriculture and Health538 Tower RoadIthacaNY 14580USA Department of Information Systems Institute of ComputingUniversity of CampinasAv.Albert Einstein1251CEP 13083-852CampinasSPBrazil Department of Plant Nutrition China Agricultural UniversityBeijing 100193China Department of Plant Breeding and Genetics Cornell UniversityIthacaNY 14853USA Centre for Plant Integrative Biology School of BiosciencesUniversity of NottinghamSutton BoningtonLE12 5RDUK College of Science King Saud UniversityRiyadh 11451Kingdom of Saudi Arabia

A plant＇s ability to maintain or improve its yield under limiting conditions,such as nutrient de ficiency or drought,can be strongly in fluenced by root system architecture（RSA）,the three-dimensional distribution of the different root types in the soil. The ability to image,track and quantify these root system attributes in a dynamic fashion is a useful tool in assessing desirable genetic and physiological root traits. Recent advances in imaging technology and phenotyping software have resulted in substantive progress in describing and quantifying RSA. We have designed a hydroponic growth system which retains the three-dimensional RSA of the plant root system,while allowing for aeration,solution replenishment and the imposition of nutrient treatments,as well as high-quality imaging of the root system. The simplicity and flexibility of the system allows for modi fications tailored to the RSA of different crop species and improved throughput. This paper details the recent improvements and innovations in our root growth and imaging system which allows for greater image sensitivity（detection of fine roots and other root details）,higher ef ficiency,and a broad array of growing conditions for plants that more closely mimic those found under field conditions.

关键词： Abiotic stress digital root phenotyping mineral nutrition root system architecture

低剂量CT对肾结石的评估:从2011—2012年至2015—2016年尚无进展

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国际医学放射学杂志 2018年第2期 228-229页

作者： K.Weisenthal P.Karthik m.shaw D.Sengupta m.Bhargavan-Chatfeld J.Burleson 孔庆倩 Department of Emergency medicine Yale School of Medicine

摘要目的为确定与2011—2012年相比,2015—2016年使用低剂量CT对肾结石的评估是否增加,根据该适应证的设备确定辐射暴露的变异性,并且通过查询国家剂量注册

关键词：肾结石低剂量 CT

SARS-CoV-2 triggers Dickkopf-1(Dkk-1)modulation of T helper cells and lung pathology in mice

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Genes & Diseases 2024年第4期11卷 9-12页

作者： Yifan Wu Freedom m.Green Stephen A.shaw Lauren J.Bonilla Shannon E.Ronca maria Elena Bottazzi Farrah Kheradmand Jill E.Weatherhead Department of Pathology&Immunology One Baylor PlazaHoustonTX 77030USA Department of Pediatrics One Baylor PlazaHoustonTX 77030USA Department of medicine One Baylor PlazaHoustonTX 77030USA National School of Tropical medicine One Baylor PlazaHoustonTX 77030USA molecular Virology&microbiology One Baylor PlazaHoustonTX77030USA Biologyof Inflammation Center Baylor College of MedicineOne BaylorPlazaHoustonTX77030USA michael E.DeBakey VA Center for Translational Research on Inflammatory Diseases HoustonTX 77030USA

Severe acute respiratory syndrome coronavirus 2(SARSCov-2)is the etiologic agent of the coronavirus disease 19(COVID-19)*** viral infections like SARS-CoV-2,a robust anti-viral type 1 immune response,including upregulation of type 1 CD4+T helper cells(Th1),is required for effective viral clearance while minimizing end-organ pathology and collateral tissue damage.

关键词： pathology acute respiratory

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肥胖妇女有孕育神经管缺陷胎儿的危险

四川解剖学杂志 2002年第1期10卷 61-61页

作者： Gary m.shaw Ellen m.Velie. Donna Schaffer 吴波第三军医大学组胚教研室

为了研究肥胖对妇女孕育神经管缺陷(Neural tube defect NTD)胎儿的危险性,我们对加利福亚地区肥胖妇女孕育NTD胎儿的情况进行了一次大样本调查.从调查结果发现,肥胖妇女孕育NTD胎儿的危险性要高于正常体重的妇女.其中,尤以孕育脊柱裂(S... 详细信息

为了研究肥胖对妇女孕育神经管缺陷(Neural tube defect NTD)胎儿的危险性,我们对加利福亚地区肥胖妇女孕育NTD胎儿的情况进行了一次大样本调查.从调查结果发现,肥胖妇女孕育NTD胎儿的危险性要高于正常体重的妇女.其中,尤以孕育脊柱裂(Spina bifida)、颅脊柱裂(Craniorachishisis)和露脑(Iniencephaly)畸形胎儿的危险性更大.即使考虑其他各种可能的影响因素,如叶酸摄取、糖尿病、减肥药使用、年龄、教育、饮酒等也未能改变上述分析结果.

关键词：肥胖女性孕育神经管缺陷胎儿畸形

Female Infertility and Obesity across the United States—A Geographic Cross-Sectional Analysis

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Advances in Reproductive Sciences 2024年第3期12卷 179-189页

作者： Raegan Abadie Emily m. Dantes Jennifer H. shaw Dani Zoorob Health Sciences Center in Shreveport Louisiana State University Shreveport LA USA Department of Biomedical Sciences Philadelphia College of Osteopathic Medicine South Georgia Moultrie GA USA Health Sciences Center in Shreveport Department of Obstetrics and Gynecology Louisiana State University Shreveport LA USA

This cross-sectional study investigates a connection between female infertility and obesity across various regions of the United States, utilizing data from the NIH’s “All of Us” Researcher Workbench. Analysis suggested that the Southern region exhibited the highest percentage of concurrently infertile and obese females at 32.3%, in contrast to the lowest in the Western region at 28.7%. The findings underscore the significant regional disparities in obesity-related infertility, particularly in medically underserved areas where healthcare access is limited. The study highlights the urgent need for targeted public health interventions, particularly in the Southern United States, to address the rising prevalence of obesity and its impact on infertility. Further, these results advocate for enhanced public health education and policies aimed at improving healthcare accessibility, with the goal of mitigating the adverse effects of obesity on reproductive health.

关键词： Female Infertility medical Deserts Obesity South

母亲暴露于常规空气污染物与后代的先天性心脏缺陷:来自全国出生缺陷预防研究的结果

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环境与职业医学 2014年第12期31卷 929-929页

作者： Jeanette A.Stingone Thomas J.Luben Julie L.Daniels montserrat Fuentes David B.Richardson Arthur S.Aylsworth Amy H.Herring marlene Anderka Lorenzo Botto Adolfo Correa Suzanne m.Gilboa Peter H.Langlois Bridget mosley Gary m.shaw Csaba Siffel Andrew F.Olshan National Birth Defects Prevention Study

[背景]流行病学文献表明,空气污染物暴露与胎儿的发育相关联。[目的]探讨产妇在妊娠2-8周期间的空气污染物暴露及其与先天性心脏缺陷的关联。[方法]此项出生缺陷预防研究是一项由9个州参加的病例对照研究。给参加这项研究的妊娠妇女分配... 详细信息

[背景]流行病学文献表明,空气污染物暴露与胎儿的发育相关联。[目的]探讨产妇在妊娠2-8周期间的空气污染物暴露及其与先天性心脏缺陷的关联。[方法]此项出生缺陷预防研究是一项由9个州参加的病例对照研究。给参加这项研究的妊娠妇女分配1周和7周里一氧化碳、二氧化氮、臭氧、二氧化硫的每日最高浓度平均值,以及细颗粒物和粗颗粒物的24 h测量值,采用的方法是在妊娠早期收集这些妇女住所50 km内最接近的空气监测点的测量值。根据不同的污染物,最多4 632例活产对照和3 328例活产、死胎或流产病例有空气污染暴露的数据。应用分层回归模型,并以产妇的人口统计学、烟草和酒精使用情况进行调整。对于多污染物共同暴露的情况,则采用主成分分析来评估这些关联。[结果]二氧化氮暴露与主动脉缩窄及肺动脉瓣狭窄之间存在正性关联。细颗粒物暴露与左室发育不良心脏综合征呈正性相关,但与房间隔缺损呈负性相关。检测个体的暴露周数表明,使用7周的平均水平未观察到污染物与缺陷之间的关联。多污染物分析的结果支持左室流出道阻塞与二氧化氮之间、左室发育不良心脏综合征与颗粒物之间存在关联,尽管在最高的暴露水平时估计值是下降的。[结论]采用每日最高污染物水平探讨个体暴露周数揭示了某些污染物与心脏缺陷之间存在一些正向关联,并且提示在妊娠期间存在潜在的敏感性窗口期。

关键词：先天性心脏缺陷空气污染物出生缺陷预防母亲暴露病例对照研究心脏综合征细颗粒物后代

The BRICS and Beyond： Insights into Human Development/Security from ＂Global Governance＂？

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Fudan Journal of the Humanities and Social Sciences 2014年第3期7卷 381-394页

作者： Timothy m. shaw mcCormack Graduate School University of Massachusetts Boston 100 Morrissey BoulevardBoston MA 02125-3393 USA

The decade of the BRICS is leading to the reanalysis of global relations, encouraged by the simultaneous rise of emerging markets and decline of the eurozone PIIGS. But is the trajectory towards global reorder and/or disorder？ Development like capitalisms and regionalisms is increasingly diverse： heterogeneous transnational networks best approached through a global studies frame？ Together these factors impact the balance between developmental and fragile states in African as elsewhere. And there are debates about what is emerging： companies？ econo- mies？ states？ and/or societies？ meanwhile, the ＂global＂ increasingly includes informal and illegal economies, especially TOC, including transnational Chinese mafias. Transnational governance continues to widen its scope to include airline and container alliances as well as a trio of commissions on drugs.

关键词： BRICS Development Global governance Regionalisms. Transnational

Analysis on variety and characteristics of maghemite

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Science China Earth Sciences 2010年第8期53卷 1153-1162页

作者： shaw John BLOEmENDAL Jan HESSE Paul ROLPH Tim Department of Earth Sciences University of Liverpool Department of Geography University of Liverpool Department of Environment and Geography Macquarie University Department of Geology University of Newcastle

maghemite (γ-Fe2O3) is a very common mineral at the earth’s surface and also an important material for making music and video tapes. maghemite is usually synthesized from magnetite under oxidizing conditions after a few hours or a few days below a temperature of 300°C. The magnetic property of thermal instability and the chemical action after heating is an important character for maghemite. That is, it will become hematite in certain proportion after being heated above 250°C. maghemite is therefore actually unable to have its Curie temperature measured. But late using synthetic sample, maghemite was further found partially thermal stable with a measurable Curie temperature ~645°C. During our thermally magnetic experiments for a set of synthetic magnetite, we found that extra fined grain size (pseudo single domain (PSD) and small multi-domain (mD), mainly 1-10 μm) magnetite was formed to a completely thermally stable maghemite. This maghemite can also be produced by heating the same powder up to 700°C in an oven and keeping this temperature for 10 min, then cooling it down. When the generated maghemite by these two ways is heated from room temperature to 700°C, it shows almost fully reversible, or thermally stable. We used X-ray powder diffraction and mssbauer spectroscopy to confirm the identity of this maghemite and compared its magnetic hysteresis, high temperature magnetization, low temperature thermal demagnetization, and low temperature susceptibility with those of the original preheated magnetite. Such quickly oxidized maghemite by heating to high temperature implies some types of maghemite formed in certain natural condition can carry a thermal remnant magnetization (TRm). Four types of maghemite were characterized and discussed according to their thermal stability. Among them, partially stable and fully thermally stable maghemite after heating should possess capability of carrying TRm. There is possibly a compensation of synthetizing maghemite between heatin

关键词： maghemite paleomagnetism environmental magnetism magnetic mineral thermal stability TRm