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脑性瘫痪早产儿伸展运动中姿势控制的运动学特征

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世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 61-61页

作者： Van Der Heide J.C. Fock J.m. Otten B. m. Hadders-Algra 虎小毅 Universit y Hospital Groningen Developmental Neurology Hanzeplein 1 9713 GZ Groningen Netherlands Dr.

The relationships between kinematic characteristics of sitting posture during reaching movements of the dominant arm and 1)the kinematics of the reaching move ment itself and 2) functional performance during daily life activities (PEDI) we re assessed in 51 sitting preterm children with cerebral palsy (CP). The childre n were 2-11 y, 33 had spastic hemiplegia (sh) and 18 bilateral CP (Bi-CP). The data were compared with those of 26 typically developing children (TD). Sitting posture before the onset of reaching of children with CP differed from that of TD children: they sat with a more reclined pelvis and a more collapsed trunk. Th e more reclined pelvic position was associated with a better quality of reaching movements. The different sitting postures of pelvis and trunk were not related to functional performance during daily life activities. Displacement of the head , trunk, and pelvis of the children with CP did not differ from that of the TD c hildren. Nevertheless, in the children with CP a more stable head, a more mobile trunk, and a more stable pelvis were related to better functional performance a nd/or a better quality of reaching. This suggests that physiotherapeutic guidanc e of children with CP should focus rather on the latter postural parameters than on the different sitting posture of pelvis and trunk.

关键词：脑性瘫痪伸展运动运动学特征痉挛性偏瘫臂运动数据资料双侧性

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海南三亚河红树凋落物产量与季节变化研究

生态学报 2003年第10期23卷 1977-1983页

作者：张乔民陈永福中国科学院南海海洋研究所与广州地球化学研究所边缘海地质重点实验室广州510301 中国科学院海南热带海洋生物实验站海南三亚572000

在海南三亚河红树 (Rhizophora apiculata)纯林区设置 4个 1 m2 凋落物收集网于 1 999年全年逐旬收集 ,4个网的平均年凋落物总产量为 1 388.2 4 g/ (m2· a) ,其中叶 79.9% ,枝 8.8% ,花 6.4% ,果 4.9%。与国内外有关资料对比 ,三亚河... 详细信息

在海南三亚河红树 (Rhizophora apiculata)纯林区设置 4个 1 m2 凋落物收集网于 1 999年全年逐旬收集 ,4个网的平均年凋落物总产量为 1 388.2 4 g/ (m2· a) ,其中叶 79.9% ,枝 8.8% ,花 6.4% ,果 4.9%。与国内外有关资料对比 ,三亚河红树纯林凋落物产量是很高的 ,主要与树较高、低纬度、河流型和林带窄有关。凋落物总产量有多峰值的季节变化 ,峰月依次为 1 0～ 1 1月份、4月份和 8月份 ,谷月依次为 1 2月份、5月份和 9月份。叶的产量的峰谷变化与总产量相一致。枝的产量 77%的网次为 0 ,仅 2、8、9、1 0、1 1月份形成 5个峰值 ,其中后两个最大的峰值对总产量峰值的贡献达占 31 .7%和 31 .2 %。花的产量在 3～ 5月份略显平坦的峰值 ,8～ 1 2月份维持较低的产量。果的产量在 6～ 7月份有一个较宽的峰 ,1 0和 1 1月份有两个窄峰 ,1 2月份至来年 4月份基本上没有产量。花和果的凋落物产量变化明显与植物物候期有关。取 1 999年逐旬平均气温、降水量和平均风速资料与相应的凋落物产量进行相关分析显示 ,平均气温宏观控制叶凋落物产量和凋落物总产量 ,枝凋落物产量主要受平均风速影响。估算整个三亚河 1 4 hm2 红树林区可年产凋落物1 9 4t。

关键词：红树林凋落物红树(Rhizophora apiculata) 海南三亚

基于SOX9的生物学研究及其在肝癌干细胞中的研究进展

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中国临床医学 2016年第6期23卷 838-840页

作者：王孟超黄罡周伟平第二军医大学东方肝胆外科医院肝外三科上海200433

肿瘤干细胞是指在肿瘤组织中高度恶性的细胞亚群,具有高侵袭性、易转移性、多耐药性特点,与肿瘤复发密切相关。因此,肿瘤干细胞可能成为未来肿瘤治疗的靶点。目前发现的肿瘤干细胞标志物包括CD133、CD90、CD44等。SOX9(sex determining ... 详细信息

肿瘤干细胞是指在肿瘤组织中高度恶性的细胞亚群,具有高侵袭性、易转移性、多耐药性特点,与肿瘤复发密切相关。因此,肿瘤干细胞可能成为未来肿瘤治疗的靶点。目前发现的肿瘤干细胞标志物包括CD133、CD90、CD44等。SOX9(sex determining region Y box-9)除了参与多个器官的生长发育外,还与组织纤维化及肿瘤的发生有着密切关系,尤其在多种肿瘤干细胞中高表达。SOX9亦在肝癌干细胞中高表达,并通过相关信号通路影响肝癌干细胞的自我更新、增殖以及耐药,因此成为肝癌潜在的预后判断指标和治疗靶点。

关键词：肿瘤干细胞肝细胞肝癌 SOX9

基质金属蛋白酶9抑制高侵袭性HSC-3口腔鳞状细胞癌细胞的运动能力

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中国口腔颌面外科杂志 2019年第2期17卷 111-111页

作者： V?yrynen O ?str?m P Nyberg P 赵泽亮不详

基质金属蛋白酶(mmP)9的促肿瘤活性与许多癌症有关,但最近还阐明了 mmP9的肿瘤抑制作用。关于该主题的多方面证据,促使我们检查mmP9在口腔舌鳞状细胞癌(OTSCC)细胞中的作用。使用明胶酶特异性抑制剂、C1T2和短发夹(sh)RNA基因沉默,研究m... 详细信息

基质金属蛋白酶(mmP)9的促肿瘤活性与许多癌症有关,但最近还阐明了 mmP9的肿瘤抑制作用。关于该主题的多方面证据,促使我们检查mmP9在口腔舌鳞状细胞癌(OTSCC)细胞中的作用。使用明胶酶特异性抑制剂、C1T2和短发夹(sh)RNA基因沉默,研究mmP9对侵袭性OTSCC细胞系HSC-3的增殖、运动和侵袭的影响。

关键词：基质金属蛋白酶9 舌鳞状细胞癌运动能力侵袭性癌细胞口腔肿瘤抑制作用 mmP9

分离结晶和部分熔融过程中 F 的估算方程式

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地球与环境 1988年第2期 32-32页

作者： W.E.Bardsley ,R.m.Briggs ,杨合群西安地质矿产研究所

一个众所周知的部分熔融方程式已由sh-aw（1970）和Arth（1976）给出:（CL/C_o）i=[Ai+FBi]-1（1）式中 Ai=sum from r-1 to m Kriρr,Bi=1-∑Κriωr。上式成立的条件是液相和残余固相保持平衡状态。参数Co是第i种微量元素在固相中的... 详细信息

一个众所周知的部分熔融方程式已由sh-aw（1970）和Arth（1976）给出:（CL/C_o）i=[Ai+FBi]-1（1）式中 Ai=sum from r-1 to m Kriρr,Bi=1-∑Κriωr。上式成立的条件是液相和残余固相保持平衡状态。参数Co是第i种微量元素在固相中的初始浓度,CL是微量元素在液相中的浓度,ρr是第r种固相的初始重量份数,ωr是熔融期间第r种相所贡献的液相份数,F是熔融的份数。Κri值是第i种微量元素和第r种矿物的固相-液相分配系数。m是所涉及的矿物数。

关键词：方程式微量元素固相矿物方程痕量元素线性函数分离结晶部分熔融

1例日本白点状视网膜炎患者的RLBP1基因新突变

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 23-23页

作者： Nakamura m. Ito Y. miyake Y. 杨秀梅 Department of Ophthalmol ogy Nagoya University Graduate School of Medicine 65 Tsuruma-cho Showa-ku Nagoya 466-8550 Japan Dr.

PURPOSE: To report a novel mutation in the RLBP1 gene and optical coherence to mographic findings in a Japanese patient with retinitis punctata albescens. DESI GN: Observational case report. mETHODS: The RLBP1 gene was analyzed by direct ge nomic sequencing. A complete ophthalmologic examination was performed. RESULTS: Compound heterozygous mutations in the RLBP1 gene were identified in the patient . The mutations were a novel missense Arg103Trp mutation and a missense Arg234Tr p mutation, the causative mutation of Bothnia dystrophy. The patient’s fundi sh owed numerouswhite dots with diffuse retinalmottling and bilateralmacular degene ration. Her visual function deteriorated progressively during 12-year follow-u p. Optical coherence tomography demonstrated decreased retinal thickness, especi ally the photoreceptor layer. CONCLUSION: A novel mutation in RLBP1 gene was fou nd in a Japanese patient with retinitis punctata albescens. Degenerative changes of the outer retina were detected by optical coherence tomography.

关键词：视网膜炎 RLBP1 光感受器视网膜外层眼部检查黄斑变性视功能杂合突变精氨酸观察性

使用生物瓣膜和机械瓣膜行主动脉瓣置换术后患者的生活质量

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世界核心医学期刊文摘（心脏病学分册） 2005年第1期1卷 60-60页

作者： Sedrakyan A. Hebert P. Vaccarino V. H.m. Krumholz 孟欣 Div. of Hlth. P lcy. and Admin. Dept. of Epidemiol. and Pub. Health Yale University School of Medicine New Haven CT United StatesDr.

Objectives We sought to determine whether changes in quality of life at 18 mon ths following aortic valve replacement differ depending on the use of tissue val ves or mechanical valves. methods We prospectively studied 73 patients with tiss ue valve replacements and 53 patients with mechanical valve replacements perform ed from April 1998 through march 1999 at Yale-New Haven Hospital. Quality of li fe was measured at baseline and at 18 months using the medical Outcomes Trust sh ort Form 36-Item Health Survey. Results Baseline unadjusted mean quality-of-l ife scores were lower in tissue valve recipients than in mechanical valve recipi ents and, for both groups, were generally lower than US population norms. At 18 months postoperatively, quality-of-life scores were greatly improved in both g roups and were comparable to population norms (ie, within one-half a standard d eviation). After adjusting for baseline quality of life, age, and other prognost ic factors in an analysis of covariance, improvements in quality-of-life score s for tissue valve recipients versus mechanical valve recipients were similar. O f 10(8 domains and 2 summary) scales examined, the only significant difference b etween the 2 groups was for the improvement in role limitations due to physical problems (Role Physical), which was more favorable in patients with mechanical v alve implants (P=.04). Conclusions The use of tissue valve implants versus mecha nical valve implants has little influence on improvement in quality of life at 1 8 months following aortic valve replacement. Thus, decisions about whether to ch oose a tissue valve or mechanical valve implant should depend upon other factors such as rates of complications and differences in the life span of the implants .

关键词：主动脉瓣置换术机械瓣膜生物瓣膜瓣膜置换生活质量医疗效果接受者美国人口身体原因协变量

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362例家族性先兆偏头痛患者的临床特点

世界核心医学期刊文摘（神经病学分册） 2005年第2期1卷 11-11页

作者： Eriksen m.K. Thomsen L.L. Andersen I. 黄卫东 University of Copenhagen Department of Neurology Glostrup University Hospital Nordre Ringvej 57 DK 2600 Glostrup Denmark Dr.

The objectives of the present study were to describe the clinical characterist ics of patients with severe familial non hemiplegic migraine with aura (NHmA) a nd to compare these data to those from cases in previous population based Danis h studies using the same methodology. NHmA families were recruited from the Dani sh patient registry and from Danish neurology practices. A total of 362 NHmA pat ients were diagnosed according to the 1988 International Headache Society criter ia using a validated semistructured physician conducted interview. Visual aura occurred in almost every NHmA attack. In aura without headache visual aura occur red primarily in isolation. Aura without headache was most common in older, male patients. Several clinical characteristics of familial NHmA differed from migra ine with aura in the general population: firstly, the age at onset was lower, se condly, the age at cessation was higher, thirdly, aura symptoms were more severe and finally, the cooccurrence of migraine without aura was higher in familial N HmA. There seems to be a correlation between more severe symptoms and familial a ggregation. These results have both clinical and scientific implications.

关键词：偏头痛患者先兆症状族性视觉先兆国际头痛协会家族聚集性就诊过程半固定式神经病学研究机构

4种T1成像序列mOLLI、shmOLLI、SAshA和SAPPHIRE准确性、精确性及可重复性的头对头对比研究

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国际医学放射学杂志 2014年第6期 573-573页

作者： S.Roujol S.Weingrtner m.Foppa K.Chow K.Kawaji R.Nezafat 杜明珊 Department of medicine(Cardiovascular Division) Beth Israel Deaconess Medical Center and Harvard Medical School300 Brookline AveBostonMA 02215

摘要目的就4种常用心肌T1mapping序列(mOLLI、sh mOLLI、SAshA、SAPPHIRE)的准确性、精确性及可重复性进行比较。材料与方法本研究遵从HIPAA,并通过伦理委员会批准。受试者均签署知情同意书。首先在体外,利用人体体

关键词：可重复性 SAshA SAPPHIRE mOLLI